CN112891296A - Hair and scalp care micro-ecological composition and preparation method thereof - Google Patents
Hair and scalp care micro-ecological composition and preparation method thereof Download PDFInfo
- Publication number
- CN112891296A CN112891296A CN202110143099.0A CN202110143099A CN112891296A CN 112891296 A CN112891296 A CN 112891296A CN 202110143099 A CN202110143099 A CN 202110143099A CN 112891296 A CN112891296 A CN 112891296A
- Authority
- CN
- China
- Prior art keywords
- stirring
- hair
- composition
- phase
- homogenizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a hair scalp care microecological composition and a preparation method thereof, wherein the composition comprises an aqueous phase composition and an active composition, and the active composition comprises the following components: yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, and hydrolyzed pea protein. The hair scalp nursing microecological composition is prepared by matching natural active components of the hair scalp nursing microecological composition with a special process, and can effectively prevent and solve the problems of dandruff and alopecia by balancing the number of scalp microecological bacteria and stimulating hair follicle cells to play a role.
Description
Technical Field
The invention belongs to the technical field of hair scalp care, and particularly relates to a hair scalp care microecological composition and a preparation method thereof.
Background
The hair grows from hair follicles of the scalp, and the hair follicles growing hair on the scalp have about 10-15 ten thousand hair follicles, so that the number of the hair of each normal person is 10-15 ten thousand hair, 2% of the hair naturally falls in the normal range in the hair follicle cell growth metabolic cycle, more than 2% of the hair naturally falls, namely more than 100 hair falls in the growth metabolic cycle, which is the disease of the hair loss, and belongs to an abnormal phenomenon, and the reason of the hair loss is not the factors of heredity and diseases, and the external research shows that most of the hair loss is caused by abnormal secretion of androgens of men and women, so the hair loss prevention agent plays the maximum effect on strengthening and stimulating the hair follicle cells and becomes one of the most effective ways for preventing the hair loss.
Dandruff is the exfoliative keratinocytes of the scalp. Normally, keratinocytes shed very little, slowly and are not seen significantly. However, under certain stimulation, the immature keratinocytes are produced in large quantity, agglomerated and fall off, and a phenomenon of 'snowflakes', which is commonly called scurf, is formed. Dandruff is the result of general skin dirt, i.e. the continuous peeling of the stratum corneum of the epidermis, and also as a result of metabolism, and is divided into physiological and pathological dandruff. Physiological dandruff is usually dry dandruff for adults, and bran-shaped, grey and white small phosphine flakes are scattered among hairs. The other is oily dandruff, the scalp and hair have a greasy, sticky and slippery feel, and crusts of varying thickness are attached to the scalp and hair, which is particularly common to young children. Pathological dandruff refers to inflammation of the scalp caused by bacterial infection, fungal infection, or other physical or chemical injury. The general symptoms are that excessive dandruff causes blockage of pores, which causes a weak hair state, bacteria easily proliferate, and skin is stimulated to generate itching.
The problem of dandruff caused by abnormal metabolism of scalp cutin, so-called seborrheic dermatitis, also occurs in the form of scaly red patches on both sides of the nasal wing, causing itching. With the increase of the working pressure of modern people, the generated scalp inflammation mechanism becomes more serious, so that how to restore the original microecological balance of the scalp and the normal keratinocyte metabolism mechanism becomes an unbearable problem.
Disclosure of Invention
The invention provides a hair scalp care microecological composition and a preparation method thereof, the hair scalp care microecological composition is prepared by matching natural active components of the hair scalp care microecological composition with a special process, and the problems of dandruff and alopecia can be effectively prevented and solved by balancing the number of scalp microecological bacteria and stimulating hair follicle cells to play a role.
In order to achieve the technical effects, the invention adopts the technical scheme that:
a hair scalp care micro-ecological composition comprising an aqueous phase composition and an active composition, the active composition comprising the following components: yeast/grape fermentation product extract, Morinda CITRIFOLIA (Morinda CITRIFOLIA) callus culture filtrate, Sesamum indicum (ERUCA SATIVA) leaf extract, Juglans REGIA (Juglans REGIA) seed extract, and hydrolyzed pea protein.
Yeast/grape fermentation product extract
The extract from fermentation of natural grapes is added into the scalp microecological total flora, and can compete for nutrient components required by malassezia causing dandruff sources, so that the quantity of the malassezia is reduced, the scalp microecological probiotic flora is gradually guided to recover to a balanced state, and the problem of dandruff is integrally and gradually improved.
Morinda CITRIFOLIA (MORINDA CITRIFOLIA) callus culture filtrate
The stem cell filtrate from the natural morinda citrifolia leaf concentrated callus culture has strong bacteriostasis, can maintain the balance among microecological bad bacteria of the scalp, and the main bacteriostasis does not kill the bad bacteria which are harmful to the balance of scalp bacteria, but utilizes the fact that the stem cell filtrate has a connection signal for blocking the bad bacteria, avoids the effect of clustering to generate strong destructive power in the future, so that the bad bacteria on the scalp can maintain a mutual balance state, has the function of protecting a scalp epidermal cell barrier layer, and has the effect of conditioning excessive scalp grease secretion.
Sesamum indicum (ERUCA SATIVA) leaf extract/Juglans REGIA (Juglans REGIA) seed extract
Experiments prove that the compound extracting solution of the leaf extract/walnut (Juglans REGIA) seed extract of the common sowthistle (ERUCA SATIVA) from natural sources can promote the renewal speed of dermal hair follicle papilla cells of a human body, stimulate the regeneration function of the dermal hair follicle papilla cells, further slow down the speed of frequent alopecia, accelerate the synthesis of endogenous glutathione of the dermal hair follicle papilla cells, is also a strong natural antioxidant, and can protect endogenous DNA of cells to play a normal function.
Hydrolyzed pea protein
The hydrolyzed pea protein from natural plant can form a net moisturizing membrane with strong effect on skin, and has certain improving effect on dandruff caused by scalp epidermis dryness and frizziness caused by hair dryness.
Preferably, the aqueous phase composition comprises the following components: butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer and EDTA disodium.
Preferably, the active compound composition is used in an amount of 2.0 to 6.0%.
Preferably, the composition consists of the following components in percentage by mass: 5.0-10.0% of butanediol, 3.0-5.0% of glycerol, 1.0-1.5% of poloxamer, 1.0-1.5% of morinda officinalis callus culture filtrate, 0.5-1.0% of yeast/grape fermentation product extract, 0.5-1.0% of sesamum indicum leaf extract, 0.5-1.0% of walnut seed extract, 0.5-1.0% of hydrolyzed pea protein, 0.3-0.5% of sodium hyaluronate, 0.2-0.3% of allantoin, 0.1-0.3% of citric acid, 0.1-0.2% of EDTA disodium, 0.1-0.2% of colloidal silver and the balance of deionized water.
Preferably, the active composition is used in an amount of 5.2%.
Preferably, the composition consists of the following components in percentage by mass: 8.0% of butanediol, 4.0% of glycerol, 1.3% of poloxamer, 1.5% of morinda officinalis callus culture filtrate, 0.9% of yeast/grape fermentation product extract, 0.9% of sesamum indicum leaf extract, 1.0% of walnut seed extract, 0.9% of hydrolyzed pea protein, 0.4% of sodium hyaluronate, 0.2% of allantoin, 0.15% of citric acid, 0.15% of disodium EDTA, 0.15% of colloidal silver and the balance of deionized water.
The invention also provides a preparation method of the hair scalp care microecological composition, which comprises the following steps:
(1) heating and stirring butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water until the materials are completely dispersed, and taking the mixture as phase A for later use;
(2) dissolving citric acid in deionized water until no crystal particles exist, and taking the citric acid as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver, stirring to completely disperse as phase C;
(4) pouring the phase A into a vacuum homogenizing and stirring pot, starting a vacuumizing homogenizing and stirring blade, starting vacuumizing, continuing vacuumizing, stirring and cooling after homogenizing and stirring for 5-15 mins, adding the phase B and the phase C in sequence after releasing the vacuum pressure, starting homogenizing and stirring, continuing vacuumizing, stirring and cooling after stirring for 1-10 mins, and obtaining a semi-finished product for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 2-8 ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet for multiple times with the material body pressure control range of 30-300 Mpa, and controlling the temperature in the material body internal circulation at 1-10 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
Preferably, after the treatment by the high-pressure homogenizer, the average high-pressure homogenized emulsified particle size is in the range of 100-300 nanometers.
The production of the hair scalp care microecological composition can not reduce the whole grain diameter by the traditional high-speed homogenizing and dispersing whole machine, and can not effectively reduce the grain diameter of a composition product and the using amount of active ingredients without the matching of an ultrahigh pressure nanometer processing procedure high-pressure homogenizing machine.
The general high-speed homogeneous dispersion integral machine consists of a stainless steel rotor and a stator, and the integral grain size can only reach a sub-nanometer level, but cannot form the level of the nanometer integral grain size.
The invention utilizes the ultrahigh pressure nanometer processing program high-pressure homogenizer to solve the problem that the integral particle size of the hair scalp nursing microecological composition for production is reduced by using auxiliary equipment, the equipment can be used for achieving the preset integral particle size, the particle size can be reduced by using the equipment as long as the viscosity of any type of final product is controlled below 100cps, the requirement of the particle size is determined according to the homogenization frequency and the adjustment pressure repeatedly entering the ultrahigh pressure nanometer processing program high-pressure homogenizer, the homogenization principle is that the integral material is subjected to various turbulent impact forces, the cavitation high-frequency vibration generated by strong turbulent flow generates shearing force with the edge of a homogenizing valve and generates impact force with a homogenizing valve retaining ring, the treatment of the nanometer particle size can be between 150-200 nanometers, the effective components can rapidly permeate into the skin cuticle, the maximum effect is achieved, and the integral particle size is not too large because the traditional integral dosage form is not subjected, the active ingredients can only stay on the surface of the horny layer of the skin, the maximum efficacy of the active ingredients cannot be exerted, and on the other hand, the use level of the active ingredients can be effectively reduced by utilizing the high-pressure homogenizer of the ultrahigh-pressure nanometer processing procedure, so that the efficacy of the active ingredients with the same amount as the traditional integral functional ingredients can be achieved, and the economic and efficient functions are achieved.
Preferably, the preparation method of the hair scalp care microecological composition specifically comprises the following steps:
(1) heating, stirring and dispersing butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water to 75 ℃, and completely dispersing and dissolving to obtain phase A for later use;
(2) taking a proper amount of deionized water, stirring at room temperature, and dissolving citric acid until no crystal particles exist, wherein the citric acid serves as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver at room temperature, stirring to disperse completely as phase C;
(4) pouring the phase A into a fixed vacuum homogenizing and stirring pot, starting a fixed vacuumizing homogenizing and stirring blade at the stirring speed of 800rpm and the homogenizing speed of 2500rpm, starting vacuumizing to 0.04Mpa, after homogenizing and stirring for 10mins, continuing vacuumizing, stirring and cooling to 45 ℃, after the vacuum pressure is released, sequentially adding the phase B and the phase C, starting the stirring speed of 600rpm and the homogenizing speed of 3000rpm, after homogenizing and stirring for 5mins, continuing vacuumizing, stirring and cooling to 35 ℃, filtering a semi-finished product by using a 100-mesh stainless steel filter screen and barreling for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 5ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet 3-5 times at a material body pressure control range of 60-280 Mpa, and controlling the temperature in material body internal circulation at 3-5 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
The raw materials adopted by the invention are purchased from the market unless otherwise specified.
The invention has the technical effects that:
the scalp lipid leakage dermatitis treatment agent can thoroughly solve the problems of dandruff and scalp lipid secretion imbalance caused by the fact that the scalp stratum corneum is metabolized too fast, is suitable for any scalp skin, and achieves scalp microecological balance and relieving inflammation repair by matching and using different types of active components, so that the scalp keratin metabolic function is gradually normalized, and the frequent alopecia phenomenon is greatly improved; the present invention provides new active ingredients that lead to new mechanisms of application in the scalp care field.
Detailed Description
The invention is further illustrated by the following examples, without limiting the scope of the invention.
Example 1
A hair scalp care micro-ecological composition consisting of: butanediol 8.0KG, glycerol 4.0KG, poloxamer 1.3KG, Morinda CITRIFOLIA (MORINDA CITRIFOLIA) callus culture filtrate 1.5KG, yeast/grape fermentation product extract 0.9KG, Sesamum indicum (ERUCA SATIVA) leaf extract 0.9KG, walnut (Juglans REGIA) seed extract 1.0KG, hydrolyzed pea protein 0.9KG, sodium hyaluronate 0.4KG, allantoin 0.2KG, citric acid 0.15KG, disodium EDTA 0.15KG, colloidal silver 0.15KG, and deionized water 80.45 KG.
The hair scalp care micro-ecological composition is prepared by the following steps:
(1) heating, stirring and dispersing butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water to 75 ℃, and completely dispersing and dissolving to obtain phase A for later use;
(2) taking a proper amount of deionized water, stirring at room temperature, and dissolving citric acid until no crystal particles exist, wherein the citric acid serves as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver at room temperature, stirring to disperse completely as phase C;
(4) pouring the phase A into a fixed vacuum homogenizing and stirring pot, starting a fixed vacuumizing homogenizing and stirring blade at the stirring speed of 800rpm and the homogenizing speed of 2500rpm, starting vacuumizing to 0.04Mpa, after homogenizing and stirring for 10mins, continuing vacuumizing, stirring and cooling to 45 ℃, after the vacuum pressure is released, sequentially adding the phase B and the phase C, starting the stirring speed of 600rpm and the homogenizing speed of 3000rpm, after homogenizing and stirring for 5mins, continuing vacuumizing, stirring and cooling to 35 ℃, filtering a semi-finished product by using a 100-mesh stainless steel filter screen and barreling for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 5ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet 3-5 times at a material body pressure control range of 60-280 Mpa, and controlling the temperature in material body internal circulation at 3-5 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
To understand the effect of the present invention, extensive trial survey was conducted on the product in the form of questionnaire, which was incorporated into 960 men and women across the country, wherein 545 men and 415 women were aged 50 years maximum and 18 years minimum, and the average age was about 35 years, and 936 effective questionnaires were collected.
The effect is judged by observing the change of relevant indexes of the testee before and after the product is used, and the evaluation standard is as follows:
scalp oil secretion vigorous improvement: the scalp grease secretion is obviously improved; obviously improve the scalp grease secretion and is not very obvious;
improvement in reducing dandruff number: moderate improvement, obvious reduction of dandruff; the dandruff is obviously improved and not very obvious;
improvement of scalp recurrent hair loss: moderate improvement, obvious reduction of alopecia; the hair loss is not obvious after the hair is obviously improved;
improvement of scalp occasional itching: moderate improvement, obvious reduction of itching; obviously improves the itching and is not very obvious.
936 subjects (applying them to hair follicles of scalp) the self-evaluation of the degree of each index relating to dandruff and alopecia caused by abnormal secretion and metabolism of sebum by scalp after 42 days of the present invention was as follows:
scalp oil secretion vigorous improvement: moderate improvement and obvious improvement were observed in 90.1% and 92.7% of subjects, respectively;
improvement in reducing dandruff number: moderate improvement and obvious improvement were observed in 92.1% and 95.4% of the subjects, respectively;
improvement of scalp recurrent hair loss: 92.8% and 96.3% of the subjects had moderate and significant improvement, respectively;
improvement of scalp occasional itching: there were moderate and significant improvements in 86.4% and 90.8% of subjects, respectively;
as can be seen from the results of the self-evaluation of the test subjects, the product has different degrees of significant improvement on the hair sebum secretion vigorous improvement, dandruff reduction, frequent alopecia and accidental itching.
Example 2
A hair scalp care micro-ecological composition consisting of: butanediol 10.0KG, glycerol 5.0KG, poloxamer 1.5KG, Morinda CITRIFOLIA (MORINDA CITRIFOLIA) callus culture filtrate 1.5KG, yeast/grape fermentation product extract 1.0KG, Sesamum indicum (ERUCA SATIVA) leaf extract 1.0KG, walnut (Juglans REGIA) seed extract 1.0KG, hydrolyzed pea protein 1.0KG, sodium hyaluronate 0.5KG, allantoin 0.3KG, citric acid 0.15KG, EDTA disodium 0.15KG, colloidal silver 0.15KG, and deionized water 76.75 KG.
The hair scalp care micro-ecological composition is prepared by the following steps:
(1) heating, stirring and dispersing butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water to 75 ℃, and completely dispersing and dissolving to obtain phase A for later use;
(2) taking a proper amount of deionized water, stirring at room temperature, and dissolving citric acid until no crystal particles exist, wherein the citric acid serves as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver at room temperature, stirring to disperse completely as phase C;
(4) pouring the phase A into a fixed vacuum homogenizing and stirring pot, starting a fixed vacuumizing homogenizing and stirring blade at the stirring speed of 800rpm and the homogenizing speed of 2500rpm, starting vacuumizing to 0.04Mpa, after homogenizing and stirring for 10mins, continuing vacuumizing, stirring and cooling to 45 ℃, after the vacuum pressure is released, sequentially adding the phase B and the phase C, starting the stirring speed of 600rpm and the homogenizing speed of 3000rpm, after homogenizing and stirring for 5mins, continuing vacuumizing, stirring and cooling to 35 ℃, filtering a semi-finished product by using a 100-mesh stainless steel filter screen and barreling for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 5ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet 3-5 times at a material body pressure control range of 60-280 Mpa, and controlling the temperature in material body internal circulation at 3-5 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
In order to understand the using effect of the invention, extensive trial investigation is carried out on the product in the form of questionnaire, the questionnaire is totally incorporated into male and female trial users 960 all over the country, wherein the male is 540, the female is 420, the age is 50 years maximum, the minimum is 18 years, the average age is about 35 years, and 930 parts of effective questionnaires are collected.
The self-evaluation results of the degree of each index related to dandruff and alopecia caused by abnormal secretion and metabolism of scalp grease after 42 days of the invention by 930 test persons (applying the test persons to scalp hair follicles) are as follows:
scalp oil secretion vigorous improvement: 87.6% and 89.8% of the subjects had moderate and significant improvement, respectively;
improvement in reducing dandruff number: 89.2% and 92.6% of the subjects had moderate and significant improvement, respectively;
improvement of scalp recurrent hair loss: moderate improvement and obvious improvement were found in 90.6% and 93.1% of the subjects, respectively;
improvement of scalp occasional itching: moderate improvement and obvious improvement were found in 83.1% and 88.7% of subjects, respectively;
as can be seen from the results of the self-evaluation of the test subjects, the product has different degrees of significant improvement on the hair sebum secretion vigorous improvement, dandruff reduction, frequent alopecia and accidental itching.
Example 3
A hair scalp care micro-ecological composition consisting of: 5.0KG of butanediol, 3.0KG of glycerol, 1.0KG of poloxamer, 1.0KG of MORINDA officinalis (MORINDA CITRIFOLIA) callus culture filtrate, 0.5KG of yeast/grape fermentation product extract, 0.5KG of sesamum indicum (ERUCA SATIVA) leaf extract, 0.5KG of walnut (Juglans REGIA) seed extract, 0.5KG of hydrolyzed pea protein, 0.3KG of sodium hyaluronate, 0.2KG of allantoin, 0.15KG of citric acid, 0.1KG of EDTA disodium, 0.15KG of colloidal silver and 87.1KG of deionized water.
The hair scalp care micro-ecological composition is prepared by the following steps:
(1) heating, stirring and dispersing butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water to 75 ℃, and completely dispersing and dissolving to obtain phase A for later use;
(2) taking a proper amount of deionized water, stirring at room temperature, and dissolving citric acid until no crystal particles exist, wherein the citric acid serves as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver at room temperature, stirring to disperse completely as phase C;
(4) pouring the phase A into a fixed vacuum homogenizing and stirring pot, starting a fixed vacuumizing homogenizing and stirring blade at the stirring speed of 800rpm and the homogenizing speed of 2500rpm, starting vacuumizing to 0.04Mpa, after homogenizing and stirring for 10mins, continuing vacuumizing, stirring and cooling to 45 ℃, after the vacuum pressure is released, sequentially adding the phase B and the phase C, starting the stirring speed of 600rpm and the homogenizing speed of 3000rpm, after homogenizing and stirring for 5mins, continuing vacuumizing, stirring and cooling to 35 ℃, filtering a semi-finished product by using a 100-mesh stainless steel filter screen and barreling for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 5ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet 3-5 times at a material body pressure control range of 60-280 Mpa, and controlling the temperature in material body internal circulation at 3-5 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
In order to understand the using effect of the invention, extensive trial investigation is carried out on the product in the form of questionnaire, the questionnaire is totally incorporated into 960 male and female testers all over the country, wherein 555 male and 405 female patients are at the maximum age of 50, 18 and 35 years in average, and 934 effective questionnaires are collected.
934 test subjects used (applied to hair follicles of the scalp), the self-evaluation result of the degree of each index of dandruff and alopecia caused by abnormal secretion and metabolism of sebum and grease after 42 days of the invention is as follows:
scalp oil secretion vigorous improvement: moderate improvement and obvious improvement were found in 82.1% and 84.7% of subjects, respectively;
improvement in reducing dandruff number: there were moderate and significant improvement in 84.3% and 88.1% of subjects, respectively;
improvement of scalp recurrent hair loss: 85.6% and 88.9% of the subjects had moderate and significant improvement, respectively;
improvement of scalp occasional itching: 80.1% and 83.5% of the subjects had moderate and significant improvement, respectively;
as can be seen from the results of the self-evaluation of the test subjects, the product has different degrees of significant improvement on the hair sebum secretion vigorous improvement, dandruff reduction, frequent alopecia and accidental itching.
Example 4
A hair scalp care micro-ecological composition consisting of: butanediol 8.0KG, glycerol 4.0KG, poloxamer 1.3KG, Morinda CITRIFOLIA (MORINDA CITRIFOLIA) callus culture filtrate 1.5KG, yeast/grape fermentation product extract 0.9KG, Sesamum indicum (ERUCA SATIVA) leaf extract 0.9KG, walnut (Juglans REGIA) seed extract 1.0KG, hydrolyzed pea protein 0.9KG, sodium hyaluronate 0.4KG, allantoin 0.2KG, citric acid 0.15KG, disodium EDTA 0.15KG, colloidal silver 0.15KG, and deionized water 80.45 KG.
The hair scalp care micro-ecological composition is prepared by the following steps:
(1) heating, stirring and dispersing butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water to 75 ℃, and completely dispersing and dissolving to obtain phase A for later use;
(2) taking a proper amount of deionized water, stirring at room temperature, and dissolving citric acid until no crystal particles exist, wherein the citric acid serves as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver at room temperature, stirring to disperse completely as phase C;
(4) pouring the phase A into a fixed vacuum homogenizing and stirring pot, starting a fixed vacuumizing homogenizing and stirring blade at the stirring speed of 600rpm and the homogenizing speed of 2000rpm, starting vacuumizing to 0.06Mpa, after homogenizing and stirring for 10mins, continuing vacuumizing, stirring and cooling to 40 ℃, after the vacuum pressure is released, sequentially adding the phase B and the phase C, starting the stirring speed of 800rpm and the homogenizing speed of 2000rpm, after homogenizing and stirring for 5mins, continuing vacuumizing, stirring and cooling to 30 ℃, filtering a semi-finished product by using a 100-mesh stainless steel filter screen and barreling for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at 8ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet 3-5 times at a material body pressure control range of 60-280 Mpa, and controlling the temperature in material body internal circulation at 3-5 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
To understand the effect of the present invention, the product was widely used as a questionnaire, which was incorporated into 945 male and female subjects across the country, wherein 540 male subjects and 405 female subjects were aged 50 years old, 18 years old and 18 years old at the minimum, and the average age was about 35 years old, and 928 effective questionnaires were collected.
928 test subjects who used (smeared on hair follicles of scalp) the self-evaluation result of the degree of each index of dandruff and alopecia caused by abnormal secretion and metabolism of sebum and grease after 42 days of the invention is as follows:
scalp oil secretion vigorous improvement: moderate improvement and obvious improvement were found in 87.1% and 89.3% of the subjects, respectively;
improvement in reducing dandruff number: there were moderate and significant improvements in 88.9% and 92.1% of subjects, respectively;
improvement of scalp recurrent hair loss: moderate improvement and obvious improvement were found in 90.3% and 93.3% of the subjects, respectively;
improvement of scalp occasional itching: moderate improvement and obvious improvement were found in 83.4% and 88.8% of subjects, respectively;
as can be seen from the results of the self-evaluation of the test subjects, the product has different degrees of significant improvement on the hair sebum secretion vigorous improvement, dandruff reduction, frequent alopecia and accidental itching.
The ultrahigh pressure nanocrystallization process is to homogenize the inner material for the second time through a high pressure homogenizer to obtain the final product. The experimental data of the composition find that the composition has certain improvement effect on dandruff troubled by consumers for a long time, namely so-called seborrheic dermatitis and frequent alopecia, and in addition, the composition has remarkable effect on previous dandruff hyperplasia and easy alopecia abnormal symptoms after being applied to hair follicles of the scalp for a long time for 42 days. In addition, the particle size of the microecological composition product is converted into nanometer by an ultrahigh pressure nanometer processing procedure method, and the microecological nanometer composition can quickly permeate into the root of hair follicles to carry out deep restoration and conditioning, so that the phenomenon of excessive grease secretion of hair and scalp is gradually conditioned to be in a healthy and normal state.
And according to the survey results, displaying that: the components of the invention are matched with a high-pressure homogenizer to assist the nano preparation method, so that the phenomena of normal scalp hair follicle grease secretion, scalp cutin metabolism abnormality, frequent alopecia and pruritus can be well repaired and recovered, and the scalp health state can be recovered.
It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application.
Claims (9)
1. A hair scalp care micro-ecological composition characterized by: the composition comprises an aqueous phase composition and an active composition, wherein the active composition comprises the following components: yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, and hydrolyzed pea protein.
2. The hair scalp care micro-ecological composition according to claim 1, characterized in that: the aqueous phase composition comprises the following components: butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer and EDTA disodium.
3. The hair scalp care micro-ecological composition according to claim 1, characterized in that: the active matter composition is used in an amount of 2.0-6.0%.
4. The hair scalp care micro-ecological composition according to claim 1, characterized in that: the composition comprises the following components in percentage by mass: 5.0-10.0% of butanediol, 3.0-5.0% of glycerol, 1.0-1.5% of poloxamer, 1.0-1.5% of morinda officinalis callus culture filtrate, 0.5-1.0% of yeast/grape fermentation product extract, 0.5-1.0% of sesamum indicum leaf extract, 0.5-1.0% of walnut seed extract, 0.5-1.0% of hydrolyzed pea protein, 0.3-0.5% of sodium hyaluronate, 0.2-0.3% of allantoin, 0.1-0.3% of citric acid, 0.1-0.2% of EDTA disodium, 0.1-0.2% of colloidal silver and the balance of deionized water.
5. The hair scalp care micro-ecological composition according to claim 4, characterized in that: the active matter composition dosage is 5.2%.
6. The hair scalp care micro-ecological composition according to claim 5, characterized in that: the composition comprises the following components in percentage by mass: 8.0% of butanediol, 4.0% of glycerol, 1.3% of poloxamer, 1.5% of morinda officinalis callus culture filtrate, 0.9% of yeast/grape fermentation product extract, 0.9% of sesamum indicum leaf extract, 1.0% of walnut seed extract, 0.9% of hydrolyzed pea protein, 0.4% of sodium hyaluronate, 0.2% of allantoin, 0.15% of citric acid, 0.15% of disodium EDTA, 0.15% of colloidal silver and the balance of deionized water.
7. A method for preparing a hair scalp care micro-ecological composition according to any one of claims 1 to 7, characterized in that it comprises the following steps:
(1) heating and stirring butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water until the materials are completely dispersed, and taking the mixture as phase A for later use;
(2) dissolving citric acid in deionized water until no crystal particles exist, and taking the citric acid as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver, stirring to completely disperse as phase C;
(4) pouring the phase A into a vacuum homogenizing and stirring pot, starting a vacuumizing homogenizing and stirring blade, starting vacuumizing, continuing vacuumizing, stirring and cooling after homogenizing and stirring for 5-15 mins, adding the phase B and the phase C in sequence after releasing the vacuum pressure, starting homogenizing and stirring, continuing vacuumizing, stirring and cooling after stirring for 1-10 mins, and obtaining a semi-finished product for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 2-8 ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet for multiple times with the material body pressure control range of 30-300 Mpa, and controlling the temperature in the material body internal circulation at 1-10 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
8. A method of preparing a hair scalp care micro-ecological composition according to claim 7, characterized in that: after being processed by a high-pressure homogenizer, the average high-pressure homogenizing emulsified particle size is within the range of 100-300 nanometers.
9. Method for preparing a hair scalp care micro-ecological composition according to claims 7 or 8, characterized in that it comprises in particular the following steps:
(1) heating, stirring and dispersing butanediol, glycerol, sodium hyaluronate, allantoin, poloxamer, EDTA disodium and deionized water to 75 ℃, and completely dispersing and dissolving to obtain phase A for later use;
(2) taking a proper amount of deionized water, stirring at room temperature, and dissolving citric acid until no crystal particles exist, wherein the citric acid serves as a phase B for later use;
(3) mixing yeast/grape fermentation product extract, Morinda citrifolia callus culture filtrate, Sesamum indicum leaf extract, semen Juglandis extract, hydrolyzed pea protein, and colloidal silver at room temperature, stirring to disperse completely as phase C;
(4) pouring the phase A into a fixed vacuum homogenizing and stirring pot, starting a fixed vacuumizing homogenizing and stirring blade at the stirring speed of 800rpm and the homogenizing speed of 2500rpm, starting vacuumizing to 0.04Mpa, after homogenizing and stirring for 10mins, continuing vacuumizing, stirring and cooling to 45 ℃, after the vacuum pressure is released, sequentially adding the phase B and the phase C, starting the stirring speed of 600rpm and the homogenizing speed of 3000rpm, after homogenizing and stirring for 5mins, continuing vacuumizing, stirring and cooling to 35 ℃, filtering a semi-finished product by using a 100-mesh stainless steel filter screen and barreling for later use;
(5) carrying out ultrahigh pressure nanocrystallization processing procedures on the semi-finished products, respectively mixing the semi-finished products according to the weight parts of the semi-finished products, quantitatively adding the mixture into a feed inlet of a high-pressure homogenizer at a rate of 5ml/sec through a peristaltic pump, starting a pressure control valve and a temperature control internal circulation machine, adding the mixture into the feed inlet 3-5 times at a material body pressure control range of 60-280 Mpa, and controlling the temperature in material body internal circulation at 3-5 ℃; and (3) after the appearance of the material body is semitransparent and the particle size is controlled to be 150-200 nanometers, conveying, filtering and discharging through an external circulation rotor pump to obtain the hair and scalp care microecological composition.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110143099.0A CN112891296A (en) | 2021-02-02 | 2021-02-02 | Hair and scalp care micro-ecological composition and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110143099.0A CN112891296A (en) | 2021-02-02 | 2021-02-02 | Hair and scalp care micro-ecological composition and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112891296A true CN112891296A (en) | 2021-06-04 |
Family
ID=76121344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110143099.0A Pending CN112891296A (en) | 2021-02-02 | 2021-02-02 | Hair and scalp care micro-ecological composition and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112891296A (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110132209A (en) * | 2010-06-01 | 2011-12-07 | 프롬네이처(주) | A cosmetic composition for improving skin barrier |
CN106619239A (en) * | 2016-12-16 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Red algae extract-containing composition and application thereof |
CN108014045A (en) * | 2017-12-25 | 2018-05-11 | 广东芭薇生物科技股份有限公司 | A kind of man's skin care compositions and its application |
CN109464313A (en) * | 2019-01-22 | 2019-03-15 | 杭州百芮生物科技有限公司 | A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence |
CN109846773A (en) * | 2018-11-26 | 2019-06-07 | 广州瑞誉化工科技有限公司 | A kind of scalp composition and its preparation method and application can inhibit alopecia seborrheica |
-
2021
- 2021-02-02 CN CN202110143099.0A patent/CN112891296A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110132209A (en) * | 2010-06-01 | 2011-12-07 | 프롬네이처(주) | A cosmetic composition for improving skin barrier |
CN106619239A (en) * | 2016-12-16 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Red algae extract-containing composition and application thereof |
CN108014045A (en) * | 2017-12-25 | 2018-05-11 | 广东芭薇生物科技股份有限公司 | A kind of man's skin care compositions and its application |
CN109846773A (en) * | 2018-11-26 | 2019-06-07 | 广州瑞誉化工科技有限公司 | A kind of scalp composition and its preparation method and application can inhibit alopecia seborrheica |
CN109464313A (en) * | 2019-01-22 | 2019-03-15 | 杭州百芮生物科技有限公司 | A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence |
Non-Patent Citations (1)
Title |
---|
上海姿尚化妆品有限公司: "《https://hzpba.nmpa.gov.cn/gccx/chakanHis.html?prodId=20150701171239sg22q&gb=G》", 24 July 2015, 国产非特殊用途化妆品备案服务平台 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111643446A (en) | Biological nutrition scalp hair follicle hair growth essence and preparation method thereof | |
CN111973641B (en) | Antidandruff compositions and methods of use thereof | |
CN108969429A (en) | A kind of anti-acne essence | |
CN109260075B (en) | Acne-removing conditioning water | |
WO2021093632A1 (en) | Active essence compounded with postbiotics and preparation method | |
CN111467285A (en) | Plant anti-dandruff shampoo and preparation method thereof | |
CN108524393B (en) | Ginger shampoo and preparation method thereof | |
CN110302223B (en) | Hair nourishing liquid preparation for repairing hair follicle and preparation method thereof | |
CN115120547B (en) | Non-irritating hair repair composition and anti-hair-loss shampoo | |
CN111407686A (en) | Multi-effect repair spray with vegetable protein and polypeptide formula and preparation method thereof | |
KR20130015339A (en) | Cream composition for treating acne | |
CN108272700A (en) | A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies | |
CN106727248A (en) | A kind of face mask of traditional Chinese medicine and preparation method thereof | |
CN112107533A (en) | Composition with effects of controlling oil, tendering skin and collecting fine pores and preparation method and application thereof | |
CN111671692A (en) | Acne-removing composition and preparation method and application thereof | |
KR101817514B1 (en) | New use of hesperetin | |
CN115607463A (en) | Composition for preventing or treating scalp seborrheic dermatitis and application thereof | |
CN115054566B (en) | Scalp aging resisting composition and preparation method thereof | |
EP2086554A2 (en) | Methods and compositions for treatment of skin conditions | |
CN112891296A (en) | Hair and scalp care micro-ecological composition and preparation method thereof | |
CN115054544B (en) | Anti-allergy and soothing foundation formula rich in yeast fermentation broth Supferm PO and preparation method thereof | |
CN110522662A (en) | A kind of ganoderma lucidum face cream and preparation method thereof | |
CN111700847B (en) | Composition for treating dark eye circles by synergistic laser, eye essence and preparation method | |
CN113425642A (en) | Eye care composition for relieving asthenopia and preventing vision deterioration | |
CN113768803A (en) | Composition of spray for preventing alopecia and removing dandruff and preparation method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |