DK1485377T5 - Pyranoner egnede som ATM-inhibitorer - Google Patents

Pyranoner egnede som ATM-inhibitorer

Info

Publication number
DK1485377T5
DK1485377T5 DK03742608.7T DK03742608T DK1485377T5 DK 1485377 T5 DK1485377 T5 DK 1485377T5 DK 03742608 T DK03742608 T DK 03742608T DK 1485377 T5 DK1485377 T5 DK 1485377T5
Authority
DK
Denmark
Prior art keywords
pyranones
atm inhibitors
sulfonamino
acylamido
prodrugs
Prior art date
Application number
DK03742608.7T
Other languages
English (en)
Other versions
DK1485377T3 (da
Inventor
Graeme C M Smith
Niall M B Martin
Stephen P Jackson
Mark J O'connor
Alan Y K Lau
Ian Timothy Williams Matthews
Keith Allan Menear
Laurent Jean Martin Rigoreau
Marc Geoffrey Hummersone
Roger John Griffin
Xiao-Ling Fan Cockcroft
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of DK1485377T3 publication Critical patent/DK1485377T3/da
Application granted granted Critical
Publication of DK1485377T5 publication Critical patent/DK1485377T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK03742608.7T 2002-02-25 2003-02-24 Pyranoner egnede som ATM-inhibitorer DK1485377T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0204350.3A GB0204350D0 (en) 2002-02-25 2002-02-25 ATM inhibitors
US39588402P 2002-07-15 2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en) 2002-02-25 2003-02-24 Pyranones useful as atm inhibitors

Publications (2)

Publication Number Publication Date
DK1485377T3 DK1485377T3 (da) 2010-04-19
DK1485377T5 true DK1485377T5 (da) 2010-12-06

Family

ID=27758841

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03742608.7T DK1485377T5 (da) 2002-02-25 2003-02-24 Pyranoner egnede som ATM-inhibitorer

Country Status (20)

Country Link
EP (2) EP2174939A1 (da)
JP (1) JP2005521689A (da)
CN (1) CN100358891C (da)
AT (1) ATE451365T1 (da)
AU (1) AU2003209990B8 (da)
BR (1) BR0307944A (da)
CA (1) CA2473100A1 (da)
CY (1) CY1109835T1 (da)
DE (1) DE60330442D1 (da)
DK (1) DK1485377T5 (da)
ES (1) ES2336206T3 (da)
GB (1) GB2401606B (da)
HK (1) HK1069827A1 (da)
MX (1) MXPA04007809A (da)
NO (1) NO329806B1 (da)
NZ (1) NZ534821A (da)
PL (1) PL370074A1 (da)
PT (1) PT1485377E (da)
SI (1) SI1485377T1 (da)
WO (1) WO2003070726A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
EP1501822B1 (en) 2002-04-30 2010-12-15 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7122189B2 (en) * 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7413738B2 (en) 2002-08-13 2008-08-19 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on biodegradable linkers
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
WO2004097426A2 (en) * 2003-05-01 2004-11-11 Kudos Pharmaceuticals Limited Methods and means for the treatment of disorders associated with cellular senescence
CA2534300A1 (en) 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as atm inhibitors
HUE025996T2 (en) 2003-12-01 2016-05-30 Kudos Pharm Ltd Inhibitors of DNA damage repair for the treatment of cancer
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
AU2005286329A1 (en) 2004-09-20 2006-03-30 Cancer Research Technology Limited DNA-PK inhibitors
WO2006085067A1 (en) * 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Atm inhibitors
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
TW200745094A (en) * 2005-08-31 2007-12-16 Kudos Pharm Ltd ATM inhibitor
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
WO2009034326A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
DK2346495T4 (da) 2008-10-07 2023-08-28 Kudos Pharm Ltd Farmaceutisk formulering 514
EP2486923B1 (en) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histone deacetylase (HDAC) inhibiting compounds and method of making same
AU2012275841A1 (en) 2011-06-27 2014-01-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
JP6074043B2 (ja) 2013-08-29 2017-02-01 富士フイルム株式会社 新規なモルホリン誘導体またはその塩
CN116194109A (zh) 2020-06-24 2023-05-30 阿斯利康(英国)有限公司 抗体-药物缀合物和atm抑制剂的组合
CN112094210A (zh) * 2020-09-24 2020-12-18 江苏扬农化工股份有限公司 一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
DE68914495T2 (de) * 1988-03-02 1994-10-27 Merck & Co Inc Antihypercholesterolemisches Mittel.
DK0489877T3 (da) * 1990-06-29 1996-02-05 Upjohn Co Antiatherosklerotiske og antithrombotiske 2-amino-6-phenyl-4H-pyran-4-oner
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
WO1997043434A1 (fr) * 1996-05-14 1997-11-20 Snow Brand Milk Products Co., Ltd. Nouvelle substance active sur le plan physiologique et son procede de preparation
FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
CA2272896A1 (en) * 1997-09-26 1999-04-08 Toray Industries, Inc. Cyclic ketone derivative and pharmaceutical use thereof
WO1999046262A1 (fr) * 1998-03-12 1999-09-16 Teijin Limited Derives de benzofurylpyrone

Also Published As

Publication number Publication date
EP1485377A1 (en) 2004-12-15
EP1485377B9 (en) 2010-10-06
DE60330442D1 (de) 2010-01-21
ATE451365T1 (de) 2009-12-15
DK1485377T3 (da) 2010-04-19
CN1639154A (zh) 2005-07-13
GB0419534D0 (en) 2004-10-06
BR0307944A (pt) 2005-02-01
AU2003209990B8 (en) 2008-10-30
HK1069827A1 (en) 2005-06-03
GB2401606A (en) 2004-11-17
CN100358891C (zh) 2008-01-02
EP2174939A1 (en) 2010-04-14
NO329806B1 (no) 2010-12-20
MXPA04007809A (es) 2004-10-15
NZ534821A (en) 2006-07-28
EP1485377B1 (en) 2009-12-09
NO20044063L (no) 2004-09-24
CA2473100A1 (en) 2003-08-28
AU2003209990B2 (en) 2008-10-09
PT1485377E (pt) 2010-03-12
CY1109835T1 (el) 2014-09-10
PL370074A1 (en) 2005-05-16
GB2401606B (en) 2005-08-31
JP2005521689A (ja) 2005-07-21
WO2003070726A1 (en) 2003-08-28
EP1485377B8 (en) 2010-02-24
AU2003209990A1 (en) 2003-09-09
ES2336206T3 (es) 2010-04-09
ES2336206T9 (es) 2011-03-24
SI1485377T1 (sl) 2010-04-30

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