IT1303272B1 - Derivati triciclici inibitori della fosfodiesterasi 4 - Google Patents

Derivati triciclici inibitori della fosfodiesterasi 4

Info

Publication number
IT1303272B1
IT1303272B1 IT1998MI002319A ITMI982319A IT1303272B1 IT 1303272 B1 IT1303272 B1 IT 1303272B1 IT 1998MI002319 A IT1998MI002319 A IT 1998MI002319A IT MI982319 A ITMI982319 A IT MI982319A IT 1303272 B1 IT1303272 B1 IT 1303272B1
Authority
IT
Italy
Prior art keywords
optionally substituted
group
optionally
alkyl
hydroxy
Prior art date
Application number
IT1998MI002319A
Other languages
English (en)
Inventor
Mauro Napoletano
Gabriele Norcini
Franco Pellacini
Gabriele Morazzoni
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI982319A0 publication Critical patent/ITMI982319A0/it
Priority to IT1998MI002319A priority Critical patent/IT1303272B1/it
Priority to DE69919192T priority patent/DE69919192D1/de
Priority to US09/830,679 priority patent/US6525055B1/en
Priority to AU63324/99A priority patent/AU766129B2/en
Priority to EP99950599A priority patent/EP1124829B1/en
Priority to IL14171999A priority patent/IL141719A0/xx
Priority to CA002345337A priority patent/CA2345337A1/en
Priority to PCT/EP1999/007304 priority patent/WO2000026218A1/en
Priority to JP2000579606A priority patent/JP2002528549A/ja
Priority to AT99950599T priority patent/ATE272638T1/de
Publication of ITMI982319A1 publication Critical patent/ITMI982319A1/it
Application granted granted Critical
Publication of IT1303272B1 publication Critical patent/IT1303272B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT1998MI002319A 1998-10-29 1998-10-29 Derivati triciclici inibitori della fosfodiesterasi 4 IT1303272B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT1998MI002319A IT1303272B1 (it) 1998-10-29 1998-10-29 Derivati triciclici inibitori della fosfodiesterasi 4
EP99950599A EP1124829B1 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
US09/830,679 US6525055B1 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
AU63324/99A AU766129B2 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
DE69919192T DE69919192D1 (de) 1998-10-29 1999-10-01 Trizyklische phthalazin-derivate als phosphodiesterase 4 inhibitoren
IL14171999A IL141719A0 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
CA002345337A CA2345337A1 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
PCT/EP1999/007304 WO2000026218A1 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
JP2000579606A JP2002528549A (ja) 1998-10-29 1999-10-01 ホスホジエステラーゼ４阻害剤としての三環性フタラジン誘導体
AT99950599T ATE272638T1 (de) 1998-10-29 1999-10-01 Trizyklische phthalazin-derivate als phosphodiesterase 4 inhibitoren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002319A IT1303272B1 (it) 1998-10-29 1998-10-29 Derivati triciclici inibitori della fosfodiesterasi 4

Publications (3)

Publication Number Publication Date
ITMI982319A0 ITMI982319A0 (it) 1998-10-29
ITMI982319A1 ITMI982319A1 (it) 2000-04-29
IT1303272B1 true IT1303272B1 (it) 2000-11-06

Family

ID=11380959

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI002319A IT1303272B1 (it) 1998-10-29 1998-10-29 Derivati triciclici inibitori della fosfodiesterasi 4

Country Status (10)

Country Link
US (1) US6525055B1 (it)
EP (1) EP1124829B1 (it)
JP (1) JP2002528549A (it)
AT (1) ATE272638T1 (it)
AU (1) AU766129B2 (it)
CA (1) CA2345337A1 (it)
DE (1) DE69919192D1 (it)
IL (1) IL141719A0 (it)
IT (1) IT1303272B1 (it)
WO (1) WO2000026218A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224316A1 (en) 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
ATE524471T1 (de) 2002-11-06 2011-09-15 Aska Pharm Co Ltd Pyrazolonaphthyridinderivat
ES2291729T7 (es) * 2003-01-09 2010-03-31 Astellas Pharma Inc. Derivados de pirrolopiridazina.
AU2005279221C9 (en) * 2004-09-02 2012-08-23 Takeda Gmbh Triazolophthalazines
DE602005027866D1 (de) * 2004-09-08 2011-06-16 Nycomed Gmbh 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4-inhibitoren
JP4960870B2 (ja) * 2004-09-08 2012-06-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−チア−１０−アザ−フェナントレン誘導体
US8106047B2 (en) * 2005-01-05 2012-01-31 Nycomed Gmbh Triazolophthalazines
ES2397082T3 (es) * 2005-01-05 2013-03-04 Nycomed Gmbh Triazoloftalazinas como inhibidores de PDE2
ES2412481T3 (es) 2006-05-19 2013-07-11 Dart Neuroscience Llc Inhibidores de la fosfodiesterasa 4 para la rehabilitación motora
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
RU2009141592A (ru) * 2007-04-11 2011-05-20 Алькон Рисерч, Лтд. (Us) ПРИМЕНЕНИЕ ИНГИБИТОРА TNFα В СОЧЕТАНИИ С АНТИГИСТАМИННЫМ СРЕДСТВОМ ДЛЯ ЛЕЧЕНИЯ АЛЛЕРГИЧЕСКОГО РИНИТА И АЛЛЕРГИЧЕСКОГО КОНЪЮНКТИВИТА
WO2011041640A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
GB2575490A (en) * 2018-07-12 2020-01-15 Recordati Ind Chimica E Farmaceutica Spa P2X3 receptor antagonists
KR20210110623A (ko) 2018-12-28 2021-09-08 리제너론 파마슈티칼스 인코포레이티드 아라키도네이트15-리폭시게나제 (alox15) 억제제를 사용하는 호흡기 장애의 치료

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3704300A (en) * 1971-04-09 1972-11-28 Sandoz Ag Imidazo(2,1-a)phthalazines
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
JP3245165B2 (ja) * 1991-10-09 2002-01-07 シンテックス（ユー・エス・エイ）・インコーポレイテッド ピリドピリダジノンおよびピリダジンチオン化合物
TW211013B (it) 1991-12-27 1993-08-11 Takeda Pharm Industry Co Ltd
EP0620224B1 (en) 1993-04-12 1998-07-15 Takeda Chemical Industries, Ltd. Triazolopyridazine derivatives, their production and use
ES2224130T3 (es) * 1994-08-09 2005-03-01 Eisai Co., Ltd. Compuesto de piridazina condensada.
DE19617862A1 (de) 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
YU2899A (sh) * 1996-07-25 2000-03-21 Merck Sharp & Dohme Limited Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore
NZ333354A (en) 1996-08-20 2000-05-26 Eisai Co Ltd Fused pyridazine compounds for erectile dysfunction
CN1090188C (zh) 1996-11-11 2002-09-04 比克·古尔顿·劳姆贝尔格化学公司 新的苯并萘啶类化合物
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
IT1296984B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4

Also Published As

Publication number Publication date
JP2002528549A (ja) 2002-09-03
ITMI982319A1 (it) 2000-04-29
AU6332499A (en) 2000-05-22
ATE272638T1 (de) 2004-08-15
IL141719A0 (en) 2002-03-10
CA2345337A1 (en) 2000-05-11
WO2000026218A1 (en) 2000-05-11
EP1124829B1 (en) 2004-08-04
US6525055B1 (en) 2003-02-25
DE69919192D1 (de) 2004-09-09
ITMI982319A0 (it) 1998-10-29
AU766129B2 (en) 2003-10-09
EP1124829A1 (en) 2001-08-22

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