CN106137916A - The cosmetic composition of a kind of removing acnes and controlling oil whitening and application thereof - Google Patents
The cosmetic composition of a kind of removing acnes and controlling oil whitening and application thereof Download PDFInfo
- Publication number
- CN106137916A CN106137916A CN201610663566.1A CN201610663566A CN106137916A CN 106137916 A CN106137916 A CN 106137916A CN 201610663566 A CN201610663566 A CN 201610663566A CN 106137916 A CN106137916 A CN 106137916A
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- Prior art keywords
- cosmetic composition
- skin
- maintenance liquid
- extract
- skin maintenance
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Abstract
The present invention relates to cosmetic composition and the application thereof of a kind of removing acnes and controlling oil whitening, belong to cosmetic technical field.A kind of cosmetic composition of removing acnes and controlling oil whitening, described cosmetic composition includes following component count by weight percentage: nanometer Margarita powder 3～8%, bletilla striata extract 0.5～0.8%, Semen Coicis extract 0.6～1.2%, Radix et Caulis Opuntiae Dillenii extract 1.3～1.5%, tea tree ethereal oil 0.01～0.03%, Rice oil 0.5～1.0%, Extraction of rutin thing 0.5～1.0%, Semen Vitis viniferae extract 1～2%, skin maintenance liquid 40～60%, surplus is water.The cosmetic composition of the present invention selects multiple natural plant extracts and skin maintenance liquid to compound, significant anti-acne can be produced except pox effect, can subside a swelling and promote disappearing of scytitis, improve, desalinate and dispel pox print, simultaneously work as the effect of skin whitening and preventing and treating pigment speckle.
Description
Technical field
The present invention relates to cosmetic composition and the application thereof of a kind of removing acnes and controlling oil whitening, belong to cosmetic technical field.
Background technology
Comedo, medically known as acne vulgaris have another name called acne of youth, are the chronic inflammatory diseases of a kind of hair follicle, sebaceous gland, main
Occurring, in the greasiness such as face and thoracic dorsal district, have self limiting, skin lesion multiform, such as acne, pimple, pustule, tuberosity.It is often accompanied by sebum
Overflow, after adolescence, mostly fully recover or alleviate.Acne was considered as disease of sebaceous glands in the past, and substantial damage includes hair follicle, skin
Adipose gland and epidermis, belong to the traditional Chinese medical science " rosacea caused by lung-wind " category.Comedo is not only relatively conventional in teenager, in adult also than
More universal.Grow comedo, not only affected appearance, and easily cause the psychology felt oneself inferior.
Determining the state of the mainly epidermis of our skin appearance, epidermis is thin by keratinocyte and outermost cutin
Born of the same parents are constituted, and they suffer from oneself powerful updating ability, as long as cell moisture is sufficient, their self-repairing capability is can not
Limitation.Water is lifespring, and most skin problem all has relation with hydropenia, and it is undue that water deficient is easily caused sebaceous gland
, there is small pox, collagen fiber also can be made to follow the string and support force, wrinkle, cutis laxa occur, water deficient is also in secretion oils and fats
The metabolic rate of cell can be slowed down so that too much pigment cannot homergy and deposit, thus moisture is skin beauty
The first element, only carry out moisturizing work, could take a firm foundation for facial cosmetic.Existing various beauty treatment anti-acnes are produced
Product, some contains hormone, some DeGrain, and after also some uses, xerosis cutis is dark and gloomy.
Summary of the invention
The present invention is for overcoming above-mentioned the deficiencies in the prior art, it is provided that a kind of safety is the most natural, will not injured skin and keep skin
The cosmetic composition of the removing acnes and controlling oil whitening of skin moisture.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of cosmetic composition of removing acnes and controlling oil whitening, described cosmetic composition include following by weight percentage
The component calculated: nanometer Margarita powder 3～8%, bletilla striata extract 0.5～0.8%, Semen Coicis extract 0.6～1.2%, celestial being
The palm extract 1.3～1.5%, tea tree ethereal oil 0.01～0.03%, Rice oil 0.5～1.0%, Extraction of rutin thing 0.5～
1.0%, Semen Vitis viniferae extract 1～2%, skin maintenance liquid 40～60%, surplus is water；Skin maintenance liquid, skin maintenance liquid master
If adding suitable quantity of water after the raw material mixed by rice, tender okra pod and Abelmoschus esculentus flower, pulverizing to make through composite bacteria fermentation,
Described composite bacteria is made up of at least two at least two in I class strain and II class strain, and wherein I class strain includes planting
Thing lactobacillus, Bafillus natt and bacillus acidophilus；II class strain includes Lactobacillus saki, bacillus subtilis and wine brewing ferment
Female.The cosmetic composition of the present invention can add some raw materials conventional in cosmetics, such as xanthan gum, hyaluronate sodium, fourth
Glycol, glycosyl trehalose etc. are to regulate and to improve state and the viscosity of product.The cosmetic composition of the present invention selects multiple sky
So plant extract and skin maintenance liquid compound, and can produce significant anti-acne and remove pox effect, can subside a swelling and promote scytitis
Disappear, improve, desalinate and dispel pox print, simultaneously work as skin whitening with preventing and treating pigment speckle effect.
Bletilla striata extract is rich in multipleization such as Pseudobulbus Bletillae (Rhizoma Bletillae) colloid, starch, glucose, volatile oil, phlegmatic temperament and anthraquinone derivatives
Studying point, have effect of whitening and speckle dispelling, astringing to arrest bleeding, detumescence and promoting granulation, external is embrocated, and can eliminate the vestige on the face as acne,
Active balance skin, keeps skin water profit.Epithelial cell reparation can be promoted, directly participate in damaged tissues and the reparation of cell and generation
Apologize for having done sth. wrong journey.Especially contained Pseudobulbus Bletillae (Rhizoma Bletillae) colloid i.e. Pseudobulbus Bletillae (Rhizoma Bletillae) glucosan is considered as the stimulation non-undetermined in immune system for a long time
Thing, it will usually cause macrophage activation, and macrophage activation can cause a series of reaction, first can cause fiber former carefully
Born of the same parents and the migration of keratinocyte, thus produce epithelical cell growth factor (ECGF) and angiogenesis factor (AF) comes defying age
Wrinkling skin, simultaneously facilitates the generation of collagen protein and elastin laminin, thus improves skin appearance, smooth away wrinkles.
Rutin itself has the effect of radioprotective, anti-ultraviolet, and Extraction of rutin thing also has the function of antiinflammatory antiinflammatory.Semen Coicis
Core extract energy antiinflammatory, evacuation of pus pain relieving, can control acne, pachylosis etc. with the cosmetics of its preparation, and have absorption ultraviolet
Effect.Semen Coicis extract, Radix et Caulis Opuntiae Dillenii extract and Extraction of rutin thing coordinated, equal to UVA with the UVB composition of ultraviolet
There is the sun-proof result of excellence, be conducive to desalination pox print and spot.Tea tree ethereal oil has bactericidal antiphlogistic, restrains effect of pore,
Auxiliary adds a small amount of Rice oil and nourishes skin, plays the effect promoting skin repair.
Semen Vitis viniferae extract is described as natural sunlight overcover, can shielding of ultraviolet infringement skin；Prevention skin is excessive
Crosslinking, keep appropriately crosslinked, postpone and reduce the appearance of wrinkle of skin, keep the submissive smooth of skin；To controlling comedo, color
Speckle, whitening etc. have remarkable result.
As preferably, the particle diameter of nanometer Margarita powder is 10～100 nanometers.
As preferably, described cosmetic composition also includes isopropyl myristate 1%, shea butter 0.5～
1%, natural complex C 0.5～0.8%.This formula whitening effect more preferably, is also easy to make product be coated on face etc. uniformly
Skin surface.
As preferably, described cosmetic composition also includes propylene glycol or butanediol 12～20%.
As preferably, the preparation method of skin maintenance liquid is: mix with water after described raw material pulverizing, and material-water ratio is 1:4
～5, then composite bacteria is seeded in mixed liquor, after stirring 200～350rpm, 30 DEG C～37 DEG C of lucifuges fermentation 24-
36h, obtains skin maintenance liquid through sterilization treatment after standing and filter removal fermentation residue.Composite bacteria is that activated liquid cultivates bacterium
Kind, its inoculum concentration is 5.0 × 107～10.0 × 107cfu/mL。
As preferably, described raw material is tender okra pod and Abelmoschus esculentus flower mixes with the weight ratio of 1:1～2.
The preparation method of the cosmetic composition of a kind of removing acnes and controlling oil whitening, described cosmetic composition is by described group
Point being mixed, wherein the preparation method of skin maintenance liquid is: mix with water after described raw material pulverizing, material-water ratio be 1:4～
5, then composite bacteria is seeded in mixed liquor, after stirring 200～350rpm, 30 DEG C～37 DEG C of lucifuges fermentation 24-
36h, obtains skin maintenance liquid through sterilization treatment after standing and filter removal fermentation residue.
A kind of facial film with moisturizing and after-sun restorative function, by the cosmetic composition described in mask substrate immersion 15
～take out after 30min, packaging, obtain mask product.
Margarita powder is described as holy product of improving looks since ancient times, and external Margarita powder can solve face oil and dead bark problem, whitening skin
Skin can effectively allow skin glosser beautiful, specifically, is played the effect of defying age by the activity of enhancement of SOD, makes skin clear
Refreshing soft and smooth, pale can people.Margarita has the effects such as arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, and the Margarita powder content in formula is fitted
When regulation can change the forms such as the cream of cosmetic composition, frost, breast, it also it is natural regulator.
In rare emplastic (sugar polymer), main component contains pectin, viscous glycoprotein, vitamin A and potassium.Yellow
The mucus of Flos abelmoschi manihot can be additionally used in medicine aspect, as emollient, tranquillizer and only expectorant agent.It is ground to squeeze the juice and smears by many women
Face, does not only has the effect of lubrication protection skin because of it, and has and make skin-whitening, delicacy, anti-black special efficacy.
Abelmoschus esculentus in inventive formulation rich in glycoprotein, pectin, Lac Bovis seu Bubali polysaccharide, Radix Acaciae senegalis, flavone, carotene,
The multiple nutritional components such as vitamin and selenium, phosphorus, ferrum, zinc, magnesium, abundant water soluble dietary fiber and vitamin C, not only to skin
With health role, and skin-whitening, delicacy can be made, be conducive to the skin repair after sunburn.It is solvable that Abelmoschus esculentus flower enriches
Property dietary fiber and vitamin C, not only with health role to skin, and skin-whitening, delicacy can be made.In Abelmoschus esculentus flower rich
Rich plant flavone glycoside, can promote the omnibearing self-care of human body in conjunction with each nutrient, has promotion incretion balance, resists
The effects such as aging, skin whitening, quickening blood microcirculation, especially have the effect of luxuriant growth youth to adult female.
The feature that the present inventor cannot effectively preserve for the fresh Abelmoschus esculentus gathered and flower thereof, is processed place to it
Reason so that it is can apply to beauty and make-up product aspect, be effectively kept Abelmoschus esculentus fresh goods and rice through special strain fermentation
Important nutrient in meter, does not stimulate skin, stable in properties, can participate in adjusting the metabolism of skin, repair and endure small pox to the fullest extent
The skin wrecked, maintains skin moisture, makes nutrient go deep into skin histology, and the multiple enzyme contained in the product of the present invention can suppress
Skin aging, participates in horny layer metabolism, therefore can desalinate and dispel the pox print of face with antiinflammatory.The product composition of the present invention
Natural, safe and reliable, preparation process is controlled, and the constant product quality obtained is suitable to large-scale production, has good city
Field prospect.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in further detail.Should be appreciated that this
Bright enforcement is not limited to the following examples, and any pro forma accommodation and/or the change of being made the present invention all will fall
Enter scope.
In the present invention, if not refering in particular to, all of part, percentage ratio are unit of weight, the equipment used and raw material etc.
All it is commercially available or commonly used in the art.Method in following embodiment, if no special instructions, is the normal of this area
Rule method.
Bletilla striata extract, purchased from Pu Yi bio tech ltd, Nanjing；
Semen Coicis extract, purchased from Rui Di bio tech ltd, Xi'an；
Radix et Caulis Opuntiae Dillenii extract, purchased from Ye Cao bio tech ltd, Xi'an 5；
Extraction of rutin thing, purchased from Herba Galii Bungei bio tech ltd, Xi'an；
Semen Vitis viniferae extract, purchased from rank of nobility bio tech ltd, Shanghai thousand.
Embodiment 1-9:
The cosmetic composition of a kind of removing acnes and controlling oil whitening, described cosmetic composition is by component as shown in table 1
It is mixed.
Table 1 (unit: kg)
Embodiment 1,2, in 3, the preparation method of skin maintenance liquid is: by rice, tender okra pod and Abelmoschus esculentus flower with
The weight ratio mixing of 1:1:3, is mixed and made into mixed liquor with water after pulverizing, the weight ratio of material water is 1:4, then by composite bacteria
Activated seed liquid is seeded in mixed liquor, 200rpm after stirring, is maintained at lucifuge fermentation at a temperature of 30 DEG C～37 DEG C
36h, stands after fermentation ends and filters removal fermentation residue, then sterilization treatment, obtains skin maintenance liquid.Composite bacteria is for planting
Thing lactobacillus, Bafillus natt, Lactobacillus saki and saccharomyces cerevisiae, total inoculum concentration is 10.0 × 107Cfu/mL, each strain
Inoculum concentration is identical.
Embodiment 4,5, in 6, the preparation method of skin maintenance liquid is: by rice 30%, tender okra pod 20% and Huang Qiu
The weight mixing of certain herbaceous plants with big flowers flower 50%, is mixed and made into mixed liquor with water after pulverizing, the weight ratio of material water is 1:5, then by compound bacteria
Kind activated seed liquid be seeded in mixed liquor, 350rpm after stirring, be maintained at lucifuge at a temperature of 30 DEG C～37 DEG C and send out
Ferment 24h, stands after fermentation ends and filters removal fermentation residue, then sterilization treatment, obtains skin maintenance liquid.Composite bacteria is
Bafillus natt, bacillus acidophilus, bacillus subtilis and saccharomyces cerevisiae, total inoculum concentration is 10.0 × 107Cfu/mL, each bacterium
The inoculum concentration planted is identical.
Embodiment 7,8, in 9, the preparation method of skin maintenance liquid is: by rice 40%, tender okra pod 20% and Huang Qiu
The weight mixing of certain herbaceous plants with big flowers flower 40%, is mixed and made into mixed liquor with water after pulverizing, the weight ratio of material water is 1:4, then by compound bacteria
Kind activated seed liquid be seeded in mixed liquor, 200rpm after stirring, be maintained at lucifuge at a temperature of 30 DEG C～37 DEG C and send out
Ferment 36h, stands after fermentation ends and filters removal fermentation residue, then sterilization treatment, obtains skin maintenance liquid.Composite bacteria is
Lactobacillus plantarum, Bafillus natt, bacillus acidophilus, Lactobacillus saki and saccharomyces cerevisiae, total inoculum concentration is 10.0 ×
107Cfu/mL, the inoculum concentration of each strain is identical.
Embodiment 10:
The cosmetic composition of a kind of removing acnes and controlling oil whitening, its formula and preparation method are with embodiment 1, and difference is group
49.9kg water in Fen is replaced by xanthan gum 10kg, hyaluronate sodium 15kg and 24.9kg water.
Embodiment 11:
The cosmetic composition of a kind of removing acnes and controlling oil whitening, its formula and preparation method are with embodiment 1, and difference is group
49.37kg water in Fen is replaced by xanthan gum 10kg, hyaluronate sodium 15kg and 24.37kg butanediol.
Embodiment 12:
The cosmetic composition of a kind of removing acnes and controlling oil whitening, its formula and preparation method are with embodiment 1, and difference is group
49.37kg water in Fen is replaced by glycosyl trehalose 10kg, hyaluronate sodium 15kg and 24.37kg butanediol.
Embodiment 13:
The cosmetic composition of a kind of removing acnes and controlling oil whitening, its formula and preparation method are with embodiment 5, and difference is group
Possibly together with Oleum Vitis viniferae 0.5kg in Fen.
Embodiment 14:
A kind of facial film with moisturizing and after-sun restorative function, preparation method is: mask substrate immerses institute in embodiment 9
The cosmetic composition stated takes out after 30min, packaging, obtain mask product.Can add appropriate during packaging in packaging bag
Cosmetic composition is to improve effect.
Embodiment 15:
A kind of facial film with moisturizing and after-sun restorative function, preparation method is: mask substrate immerses institute in embodiment 5
The cosmetic composition stated takes out after 20min, packaging, obtain mask product.Can add appropriate during packaging in packaging bag
Cosmetic composition is to improve effect.
The cosmetic composition of the present invention can add some raw materials conventional in cosmetics, such as xanthan gum, hyaluronic acid
Sodium, butanediol, glycosyl trehalose etc., to regulate and to improve state and the viscosity of product, do not do tired one by one stating at this.The present invention is real
Executing the sterilization treatment described in example is this area routine techniques.
Test example 1 irritation test
120 example experimenters, are randomly divided into 6 groups, often organize 20 people, take 0.03ml sample with syringe and are placed in the medicine of speckle examination adhesive tape
Indoor, try the speckle being equipped with sample adhesive tape immediately and start from bottom to be longitudinally affixed on the normal skin of left forearm, the lightest
Pressing room is to drive away air, and makes trier be uniformly distributed.Labelling is carried out at test position, in order to observe.Skin is pasted every 24 hours
Once, open half an hour after paster, then checked according to the term of CTFA guide (1981).6 speckles are carried out altogether
Sturdy test, patch skin terminate after the 6th day, in order to observe late response, carried out additional inspection.Data then utilize last inspection
Come to an end fruit, compares.Identify and carry out for standard with table 2.Substances is respectively the cosmetic composition of embodiment 1～6,
The results are shown in Table 3.
Table 2. standard of perfection
Table 3. irritation test result
From table 3 it is observed that after using the cosmetic composition of the present invention, human body does not has any allergy and discomfort, says
The cosmetic composition of the bright present invention has good safety and non-stimulated feature.
Test example 2 skin repair and anti-acne test
Using method: one day one to twice.First with clear water after face wash clean, spread upon equably by the present invention and be on the face
Can.Sleep front using effect optimal.
Test proves, the compounding cosmetic composition of the present invention, all effective to all types of comedos, its effective percentage
93%.It is preferable that the experimenter of 80% reacts this product effect of deoiling, and uses rear skin the most tight, and moisturizing is effective；75% tested
Person thinks that this product has obvious whitening effect, can realize the after-sun of skin, and the effect of sunburn is gone in antiinflammatory.
For I degree of (slightly) acne, the most once take effect, can disappear completely at 2～3 days.
II degree of (moderate) acne, uses 1～2 day, and pimple diminishes, substantially disappears, and within 3～5 days, disappears completely.
III degree of (severe) acne, can control it and further develop, and disappears substantially at 3～7 days in red and swollen position, after 15 days,
Pus head absorbs or rides out voluntarily.For redness, cyst, blackhead, by the difference of weight, can there is significantly effect after a procedure
Really, within 3～15 days, dispel completely.The present invention can improve maintenance long pox skin, it is to avoid the possibility that comedo is inflamed, is using
The quantity forming blackhead after 10 days significantly reduces, and reduces number of times and area that comedo occurs.(i.e. blue or green for dispelling pox print
The impression that spring pox stays the most afterwards) effective time be, according to comedo, the degree of skin lesion is generally 2～10 days.
Embodiment described above is the one preferably scheme of the present invention, not makees the present invention any pro forma
Limit, on the premise of without departing from the technical scheme described in claim, also have other variant and remodeling.
Claims (8)
1. the cosmetic composition of a removing acnes and controlling oil whitening, it is characterised in that described cosmetic composition include following by
The component that percentage by weight calculates:
Nanometer Margarita powder 3～8%, bletilla striata extract 0.5～0.8%,
Semen Coicis extract 0.6～1.2%, Radix et Caulis Opuntiae Dillenii extract 1.3～1.5%, tea tree ethereal oil 0.01～0.03%, Rice oil 0.5
～1.0%, Extraction of rutin thing 0.5～1.0%, Semen Vitis viniferae extract 1～2%, skin maintenance liquid 40～60%, surplus is water；Skin
Maintenance liquid, skin maintenance liquid is mainly added suitable quantity of water by after rice, tender okra pod and the raw material of Abelmoschus esculentus flower mixing, pulverizing
Making through composite bacteria fermentation, described composite bacteria is by least two group at least two in I class strain and II class strain
Becoming, wherein I class strain includes Lactobacillus plantarum, Bafillus natt and bacillus acidophilus；II class strain include Lactobacillus saki,
Bacillus subtilis and saccharomyces cerevisiae.
Cosmetic composition the most according to claim 1, it is characterised in that: the particle diameter of nanometer Margarita powder is 10 ~ 100 to receive
Rice.
Cosmetic composition the most according to claim 1, it is characterised in that: described cosmetic composition also includes meat
Myristic acid isopropyl ester 1%, shea butter 0.5～1%, natural complex C 0.5～0.8%.
Cosmetic composition the most according to claim 1, it is characterised in that: described cosmetic composition also includes third
Glycol or butanediol 12～20%.
Cosmetic composition the most according to claim 1, it is characterised in that: the preparation method of skin maintenance liquid is: by institute
Mixing with water after stating raw material pulverizing, material-water ratio is 1:4～5, is then seeded in mixed liquor by composite bacteria, after stirring
200～350rpm, 30 DEG C～37 DEG C of lucifuge fermentation 24-36h, after standing and filter removal fermentation residue, obtain flesh through sterilization treatment
Skin maintenance liquid.
Cosmetic composition the most according to claim 1, it is characterised in that: described raw material components mass fraction is rice
20～40%, tender okra pod 20～40% and the Abelmoschus esculentus flower of surplus.
7. the preparation method of the cosmetic composition of a removing acnes and controlling oil whitening, it is characterised in that described cosmetic composition
Being mixed by the component described in claim 1, wherein the preparation method of skin maintenance liquid is: by after described raw material pulverizing with water
Mixing, material-water ratio is 1:4～5, is then seeded in mixed liquor by composite bacteria, after stirring 200～350rpm, 30 DEG C～
37 DEG C of lucifuge fermentation 24-36h, obtain skin maintenance liquid through sterilization treatment after standing and filter removal fermentation residue.
8. a facial film with moisturizing and after-sun restorative function, it is characterised in that mask substrate is immersed described in claim 1
Cosmetic composition in take out after 15～30min, packaging, obtain mask product.
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| CN201610663566.1A CN106137916A (en) | 2016-08-11 | 2016-08-11 | The cosmetic composition of a kind of removing acnes and controlling oil whitening and application thereof |
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| CN106176556A (en) * | 2016-08-31 | 2016-12-07 | 张进 | A kind of removing acnes and controlling oil whitening cream |
| CN106691976A (en) * | 2017-03-03 | 2017-05-24 | 北京华奥光程化妆品有限公司 | Plant extract capable of controlling oil and shrinking pores and preparation method and application of plant extract |
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| CN106880565A (en) * | 2017-03-03 | 2017-06-23 | 北京华奥光程化妆品有限公司 | A kind of plant extracts for the light spot of skin-whitening and its preparation method and application |
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| CN107496288A (en) * | 2017-08-29 | 2017-12-22 | 广西贵港市恒桥米业有限公司 | A kind of ivory scented rice spot-dispelling liquid and preparation method thereof |
| CN108904376A (en) * | 2018-08-02 | 2018-11-30 | 广东轻工职业技术学院 | It is a kind of to have effects that the Chinese medicine compound prescription fermentation liquid used for cosmetic of oil control and acne removal and its preparation and application |
| CN108904376B (en) * | 2018-08-02 | 2020-07-10 | 广东赛安特新材料有限公司 | Traditional Chinese medicine compound fermentation liquor for cosmetics with oil control and acne removal effects and preparation and application thereof |
| CN109316419A (en) * | 2018-11-14 | 2019-02-12 | 广东轻工职业技术学院 | A kind of the plant composition fermentation magma and preparation and application of balance skin Tiny ecosystem |
| CN109316419B (en) * | 2018-11-14 | 2022-12-13 | 广州市茗妍化妆品有限公司 | Plant composition fermentation raw stock for balancing skin micro-ecology and preparation and application thereof |
| CN109620779A (en) * | 2019-02-16 | 2019-04-16 | 陈伟伟 | A kind of anti-acne moisturizing cosmetic face cream and preparation method thereof |
| CN110420159A (en) * | 2019-05-27 | 2019-11-08 | 广州好蝶化妆品有限公司 | A kind of anti-acne maintenance essence cream and preparation method |
| CN112494391A (en) * | 2020-12-22 | 2021-03-16 | 上海浙星新型材料科技有限公司 | Green and safe acne-removing composition |
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