ATE264295T1 - 7-substituierte kondensierte ring-tetrazyclin- verbindungen - Google Patents

7-substituierte kondensierte ring-tetrazyclin- verbindungen

Info

Publication number
ATE264295T1
ATE264295T1 AT01933263T AT01933263T ATE264295T1 AT E264295 T1 ATE264295 T1 AT E264295T1 AT 01933263 T AT01933263 T AT 01933263T AT 01933263 T AT01933263 T AT 01933263T AT E264295 T1 ATE264295 T1 AT E264295T1
Authority
AT
Austria
Prior art keywords
condensed ring
tetracycline compounds
substituted condensed
ring tetracycline
hydroxyl
Prior art date
Application number
AT01933263T
Other languages
English (en)
Inventor
Mark L Nelson
Laura Mcintyre
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Application granted granted Critical
Publication of ATE264295T1 publication Critical patent/ATE264295T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
AT01933263T 2000-05-15 2001-05-10 7-substituierte kondensierte ring-tetrazyclin- verbindungen ATE264295T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20415800P 2000-05-15 2000-05-15
PCT/US2001/015068 WO2001087824A2 (en) 2000-05-15 2001-05-10 7-substituted fused ring tetracycline compounds

Publications (1)

Publication Number Publication Date
ATE264295T1 true ATE264295T1 (de) 2004-04-15

Family

ID=22756861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01933263T ATE264295T1 (de) 2000-05-15 2001-05-10 7-substituierte kondensierte ring-tetrazyclin- verbindungen

Country Status (8)

Country Link
US (5) US6642270B2 (de)
EP (2) EP1286954B1 (de)
JP (2) JP2003533504A (de)
AT (1) ATE264295T1 (de)
AU (1) AU2001259701A1 (de)
CA (1) CA2409063A1 (de)
DE (1) DE60102815D1 (de)
WO (1) WO2001087824A2 (de)

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US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001052858A1 (en) 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
WO2001074761A1 (en) * 2000-03-31 2001-10-11 Trustees Of Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
DE60102815D1 (de) * 2000-05-15 2004-05-19 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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JP2012503017A (ja) * 2008-09-19 2012-02-02 パラテック ファーマシューティカルズ インコーポレイテッド 関節リウマチの治療用のテトラサイクリン化合物および関連する治療方法
JP5656399B2 (ja) * 2008-12-26 2015-01-21 大塚製薬株式会社 医薬及び医薬製剤
EP2424834B1 (de) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthese von tetracyclinen und deren zwischenprodukte
KR102077871B1 (ko) * 2010-11-16 2020-02-14 유니버시티 오브 써던 캘리포니아 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 ｃｂｐ/카테닌 길항제
JP7545803B2 (ja) 2016-11-01 2024-09-05 パラテック ファーマシューティカルズ，インコーポレイテッド ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用

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US20020045602A1 (en) 2002-04-18
JP2013040173A (ja) 2013-02-28
AU2001259701A1 (en) 2001-11-26
EP1286954A2 (de) 2003-03-05
US6642270B2 (en) 2003-11-04
JP2003533504A (ja) 2003-11-11
US20110207951A1 (en) 2011-08-25
US8288570B2 (en) 2012-10-16
WO2001087824A2 (en) 2001-11-22
EP2308863A1 (de) 2011-04-13
CA2409063A1 (en) 2001-11-22
DE60102815D1 (de) 2004-05-19
US20080300424A1 (en) 2008-12-04
EP1286954B1 (de) 2004-04-14
WO2001087824A3 (en) 2002-04-11
US20060148765A1 (en) 2006-07-06
US20040048835A1 (en) 2004-03-11
US7893282B2 (en) 2011-02-22
US7612053B2 (en) 2009-11-03

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