ATE451365T1 - Als atm-inhibitoren geeignete pyranone - Google Patents

Als atm-inhibitoren geeignete pyranone

Info

Publication number: ATE451365T1
Authority: AT; Austria
Prior art keywords: pyranones; atm inhibitors; sulfonamino; acylamido; prodrugs
Prior art date: 2002-02-25

Application number

AT03742608T

Other languages

English (en)

Inventor

Graeme Smith

Niall Martin

Stephen Jackson

Mark O'connor

Alan Lau

Xiao-Ling Fan Cockcroft

Ian Matthews

Keith Menear

Laurent Rigoreau

Marc Hummersone

Roger Griffin

Original Assignee

Kudos Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-25

Filing date

2003-02-24

Publication date

2009-12-15

2002-02-25 Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en

2003-02-24 Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd

2009-12-15 Application granted granted Critical

2009-12-15 Publication of ATE451365T1 publication Critical patent/ATE451365T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Immunology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03742608T 2002-02-25 2003-02-24 Als atm-inhibitoren geeignete pyranone ATE451365T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0204350.3A GB0204350D0 (en)	2002-02-25	2002-02-25	ATM inhibitors
US39588402P	2002-07-15	2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en)	2002-02-25	2003-02-24	Pyranones useful as atm inhibitors

Publications (1)

Publication Number	Publication Date
ATE451365T1 true ATE451365T1 (de)	2009-12-15

Family

ID=27758841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03742608T ATE451365T1 (de)	2002-02-25	2003-02-24	Als atm-inhibitoren geeignete pyranone

Country Status (20)

Country	Link
EP (2)	EP2174939A1 (de)
JP (1)	JP2005521689A (de)
CN (1)	CN100358891C (de)
AT (1)	ATE451365T1 (de)
AU (1)	AU2003209990B8 (de)
BR (1)	BR0307944A (de)
CA (1)	CA2473100A1 (de)
CY (1)	CY1109835T1 (de)
DE (1)	DE60330442D1 (de)
DK (1)	DK1485377T5 (de)
ES (1)	ES2336206T3 (de)
GB (1)	GB2401606B (de)
HK (1)	HK1069827A1 (de)
MX (1)	MXPA04007809A (de)
NO (1)	NO329806B1 (de)
NZ (1)	NZ534821A (de)
PL (1)	PL370074A1 (de)
PT (1)	PT1485377E (de)
SI (1)	SI1485377T1 (de)
WO (1)	WO2003070726A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
GB0119865D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
GB0119863D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
EP1501822B1 (de)	2002-04-30	2010-12-15	Kudos Pharmaceuticals Limited	Phthalazinonderivate
US7122189B2 (en) *	2002-08-13	2006-10-17	Enzon, Inc.	Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7413738B2 (en)	2002-08-13	2008-08-19	Enzon Pharmaceuticals, Inc.	Releasable polymeric conjugates based on biodegradable linkers
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
WO2004097426A2 (en) *	2003-05-01	2004-11-11	Kudos Pharmaceuticals Limited	Methods and means for the treatment of disorders associated with cellular senescence
CA2534300A1 (en)	2003-08-13	2005-02-24	Kudos Pharmaceuticals Limited	Aminopyrones and their use as atm inhibitors
HUE025996T2 (en)	2003-12-01	2016-05-30	Kudos Pharm Ltd	Inhibitors of DNA damage repair for the treatment of cancer
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
AU2005286329A1 (en)	2004-09-20	2006-03-30	Cancer Research Technology Limited	DNA-PK inhibitors
WO2006085067A1 (en) *	2005-02-09	2006-08-17	Kudos Pharmaceuticals Limited	Atm inhibitors
AR054438A1 (es)	2005-04-15	2007-06-27	Kudos Pharm Ltd	Inhibidores de adn -pk
TW200745094A (en) *	2005-08-31	2007-12-16	Kudos Pharm Ltd	ATM inhibitor
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
WO2009034326A1 (en)	2007-09-14	2009-03-19	Astrazeneca Ab	Phthalazinone derivatives
DK2346495T4 (da)	2008-10-07	2023-08-28	Kudos Pharm Ltd	Farmaceutisk formulering 514
EP2486923B1 (de) *	2011-02-11	2015-09-09	Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG	Histon-Deacetylase (HDAC) hemmende Verbindungen und Verfahren zu deren Herstellung
AU2012275841A1 (en)	2011-06-27	2014-01-16	The Jackson Laboratory	Methods and compositions for treatment of cancer and autoimmune disease
JP6074043B2 (ja)	2013-08-29	2017-02-01	富士フイルム株式会社	新規なモルホリン誘導体またはその塩
CN116194109A (zh)	2020-06-24	2023-05-30	阿斯利康(英国)有限公司	抗体-药物缀合物和atm抑制剂的组合
CN112094210A (zh) *	2020-09-24	2020-12-18	江苏扬农化工股份有限公司	一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4282155A (en) *	1980-02-04	1981-08-04	Merck & Co., Inc.	Antihypercholesterolemic compounds
DE68914495T2 (de) *	1988-03-02	1994-10-27	Merck & Co Inc	Antihypercholesterolemisches Mittel.
DK0489877T3 (da) *	1990-06-29	1996-02-05	Upjohn Co	Antiatherosklerotiske og antithrombotiske 2-amino-6-phenyl-4H-pyran-4-oner
IL129871A (en) *	1994-05-06	2003-11-23	Pharmacia & Upjohn Inc	Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
WO1997043434A1 (fr) *	1996-05-14	1997-11-20	Snow Brand Milk Products Co., Ltd.	Nouvelle substance active sur le plan physiologique et son procede de preparation
FR2765579A1 (fr) *	1997-07-01	1999-01-08	Lipha	Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
CA2272896A1 (en) *	1997-09-26	1999-04-08	Toray Industries, Inc.	Cyclic ketone derivative and pharmaceutical use thereof
WO1999046262A1 (fr) *	1998-03-12	1999-09-16	Teijin Limited	Derives de benzofurylpyrone

2003
- 2003-02-24 EP EP09014921A patent/EP2174939A1/de not_active Withdrawn
- 2003-02-24 DK DK03742608.7T patent/DK1485377T5/da active
- 2003-02-24 NZ NZ534821A patent/NZ534821A/en not_active IP Right Cessation
- 2003-02-24 GB GB0419534A patent/GB2401606B/en not_active Expired - Fee Related
- 2003-02-24 CN CNB038045478A patent/CN100358891C/zh not_active Expired - Fee Related
- 2003-02-24 CA CA002473100A patent/CA2473100A1/en not_active Abandoned
- 2003-02-24 BR BR0307944-9A patent/BR0307944A/pt not_active IP Right Cessation
- 2003-02-24 AT AT03742608T patent/ATE451365T1/de not_active IP Right Cessation
- 2003-02-24 JP JP2003569633A patent/JP2005521689A/ja active Pending
- 2003-02-24 MX MXPA04007809A patent/MXPA04007809A/es active IP Right Grant
- 2003-02-24 ES ES03742608T patent/ES2336206T3/es not_active Expired - Lifetime
- 2003-02-24 PT PT03742608T patent/PT1485377E/pt unknown
- 2003-02-24 AU AU2003209990A patent/AU2003209990B8/en not_active Ceased
- 2003-02-24 WO PCT/GB2003/000770 patent/WO2003070726A1/en active Application Filing
- 2003-02-24 PL PL03370074A patent/PL370074A1/xx not_active Application Discontinuation
- 2003-02-24 DE DE60330442T patent/DE60330442D1/de not_active Expired - Lifetime
- 2003-02-24 EP EP03742608A patent/EP1485377B9/de not_active Expired - Lifetime
- 2003-02-24 SI SI200331759T patent/SI1485377T1/sl unknown
2004
- 2004-09-24 NO NO20044063A patent/NO329806B1/no not_active IP Right Cessation
2005
- 2005-04-19 HK HK05103310A patent/HK1069827A1/xx not_active IP Right Cessation
2010
- 2010-02-18 CY CY20101100162T patent/CY1109835T1/el unknown

Also Published As

Publication number	Publication date
EP1485377A1 (de)	2004-12-15
EP1485377B9 (de)	2010-10-06
DE60330442D1 (de)	2010-01-21
DK1485377T3 (da)	2010-04-19
CN1639154A (zh)	2005-07-13
GB0419534D0 (en)	2004-10-06
BR0307944A (pt)	2005-02-01
AU2003209990B8 (en)	2008-10-30
HK1069827A1 (en)	2005-06-03
GB2401606A (en)	2004-11-17
CN100358891C (zh)	2008-01-02
EP2174939A1 (de)	2010-04-14
NO329806B1 (no)	2010-12-20
MXPA04007809A (es)	2004-10-15
NZ534821A (en)	2006-07-28
EP1485377B1 (de)	2009-12-09
DK1485377T5 (da)	2010-12-06
NO20044063L (no)	2004-09-24
CA2473100A1 (en)	2003-08-28
AU2003209990B2 (en)	2008-10-09
PT1485377E (pt)	2010-03-12
CY1109835T1 (el)	2014-09-10
PL370074A1 (en)	2005-05-16
GB2401606B (en)	2005-08-31
JP2005521689A (ja)	2005-07-21
WO2003070726A1 (en)	2003-08-28
EP1485377B8 (de)	2010-02-24
AU2003209990A1 (en)	2003-09-09
ES2336206T3 (es)	2010-04-09
ES2336206T9 (es)	2011-03-24
SI1485377T1 (sl)	2010-04-30

Legal Events

Date

Code

Title

Description

2010-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1485377

Country of ref document: EP

2011-11-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
HK1069827A1 (en)	2005-06-03	Pyranones useful as atm inhibitors.
HK1097273A1 (en)	2007-06-22	Aminopyrones and their use as atm inhibitors
BR0316241A (pt)	2005-10-04	Pirrolobenzodiazepinas
HRP20070307T3 (en)	2007-09-30	Derivatives of n-[ phenyl(pyrrolidine-2-yl)methyl]benzamide and n-[ (azepan-2-yl)phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics
MEP61208A (en)	2011-05-10	Novel compounds having inhibitory activity against sodium-dependant transporter
UY26727A1 (es)	2001-12-28	Derivados de tropano útiles en terapia
ATE449099T1 (de)	2009-12-15	Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
UA88329C2 (en)	2009-10-12	Dna-pk inhibitors
HUP0301607A2 (hu)	2003-12-29	Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
EA200000400A1 (ru)	2000-10-30	Галогензамещенные тетрациклические производные тетрагидрофурана
RS51193B (sr)	2010-10-31	Hidantoinski derivati korisni kao inhibitori metaloproteinaza
CO5580821A2 (es)	2005-11-30	4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas
ATE374750T1 (de)	2007-10-15	Serotoninwiederaufnahme-inhibitoren
RS51320B (sr)	2010-12-31	Derivati imidazohinolina kao veznici a3 receptora adenozina
ES2064057T3 (es)	1995-01-16	Unos derivados de 2-(aminoalquil)-5-(arilalquil)-1,3-dioxanos, su preparacion y su aplicacion en terapeutica.
HRP20020440B1 (en)	2008-02-29	1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
FI930264A (fi)	1993-07-24	4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxokinolinderivat saosom antihyperkolesterolemiska och antiaterosklerotiska medel
ATE500243T1 (de)	2011-03-15	Carbonsäureamidverbindung und deren verwendung
EA199800083A1 (ru)	1998-08-27	Производные 1,3-оксазин-4-она в качестве гербицидов
DE60202575D1 (de)	2005-02-17	3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren
IL178548A0 (en)	2007-02-11	Derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, and applications thereof
ECSP014089A (es)	2003-01-13	Derivados de tropano utiles en terapia