CY2476B1 - Benzonaphthyridines as bronchial therapeutics. - Google Patents

Benzonaphthyridines as bronchial therapeutics.

Info

Publication number
CY2476B1
CY2476B1 CY0400068A CY0400068A CY2476B1 CY 2476 B1 CY2476 B1 CY 2476B1 CY 0400068 A CY0400068 A CY 0400068A CY 0400068 A CY0400068 A CY 0400068A CY 2476 B1 CY2476 B1 CY 2476B1
Authority
CY
Cyprus
Prior art keywords
pct
benzonaphthyridines
bronchial therapeutics
date
sec
Prior art date
Application number
CY0400068A
Other languages
English (en)
Inventor
Beate Gutterer
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Thomas Baer
Armin Hatzelmann
Karl Sanders
Rolf Beume
Hildegard Boss
Dietrich Haefner
Hans-Peter Kley
Karl-Josef Goebel
Dieter Flockerzi
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of CY2476B1 publication Critical patent/CY2476B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY0400068A 1996-11-11 2004-09-03 Benzonaphthyridines as bronchial therapeutics. CY2476B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05

Publications (1)

Publication Number Publication Date
CY2476B1 true CY2476B1 (en) 2005-05-03

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0400068A CY2476B1 (en) 1996-11-11 2004-09-03 Benzonaphthyridines as bronchial therapeutics.

Country Status (31)

Country Link
US (1) US6008215A (xx)
EP (1) EP0937074B1 (xx)
JP (1) JP4223075B2 (xx)
KR (1) KR100484045B1 (xx)
CN (1) CN1090188C (xx)
AT (1) ATE234300T1 (xx)
AU (1) AU733129B2 (xx)
BG (1) BG63695B1 (xx)
BR (1) BR9713338B1 (xx)
CA (1) CA2270964C (xx)
CY (1) CY2476B1 (xx)
CZ (1) CZ288752B6 (xx)
DE (1) DE69719778T2 (xx)
DK (1) DK0937074T3 (xx)
EA (1) EA001551B1 (xx)
EE (1) EE03829B1 (xx)
ES (1) ES2195189T3 (xx)
GE (1) GEP20012390B (xx)
HK (1) HK1022151A1 (xx)
HU (1) HU226981B1 (xx)
ID (1) ID22042A (xx)
IL (1) IL129054A (xx)
NO (1) NO312764B1 (xx)
NZ (1) NZ334976A (xx)
PL (1) PL189641B1 (xx)
PT (1) PT937074E (xx)
RS (1) RS49607B (xx)
SI (1) SI0937074T1 (xx)
SK (1) SK283269B6 (xx)
TR (1) TR199900856T2 (xx)
WO (1) WO1998021208A1 (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1075477B1 (de) 1998-05-05 2003-03-12 ALTANA Pharma AG Neue Benzonaphtyridin-N-oxide
JP2002523505A (ja) 1998-08-31 2002-07-30 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
DE60033918D1 (de) * 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
BR0007527B1 (pt) * 1999-01-15 2011-12-27 fenilfenantridinas com atividade inibitària de pde-iv, seu uso, bem como medicamento compreendendo as mesmas.
ES2241571T3 (es) 1999-01-15 2005-11-01 Altana Pharma Ag N-oxidos de fenantrinida con actividad inhividora de pde-iv.
AU2107700A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity
HU229439B1 (hu) * 1999-08-21 2013-12-30 Takeda Gmbh Roflumilast és salmeterol szinergetikus kombinációja
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
PT1377574E (pt) 2001-02-21 2005-05-31 Byk Gulden Lomberg Chem Fab 6-fenilbenzonaftiridinas
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
WO2004018465A2 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Benzonaphthyridines with pde 3/4 inhibiting activity
JP4638736B2 (ja) * 2002-09-04 2011-02-23 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のベンゾナフチリジン
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
SG182194A1 (en) 2004-03-03 2012-07-30 Nycomed Gmbh Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors
BRPI0508481A (pt) * 2004-03-10 2007-07-31 Altana Pharma Ag hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4
CA2559200A1 (en) 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
AU2005281703B2 (en) * 2004-09-08 2011-11-17 Takeda Gmbh Novel 3-thia-10-aza-phenanthrene derivatives
WO2006027344A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
DK1856093T3 (da) 2005-03-02 2010-03-15 Nycomed Gmbh (2R,4aR,10bR)-6-(2,6-dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol, HCI-salt
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
DK2061765T3 (en) * 2006-09-01 2015-01-26 Senhwa Biosciences Inc Serine-threonine protein kinase AND PARP-MODULATOR
WO2009132136A1 (en) 2008-04-23 2009-10-29 Rigel Pharmaceuticals, Inc. Carboxamide compounds for the treatment of metabolic disorders
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
IL129054A (en) 2002-07-25
NO992282L (no) 1999-05-11
IL129054A0 (en) 2000-02-17
EA199900421A1 (ru) 1999-10-28
DK0937074T3 (da) 2003-06-23
ID22042A (id) 1999-08-26
HUP0000426A2 (hu) 2001-02-28
AU5317098A (en) 1998-06-03
ES2195189T3 (es) 2003-12-01
DE69719778T2 (de) 2004-02-05
SK283269B6 (sk) 2003-04-01
CN1090188C (zh) 2002-09-04
EA001551B1 (ru) 2001-04-23
CZ288752B6 (cs) 2001-08-15
CA2270964C (en) 2007-07-31
EE9900105A (et) 1999-10-15
SK62399A3 (en) 1999-10-08
SI0937074T1 (en) 2003-08-31
PT937074E (pt) 2003-07-31
NO312764B1 (no) 2002-07-01
HUP0000426A3 (en) 2001-04-28
BG63695B1 (bg) 2002-09-30
BR9713338A (pt) 2000-05-09
PL189641B1 (pl) 2005-09-30
ATE234300T1 (de) 2003-03-15
AU733129B2 (en) 2001-05-10
DE69719778D1 (de) 2003-04-17
HU226981B1 (hu) 2010-04-28
HK1022151A1 (en) 2000-07-28
JP4223075B2 (ja) 2009-02-12
CA2270964A1 (en) 1998-05-22
NO992282D0 (no) 1999-05-11
KR100484045B1 (ko) 2005-04-20
GEP20012390B (en) 2001-03-25
BR9713338B1 (pt) 2009-12-01
EP0937074A1 (en) 1999-08-25
JP2001503442A (ja) 2001-03-13
NZ334976A (en) 2000-10-27
PL333429A1 (en) 1999-12-06
US6008215A (en) 1999-12-28
RS49607B (sr) 2007-06-04
CZ167599A3 (cs) 1999-11-17
EP0937074B1 (en) 2003-03-12
CN1236367A (zh) 1999-11-24
WO1998021208A1 (en) 1998-05-22
TR199900856T2 (xx) 1999-07-21
KR20000053100A (ko) 2000-08-25
BG103310A (en) 2000-05-31
YU19499A (sh) 2001-09-28
EE03829B1 (et) 2002-08-15

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