CR20210042A - RECEPTORES DE ANTÍGENOS QUIMÉRICOS DIRIGIDOS A BCMA Y MÉTODOS DE USO DE ESTOS (Divisional 2019-0050) - Google Patents

RECEPTORES DE ANTÍGENOS QUIMÉRICOS DIRIGIDOS A BCMA Y MÉTODOS DE USO DE ESTOS (Divisional 2019-0050)

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Publication number
CR20210042A
CR20210042A CR20210042A CR20210042A CR20210042A CR 20210042 A CR20210042 A CR 20210042A CR 20210042 A CR20210042 A CR 20210042A CR 20210042 A CR20210042 A CR 20210042A CR 20210042 A CR20210042 A CR 20210042A
Authority
CR
Costa Rica
Prior art keywords
chimeric antigen
antigen receptors
methods
bcma
car
Prior art date
Application number
CR20210042A
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English (en)
Inventor
Jiaying Hao
Xiaohu Fan
Dan Zhao
Xian He
Lei Yang
Pingyan Wang
Qiuchuan Zhuang
Lin Wang
Original Assignee
Legend Biotech Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Legend Biotech Usa Inc filed Critical Legend Biotech Usa Inc
Publication of CR20210042A publication Critical patent/CR20210042A/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
    • A61K2239/29—Multispecific CARs
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Abstract

<p>La presente solicitud proporciona anticuerpos de dominio simple dirigidos a BCMA, y receptores de antígenos quiméricos (tal como CAR monovalente, y CAR multivalente que incluye CAR biepitópico) que comprende uno o más anticuerpos de dominio simple anti-BCMA. También se proporcionan células efectoras inmunitarias modificadas genéticamente (tales como linfocitos T) que comprenden los receptores de antígenos quiméricos. También se proporcionan composiciones farmacéuticas, kits y métodos para tratar el cáncer.</p>
CR20210042A 2015-08-11 2017-08-10 RECEPTORES DE ANTÍGENOS QUIMÉRICOS DIRIGIDOS A BCMA Y MÉTODOS DE USO DE ESTOS (Divisional 2019-0050) CR20210042A (es)

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