DE60202575D1 - 3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren - Google Patents

3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren

Info

Publication number
DE60202575D1
DE60202575D1 DE60202575T DE60202575T DE60202575D1 DE 60202575 D1 DE60202575 D1 DE 60202575D1 DE 60202575 T DE60202575 T DE 60202575T DE 60202575 T DE60202575 T DE 60202575T DE 60202575 D1 DE60202575 D1 DE 60202575D1
Authority
DE
Germany
Prior art keywords
dihydro
highly selective
inhibitors
selective cyclooxygenase
naphthalene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60202575T
Other languages
English (en)
Other versions
DE60202575T2 (de
Inventor
Il Hwan Cho
Jee Woong Lim
Ji Young Noh
Jong Hoon Kim
Sang Wook Park
Hyung Chul Ryu
Je Hak Kim
Hyung Ok Chun
So Young Wang
Sung Hak Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ Corp filed Critical CJ Corp
Application granted granted Critical
Publication of DE60202575D1 publication Critical patent/DE60202575D1/de
Publication of DE60202575T2 publication Critical patent/DE60202575T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60202575T 2001-10-10 2002-10-08 3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren Expired - Lifetime DE60202575T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020010062488A KR100824233B1 (ko) 2001-10-10 2001-10-10 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
KR2001062488 2001-10-10

Publications (2)

Publication Number Publication Date
DE60202575D1 true DE60202575D1 (de) 2005-02-17
DE60202575T2 DE60202575T2 (de) 2006-01-12

Family

ID=19715011

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202575T Expired - Lifetime DE60202575T2 (de) 2001-10-10 2002-10-08 3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren

Country Status (8)

Country Link
US (2) US6686493B2 (de)
EP (1) EP1306368B1 (de)
JP (1) JP3977222B2 (de)
KR (1) KR100824233B1 (de)
CN (1) CN1239478C (de)
AT (1) ATE286878T1 (de)
DE (1) DE60202575T2 (de)
WO (1) WO2003031418A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS7839A (is) * 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
EP3548468B1 (de) * 2016-11-30 2020-09-16 Bristol-Myers Squibb Company Tricyclische rho-kinase-hemmer
CN107011266B (zh) * 2017-05-02 2023-04-14 中国人民解放军第二军医大学 苯并吲唑类衍生物的前药及其制备方法、应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US6077869A (en) * 1998-10-29 2000-06-20 Ortho-Mcneil Pharmaceutical, Inc. Aryl phenylhydrazides as selective COX-2 inhibitors for treatment of inflammation
EP1099695A1 (de) 1999-11-09 2001-05-16 Laboratoire Theramex S.A. 5-Aryl-1H-1,2,4-triazolverbindungen als Cyclooxygenase-2 Inhibitoren und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
WO2003031418A1 (en) 2003-04-17
DE60202575T2 (de) 2006-01-12
EP1306368A2 (de) 2003-05-02
US6686493B2 (en) 2004-02-03
KR20030030379A (ko) 2003-04-18
EP1306368A3 (de) 2003-07-02
KR100824233B1 (ko) 2008-04-24
JP3977222B2 (ja) 2007-09-19
CN1418870A (zh) 2003-05-21
EP1306368B1 (de) 2005-01-12
JP2003176264A (ja) 2003-06-24
US20030109715A1 (en) 2003-06-12
ATE286878T1 (de) 2005-01-15
US20030187302A1 (en) 2003-10-02
CN1239478C (zh) 2006-02-01
US6768019B2 (en) 2004-07-27

Similar Documents

Publication Publication Date Title
ATE465146T1 (de) 1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
NO20062644L (no) DPP-IV inhibitorer
NO20052884L (no) Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
FR15C0086I2 (fr) Derives d'hydroxamate en tant qu'inhibiteurs de desacetylase
DK1569899T3 (da) Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)
DK1487444T3 (da) Anvendelse af pyridylamider som angiogeneseinhibitorer
RS51444B (sr) JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa
PL361404A1 (en) Synergistic combinations comprising a renin inhibitor for cardiovascular diseases
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
NO331013B1 (no) Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat
HN2002000028A (es) Pirimidinas inhibidoras de metaloproteinasas
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
ATE278661T1 (de) Anthranilsäurederivate
NO944371D0 (no) Kjemisk forbindelse med blodplateaggregeringsinhiberende virkning
ATE268751T1 (de) Biphenylamidin-derivate
ATE308540T1 (de) Antithrombosemittel
DE60034577D1 (de) In 4-stellung substituierte piperidinderivate
ATE348800T1 (de) 4'-methansulfonylbiphenylderivate als hochselektive cyclooxygenase-2-inhibitoren
DE60333578D1 (de) Lamellarinanaloga mit antitumorwirkung
DE60202575D1 (de) 3,4-Dihydro-1H-Naphthalin-Derivate als hoch selektive Cyclooxygenase-2-Inhibitoren
ATE366727T1 (de) Diaryl-1,2,4-triazolderivate als hochselektive cyclooxygenase-2-inhibitoren
PT1072601E (pt) Derivados de 4-arilpiperidina para o tratamento de prurido
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
ATE455100T1 (de) Bipyridinylderivate als hochselektive cyclooxygenase-2-inhibitoren
UY26973A1 (es) Derivados puente de piperazina

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CJ CHEILJEDANG CORP., SEOUL, KR