CN105232407A - Bromelain whitening lotion and preparation method thereof - Google Patents
Bromelain whitening lotion and preparation method thereof Download PDFInfo
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- CN105232407A CN105232407A CN201510791322.7A CN201510791322A CN105232407A CN 105232407 A CN105232407 A CN 105232407A CN 201510791322 A CN201510791322 A CN 201510791322A CN 105232407 A CN105232407 A CN 105232407A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000002087 whitening effect Effects 0.000 title abstract description 10
- 239000006210 lotion Substances 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000839 emulsion Substances 0.000 claims abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 20
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 20
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 20
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- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930182478 glucoside Natural products 0.000 claims abstract description 12
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- 239000003963 antioxidant agent Substances 0.000 claims abstract description 10
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- 238000009499 grossing Methods 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
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- 239000000284 extract Substances 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 15
- 239000000419 plant extract Substances 0.000 claims description 13
- 239000000080 wetting agent Substances 0.000 claims description 12
- 239000002156 adsorbate Substances 0.000 claims description 11
- 239000003480 eluent Substances 0.000 claims description 11
- 150000008131 glucosides Chemical class 0.000 claims description 11
- MGYUQZIGNZFZJS-KTKRTIGZSA-N 2-[2-[(z)-octadec-9-enoxy]ethoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCO MGYUQZIGNZFZJS-KTKRTIGZSA-N 0.000 claims description 10
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 10
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 230000002421 anti-septic effect Effects 0.000 claims description 9
- 235000006708 antioxidants Nutrition 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 7
- 239000008363 phosphate buffer Substances 0.000 claims description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000007670 refining Methods 0.000 claims description 6
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 5
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 5
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 5
- 238000002386 leaching Methods 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 5
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 5
- 229960003415 propylparaben Drugs 0.000 claims description 5
- 240000004307 Citrus medica Species 0.000 claims description 4
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 4
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 4
- CEEMRWKKNNEQDT-UHFFFAOYSA-N Rosmanol Natural products CC(C)c1cc2C(OC(=O)C)C3OC(=O)C4(CCCC(C)(C)C34)c2c(OC(=O)C)c1OC(=O)C CEEMRWKKNNEQDT-UHFFFAOYSA-N 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 4
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 4
- 229930003944 flavone Natural products 0.000 claims description 4
- 150000002212 flavone derivatives Chemical class 0.000 claims description 4
- 235000011949 flavones Nutrition 0.000 claims description 4
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 4
- 229960004999 lycopene Drugs 0.000 claims description 4
- 235000012661 lycopene Nutrition 0.000 claims description 4
- 239000001751 lycopene Substances 0.000 claims description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 4
- 235000013824 polyphenols Nutrition 0.000 claims description 4
- LCAZOMIGFDQMNC-FORWCCJISA-N rosmanol Chemical compound C1CCC(C)(C)[C@@H]2[C@H]3[C@@H](O)C(C=C(C(=C4O)O)C(C)C)=C4[C@]21C(=O)O3 LCAZOMIGFDQMNC-FORWCCJISA-N 0.000 claims description 4
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 4
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000012676 herbal extract Substances 0.000 abstract 1
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- 229920000056 polyoxyethylene ether Polymers 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
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- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 244000099147 Ananas comosus Species 0.000 description 2
- 235000007119 Ananas comosus Nutrition 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
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- 239000003205 fragrance Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
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- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides bromelain whitening lotion and a preparation method thereof. The lotion is prepared from the following components in parts by weight: 0.5-1 part of bromelain, 2-10 parts of hyaluronic acid, 50-70 parts of humectant, 2-20 parts of carbomer, 10-20 parts of polyoxyethylene sorbitan monolaurate, 2-20 parts of n-hexyl glucoside, 5-20 parts of triethanolamine, 2-10 parts of oleic alcohol polyoxyethylene ether, 1-2 parts of preservative, 10-20 parts of herbal extract, 5-20 parts of antioxidant and 840-880 parts of deionized water. The preparation method comprises the steps of preparing bromelain, preparing a base solution, preparing an emulsion and compounding. The lotion is prepared by using natural substances as whitening active ingredients, has the advantages of light and thin texture and good absorption, and cannot easily cause skin allergy.
Description
Technical field
The present invention relates to technical field skin care field, be specifically related to tender white toner/smoothing toner of a kind of bromelain and preparation method thereof.
Background technology
Bromelain (Bromelain, be called for short bromelain, also be called bromelin or Fructus Ananadis comosi ferment) be extract from Fructus Ananadis comosi stem end, leaf, skin, through refining, purify, concentrated, enzyme immobilization, lyophilization and a kind of natural plant enzyme of obtaining.Its outward appearance is light gray powder, and molecular weight is 33000, and isoelectric point, IP is 9.55.Bromelain is water-soluble, is insoluble to ethanol, chloroform and ether.Excellent effect that bromelain has skin care, speckle is removed in whitening.Basic role principle: bromelain can act on the aging cutin layer on human body skin, impels it to degenerate, decomposes, removes, promote skin metabolism, reduce the skin color depth phenomenon because Exposure to Sunlight causes, make skin care present good delicate state.
Summary of the invention
The object of the present invention is to provide a kind of tender white toner/smoothing toner of bromelain with skin care whitening effect.
For achieving the above object, the technical solution adopted in the present invention is as follows:
The tender white toner/smoothing toner of a kind of bromelain, be made up of following component by weight: the bromelain of 0.5-1 weight portion, the hyaluronic acid of 2-10 weight portion, the wetting agent of 50-70 weight portion, the carbomer of 2-20 weight portion, the polyoxyethylene 20 sorbitan monolaurate of 10-20 weight portion, 2-20 weight portion is base glucoside just, the triethanolamine of 5-20 weight portion, the Brij92 of 2-10 weight portion, the antiseptic of 1-2 weight portion, the plant extract of 10-20 weight portion, the antioxidant of 5-20 weight portion and the deionized water of 840-880 weight portion,
Described wetting agent is any one or its mixture in propylene glycol, butanediol, glycerol, Polyethylene Glycol; Described antiseptic is methyl hydroxybenzoate and/or propylparaben; Described antioxidant is the one in tea polyphenols, rosmanol, Folium Bambosae flavone and lycopene;
Described plant extract is any one in Flos Rosae Rugosae extract, Fructus actinidiae chinensis extract, citron extract, Fructus Chaenomelis extract.
As preferably, described bromelain is made up of following steps:
A) squeeze the juice: Fructus Ananadis comosi leftover bits and pieces is cleaned, extrudes juice with squeezer, and cross leaching filtrate;
B) adsorb: filtrate a) obtained to step adds anhydrous calcium chloride, stirring and adsorbing, except supernatant, obtains adsorbate;
C) eluting: adsorbate pH value is adjusted to 7.0 with 1M dilute hydrochloric acid, adds EDTA and carries out eluting, centrifugal, collects eluent;
D) saltout: with 1M dilute hydrochloric acid, eluent pH value is adjusted to 5.0, add ammonium sulfate powder, until completely dissolved, saltout for 4 DEG C, centrifugal collecting precipitation is saltoutd thing, i.e. thick enzyme;
F) refining: to be dissolved by thick enzyme, adjust pH to 7.0-7.5 with phosphate buffer, filter to stir and collect filtrate, with 1M dilute hydrochloric acid, pH value is adjusted to 4.0, leave standstill and enzyme is separated out, centrifuging and taking precipitate, lyophilizing at-80 DEG C of temperature, obtains bromelain.
Another object of the present invention is to the preparation method that the tender white toner/smoothing toner of above-mentioned bromelain is provided, comprise the following steps:
1) bromelain is prepared: prepare bromelain with Fructus Ananadis comosi leftover bits and pieces;
2) base soln is prepared:
The hyaluronic acid of 2-10 weight portion is added in the deionized water of 200 weight portions, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 2-20 weight portion carbomer, 200 parts by weight of deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add the wetting agent of 50-70 weight portion, the polyoxyethylene 20 sorbitan monolaurate of 10-20 weight portion, the triethanolamine of 5-20 weight portion, the 2-20 weight portion Brij92 of base glucoside, 2-10 weight portion, the antiseptic of 1-2 weight portion and the water of surplus just, heated and stirred to all the components dissolves completely and emulsifying is even, be cooled to 70-80 DEG C, obtain emulsion;
4) composite: to step 3) emulsion prepared adds the plant extract of 10-20 weight portion and the antioxidant of 5-20 weight portion, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add the bromelain of 0.5-1 weight portion, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain the tender white toner/smoothing toner of bromelain.
As preferably, step 1) in, prepare bromelain with Fructus Ananadis comosi leftover bits and pieces and comprise the following steps:
A) squeeze the juice: Fructus Ananadis comosi leftover bits and pieces is cleaned, extrudes juice with squeezer, and cross leaching filtrate;
B) adsorb: to step 1) filtrate that obtains adds anhydrous calcium chloride, stirring and adsorbing, except supernatant, obtains adsorbate;
C) eluting: adsorbate pH value is adjusted to 7.0 with 1M dilute hydrochloric acid, adds EDTA and carries out eluting, centrifugal, collects eluent;
D) saltout: with 1M dilute hydrochloric acid, eluent pH value is adjusted to 5.0, add ammonium sulfate powder, until completely dissolved, saltout for 4 DEG C, centrifugal collecting precipitation is saltoutd thing, i.e. thick enzyme;
F) refining: to be dissolved by thick enzyme, adjust pH to 7.0-7.5 with phosphate buffer, filter to stir and collect filtrate, with 1M dilute hydrochloric acid, pH value is adjusted to 4.0, leave standstill and enzyme is separated out, centrifuging and taking precipitate, lyophilizing at-80 DEG C of temperature, obtains bromelain.
As preferably, step 2) in, described wetting agent is made up of the propylene glycol of 20 weight portions, the glycerol of 20 weight portions and the Polyethylene Glycol of 10-20 weight portion, the butanediol of 0-20 weight portion.
Relative to prior art, the present invention has following technique effect:
1, the pure natural bromelain extracted is applied in toner/smoothing toner by the present invention, and toner/smoothing toner is more easily absorbed by the skin, and its tender white effect is remarkable;
2, toner/smoothing toner provided by the invention is general transparent aqueous, normally after with clean dirts adhered on skin such as cleansing milk, for keeping the skin wet and moisturizing ingredient to the horny layer of skin, make skin emolliency, the cosmetics that adjustment skin physiology act as object and uses;
3, toner/smoothing toner oil content provided by the invention is few, has pleasant sensation, has good tender white effect, and the scope of application is wide, is applicable to various skin quality;
4, the cosmetics prepared using plant extract as active component are compared with Traditional makeup, and security performance is higher, and natural constituents is more easily absorbed by the skin, and make the skin care whitening effect of product more remarkable.
Below in conjunction with concrete embodiment, the present invention is described in further detail.
Detailed description of the invention
The invention provides the tender white toner/smoothing toner of a kind of bromelain, be made up of following component by weight: the bromelain of 0.5-1 weight portion, the hyaluronic acid of 2-10 weight portion, the wetting agent of 50-70 weight portion, the carbomer of 2-20 weight portion, the polyoxyethylene 20 sorbitan monolaurate of 10-20 weight portion, 2-20 weight portion is base glucoside just, the triethanolamine of 5-20 weight portion, the Brij92 of 2-10 weight portion, the antiseptic of 1-2 weight portion, the plant extract of 10-20 weight portion, the antioxidant of 5-20 weight portion and the deionized water of 840-880 weight portion,
Described wetting agent is any one or its mixture in propylene glycol, butanediol, glycerol, Polyethylene Glycol; Described antiseptic is methyl hydroxybenzoate and/or propylparaben; Described antioxidant is the one in tea polyphenols, rosmanol, Folium Bambosae flavone and lycopene.
With the principle active component that bromelain, hyaluronic acid and plant extract are whitening and softening skin in the present invention, be equipped with basic wetting agent and thickening agent, and by add just base glucoside and triethanolamine to promote dissolubility and the stability of bromelain bioactive ingredients, to prepare the tender white toner/smoothing toner of the stable bromelain with whitening and softening skin function.
Described plant extract is any one in Flos Rosae Rugosae extract, Fructus actinidiae chinensis extract, citron extract, Fructus Chaenomelis extract, and described plant extract all has certain skin care skin moistening, desalination black speck, the effect making whitening skin tender.These plant extracts serve the effect with bromelain, the tender white soft skin in hyaluronic acid concertedness ground in toner/smoothing toner.
The preparation method of the tender white toner/smoothing toner of this bromelain comprises the following steps:
1) bromelain is prepared: prepare bromelain with Fructus Ananadis comosi leftover bits and pieces;
2) prepare base soln: added by the hyaluronic acid of 2-10 weight portion in the deionized water of 200 weight portions, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 2-20 weight portion carbomer, 200 parts by weight of deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add the wetting agent of 50-70 weight portion, the Brij92 of 2-10 weight portion, the triethanolamine of 5-20 weight portion, the 2-20 weight portion Brij92 of base glucoside, 2-10 weight portion, the antiseptic of 1-2 weight portion and the water of surplus just, heated and stirred to all the components dissolves completely and emulsifying is even, be cooled to 70-80 DEG C, obtain emulsion;
4) composite: to step 3) emulsion prepared adds the plant extract of 10-20 weight portion and the antioxidant of 5-20 weight portion, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add the bromelain of 0.5-1 weight portion, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain the tender white toner/smoothing toner of bromelain.
In following examples, described phosphate buffer is the sodium hydroxide solution of potassium dihydrogen phosphate, and the pH value of described phosphate buffer is 7.2.
embodiment 1
The present embodiment provides the preparation method of bromelain, comprises the following steps:
A) squeeze the juice: Fructus Ananadis comosi leftover bits and pieces is cleaned, extrudes juice with squeezer, and cross leaching filtrate;
Described Fructus Ananadis comosi leftover bits and pieces comprises as pineapple peel, pineapple leaves;
B) adsorb: to step 1) filtrate that obtains adds anhydrous calcium chloride, stirring and adsorbing, except supernatant, obtains adsorbate;
Get in the filtrate that 1L step a) obtains and add 50g anhydrous calcium chloride, stirring and adsorbing, except supernatant, obtain adsorbate;
C) eluting: adsorbate pH value is adjusted to 7.0 with 1M dilute hydrochloric acid, adds EDTA and carries out eluting, centrifugal, collects eluent;
D) saltout: with 1M dilute hydrochloric acid, eluent pH value is adjusted to 5.0, add the ammonium sulfate powder of 1/4 eluent quality, until completely dissolved, saltout for 4 DEG C, centrifugal collecting precipitation is saltoutd thing, i.e. thick enzyme;
F) refining: to be dissolved by thick enzyme, adjust pH to 7.0-7.5 with phosphate buffer, filter to stir and collect filtrate, with 1M dilute hydrochloric acid, pH value is adjusted to 4.0, leave standstill and enzyme is separated out, centrifuging and taking precipitate, lyophilizing at-80 DEG C of temperature, obtains bromelain.
embodiment 2
A preparation method for the tender white toner/smoothing toner of bromelain, comprises the following steps:
1) bromelain is prepared: adopt the method for embodiment 1 to prepare bromelain from Fructus Ananadis comosi leftover bits and pieces;
2) prepare base soln: added in 20g deionized water by the hyaluronic acid of 1g, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 0.2g carbomer, 20g deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add 2g propylene glycol, 2g glycerol, 1g Polyethylene Glycol, 1g polyoxyethylene 20 sorbitan monolaurate, 0.5g triethanolamine, 1g base glucoside, 0.5g Brij92,0.05g methyl hydroxybenzoate and 0.05g propylparaben just, add water and be supplemented to 100g, heated and stirred to all the components dissolves completely and emulsifying is even, be cooled to 70-80 DEG C, obtain emulsion;
4) composite: to step 3) emulsion prepared adds 1.5g Flos Rosae Rugosae extract and 1g tea polyphenols, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add 0.05g bromelain, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain the tender white toner/smoothing toner of bromelain.
embodiment 3
A preparation method for the tender white toner/smoothing toner of bromelain, comprises the following steps:
1) bromelain is prepared: adopt the method for embodiment 1 to prepare bromelain from Fructus Ananadis comosi leftover bits and pieces;
2) prepare base soln: added in 20g deionized water by the hyaluronic acid of 1g, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 1g carbomer, 20g deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add 2g propylene glycol, 2g glycerol, 1g Polyethylene Glycol, 2g polyoxyethylene 20 sorbitan monolaurate, 2g triethanolamine, 2g base glucoside, 0.2g Brij92 and 0.1g methyl hydroxybenzoate just, add water and be supplemented to 100g, heated and stirred to all the components dissolves completely and emulsifying is even, be cooled to 70-80 DEG C, obtain emulsion;
4) composite: to step 3) emulsion prepared adds 1g Fructus actinidiae chinensis extract and 1.5g rosmanol, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add 0.1g bromelain, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain bromelain toner/smoothing toner.
embodiment 4
A preparation method for the tender white toner/smoothing toner of bromelain, comprises the following steps:
1) bromelain is prepared: adopt the method for embodiment 1 to prepare bromelain from Fructus Ananadis comosi leftover bits and pieces;
2) prepare base soln: added in 20g deionized water by the hyaluronic acid of 0.5g, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 0.5g carbomer, 20g deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add 2g propylene glycol, 2g glycerol, 2g Polyethylene Glycol, 1g polyoxyethylene 20 sorbitan monolaurate, 2g triethanolamine, 0.5g base glucoside, 0.5g Brij92 and 0.1g propylparaben just, add water and be supplemented to 100g, heated and stirred to all the components dissolves also emulsifying Homogeneous cooling completely and, to 70-80 DEG C, obtains emulsion;
4) composite: to step 3) emulsion prepared adds 2g citron extract and 0.5g Folium Bambosae flavone, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add 0.08g bromelain, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain bromelain toner/smoothing toner.
embodiment 5
A preparation method for the tender white toner/smoothing toner of bromelain, comprises the following steps:
1) bromelain is prepared: adopt the method for embodiment 1 to prepare bromelain from Fructus Ananadis comosi leftover bits and pieces;
2) prepare base soln: added in 20g deionized water by the hyaluronic acid of 0.2g, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 2g carbomer, 20g deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add 2g propylene glycol, 2g butanediol, 2g glycerol, 1g Polyethylene Glycol, 1g polyoxyethylene 20 sorbitan monolaurate, 1g triethanolamine, 0.2g base glucoside, 1g Brij92 and 0.2g methyl hydroxybenzoate just, add water and be supplemented to 100g, heated and stirred to all the components dissolves completely and emulsifying is even, be cooled to 70-80 DEG C, obtain emulsion;
4) composite: to step 3) emulsion prepared adds 1g Fructus Chaenomelis extract and 2g lycopene, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add 0.1g bromelain, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain bromelain toner/smoothing toner.
Detect embodiment
1. physicochemical property
Carry out physicochemical property detection to the bromelain toner/smoothing toner of embodiment 2-5, the bromelain toner/smoothing toner that embodiment 2 obtains is transparency liquid, free from foreign meter, has extremely light Flos Rosae Rugosae fragrance, and pH value is 7.2; The bromelain toner/smoothing toner that embodiment 3 obtains is transparency liquid, free from foreign meter, has extremely light Herba Rosmarini Officinalis gas, and pH value is 7.0; The bromelain toner/smoothing toner that embodiment 4 obtains is transparency liquid, free from foreign meter, has extremely light citris aromas, and pH value is 7.0; The bromelain toner/smoothing toner that embodiment 5 obtains is transparency liquid, free from foreign meter, has extremely light Fructus Chaenomelis delicate fragrance, and pH value is 6.8.
2. experience test
Experimenter is totally 12 people, be numbered No. 1-12, be women, facial skin has pigment, the shape such as obscure in various degree, sooner or later respectively uses once bromelain toner/smoothing toner provided by the invention, wherein, the product of No. 1-3 use embodiment 2, the product of No. 4-6 use embodiment 3, the product of No. 7-9 use embodiment 4, the product of No. 10-12 use embodiment 5.First clean skin before using, then falls product of the present invention in cotton pads, allows toner/smoothing toner fully infiltrate cotton piece, approximately each about 3mL, but reach the degree fully infiltrating cotton piece and can not drip.Wiping facial skin gently, to reach again clean effect.The toner/smoothing toner again instilling 1 point of coin-size is in the heart in one's hands, and after rubbing palm raising palm of the hand temperature, pressing also pats facial skin gently, accelerates and promote the infiltration of toner/smoothing toner.Test is carried out after one month, and grading to the resultant effect of the facial skin whitening effect of experimenter after test, is to no effect I level, has slight effect to be II level, and effective is III level, and Be very effective is IV level, and its result is as shown in table 1,
Result of the test experienced by table 1
| Product | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Effect | III | IV | III | IV |
In process of the test, there is not skin adverse reaction in experimenter, and facial skin all has the effects such as bleaching in various degree, mottle desalination.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, change and the replacement of any unsubstantiality that those skilled in the art does on basis of the present invention all belong to the present invention's scope required for protection.
Claims (5)
1. the tender white toner/smoothing toner of bromelain, it is characterized in that, be made up of following component by weight: the bromelain of 0.5-1 weight portion, the hyaluronic acid of 2-10 weight portion, the wetting agent of 50-70 weight portion, the carbomer of 2-20 weight portion, the polyoxyethylene 20 sorbitan monolaurate of 10-20 weight portion, 2-20 weight portion is base glucoside just, the triethanolamine of 5-20 weight portion, the Brij92 of 2-10 weight portion, the antiseptic of 1-2 weight portion, the plant extract of 10-20 weight portion, the antioxidant of 5-20 weight portion and the deionized water of 840-880 weight portion,
Described wetting agent is any one or its mixture in propylene glycol, butanediol, glycerol, Polyethylene Glycol; Described antiseptic is methyl hydroxybenzoate and/or propylparaben; Described antioxidant is the one in tea polyphenols, rosmanol, Folium Bambosae flavone and lycopene;
Described plant extract is any one in Flos Rosae Rugosae extract, Fructus actinidiae chinensis extract, citron extract, Fructus Chaenomelis extract.
2. the tender white toner/smoothing toner of bromelain as claimed in claim 1, it is characterized in that, described bromelain is made up of following steps:
A) squeeze the juice: Fructus Ananadis comosi leftover bits and pieces is cleaned, extrudes juice with squeezer, and cross leaching filtrate;
B) adsorb: filtrate a) obtained to step adds anhydrous calcium chloride, stirring and adsorbing, except supernatant, obtains adsorbate;
C) eluting: adsorbate pH value is adjusted to 7.0 with 1M dilute hydrochloric acid, adds EDTA and carries out eluting, centrifugal, collects eluent;
D) saltout: with 1M dilute hydrochloric acid, eluent pH value is adjusted to 5.0, add ammonium sulfate powder, until completely dissolved, saltout for 4 DEG C, centrifugal collecting precipitation is saltoutd thing, i.e. thick enzyme;
F) refining: to be dissolved by thick enzyme, adjust pH to 7.0-7.5 with phosphate buffer, filter to stir and collect filtrate, with 1M dilute hydrochloric acid, pH value is adjusted to 4.0, leave standstill and enzyme is separated out, centrifuging and taking precipitate, lyophilizing at-80 DEG C of temperature, obtains bromelain.
3. the preparation method of the tender white toner/smoothing toner of the bromelain as described in any one of claim 1-2, comprises the following steps:
1) bromelain is prepared: prepare bromelain with Fructus Ananadis comosi leftover bits and pieces;
2) prepare base soln: added by the hyaluronic acid of 2-10 weight portion in the deionized water of 200 weight portions, be heated to 90-95 DEG C, keep this temperature 20-30min, do not stop to stir until hyaluronic acid dissolves completely simultaneously; Add 2-20 weight portion carbomer, 200 parts by weight of deionized water again, heated and stirred, keep the temperature 60-90min of 90-95 DEG C, until carbomer dissolves completely, obtain base soln;
3) prepare emulsion: to step 2) base soln in add the wetting agent of 50-70 weight portion, the polyoxyethylene 20 sorbitan monolaurate of 10-20 weight portion, the triethanolamine of 5-20 weight portion, the 2-20 weight portion Brij92 of base glucoside, 2-10 weight portion, the antiseptic of 1-2 weight portion and the water of surplus just, heated and stirred to all the components dissolves completely and emulsifying is even, be cooled to 70-80 DEG C, obtain emulsion;
4) composite: to step 3) emulsion prepared adds the plant extract of 10-20 weight portion and the antioxidant of 5-20 weight portion, after stirring, leave standstill, treat that its temperature drops to 50 DEG C, add the bromelain of 0.5-1 weight portion, stir and make it dissolve, after bromelain dissolves completely, leave standstill 24h, namely obtain the tender white toner/smoothing toner of bromelain.
4., as right asks the method as described in 3, it is characterized in that, step 1) in, prepare bromelain with Fructus Ananadis comosi leftover bits and pieces and comprise the following steps:
A) squeeze the juice: Fructus Ananadis comosi leftover bits and pieces is cleaned, extrudes juice with squeezer, and cross leaching filtrate;
B) adsorb: filtrate a) obtained to step adds anhydrous calcium chloride, stirring and adsorbing, except supernatant, obtains adsorbate;
C) eluting: adsorbate pH value is adjusted to 7.0 with 1M dilute hydrochloric acid, adds EDTA and carries out eluting, centrifugal, collects eluent;
D) saltout: with 1M dilute hydrochloric acid, eluent pH value is adjusted to 5.0, add ammonium sulfate powder, until completely dissolved, saltout for 4 DEG C, centrifugal collecting precipitation is saltoutd thing, i.e. thick enzyme;
F) refining: to be dissolved by thick enzyme, adjust pH to 7.0-7.5 with phosphate buffer, filter to stir and collect filtrate, with 1M dilute hydrochloric acid, pH value is adjusted to 4.0, leave standstill and enzyme is separated out, centrifuging and taking precipitate, lyophilizing at-80 DEG C of temperature, obtains bromelain.
5., as right asks the method as described in 3, it is characterized in that, step 2) in, described wetting agent is made up of the propylene glycol of 20 weight portions, the glycerol of 20 weight portions and the Polyethylene Glycol of 10-20 weight portion, the butanediol of 0-20 weight portion.
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| CN107961183A (en) * | 2017-12-11 | 2018-04-27 | 广州市汇吉科技企业孵化器有限公司 | A kind of toxin expelling anti-inflammatory facial mask |
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| CN105878107A (en) * | 2016-04-13 | 2016-08-24 | 广州丹奇日用化工厂有限公司 | Skin-care product composition for sensitive skin |
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| CN105943479A (en) * | 2016-05-20 | 2016-09-21 | 秦瑜 | Easing, whitening and acne removing liquid |
| CN107961183A (en) * | 2017-12-11 | 2018-04-27 | 广州市汇吉科技企业孵化器有限公司 | A kind of toxin expelling anti-inflammatory facial mask |
| CN109464313A (en) * | 2019-01-22 | 2019-03-15 | 杭州百芮生物科技有限公司 | A kind of preparation method and biology cellulose diaphragm of external preparation for skin Essence |
| CN110089664A (en) * | 2019-05-31 | 2019-08-06 | 广东省广窑记餐饮管理服务有限公司 | The production method of kiln chicken |
| CN113797143A (en) * | 2021-10-15 | 2021-12-17 | 中国热带农业科学院农产品加工研究所 | Bromelain acne-removing essence and preparation method thereof |
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