BRPI0413073A - processo para a produção de compostos, óleo, lipìdeo ou ácido graxo, ou uma fração dos mesmos, composição de óleo, lipìdeo ou ácido graxo, processo para a produção de óleos, lipìdeos ou composições de ácido graxo, uso de óleo, lipìdeo ou ácidos graxos ou de composições de óleo, lipìdeo ou ácido graxo ou de óleos, lipìdeos ou composições de ácido graxo, seqüência de ácido nucleico isolado, seqüência de aminoácidos, construção de gene, vetor, e, organismo não humano transgênico - Google Patents

processo para a produção de compostos, óleo, lipìdeo ou ácido graxo, ou uma fração dos mesmos, composição de óleo, lipìdeo ou ácido graxo, processo para a produção de óleos, lipìdeos ou composições de ácido graxo, uso de óleo, lipìdeo ou ácidos graxos ou de composições de óleo, lipìdeo ou ácido graxo ou de óleos, lipìdeos ou composições de ácido graxo, seqüência de ácido nucleico isolado, seqüência de aminoácidos, construção de gene, vetor, e, organismo não humano transgênico

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Publication number
BRPI0413073A
BRPI0413073A BRPI0413073-1A BRPI0413073A BRPI0413073A BR PI0413073 A BRPI0413073 A BR PI0413073A BR PI0413073 A BRPI0413073 A BR PI0413073A BR PI0413073 A BRPI0413073 A BR PI0413073A
Authority
BR
Brazil
Prior art keywords
fatty acid
lipid
oil
oils
production
Prior art date
Application number
BRPI0413073-1A
Other languages
English (en)
Inventor
Thorsten Zank
Joerg Bauer
Petra Cirpus
Amine Abbadi
Ernst Heinz
Xiao Qiu
Patricia Vrinten
Petra Sperling
Frederic Domergue
Astrid Meyer
Jelena Kirsch
Original Assignee
Basf Plant Science Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34120175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0413073(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Basf Plant Science Gmbh filed Critical Basf Plant Science Gmbh
Publication of BRPI0413073A publication Critical patent/BRPI0413073A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6431—Linoleic acids [18:2[n-6]]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
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    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19003—Linoleoyl-CoA desaturase (1.14.19.3)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01199—Very-long-chain 3-oxoacyl-CoA synthase (2.3.1.199)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
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  • Physics & Mathematics (AREA)
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  • Plant Pathology (AREA)
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  • Hematology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A PRODUçãO DE COMPOSTOS, óLEO, LIPìDEO OU áCIDO GRAXO, OU UMA FRAçãO DOS MESMOS, COMPOSIçãO DE óLEO, LIPìDEO OU áCIDO GRAXO, PROCESSO PARA A PRODUçãO DE óLEOS, LIPìDEOS OU COMPOSIçõES DE áCIDO GRAXO, USO DE óLEO, LIPìDEO OU áCIDOS GRAXOS OU DE COMPOSIçõES DE óLEO, LIPìDEO OU áCIDO GRAXO OU DE óLEOS, LIPìDEOS OU COMPOSIçõES DE áCIDO GRAXO, SEQüêNCIA DE áCIDO NUCLEICO ISOLADO, SEQüêNCIA DE AMINOáCIDOS, CONSTRUçãO DE GENE, VETOR, E, ORGANISMO NãO HUMANO TRANSGêNICO". A invenção refere-se a um método para a produção de ácidos graxos multiplamente insaturados em um organismo, para dentro do qual ácidos nucleicos têm sido introduzidos, que codificam polipeptídeos com atividade de <30>-5 elongase. As citadas seqüências de ácido graxo, opcionalmente com outras seqüências de ácido nucleico, codificadoras de polipeptídeos para a biossíntese de ácidos graxos e metabolismo de lipídeo, são vantajosamente expressadas no organismo. As seqüências de ácido nucleico codificadoras de uma atividade de <30>-6 dessaturase, <30>-5 dessaturase, <30>-4 dessaturase e/ou <30>-6 elongase são particularmente vantajosas e, vantajosamente, as citadas saturases e elongases são derivadas de Thalassiosira, Euglena ou Ostreococcus. A invenção refere-se adicionalmente a um método para a produção de óleos e/ou triacilglicerídeos com um conteúdo aumentado de ácidos graxos multiplamente insaturados, de cadeia longa. Uma modalidade específica da invenção é um método para a produção de ácidos graxos insaturados <sym>-3 e um método para a produção de triglicerídeos com um conteúdo aumentado de ácidos graxos insaturados, em particular de ácidos graxos <30>-3 com mais do que três ligações duplas. Também é descrita a produção de um organismo transgênico, preferivelmente uma planta transgênica, ou um microorganismo transgênico com conteúdo aumentado de ácidos graxos, óleos ou lipídeos <sym>-3 com ligações duplas <sym>-3 como um resultado da expressão das elongases e dessaturases empregadas no método acima, preferivelmente em combinação com <sym>-3 dessaturases, por exemplo uma <sym>-3 dessaturase de fungos da família Pythiaceae tal como do gênero Phytophtora, por exemplo, do gênero e da espécie Phytophtora infestans, ou uma <sym>-3 dessaturase de algas tais como da família Prasinophyceae, por exemplo, do gênero Ostreococcus e, particularmente, do gênero e da espécie Ostreococcus tauri ou diatomácea tal como do gênero Thalassiosira e, particularmente, do gênero e da espécie Thalassiosira pseudonana. A invenção também se refere às seqüências de ácido nucleico, às construções de ácido nucleico, aos vetores e aos organismos contendo as seqüências de ácido nucleico, as construções de ácido nucleico e/ou os vetores. Uma outra parte da invenção refere-se aos óleos, lipídeos e/ou ácidos graxos produzidos de acordo com o método acima e ao seu uso e, em adição, aos ácidos graxos insaturados e triglicerídeos com um conteúdo aumentado de ácidos graxos insaturados e ao seu uso.
BRPI0413073-1A 2003-08-01 2004-07-16 processo para a produção de compostos, óleo, lipìdeo ou ácido graxo, ou uma fração dos mesmos, composição de óleo, lipìdeo ou ácido graxo, processo para a produção de óleos, lipìdeos ou composições de ácido graxo, uso de óleo, lipìdeo ou ácidos graxos ou de composições de óleo, lipìdeo ou ácido graxo ou de óleos, lipìdeos ou composições de ácido graxo, seqüência de ácido nucleico isolado, seqüência de aminoácidos, construção de gene, vetor, e, organismo não humano transgênico BRPI0413073A (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE10335992 2003-08-01
DE10344557 2003-09-24
DE10347869 2003-10-10
DE10359593 2003-12-18
DE102004009457 2004-02-27
DE102004012370 2004-03-13
DE102004024014 2004-05-14
PCT/EP2004/007957 WO2005012316A2 (de) 2003-08-01 2004-07-16 Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen

Publications (1)

Publication Number Publication Date
BRPI0413073A true BRPI0413073A (pt) 2006-10-03

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Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO347177B1 (no) * 2003-08-01 2023-06-19 Basf Plant Science Gmbh Fremgangsmåte for fremstilling av flerumettede fettsyrer i transgene organismer
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
EP1656449B1 (en) * 2003-08-21 2009-05-06 Monsanto Technology LLC Fatty acid desaturases from primula
BRPI0507716A (pt) * 2004-02-17 2007-07-03 Univ York célula transgênica, planta, semente, vaso de reação, e, método para dessaturar um substrato de ácido graxo
EP4219670A3 (de) * 2004-02-27 2023-08-09 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen
EP3543324B1 (de) * 2004-02-27 2022-11-30 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigten fettsäuren in transgenen pflanzen
WO2005083053A2 (de) 2004-02-27 2005-09-09 Basf Plant Science Gmbh Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen
BRPI0509944A (pt) * 2004-04-16 2007-09-25 Monsanto Technology Llc expressão de dessaturases de ácido graxo em milho
CN102559364B (zh) * 2004-04-22 2016-08-17 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
EP1756280B2 (en) * 2004-04-22 2024-01-17 Commonwealth Scientific and Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
US7256033B2 (en) 2004-06-25 2007-08-14 E. I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
JP4587451B2 (ja) 2004-08-20 2010-11-24 サントリーホールディングス株式会社 ω３脂肪酸不飽和化活性を有するポリペプチドおよびそのポリペプチドをコードするポリヌクレオチドならびにそれらの利用
US7550286B2 (en) * 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DE102004063326A1 (de) * 2004-12-23 2006-07-06 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
DE102005013779A1 (de) * 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
CN101321872B (zh) * 2005-05-23 2012-09-05 阿凯迪亚生物科学公司 高γ-亚麻酸红花
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
DK1951866T3 (da) 2005-11-23 2014-10-27 Du Pont Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer
US7723574B2 (en) * 2005-11-24 2010-05-25 Basf Plant Science Gmbh Process for the production of Δ5-unsaturated fatty acids in transgenic organisms
JP4803584B2 (ja) * 2006-02-08 2011-10-26 独立行政法人産業技術総合研究所 脂質生産性の高い形質転換微生物
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US7465793B2 (en) * 2006-04-20 2008-12-16 E.I. Du Pont De Nemours And Company Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids
US7678560B2 (en) 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) * 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
EP2500420B1 (en) * 2006-08-24 2016-06-22 BASF Plant Science GmbH Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains
AU2013202498B2 (en) * 2006-08-24 2015-04-30 Basf Plant Science Gmbh Isolation and characterization of a novel Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains
RU2009111266A (ru) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
AU2013273704C1 (en) * 2006-10-06 2023-03-16 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
ES2531391T3 (es) 2006-10-06 2015-03-13 Basf Plant Science Gmbh Delta-5 desaturasas y procedimiento para la preparación de ácidos grasos poliinsaturados en organismos transgénicos no humanos
AU2007322223B2 (en) 2006-10-23 2012-12-13 Corteva Agriscience Llc Delta-8 desaturases and their use in making polyunsaturated fatty acids
WO2008073275A2 (en) 2006-12-07 2008-06-19 E. I. Du Pont De Nemours And Company Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids
US7709239B2 (en) 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
NZ578165A (en) * 2007-01-03 2012-04-27 Monsanto Technology Llc Food compositions incorporating additional long chain fatty acids
EP2441842A1 (en) * 2007-02-12 2012-04-18 E. I. du Pont de Nemours and Company Production of arachidonic acid in oilseed plants
JP2010523113A (ja) * 2007-04-03 2010-07-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー マルチザイム（ｍｕｌｔｉｚｙｍｅ）および多価不飽和脂肪酸の製造におけるその使用
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
JP2010533003A (ja) * 2007-07-13 2010-10-21 オーシャン ニュートリッション カナダ リミテッド Ｄ４デサチュラーゼ及びｄ５エロンガーゼ
WO2009016208A2 (de) * 2007-07-31 2009-02-05 Basf Plant Science Gmbh Elongasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen
US20090110800A1 (en) * 2007-10-24 2009-04-30 Wilkes Richard S Food compositions incorporating additional long chain fatty acids
JP2011519552A (ja) * 2008-04-25 2011-07-14 ビーエーエスエフ プラント サイエンス ゲーエムベーハー 植物種子油
ES2334744B1 (es) * 2008-07-11 2011-04-06 Zurko Research S.L. Procedimiento enzimatico para la obtencion del acido docosahexaenoicoomega-3 y del acido docosapentaenoico omega-6, a partir de aceites vegetales, y sus productos.
US9090902B2 (en) * 2008-08-26 2015-07-28 Basf Plant Science Gmbh Nucleic acids encoding desaturases and modified plant oil
BRPI0913714A2 (pt) 2008-09-19 2020-10-13 E. I. Du Pont De Nemours And Company polipeptídeo mutante que possui atividade de a5 dessaturase, molécula de ácido nucleico isolada, célula hospedeira microbiana e métodos de produção de ácido araquidônico e de ácido eicosapentaenoico
AU2015224521B2 (en) * 2008-11-18 2017-09-14 Commonwealth Scientific And Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
NO2358882T3 (pt) 2008-11-18 2017-12-23
WO2010101220A1 (ja) * 2009-03-04 2010-09-10 国立大学法人九州大学 新規酵素及びそれをコードするｄｎａ
EP2821492A3 (en) 2009-05-13 2015-04-08 BASF Plant Science Company GmbH Acyltransferases and uses thereof in fatty acid production
EP2440662B1 (en) 2009-06-08 2018-08-01 BASF Plant Science Company GmbH Novel fatty acid elongation components and uses thereof
AU2010272536B2 (en) 2009-07-17 2016-09-08 Basf Plant Science Company Gmbh Novel fatty acid desaturases and elongases and uses thereof
CA2772267A1 (en) 2009-08-31 2011-03-03 Basf Plant Science Company Gmbh Regulatory nucleic acid molecules for enhancing seed-specific gene expression in plants promoting enhanced polyunsaturated fatty acid synthesis
US9150891B2 (en) 2009-09-24 2015-10-06 Kyushu University, National University Corporation Method for transforming stramenopiles
US9347049B2 (en) 2009-11-24 2016-05-24 Basf Plant Science Company Gmbh Fatty acid elongase and uses thereof
WO2011064181A1 (en) 2009-11-24 2011-06-03 Basf Plant Science Company Gmbh Novel fatty acid desaturase and uses thereof
EP2585603B1 (en) 2010-06-25 2017-12-20 BASF Plant Science Company GmbH Acyltransferases and uses therof in fatty acid production
KR20140008295A (ko) 2010-08-26 2014-01-21 이 아이 듀폰 디 네모아 앤드 캄파니 돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도
AU2011293180B2 (en) 2010-08-26 2017-03-02 E. I. Du Pont De Nemours And Company Recombinant microbial host cells for high eicosapentaenoic acid production
WO2012052468A2 (en) 2010-10-21 2012-04-26 Basf Plant Science Company Gmbh Novel fatty acid desaturases, elongases, elongation components and uses therof
CN102191257A (zh) * 2011-04-04 2011-09-21 山东农业大学 马铃薯致病疫霉Δ6去饱和酶基因PinD6的克隆及其应用
CA2869738C (en) 2012-04-12 2022-04-05 Rothamsted Research Ltd Production of omega-3 long chain polyunsaturated fatty acids
MX349678B (es) 2012-06-15 2017-08-08 Commw Scient Ind Res Org Producción de ácidos grasos poliinsaturados de cadena larga en células vegetales.
EP2880050B1 (en) 2012-08-03 2018-07-04 BASF Plant Science Company GmbH Novel enzymes, enzyme components and uses thereof
GB201217524D0 (en) 2012-10-01 2012-11-14 Rothamsted Res Ltd Recombinant organisms
EP2931739A4 (en) * 2012-12-05 2016-08-03 Exxonmobil Res & Eng Co Nannochloropsis-KOZAK SEQUENCE
CN103173445B (zh) * 2013-04-15 2014-07-30 南京江辉生物科技有限公司 一种欧米伽3的合成基因、含有合成基因的大肠菌及其构建方法
JP2014212732A (ja) * 2013-04-25 2014-11-17 旭硝子株式会社 リシノール酸産生酵母
AU2014285720B2 (en) 2013-07-05 2020-10-15 Basf Plant Science Company Gmbh Gene expression or activity enhancing elements
US10308953B2 (en) 2013-12-18 2019-06-04 BASF Agro B.V. Plants having increased tolerance to herbicides
EP3082405A4 (en) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
KR102527795B1 (ko) 2014-06-27 2023-05-02 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 도코사펜타에노산을 포함하는 지질
CN115094081A (zh) 2014-11-14 2022-09-23 巴斯夫植物科学有限公司 增加种子油中生育酚含量的材料和方法
US10513718B2 (en) 2017-06-06 2019-12-24 City University Of Hong Kong Method of producing polyunsaturated fatty acid
CN110373436B (zh) * 2018-12-11 2022-09-23 山东理工大学 一种产双高-γ-亚麻酸卷枝毛霉细胞工厂的构建方法及发酵技术
WO2020168277A1 (en) 2019-02-14 2020-08-20 Cargill, Incorporated Brassica plants producing elevated levels of polyunsaturated fatty acids
CN110334869A (zh) * 2019-08-15 2019-10-15 重庆大学 一种基于动态群优化算法的红树林生态健康预测训练方法
US20230397562A1 (en) 2020-11-04 2023-12-14 Cargill, Incorporated Harvest Management
CN117042596A (zh) 2021-03-25 2023-11-10 巴斯夫植物科学有限公司 肥料管理
WO2023196923A1 (en) * 2022-04-07 2023-10-12 Checkerspot, Inc. Ricinoleate oil production and uses thereof

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352605A (en) 1983-01-17 1994-10-04 Monsanto Company Chimeric genes for transforming plant cells using viral promoters
EP0131623B2 (en) 1983-01-17 1999-07-28 Monsanto Company Chimeric genes suitable for expression in plant cells
US5504200A (en) 1983-04-15 1996-04-02 Mycogen Plant Science, Inc. Plant gene expression
US5420034A (en) 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
DK162399C (da) 1986-01-28 1992-03-23 Danisco Fremgangsmaade til ekspression af gener i baelgplanteceller, dna-fragment, rekombineret dna-fragment samt plasmid til brug ved udoevelsen af fremgangsmaaden
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US5110728A (en) 1986-07-31 1992-05-05 Calgene, Inc. Acyl carrier protein - DNA sequence and synthesis
US5614395A (en) 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
NZ228320A (en) 1988-03-29 1991-06-25 Du Pont Nucleic acid promoter fragments of the promoter region homologous to the em gene of wheat, dna constructs therefrom and plants thereof
CA1341467C (en) 1988-07-29 2004-12-07 John C. Rogers Producing commercially valuable polypeptides with genetically transformed endosperm tissue
DE3843628A1 (de) 1988-12-21 1990-07-05 Inst Genbiologische Forschung Wundinduzierbare und kartoffelknollenspezifische transkriptionale regulation
HU218717B (hu) 1989-03-17 2000-11-28 E. I. Du Pont De Nemours And Co. Nukleinsav-termelést fokozó növényi eredetű génfragmentek és eljárás előállításukra
JPH04506155A (ja) 1990-03-16 1992-10-29 カルジーン，インコーポレイティド 初期種子形成において優先的に発現される新規配列およびそれに関連する方法
CA2077896C (en) 1990-03-16 2008-02-19 Gregory A. Thompson Plant desaturases - compositions and uses
US5187267A (en) 1990-06-19 1993-02-16 Calgene, Inc. Plant proteins, promoters, coding sequences and use
WO1993020216A1 (en) 1991-02-22 1993-10-14 University Technologies International, Inc. Oil-body protein cis-elements as regulatory signals
AU669478B2 (en) 1991-04-09 1996-06-13 Unilever Plc Plant promoter involved in controlling lipid biosynthesis in seeds
US5614393A (en) 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
PH31293A (en) 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
EP0616644B1 (en) 1991-12-04 2003-07-02 E.I. Du Pont De Nemours And Company Fatty acid desaturase genes from plants
CA2084348A1 (en) 1991-12-31 1993-07-01 David F. Hildebrand Fatty acid alteration by a d9 desaturase in transgenic plant tissue
DE4208050A1 (de) 1992-03-13 1993-09-23 Bayer Ag Azolylmethyl-fluorcyclopropyl-derivate
CA2092069A1 (en) 1992-03-27 1993-09-28 Asako Iida An expression plasmid for seeds
EP0637339B1 (en) 1992-04-13 2001-10-31 Syngenta Limited Dna constructs and plants incorporating them
JPH0662870A (ja) 1992-08-18 1994-03-08 Mitsui Giyousai Shokubutsu Bio Kenkyusho:Kk 大豆ホスホエノールピルビン酸カルボキシラーゼ遺伝子のプロモーター領域及び５’非翻訳領域
DK0668919T3 (da) 1992-11-17 2003-09-15 Du Pont Gener for mikorsomale delta-12-fedtsyredesaturaser og beslægtede enzymer fra planter
CA2150133A1 (en) 1993-02-05 1994-08-18 Vincent Jean-Marie Armel Arondel Altered linolenic and linoleic acid content in plants
GB9324707D0 (en) 1993-12-02 1994-01-19 Olsen Odd Arne Promoter
CA2178729A1 (en) 1993-12-09 1995-06-15 Eric B. Kmiec Compounds and methods for site-directed mutations in eukaryotic cells
US5576198A (en) 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
CN1108382C (zh) * 1993-12-28 2003-05-14 麒麟麦酒株式会社 脂肪酸去饱和酶基因,含该基因的载体和用该基因转化的植物细胞
GB9403512D0 (en) 1994-02-24 1994-04-13 Olsen Odd Arne Promoter
US6310194B1 (en) 1994-09-26 2001-10-30 Carnegie Institution Of Washington Plant fatty acid hydroxylases
GB9421286D0 (en) 1994-10-21 1994-12-07 Danisco Promoter
US5689040A (en) 1995-02-23 1997-11-18 The Regents Of The University Of California Plant promoter sequences useful for gene expression in seeds and seedlings
ES2293649T3 (es) 1995-07-05 2008-03-16 Sapporo Breweries Ltd. Metodo que emplea un promotor especifico de tejido.
CA2225652C (en) 1995-08-10 2007-11-20 Pal Maliga Nuclear-encoded transcription system in plastids of higher plants
EP0880312B1 (en) 1995-12-14 2006-03-08 Cargill Incorporated Plants having mutant sequences that confer altered fatty acid profiles
EP0794250A1 (en) 1996-03-04 1997-09-10 Soremartec S.A. Isolation and sequencing of the hazel FAd2-N gene
DE19626564A1 (de) 1996-07-03 1998-01-08 Hoechst Ag Genetische Transformation von Ciliatenzellen durch Microcarrier-Bombardement mit DNA beladenen Goldpartikeln
US5981841A (en) 1996-08-30 1999-11-09 Monsanto Company Early seed 5' regulatory sequence
US6194167B1 (en) 1997-02-18 2001-02-27 Washington State University Research Foundation ω-3 fatty acid desaturase
US5977436A (en) 1997-04-09 1999-11-02 Rhone Poulenc Agrochimie Oleosin 5' regulatory region for the modification of plant seed lipid composition
AR013633A1 (es) 1997-04-11 2001-01-10 Calgene Llc METODO PARA LA ALTERACIoN DE LA COMPOSICIoN DE ÁCIDOS GRASOS DE CADENA MEDIA EN SEMILLAS VEGETALES QUE EXPRESAN UNA TIOESTERASA QUE PREFIERE CADENA MEDIA VEGETAL HETERoLOGA.
DK0996732T3 (da) 1997-04-11 2005-10-17 Calgene Llc Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer i planter
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US5972664A (en) 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
JP3923144B2 (ja) * 1997-07-31 2007-05-30 大日本印刷株式会社 ホログラム作成方法
EP1019517B2 (en) 1997-09-30 2014-05-21 The Regents of The University of California Production of proteins in plant seeds
GB9724783D0 (en) 1997-11-24 1998-01-21 Inst Arable Crops Research Novel polypeptides
JP4378452B2 (ja) * 1998-02-09 2009-12-09 豊博 小林 ホログラム構成物
EP1062351B1 (en) 1998-03-11 2006-05-10 Syngenta Participations AG Novel plant plastid promoter sequence
EP2816116B1 (en) * 1998-06-12 2016-02-03 Calgene LLC Polyunsaturated fatty acids in plants
WO1999064616A2 (en) 1998-06-12 1999-12-16 Abbott Laboratories Polyunsaturated fatty acids in plants
US20030163845A1 (en) 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
US6555732B1 (en) 1998-09-14 2003-04-29 Pioneer Hi-Bred International, Inc. Rac-like genes and methods of use
JP2002527051A (ja) 1998-10-09 2002-08-27 メルク エンド カムパニー インコーポレーテッド デルタ６脂肪酸デサチュラーゼ
ATE353952T1 (de) 1998-12-07 2007-03-15 Univ Washington Desaturasen und verfahren ihrer anwendung zur synthese von mehrfach ungesättigten fettsäuren
CA2365096A1 (en) * 1999-03-18 2000-09-21 The University Of Bristol Polyunsaturated fatty acid (pufa) elongase from caenorhabditis elegans
JP4547122B2 (ja) * 2000-02-09 2010-09-22 ビーエーエスエフ ソシエタス・ヨーロピア 新規エロンガーゼ遺伝子および高度不飽和脂肪酸の生産方法
JP3425622B2 (ja) * 2000-03-30 2003-07-14 独立行政法人産業技術総合研究所 ラビリンチュラ属菌を用いた高度不飽和脂肪酸含有培養物および高度不飽和脂肪酸含有油脂の製造方法
AU2001264161A1 (en) 2000-05-09 2001-11-20 Bioriginal Food And Science Corp. Production of conjugated linoleic and linolenic acids in plants
CN101845446B (zh) 2000-09-28 2016-01-20 生物源食物及科学公司 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用
AU2002221404B2 (en) 2000-11-29 2008-01-03 Xenon Genetics Inc Human elongase genes and uses thereof
DE10102337A1 (de) 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte
DE10102338A1 (de) 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten
EP1392823B1 (en) 2001-01-25 2011-11-30 Abbott Laboratories Desaturase genes and uses thereof
CA2439654A1 (en) 2001-03-12 2002-09-19 The General Hospital Corporation Compositions and methods for modifying the content of polyunsaturated fatty acids in mammalian cells
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
US7045683B2 (en) 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
WO2002092540A1 (en) 2001-05-14 2002-11-21 Martek Biosciences Corporation Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsatruated fatty acids from microbes, genetically modified plant seeds and marine organisms
US7211656B2 (en) 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
DE10219203A1 (de) 2002-04-29 2003-11-13 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen
AU2003258496A1 (en) 2002-07-03 2004-01-23 Basf Plant Science Gmbh Method for the production of conjugated polyunsaturated fatty acids comprising at least two double bonds in plants
BR0317304A (pt) 2002-12-19 2005-11-08 Univ Bristol Processo para a produção de compostos, sequência de ácido nucleico isolada, sequência de aminoácidos, construção gênica, vetor, e, organismo
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
WO2004076617A2 (de) 2003-02-27 2004-09-10 Basf Plant Science Gmbh Verfahren zur herstellung mehrfach ungesättigter fettsäuren
WO2004087902A2 (de) 2003-03-31 2004-10-14 University Of Bristol Neue pflanzliche acyltransferasen spezifisch für langkettige mehrfach ungesättigte fettsäuren
BRPI0409209A (pt) 2003-04-08 2006-03-28 Basf Plant Science Gmbh seqüência de ácido nucleico isolado, construto de gene, vetor, organismo não-humano transgênico, processo para produzir ácidos graxos poliinsaturados, óleo, lipìdeos ou ácidos graxos ou uma fração dos mesmos, composição de óleo, de lipìdeo ou de ácido graxo, e, uso de óleo, de lipìdeos ou de ácidos graxos ou de composição de óleo, de lipìdeo ou de ácido graxo
NO347177B1 (no) 2003-08-01 2023-06-19 Basf Plant Science Gmbh Fremgangsmåte for fremstilling av flerumettede fettsyrer i transgene organismer
WO2005083053A2 (de) 2004-02-27 2005-09-09 Basf Plant Science Gmbh Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen
EP4219670A3 (de) 2004-02-27 2023-08-09 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen
EP3543324B1 (de) 2004-02-27 2022-11-30 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigten fettsäuren in transgenen pflanzen
EP1756280B2 (en) 2004-04-22 2024-01-17 Commonwealth Scientific and Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
DE102004060340A1 (de) 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
KR200414237Y1 (ko) * 2006-02-06 2006-04-17 주식회사 스토리오브 카메라의 보케 효과용 외부 필터
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
JP2011519552A (ja) 2008-04-25 2011-07-14 ビーエーエスエフ プラント サイエンス ゲーエムベーハー 植物種子油
BRPI0911892A8 (pt) 2008-04-30 2018-06-26 Rothamsted Res Ltd polinucleotídeo, vetor, célula hospedeira, polipeptídeo e organismo não humano, transgênico, e uso dos mesmos, processo de geração de um polipeptídio com atividade de desaturase ou elongase, anticorpo e processo para a produção de uma composição de óleo, lipídio ou ácido graxo
NO2358882T3 (pt) 2008-11-18 2017-12-23
EP2440662B1 (en) 2009-06-08 2018-08-01 BASF Plant Science Company GmbH Novel fatty acid elongation components and uses thereof
AU2010272536B2 (en) 2009-07-17 2016-09-08 Basf Plant Science Company Gmbh Novel fatty acid desaturases and elongases and uses thereof
JP6572206B2 (ja) 2013-09-25 2019-09-04 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ファインケミカルの生産改善のための組換え微生物
JP6685910B2 (ja) 2013-12-13 2020-04-22 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ファインケミカルの生産改善のための組換え微生物
CA2942990A1 (en) 2014-03-19 2015-09-24 Basf Se The use of glycerol with limited feed of carbohydrates for fermentation
KR102527795B1 (ko) 2014-06-27 2023-05-02 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 도코사펜타에노산을 포함하는 지질
BR112017019631A2 (pt) 2015-03-18 2018-05-15 Basf Se ?microrganismo recombinante, composição, métodos para produzir um microrganismo recombinante, para produzir piruvato, succinato, aspartato, malato, lactato, valina, leucina e/ou alanina, e para cultivar ou desenvolver um microrganismo geneticamente modificado, uso de um microrganismo recombinante, processo para produção fermentativa de piruvato, succinato, aspartato, malato, lactato, valina, leucina e/ou alanina, construção de expressão recombinante, e, vetor recombinante?
JP7071124B2 (ja) 2015-06-04 2022-05-18 ビーエーエスエフ ソシエタス・ヨーロピア ファインケミカルの生産改善のための組換え微生物
EP3307902A1 (en) 2015-06-12 2018-04-18 Basf Se Recombinant microorganism for improved production of alanine
JP6502442B2 (ja) * 2017-09-01 2019-04-17 株式会社長英 カメラ用フィルタ
JP2019105703A (ja) * 2017-12-12 2019-06-27 有限会社 高度技術研究所 位相差画像検査装置及び位相差画像検査方法

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