CN109464313A - A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence - Google Patents
A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention relates to a kind of preparation method of external preparation for skin Essence and biology cellulose diaphragms, the material liquid of Essence is made first, material liquid is placed in vacuum homogeneous agitated kettle after carrying out vacuum homogeneous and obtains the discharging of time processing program, catalyzing enzyme is added in the discharging of time processing program, is placed among ultra high pressure treatment device after carrying out super-pressure catalysis and obtains the discharging of secondary operation program；The discharging of secondary operation program is added in high pressure homogenizer after progress is high-pressure homogeneous and obtains external preparation for skin Essence；Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biology cellulose diaphragm be made.After the present invention is handled via ultra high pressure treatment device, Essence can rapid osmotic enter among corneocyte, play its own ingredient maximum effect, moisturizing and moist effect are reinforced；In addition, being further processed by high pressure homogenizer, makes dressing entirety partial size become smaller, is easier to be absorbed by keratoderma.
Description
Technical field
The invention belongs to facial mask preparation technical fields, concretely relate to a kind of preparation method of external preparation for skin Essence
And biology cellulose diaphragm.
Background technique
Skin is the maximum organ of human body, divides epidermis, corium and subcutaneous tissue.Wherein, skin epidermis is from outside to inside again
Cuticula, hyaline layer, stratum granulosum, stratum aculeatum and basal layer can be divided into.Skin epidermis outermost layer is cuticula, basal layer of epidermis point
Born cell can be shifted onto below cuticula after 14 days by the constantly mitogenetic cell come out, then gradually keratinization, become
Dead cuticula, then then fell off naturally through 14 days, cutin ingredient is mainly protein derivatives.Cuticula itself can absorb water
Point, but it is compact because arranging, it can prevent moisture from entering and seek to prevent moisture from evaporating with evolution epidermis, so-called moisture-keeping functions,
And cuticula is allowed to possess humidity and pliability appropriate.Due to institute in the water suction of cuticula itself, barrier function and cuticula
The effect of the natural moisture preserving factor i.e. amino acids, lactate and the carbohydrate that contain etc. makes cuticula be able to maintain certain water content,
Maintain the wet of skin.And the appearance of skin is related with the moisture content of cuticula, normal keratoderma usually contains
10%~30% moisture, to maintain the softness and elasticity of skin.But with advancing age, keratoderma water holding capacity meeting
It gradually decreases, and the moisture content of cuticula is caused to gradually decrease, and when the moisture content of keratoderma is lower than 10%, skin
Skin just will appear dry, tight, coarse and furfur etc..Therefore, moisturizing is the main demand of maintenance cosmetics.
Facial mask is common cosmetology cosmetics, and skin care is using the of short duration time for being covered on face, temporarily
When the extraneous air of isolation and pollution, improve skin temperature, the pore expansion of skin promotes sweat gland secretion and metabolism, makes
The oxygen content of skin rises, and is conducive to skin and excludes the product of epidermal cell metabolism and the oil substances of accumulation, facial mask
In moisture penetrate into the cuticula of epidermis, skin becomes soft, and light is flexible naturally for skin.In existing facial mask packaging,
Essence impregnates face paper (deposited material), and face paper makes the facial effective component that can absorb Essence when being covered on face.
However, existing Essence, is typically vacuumized mulser production by traditional and obtain, emulsified partial size and stop mostly
Time nanometer is stayed in, equipment specially treated is not passed through, the active matter in formula can only rest on cutin layer surface, can not play it
Effect；In addition, the deposited material of existing nonwoven fabric belongs to artificial synthesized fiber, it is inevitable in its woven fabric production bleaching process
Ground can be added hydrogen peroxide and be bleached, and fluorescent whitening agent is added, and easily cause the reaction containing fluorescer, and cause skin
The phenomenon that allergy, long-time service causes skin damage, and its is conformable general, is also easy to produce the situation that deposited material liquid is killed and fallen off
Occur.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation method of external preparation for skin Essence and biology cellulose diaphragm, via
Vacuum homogeneous, extra-high tension unit and high pressure homogenizer step process, so that Essence entirety partial size tends to nanoscale, more preferably by skin
Skin cuticula is absorbed, and anti-oxidant and moist skin effect is reached, and cooperation biological cellulose membrane applies the use of material, can be processed
Composition efficacy exertion afterwards is to maximum efficiency.
In order to achieve the above object, the technical solution adopted by the present invention are as follows:
A kind of preparation method of external preparation for skin Essence, includes the following steps:
(1) material liquid of Essence is made first；
(2) material liquid is placed in vacuum homogeneous agitated kettle after carrying out vacuum homogeneous and obtains the discharging of time processing program；
(3) catalyzing enzyme is added in the discharging of time processing program, is placed in progress super-pressure catalysis among ultra high pressure treatment device
After obtain secondary operation program discharging；
(4) discharging of secondary operation program is added in high pressure homogenizer after progress is high-pressure homogeneous and obtains external preparation for skin Essence.
The present invention has sequentially carried out vacuum homogeneous (processing program for the first time), ultra high pressure treatment device catalysis (secondary operation journey
Sequence), high pressure homogenizer processing (processing program three times), after the present invention is handled via special ultra high pressure treatment device, combination
The oil-phase component of object, after contact angle becomes smaller, can rapid osmotic enter among corneocyte, play its own ingredient maximum work
Effect, moisturizing and moist effect are reinforced, and the addition of active constituent also can more effectively reduce ratio, property than tradition proportion in proportion
Valence is than high, in addition, being further processed by high pressure homogenizer, makes Essence entirety partial size become smaller, be easier to as keratoderma
It is absorbed.
Preferably, material liquid is prepared by following step in step (1):
(a) hydrolecithin and the moist composition of natural anti-oxidation is divided to be heated to 50~75 the oily phase composition of composition of raw materials
It DEG C is completely dissolved, it is spare as A phase；
(b) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 65~85 DEG C and are completely dissolved, spare as B phase；
(c) A phase is poured into B phase up to the material liquid of Essence.
Preferably, the concrete operations of step (2) are as follows: material liquid is placed in vacuum homogeneous agitated kettle, opens paddle
Piece, 400~800rpm of mixing speed, 2000~3000rpm of homogeneous speed unlatching are evacuated to 0.02~0.06Mpa, and homogeneous stirs
After mixing 5~15mins, continue to vacuumize stirring and be cooled to 35~55 DEG C, after letting out vacuum pressure, collargol is added, opens stirring speed
400~800rpm, homogeneous 2000~3000rpm of speed are spent, after homogeneous stirs 2~10mins, continues to vacuumize stirring being cooled to
25~45 DEG C, semi-finished product discharging filtering barrelling is up to the discharging of time processing program.
Preferably, the concrete operations of step (3) are as follows: bromelain is added in semi-finished product material, is packed into complex pocket together
In, it takes out in light bag and is sealed after air, complex pocket is put among ultra high pressure treatment device, is packed into medium in ultra high pressure treatment device
For water, cracking pressure control valve, and opening temperature regulating device, 30~45 DEG C of temperature control, adjustment pressure to 100~300Mpa, etc.
Static pressure starting, interior material accelerates ferment reaction, after holding time 0.5~1.5 hour, then adjusts pressure to 200~600Mpa,
Equal static pressure starting, interior material accelerate ferment reaction, relief valve are opened after holding time 4~6 hours, pointers is waited to be returned to normally
When 1 atmospheric pressure, complex pocket sealing is opened, and obtains the discharging of secondary operation program.
Preferably, the concrete operations of step (4) are as follows: the discharging of secondary operation program is fixed with 1~3ml/sec by peristaltic pump
Amount is added in high pressure homogenizer feeding inlet, circulator in cracking pressure control valve and temperature control, and Material pressure control range is 20~
180Mpa divides 3~5 addition feeding inlets, and loop temperature-control is in 1~8 DEG C in Material；It is translucent shape to Material appearance, viscosity control
System is completed in 50~80cps, is then discharged again by outer circulation impeller pump delivery of filtered to get external preparation for skin Essence.
Preferably, the natural anti-oxidation is moistened, composition is by secondary A Ganshu benevolence oil, cactus oil extract, avocado oil
Composition, wherein secondary A Ganshu benevolence oil, cactus oil extract, avocado oil weight ratio be 1~4:0.5~2:1.Secondary A Ganshu
Benevolence oil, which originates from, gives Moroccan desert region, has the function of high moisturizing and repairs wound, is referred to as " desert Huang by locals
Gold "；Cactus oil extract, which originates from, is born in north African desert region, the special construction of growing environment, keeps its root in depth lower deep
Place, to ensure that moisture needs of growing up, the oil that seed extracts have the function of to permeate skin, play long-acting moist effect；Crocodile
Pear oil has fatty acid abundant and vitamin A. D. E, itself has been also equipped with the grease that can be absorbed through epidermis, has natural
It is anti-oxidant with the function of repairing, in addition, its grease can also cause epidermal protein to thicken epidermis and form complete cuticula.Through
After being handled by ultra high pressure treatment device, the additive amount of composition is under very low dosage, it can reaches good effect.
Preferably, the weight percent of each raw material are as follows: butanediol 3.0~5.0%, diglycerol 1.0~3.0%, hydrogenation
Lecithin 1.0~2.0%, secondary A Ganshu benevolence oil 1.0~2.0%, cactus oil extract 0.5~1.0%, avocado oil 0.5~
1.0%, Sodium Hyaluronate 0.3~0.5%, allantoin 0.15~0.25%, dipotassium glycyrrhizinate 0.15~0.25%, collargol
0.1~0.2%, EDETATE SODIUM 0.1~0.2%, bromelain 0.05~0.1%, surplus are deionized water.
The phase that the component or other patents that other are mature on the market are disclosed also can be selected in each raw material composition of the present invention
Answer component.
Preferably, the natural anti-oxidation is moistened, the weight percent of composition is 2.6%.
Preferably, the preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 65 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 75 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into and obtains the material liquid of Essence in B phase, material liquid is placed in fixation type vacuum homogeneous agitated kettle
Interior, unlatching is fixed to vacuumize homogeneous stirring blade, and mixing speed 600rpm, homogeneous speed 2500rpm unlatching are evacuated to
0.04Mpa after homogeneous stirs 10mins, continues to vacuumize stirring and is cooled to 45 DEG C, after letting out vacuum pressure, collargol is added, opens
Opening mixing speed 600rpm, homogeneous speed 2500rpm after homogeneous stirs 5mins, continues to vacuumize stirring being cooled to 35 DEG C, and half
Finished product discharging filtering barrelling, obtains the discharging of time processing program, spare；
(4) bromelain is added in the discharging of time processing program, is fitted into complex pocket together, take out close after air in light bag
Envelope, complex pocket is put among ultra high pressure treatment device, and it is water, cracking pressure control that medium is packed into ultra high pressure treatment device
Valve, and opening temperature regulating device, adjust pressure to 200Mpa, wait static pressure to start, it is anti-that interior material accelerates ferment by 37 DEG C of temperature control
It answers, after holding time 1 hour, then adjusts pressure to 400Mpa, static pressure is waited to start, interior material accelerates ferment reaction, when maintenance
Between open relief valve after 5 hours, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing open, obtain secondary operation program
Discharging, it is spare；
(5) secondary operation program discharging is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 2ml/sec, is opened
Circulator in pressure-control valve and temperature control, Material pressure control 100Mpa, point 4 addition feeding inlets, and loop temperature-control is in 3 in Material
~5 DEG C；It is translucent shape to Material appearance, viscosity control is completed in 65cps, is then conveyed again by outer circulation impeller pump
Material is filtered out to get a kind of external preparation for skin Essence.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane and applied on material by a kind of biology cellulose diaphragm, thus
Biology cellulose diaphragm is made.
The beneficial effects of the present invention are:
(1) present invention is prepared by vacuum homogeneous, super-pressure catalysis and high-pressure homogeneous processing three times, the Essence antioxygen
Change it is significant with moist performance, in addition via secondary ultra-high pressure apparatus processing program, secondary A Ganshu benevolence oil, cactus oil extract,
The oil droplets tension of avocado fluid composition can generate variation, and composition oil droplet can become smaller through HIGH PRESSURE TREATMENT rear surface tension, by
Macromolecular is converted into small molecule, and oil droplet viscosity reduces, and so that droplets contact angle is also become smaller, the penetration relative to skin can also become
By force, the effect for moistening moisturizing is also better；
(2) the content of present invention object when ultra high pressure treatment, be killed by the strain almost all in formula, therefore, prevents
The content of rotten agent can be reduced greatly, reduce the stimulation for skin, the content of composition is also because of the processing of super-pressure program
Later, the content that composition uses can be substantially reduced, with not comparing by ultra high pressure treatment, effectively reduces system
Product cost improves the cost performance of product；
(3) via processing program three times, material in Essence is placed again into high pressure homogenizer processing, by Essence entirety grain
Diameter is converted into nanoscale, more can effectively make among formula it is anti-oxidant penetrate into moist active constituent corneocyte it
In, play its own ingredient maximum effect.
(4) it selects biological cellulose membrane to apply material material and applies material better than general nonwoven fabric, with elasticity is good, toughness is strong, docile
Property it is good, be close to skin, make active constituent penetrate into skin cuticula, not will cause the advantages that allergic conditions, safety is available
Effective guarantee.
Specific embodiment
The present invention is further explained in the light of specific embodiments, but invention which is intended to be protected is not limited to
This.
Embodiment 1
The weight percent of each raw material forms are as follows: butanediol 4.0%, diglycerol 2.0%, hydrolecithin 1.5%, secondary Ah
It is sweet tree benevolence oil 1.2%, cactus oil extract 0.7%, avocado oil 0.7%, Sodium Hyaluronate 0.4%, allantoin 0.20%, sweet
Oxalic acid dipotassium 0.2%, collargol 0.15%, EDETATE SODIUM 0.15%, bromelain 0.07%, surplus are deionized water.
The preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 65 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 75 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into and obtains the material liquid of Essence in B phase, material liquid is placed in fixation type vacuum homogeneous agitated kettle
Interior, unlatching is fixed to vacuumize homogeneous stirring blade, and mixing speed 600rpm, homogeneous speed 2500rpm unlatching are evacuated to
0.04Mpa after homogeneous stirs 10mins, continues to vacuumize stirring and is cooled to 45 DEG C, after letting out vacuum pressure, collargol is added, opens
Opening mixing speed 600rpm, homogeneous speed 2500rpm after homogeneous stirs 5mins, continues to vacuumize stirring being cooled to 35 DEG C, and half
Finished product discharging filtering barrelling, obtains the discharging of time processing program, spare；
(4) bromelain is added in the discharging of time processing program, is fitted into complex pocket together, take out close after air in light bag
Envelope, complex pocket is put among ultra high pressure treatment device, and it is water, cracking pressure control that medium is packed into ultra high pressure treatment device
Valve, and opening temperature regulating device, adjust pressure to 200Mpa, wait static pressure to start, it is anti-that interior material accelerates ferment by 37 DEG C of temperature control
It answers, after holding time 1 hour, then adjusts pressure to 400Mpa, static pressure is waited to start, interior material accelerates ferment reaction, when maintenance
Between open relief valve after 5 hours, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing open, obtain secondary operation program
Discharging, it is spare；
(5) secondary operation program discharging is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 2ml/sec, is opened
Circulator in pressure-control valve and temperature control, Material pressure control 100Mpa, point 4 addition feeding inlets, and loop temperature-control is in 3 in Material
~5 DEG C；It is translucent shape to Material appearance, viscosity control is completed in 65cps, is then conveyed again by outer circulation impeller pump
Material is filtered out to get external preparation for skin Essence.
The droplet measurement of final product: Malvern laser particle analyzer detection data is utilized, laser particle analyzer test result is such as
Shown in table 1:
Table 1
| Run (number) | Angle (angle) | KCps value | ZAve (average z value) |
| 1 | 90 | 254 | 129.4 |
| 2 | 90 | 255.1 | 117.6 |
| 3 | 90 | 254.8 | 115.3 |
| Average average value | 254.6 | 120.8 | |
| +/- | 0.6 | 7.6 |
From 1 data of table: the average fineness of microemulsified external preparation for skin Essence provided by the invention is 120.8nm；Just
Minus deviation is 7.6nm.
To in the penetration evaluation item of skin and hair, often using surface tension and wettability as test index.Generally
In cognition, if being just easy to moisten if surface tension becomes smaller, that is, the penetration of skin and hair can also be improved by representing.It will moisten
Degree uses the contact angle that can be widely applied to all ranges as mark index, and the contact angle smaller also the easy to be wet
Profit.
It is measured using contact angle of the contact angle measuring appliance to external preparation for skin Essence, the contact of Essence of the present invention
Angle reaches 17.2 °, and is 27.3 ° without the product contact angle of the high-pressure homogeneous processing of super-pressure catalyst and can be confirmed that the present invention is right
The penetration of skin is obviously improved, with preferable penetration.
To understand using effect of the invention, extensive examination has been carried out to external preparation for skin Essence in the form of questionnaire survey
With investigation, 860 people of men and women trier in all parts of the country is included in this investigation altogether, wherein 160 people of male, 700 people of women, and the oldest 52
It is year, 25 years old minimum, average age 38 years old or so, 680 parts of effective questionnaire was withdrawn altogether.
680 triers are using external preparation for skin Essence of the present invention to relevant indices degree self-assessment after 56 days
Result it is as follows:
Increase skin moistnes: thering is 76.2% and 86.8% trier to there is moderate to improve and be obviously improved respectively；
It promotes skin glow: thering is 75.3% and 82.4% trier to there is moderate to improve and be obviously improved respectively；
Weaken skin lines degree: thering is 62.4% and 77.8% trier to there is moderate to improve and be obviously improved respectively；
It is glossy to skin moistnes, promotion skin is increased to can be seen that the product from the result of the self-assessment of trier
Degree, decrease skin lines degree have different degrees of significantly improve.
According to as the result is shown: external preparation for skin Essence best composition ratio of the present invention cooperation extra-high tension unit with it is high-pressure homogeneous
Machine aided nano preparation method can achieve good anti-oxidant moist effect.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biological cellulose membrane be made
Piece.Biological cellulose membrane, which applies material, can purchase material mature on the market, can also use Chinese patent CN201710505913,
Preparation method disclosed in CN201810618623, CN201810976359 etc. and be made.It is microorganism that biological cellulose membrane, which applies material,
The product of fermentation can substitute artificial skin in medical field and use, good to cutaneous safety, moreover, its conformable ratio is not knitted
The deposited material substrate of cloth is more preferable, is not likely to produce the situation that deposited material liquid is killed and fallen off and occurs.
Embodiment 2
The weight percent of each raw material forms are as follows: butanediol 3.0%, diglycerol 1.5%, hydrolecithin 1.0%, secondary Ah
It is sweet tree benevolence oil 1.0%, cactus oil extract 1.0%, avocado oil 1.0%, Sodium Hyaluronate 0.3%, allantoin 0.15%, sweet
Oxalic acid dipotassium 0.15%, collargol 0.1%, EDETATE SODIUM 0.1%, bromelain 0.05%, surplus are deionized water.
The preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 65 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 75 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into B phase and is located in fixation type vacuum homogeneous agitated kettle, opened the fixed homogeneous that vacuumizes and stir
Blade, mixing speed 600rpm, homogeneous speed 2500rpm unlatching are evacuated to 0.04Mpa, after homogeneous stirs 10mins, continue
It vacuumizes stirring and is cooled to 45 DEG C, after letting out vacuum pressure, collargol is added, open mixing speed 600rpm, homogeneous speed
2500rpm after homogeneous stirs 5mins, continues to vacuumize stirring and is cooled to 35 DEG C, semi-finished product discharging filtering barrelling is spare；
(4) bromelain is added in semi-finished product material, is fitted into complex pocket together, takes out in light bag and is sealed after air, will be answered
It closes bag to be put among ultra high pressure treatment device, it is water, cracking pressure control valve, and opening that medium is packed into ultra high pressure treatment device
Temperature-adjusting device, 37 DEG C of temperature control, adjustment pressure waits static pressure to start to 200Mpa, and interior material accelerates ferment reaction, when maintenance
Between after 1 hour, then adjust pressure to 400Mpa, wait static pressure to start, interior material accelerates ferment reaction, after holding time 5 hours
Relief valve is opened, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing is opened spare；
(5) Material is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 2ml/sec in complex pocket, cracking pressure
Circulator in control valve and temperature control, Material pressure control 100Mpa, point 4 addition feeding inlets, and loop temperature-control is in 3~5 in Material
℃；It is translucent shape to Material appearance, viscosity control is completed in 65cps, then passes through outer circulation impeller pump delivery of filtered again
Discharging is to get external preparation for skin Essence.
The droplet measurement of final product: Malvern laser particle analyzer detection data is utilized, laser particle analyzer, which is tested, to be sent out
The average fineness of the microemulsified Essence of bright offer is 145.3nm.
It is measured using contact angle of the contact angle measuring appliance to external preparation for skin Essence, the contact of Essence of the present invention
Angle reaches 19.1 °, and is 28.6 ° without the product contact angle of the high-pressure homogeneous processing of super-pressure catalyst and can be confirmed that the present invention is right
The penetration of skin is obviously improved, with preferable penetration.
To understand using effect of the invention, extensive investigation on probation has been carried out to this product in the form of questionnaire survey,
860 people of men and women trier in all parts of the country is included in this investigation altogether, wherein 160 people of male, 700 people of women, the oldest 52 years old, minimum
25 years old, average age 38 years old or so, 680 parts of effective questionnaire was withdrawn altogether.
680 triers are using external preparation for skin Essence of the present invention to relevant indices degree self-assessment after 56 days
Result it is as follows:
Increase skin moistnes: thering is 73.1% and 82.2% trier to there is moderate to improve and be obviously improved respectively；
It promotes skin glow: thering is 72.1% and 80.1% trier to there is moderate to improve and be obviously improved respectively；
Weaken skin lines degree: thering is 60.2% and 70.6% trier to there is moderate to improve and be obviously improved respectively；
It is glossy to skin moistnes, promotion skin is increased to can be seen that the product from the result of the self-assessment of trier
Degree, decrease skin lines degree have different degrees of significantly improve.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biological cellulose membrane be made
Piece.Biological cellulose membrane, which applies material, can purchase material mature on the market, can also use Chinese patent CN201710505913,
Preparation method disclosed in CN201810618623, CN201810976359 etc. and be made.It is microorganism that biological cellulose membrane, which applies material,
The product of fermentation can substitute artificial skin in medical field and use, good to cutaneous safety, moreover, its conformable ratio is not knitted
The deposited material substrate of cloth is more preferable, is not likely to produce the situation that deposited material liquid is killed and fallen off and occurs.
Embodiment 3
The weight percent of each raw material forms are as follows: butanediol 5.0%, diglycerol 2.5%, hydrolecithin 1.8%, secondary Ah
It is sweet tree benevolence oil 1.8%, cactus oil extract 0.8%, avocado oil 0.8%, Sodium Hyaluronate 0.4%, allantoin 0.2%, sweet
Oxalic acid dipotassium 0.2%, collargol 0.15%, EDETATE SODIUM 0.15%, bromelain 0.08%, surplus are deionized water.
The preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 65 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 75 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into B phase and is located in fixation type vacuum homogeneous agitated kettle, opened the fixed homogeneous that vacuumizes and stir
Blade, mixing speed 600rpm, homogeneous speed 2500rpm unlatching are evacuated to 0.04Mpa, after homogeneous stirs 10mins, continue
It vacuumizes stirring and is cooled to 45 DEG C, after letting out vacuum pressure, collargol is added, open mixing speed 600rpm, homogeneous speed
2500rpm after homogeneous stirs 5mins, continues to vacuumize stirring and is cooled to 35 DEG C, semi-finished product discharging filtering barrelling is spare；
(4) bromelain is added in semi-finished product material, is fitted into complex pocket together, takes out in light bag and is sealed after air, will be answered
It closes bag to be put among ultra high pressure treatment device, it is water, cracking pressure control valve, and opening that medium is packed into ultra high pressure treatment device
Temperature-adjusting device, 37 DEG C of temperature control, adjustment pressure waits static pressure to start to 200Mpa, and interior material accelerates ferment reaction, when maintenance
Between after 1 hour, then adjust pressure to 400Mpa, wait static pressure to start, interior material accelerates ferment reaction, after holding time 5 hours
Relief valve is opened, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing is opened spare；
(5) Material is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 2ml/sec in complex pocket, cracking pressure
Circulator in control valve and temperature control, Material pressure control 100Mpa, point 4 addition feeding inlets, and loop temperature-control is in 3~5 in Material
℃；It is translucent shape to Material appearance, viscosity control is completed in 65cps, then passes through outer circulation impeller pump delivery of filtered again
Discharging is to get external preparation for skin Essence.
The droplet measurement of final product: Malvern laser particle analyzer detection data is utilized, laser particle analyzer, which is tested, to be sent out
The average fineness of the microemulsified Essence of bright offer is 136.8nm.
It is measured using contact angle of the contact angle measuring appliance to external preparation for skin Essence, the contact of Essence of the present invention
Angle reaches 18.4 °, and is 27.8 ° without the product contact angle of the high-pressure homogeneous processing of super-pressure catalyst and can be confirmed that the present invention is right
The penetration of skin is obviously improved, with preferable penetration.
To understand using effect of the invention, extensive investigation on probation has been carried out to this product in the form of questionnaire survey,
860 people of men and women trier in all parts of the country is included in this investigation altogether, wherein 160 people of male, 700 people of women, the oldest 52 years old, minimum
25 years old, average age 38 years old or so, 680 parts of effective questionnaire was withdrawn altogether.
680 triers are using external preparation for skin Essence of the present invention to relevant indices degree self-assessment after 56 days
Result it is as follows:
Increase skin moistnes: thering is 74.2% and 84.2% trier to there is moderate to improve and be obviously improved respectively；
It promotes skin glow: thering is 73.5% and 81.6% trier to there is moderate to improve and be obviously improved respectively；
Weaken skin lines degree: thering is 61.3% and 74.9% trier to there is moderate to improve and be obviously improved respectively；
It is glossy to skin moistnes, promotion skin is increased to can be seen that the product from the result of the self-assessment of trier
Degree, decrease skin lines degree have different degrees of significantly improve.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biological cellulose membrane be made
Piece.Biological cellulose membrane, which applies material, can purchase material mature on the market, can also use Chinese patent CN201710505913,
Preparation method disclosed in CN201810618623, CN201810976359 etc. and be made.It is microorganism that biological cellulose membrane, which applies material,
The product of fermentation can substitute artificial skin in medical field and use, good to cutaneous safety, moreover, its conformable ratio is not knitted
The deposited material substrate of cloth is more preferable, is not likely to produce the situation that deposited material liquid is killed and fallen off and occurs.
Embodiment 4
The weight percent of each raw material forms are as follows: butanediol 4.0%, diglycerol 2.0%, hydrolecithin 1.5%, secondary Ah
It is sweet tree benevolence oil 1.2%, cactus oil extract 0.7%, avocado oil 0.7%, Sodium Hyaluronate 0.4%, allantoin 0.20%, sweet
Oxalic acid dipotassium 0.2%, collargol 0.15%, EDETATE SODIUM 0.15%, bromelain 0.07%, surplus are deionized water.
The preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 50 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 65 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into B phase and is located in fixation type vacuum homogeneous agitated kettle, opened the fixed homogeneous that vacuumizes and stir
Blade, mixing speed 400rpm, homogeneous speed 2000rpm unlatching are evacuated to 0.02Mpa and continue to take out after homogeneous stirs 5mins
Vacuum stirring is cooled to 35 DEG C, after letting out vacuum pressure, and collargol is added, and opens mixing speed 400rpm, homogeneous speed
2000rpm after homogeneous stirs 2mins, continues to vacuumize stirring and is cooled to 25 DEG C, semi-finished product discharging filtering barrelling is spare；
(4) bromelain is added in semi-finished product material, is fitted into complex pocket together, takes out in light bag and is sealed after air, will be answered
It closes bag to be put among ultra high pressure treatment device, it is water, cracking pressure control valve, and opening that medium is packed into ultra high pressure treatment device
Temperature-adjusting device, 30 DEG C of temperature control, adjustment pressure waits static pressure to start to 100Mpa, and interior material accelerates ferment reaction, when maintenance
Between after 1.5 hours, then adjust pressure to 200Mpa, wait static pressure to start, interior material accelerates ferment reaction, holds time 6 hours
After open relief valve, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing open it is spare；
(5) Material is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 1ml/sec in complex pocket, cracking pressure
Circulator in control valve and temperature control, Material pressure control 20Mpa, point 5 addition feeding inlets, and loop temperature-control is in 5~7 in Material
℃；It is translucent shape to Material appearance, viscosity control is completed in 50cps, then passes through outer circulation impeller pump delivery of filtered again
Discharging is to get external preparation for skin Essence.
The droplet measurement of final product: Malvern laser particle analyzer detection data is utilized, laser particle analyzer, which is tested, to be sent out
The average fineness of the microemulsified Essence of bright offer is 192.3nm.
It is measured using contact angle of the contact angle measuring appliance to external preparation for skin Essence, the contact of Essence of the present invention
Angle reaches 20.1 °, can be confirmed that the present invention has preferable penetration to skin.
To understand using effect of the invention, extensive investigation on probation has been carried out to this product in the form of questionnaire survey,
860 people of men and women trier in all parts of the country is included in this investigation altogether, wherein 160 people of male, 700 people of women, the oldest 52 years old, minimum
25 years old, average age 38 years old or so, 680 parts of effective questionnaire was withdrawn altogether.
680 triers are using external preparation for skin Essence of the present invention to relevant indices degree self-assessment after 56 days
Result it is as follows:
Increase skin moistnes: thering is 70.1% and 80.2% trier to there is moderate to improve and be obviously improved respectively；
It promotes skin glow: thering is 70.2% and 80.1% trier to there is moderate to improve and be obviously improved respectively；
Weaken skin lines degree: thering is 60.2% and 70.1% trier to there is moderate to improve and be obviously improved respectively；
It is glossy to skin moistnes, promotion skin is increased to can be seen that the product from the result of the self-assessment of trier
Degree, decrease skin lines degree have different degrees of significantly improve.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biological cellulose membrane be made
Piece.Biological cellulose membrane, which applies material, can purchase material mature on the market, can also use Chinese patent CN201710505913,
Preparation method disclosed in CN201810618623, CN201810976359 etc. and be made.It is microorganism that biological cellulose membrane, which applies material,
The product of fermentation can substitute artificial skin in medical field and use, good to cutaneous safety, moreover, its conformable ratio is not knitted
The deposited material substrate of cloth is more preferable, is not likely to produce the situation that deposited material liquid is killed and fallen off and occurs.
Embodiment 5
The weight percent of each raw material forms are as follows: butanediol 4.0%, diglycerol 2.0%, hydrolecithin 1.5%, secondary Ah
It is sweet tree benevolence oil 1.2%, cactus oil extract 0.7%, avocado oil 0.7%, Sodium Hyaluronate 0.4%, allantoin 0.20%, sweet
Oxalic acid dipotassium 0.2%, collargol 0.15%, EDETATE SODIUM 0.15%, bromelain 0.07%, surplus are deionized water.
The preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 75 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 85 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into B phase and is located in fixation type vacuum homogeneous agitated kettle, opened the fixed homogeneous that vacuumizes and stir
Blade, mixing speed 800rpm, homogeneous speed 3000rpm unlatching are evacuated to 0.06Mpa, after homogeneous stirs 15mins, continue
It vacuumizes stirring and is cooled to 55 DEG C, after letting out vacuum pressure, collargol is added, open mixing speed 800rpm, homogeneous speed
3000rpm after homogeneous stirs 10mins, continues to vacuumize stirring and is cooled to 45 DEG C, semi-finished product discharging filtering barrelling is spare；
(4) bromelain is added in semi-finished product material, is fitted into complex pocket together, takes out in light bag and is sealed after air, will be answered
It closes bag to be put among ultra high pressure treatment device, it is water, cracking pressure control valve, and opening that medium is packed into ultra high pressure treatment device
Temperature-adjusting device, 45 DEG C of temperature control, adjustment pressure waits static pressure to start to 300Mpa, and interior material accelerates ferment reaction, when maintenance
Between after 0.5 hour, then adjust pressure to 600Mpa, wait static pressure to start, interior material accelerates ferment reaction, holds time 4 hours
After open relief valve, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing open it is spare；
(5) Material is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 3ml/sec in complex pocket, cracking pressure
Circulator in control valve and temperature control, Material pressure control 180Mpa, are added three times feeding inlet, loop temperature-control is in 1~3 in Material
℃；It is translucent shape to Material appearance, viscosity control is completed in 80cps, then passes through outer circulation impeller pump delivery of filtered again
Discharging is to get external preparation for skin Essence.
The droplet measurement of final product: Malvern laser particle analyzer detection data is utilized, laser particle analyzer, which is tested, to be sent out
The average fineness of the microemulsified Essence of bright offer is 187.6nm.
It is measured using contact angle of the contact angle measuring appliance to external preparation for skin Essence, the contact of Essence of the present invention
Angle reaches 19.6 °, can be confirmed that the present invention has preferable penetration to skin.
To understand using effect of the invention, extensive investigation on probation has been carried out to this product in the form of questionnaire survey,
860 people of men and women trier in all parts of the country is included in this investigation altogether, wherein 160 people of male, 700 people of women, the oldest 52 years old, minimum
25 years old, average age 38 years old or so, 680 parts of effective questionnaire was withdrawn altogether.
680 triers are using external preparation for skin Essence of the present invention to relevant indices degree self-assessment after 56 days
Result it is as follows:
Increase skin moistnes: thering is 71.3% and 81.1% trier to there is moderate to improve and be obviously improved respectively；
It promotes skin glow: thering is 70.9% and 81.2% trier to there is moderate to improve and be obviously improved respectively；
Weaken skin lines degree: thering is 61.1% and 71.2% trier to there is moderate to improve and be obviously improved respectively；
It is glossy to skin moistnes, promotion skin is increased to can be seen that the product from the result of the self-assessment of trier
Degree, decrease skin lines degree have different degrees of significantly improve.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biological cellulose membrane be made
Piece.Biological cellulose membrane, which applies material, can purchase material mature on the market, can also use Chinese patent CN201710505913,
Preparation method disclosed in CN201810618623, CN201810976359 etc. and be made.It is microorganism that biological cellulose membrane, which applies material,
The product of fermentation can substitute artificial skin in medical field and use, good to cutaneous safety, moreover, its conformable ratio is not knitted
The deposited material substrate of cloth is more preferable, is not likely to produce the situation that deposited material liquid is killed and fallen off and occurs.
Embodiment 6
The weight percent of each raw material forms are as follows: butanediol 4.0%, diglycerol 2.5%, hydrolecithin 1.5%, secondary Ah
It is sweet tree benevolence oil 1.5%, cactus oil extract 0.8%, avocado oil 0.9%, Sodium Hyaluronate 0.4%, allantoin 0.20%, sweet
Oxalic acid dipotassium 0.2%, collargol 0.15%, EDETATE SODIUM 0.15%, bromelain 0.06%, surplus are deionized water.
The preparation method of the external preparation for skin Essence, includes the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 60 DEG C it is complete
Fully dissolved, it is spare as A phase；
(2) by water phase group ingredient glycerol, butanediol, diglycerol, the Sodium Hyaluronate, allantoin, glycyrrhizic acid of composition of raw materials
Dipotassium, EDETATE SODIUM, deionized water are heated to 70 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into B phase and is located in fixation type vacuum homogeneous agitated kettle, opened the fixed homogeneous that vacuumizes and stir
Blade, mixing speed 500rpm, homogeneous speed 2200rpm unlatching are evacuated to 0.04Mpa, after homogeneous stirs 10mins, continue
It vacuumizes stirring and is cooled to 40 DEG C, after letting out vacuum pressure, collargol is added, open mixing speed 500rpm, homogeneous speed
2200rpm after homogeneous stirs 5mins, continues to vacuumize stirring and is cooled to 30 DEG C, semi-finished product discharging filtering barrelling is spare；
(4) bromelain is added in semi-finished product material, is fitted into complex pocket together, takes out in light bag and is sealed after air, will be answered
It closes bag to be put among ultra high pressure treatment device, it is water, cracking pressure control valve, and opening that medium is packed into ultra high pressure treatment device
Temperature-adjusting device, 35 DEG C of temperature control, adjustment pressure waits static pressure to start to 250Mpa, and interior material accelerates ferment reaction, when maintenance
Between after 1 hour, then adjust pressure to 450Mpa, wait static pressure to start, interior material accelerates ferment reaction, after holding time 5 hours
Relief valve is opened, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing is opened spare；
(5) Material is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 2.5ml/sec in complex pocket, opens pressure
Circulator in force control valve and temperature control, Material pressure control 120Mpa, point 4 addition feeding inlets, in Material loop temperature-control in 3~
5℃；It is translucent shape to Material appearance, viscosity control is completed in 60cps, then passes through outer circulation impeller pump delivery of filtered again
Discharging is to get external preparation for skin Essence.
The droplet measurement of final product: Malvern laser particle analyzer detection data is utilized, laser particle analyzer, which is tested, to be sent out
The average fineness of the microemulsified Essence of bright offer is 133.6nm.
It is measured using contact angle of the contact angle measuring appliance to external preparation for skin Essence, the contact of Essence of the present invention
Angle reaches 18.1 °, can be confirmed that the present invention has preferable penetration to skin.
To understand using effect of the invention, extensive investigation on probation has been carried out to this product in the form of questionnaire survey,
860 people of men and women trier in all parts of the country is included in this investigation altogether, wherein 160 people of male, 700 people of women, the oldest 52 years old, minimum
25 years old, average age 38 years old or so, 680 parts of effective questionnaire was withdrawn altogether.
680 triers are using external preparation for skin Essence of the present invention to relevant indices degree self-assessment after 56 days
Result it is as follows:
Increase skin moistnes: thering is 75.1% and 85.2% trier to there is moderate to improve and be obviously improved respectively；
It promotes skin glow: thering is 74.3% and 82.1% trier to there is moderate to improve and be obviously improved respectively；
Weaken skin lines degree: thering is 61.9% and 75.2% trier to there is moderate to improve and be obviously improved respectively；
It is glossy to skin moistnes, promotion skin is increased to can be seen that the product from the result of the self-assessment of trier
Degree, decrease skin lines degree have different degrees of significantly improve.
Above-mentioned external preparation for skin Essence is added to biological cellulose membrane to apply on material, so that biological cellulose membrane be made
Piece.Biological cellulose membrane, which applies material, can purchase material mature on the market, can also use Chinese patent CN201710505913,
Preparation method disclosed in CN201810618623, CN201810976359 etc. and be made.It is microorganism that biological cellulose membrane, which applies material,
The product of fermentation can substitute artificial skin in medical field and use, good to cutaneous safety, moreover, its conformable ratio is not knitted
The deposited material substrate of cloth is more preferable, is not likely to produce the situation that deposited material liquid is killed and fallen off and occurs.
Claims (10)
1. a kind of preparation method of external preparation for skin Essence, it is characterised in that include the following steps:
(1) material liquid of Essence is made first；
(2) material liquid is placed in vacuum homogeneous agitated kettle after carrying out vacuum homogeneous and obtains the discharging of time processing program；
(3) catalyzing enzyme is added in the discharging of time processing program, is placed among ultra high pressure treatment device after carrying out super-pressure catalysis and obtains
It discharges to secondary operation program；
(4) discharging of secondary operation program is added in high pressure homogenizer after progress is high-pressure homogeneous and obtains external preparation for skin Essence.
2. the preparation method of external preparation for skin Essence according to claim 1, it is characterised in that material liquid passes through in step (1)
Following step is prepared:
(a) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 50~75 DEG C it is complete
Fully dissolved, it is spare as A phase；
(b) by the water phase group ingredient glycerol of composition of raw materials, butanediol, diglycerol, Sodium Hyaluronate, allantoin, dipotassium glycyrrhizinate,
EDETATE SODIUM, deionized water are heated to 65~85 DEG C and are completely dissolved, spare as B phase；
(c) A phase is poured into B phase up to the material liquid of Essence.
3. the preparation method of external preparation for skin Essence according to claim 2, it is characterised in that the concrete operations of step (2)
Are as follows: material liquid is placed in vacuum homogeneous agitated kettle, stirring blade, 400~800rpm of mixing speed, homogeneous speed 2000 are opened
~3000rpm unlatching is evacuated to 0.02~0.06Mpa, after homogeneous stirs 5~15mins, continues to vacuumize stirring being cooled to 35
~55 DEG C, after letting out vacuum pressure, collargol is added, opens 400~800rpm of mixing speed, homogeneous 2000~3000rpm of speed,
After homogeneous stirs 2~10mins, continue to vacuumize stirring and be cooled to 25~45 DEG C, semi-finished product discharging filtering barrelling up to primary plus
The discharging of engineering sequence.
4. the preparation method of external preparation for skin Essence according to claim 3, it is characterised in that the concrete operations of step (3)
Are as follows: bromelain is added in semi-finished product material, is fitted into complex pocket together, takes out in light bag and is sealed after air, complex pocket is put into
It is that water, cracking pressure control valve, and opening temperature are adjusted that medium is packed among ultra high pressure treatment device, in ultra high pressure treatment device
Device, 30~45 DEG C of temperature control, adjustment pressure to 100~300Mpa waits static pressure to start, and interior material accelerates ferment reaction, maintains
After 0.5~1.5 hour time, then pressure is adjusted to 200~600Mpa, wait static pressure to start, interior material accelerates ferment reaction, dimension
Relief valve is opened after holding 4~6 hours time, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing is opened, and is obtained secondary
Processing program discharging.
5. the preparation method of external preparation for skin Essence according to claim 4, it is characterised in that the concrete operations of step (4)
Are as follows: the discharging of secondary operation program is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 1~3ml/sec, cracking pressure
Circulator in control valve and temperature control, Material pressure control range are 20~180Mpa, divide 3~5 addition feeding inlets, follow in Material
Ring temperature control is in 1~8 DEG C；It is translucent shape to Material appearance, viscosity control is completed in 50~80cps, then again by following outside
Rotor pumps delivery of filtered discharging to get external preparation for skin Essence.
6. the preparation method of external preparation for skin Essence according to claim 2, it is characterised in that: the natural anti-oxidation is moist
Composition is made of secondary A Ganshu benevolence oil, cactus oil extract, avocado oil, wherein secondary A Ganshu benevolence oil, cactus oil extract
Object, avocado oil weight ratio be 1~4:0.5~2:1.
7. the preparation method of external preparation for skin Essence according to claim 4, it is characterised in that: the weight percent of each raw material
Are as follows: butanediol 3.0~5.0%, diglycerol 1.0~3.0%, hydrolecithin 1.0~2.0%, secondary A Ganshu benevolence oil 1.0~
2.0%, cactus oil extract 0.5~1.0%, avocado oil 0.5~1.0%, Sodium Hyaluronate 0.3~0.5%, allantoin
0.15~0.25%, dipotassium glycyrrhizinate 0.15~0.25%, collargol 0.1~0.2%, EDETATE SODIUM 0.1~0.2%, pineapple
Proteinase-10 .05~0.1%, surplus are deionized water.
8. the preparation method of external preparation for skin Essence according to claim 3, it is characterised in that: the natural anti-oxidation is moist
The weight percent of composition is 2.6%.
9. the preparation method of external preparation for skin Essence according to claim 1, it is characterised in that include the following steps:
(1) by the oily phase composition of composition of raw materials divide hydrolecithin and natural anti-oxidation moisten composition be heated to 65 DEG C it is completely molten
Solution, it is spare as A phase；
(2) by the water phase group ingredient glycerol of composition of raw materials, butanediol, diglycerol, Sodium Hyaluronate, allantoin, dipotassium glycyrrhizinate,
EDETATE SODIUM, deionized water are heated to 75 DEG C and are completely dissolved, spare as B phase；
(3) A phase is poured into and obtains the material liquid of Essence in B phase, material liquid is placed in fixation type vacuum homogeneous agitated kettle, is opened
Open it is fixed vacuumize homogeneous stirring blade, mixing speed 600rpm, homogeneous speed 2500rpm unlatching are evacuated to 0.04Mpa,
After homogeneous stirs 10mins, continue to vacuumize stirring and be cooled to 45 DEG C, after letting out vacuum pressure, collargol is added, opens stirring speed
600rpm, homogeneous speed 2500rpm are spent, after homogeneous stirs 5mins, continues to vacuumize stirring and is cooled to 35 DEG C, semi-finished product discharging
Barrelling is filtered, the discharging of time processing program is obtained, it is spare；
(4) bromelain is added in the discharging of time processing program, is fitted into complex pocket together, takes out in light bag and sealed after air,
Complex pocket is put among ultra high pressure treatment device, in ultra high pressure treatment device be packed into medium be water, cracking pressure control valve, and
Opening temperature regulating device, 37 DEG C of temperature control, adjustment pressure to 200Mpa waits static pressure to start, and interior material accelerates ferment reaction, dimension
After holding 1 hour time, then pressure being adjusted to 400Mpa, static pressure being waited to start, interior material accelerates ferment reaction, holds time 5 small
When after open relief valve, when pointers being waited to be returned to normal 1 atmospheric pressure, complex pocket sealing open, obtain secondary operation program discharging,
It is spare；
(5) secondary operation program discharging is quantitatively adding in high pressure homogenizer feeding inlet by peristaltic pump with 2ml/sec, cracking pressure
Circulator in control valve and temperature control, Material pressure control 100Mpa, point 4 addition feeding inlets, and loop temperature-control is in 3~5 in Material
℃；It is translucent shape to Material appearance, viscosity control is completed in 65cps, then passes through outer circulation impeller pump delivery of filtered again
Discharging is to get external preparation for skin Essence.
10. a kind of biology cellulose diaphragm, it is characterised in that: the external preparation for skin Essence of claim 1 is added to biological fibre
It ties up plain film to apply on material, so that biology cellulose diaphragm be made.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910058275.3A CN109464313A (en) | 2019-01-22 | 2019-01-22 | A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence |
| TW108129745A TWI732272B (en) | 2019-01-22 | 2019-08-21 | Manufacturing method for an external skin used essence and a bio cellulose membrane comprising the said essence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910058275.3A CN109464313A (en) | 2019-01-22 | 2019-01-22 | A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence |
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Cited By (4)
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| CN110169940A (en) * | 2019-07-01 | 2019-08-27 | 广州市如馨化妆品有限公司 | A kind of Biofibre facial mask Essence having thin face function, preparation method and the facial mask using Essence preparation |
| CN112891296A (en) * | 2021-02-02 | 2021-06-04 | 杭州百芮生物科技有限公司 | Hair and scalp care micro-ecological composition and preparation method thereof |
| CN112920968A (en) * | 2021-02-02 | 2021-06-08 | 杭州百芮生物科技有限公司 | Probiotic composition and application and preparation method thereof |
| WO2022114784A1 (en) * | 2020-11-30 | 2022-06-02 | 엘리케이파크 주식회사 | Composition comprising fermentation product of cactus oil and use thereof for improving skin condition |
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| CN112891296A (en) * | 2021-02-02 | 2021-06-04 | 杭州百芮生物科技有限公司 | Hair and scalp care micro-ecological composition and preparation method thereof |
| CN112920968A (en) * | 2021-02-02 | 2021-06-08 | 杭州百芮生物科技有限公司 | Probiotic composition and application and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI732272B (en) | 2021-07-01 |
| TW202031238A (en) | 2020-09-01 |
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