쐐기풀
GNAQ| 쐐기풀 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| 식별자 | |||||||||||||||||||||||||
| 별칭 | 닐스큐, CMC1, G-ALPa-q, GAQ, SWS, G단백질 서브유닛 알파q | ||||||||||||||||||||||||
| 외부 ID | OMIM: 600998 MGI: 95776 호몰로진: 1566 GeneCard: WISQ | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레스 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Cr 9: 77.72 – 78.03Mb | Cr 19: 16.11 – 16.36Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키다타 | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
구아닌 뉴클레오티드 결합 단백질 G(q) 서브유닛 알파는 인간에서 WISQ 유전자에 의해 인코딩되는 단백질이다.[5]INT11(그들의 파라로그)과 함께 Gq 알파 서브 유닛의 기능을 한다.[6]
함수
구아닌 뉴클레오티드 결합 단백질은 세포 표면, 7-트랜섬브레인 수용체와 세포 내 신호 전달 경로를 결합하는 이질 단백질 계열이다.수용체 활성화는 비활성 G단백질 알파 서브유닛에 바인딩된 GTP에 대한 GDP의 교환을 촉진하여 복합체의 순응적 변화와 분리를 초래한다.G단백질 알파와 베타감마 서브유닛은 다양한 세포이펙터를 조절할 수 있다.활성화는 G-알파 서브유닛에 내재된 GTPase에 의해 종료된다.G-알파-q는 인광 효소 C-베타(MIM 600230)의 자극을 매개하는 이질성 GTP 결합 단백질의 알파 서브 단위다.[OMIM에 의해 제공][7]
이 유전자의 돌연변이는 스터지 웨버 증후군과 포트 와인 얼룩과 관련된 것으로 밝혀졌다.[8]
상호작용
NECTQ는 다음과 상호 작용하는 것으로 나타났다.
- 베타 아드레날린 수용체 키나아제,[9]
- 브루튼의 티로신 [10]키나아제
- RGS16,[11]
- RGS4[11][12]
- RIC8A [13][14]및
- 나트륨-수소 항정신병자 3 조절기 1.[15]
참고 항목
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000156052 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000024639 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J (February 1997). "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene". Genomics. 30 (3): 470–75. doi:10.1006/geno.1995.1267. PMID 8825633.
- ^ 139313 구아닌 뉴클레오티드-결합단백질, 알파-11; OMIM의 갉11. 2015년 1월 1일 회수.
- ^ "Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide".
- ^ Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J (May 23, 2013). "Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ". The New England Journal of Medicine. 368 (21): 1971–9. doi:10.1056/NEJMoa1213507. PMC 3749068. PMID 23656586.
- ^ Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB (August 2003). "Differential interaction of GRK2 with members of the G alpha q family". Biochemistry. 42 (30): 9176–84. doi:10.1021/bi034442+. PMID 12885252.
- ^ Ma YC, Huang XY (October 1998). "Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12197–201. Bibcode:1998PNAS...9512197M. doi:10.1073/pnas.95.21.12197. PMC 22808. PMID 9770463.
- ^ a b
- ^ Druey KM, Sullivan BM, Brown D, Fischer ER, Watson N, Blumer KJ, Gerfen CR, Scheschonka A, Kehrl JH (July 1998). "Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane". J. Biol. Chem. 273 (29): 18405–10. doi:10.1074/jbc.273.29.18405. PMID 9660808.
- ^ Klattenhoff C, Montecino M, Soto X, Guzmán L, Romo X, García MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. PMID 12652642. S2CID 84975473.
- ^ Tall GG, Krumins AM, Gilman AG (March 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
- ^ Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, Parent JL (October 2002). "Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)". J. Biol. Chem. 277 (43): 40751–9. doi:10.1074/jbc.M207910200. PMID 12193606.
추가 읽기
- Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
- Van Oekelen D, Luyten WH, Leysen JE (2003). "5-HT2A and 5-HT2C receptors and their atypical regulation properties". Life Sci. 72 (22): 2429–49. doi:10.1016/S0024-3205(03)00141-3. PMID 12650852.
- Lesch KP, Manji HK (1992). "Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain". Biol. Psychiatry. 32 (7): 549–79. doi:10.1016/0006-3223(92)90070-G. PMID 1333286. S2CID 927009.
- Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways". Biochem. J. 312. ( Pt 1): 151–8. doi:10.1042/bj3120151. PMC 1136238. PMID 7492305.
- Blin N, Yun J, Wess J (1995). "Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor". J. Biol. Chem. 270 (30): 17741–8. doi:10.1074/jbc.270.30.17741. PMID 7629074.
- Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Mol. Cell. Biochem. 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744. S2CID 8911988.
- Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE (1994). "The human thyrotropin receptor activates G-proteins Gs and Gq/11". J. Biol. Chem. 269 (19): 13733–5. doi:10.1016/S0021-9258(17)36705-4. PMID 8188646.
- Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR (1993). "Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha". J. Biol. Chem. 268 (33): 25001–8. doi:10.1016/S0021-9258(19)74563-3. PMID 8227063.
- Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy". Endocrinology. 132 (6): 2484–90. doi:10.1210/en.132.6.2484. PMID 8504751.
- Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
- Denker SP, McCaffery JM, Palade GE, Insel PA, Farquhar MG (1996). "Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas". J. Cell Biol. 133 (5): 1027–40. doi:10.1083/jcb.133.5.1027. PMC 2120853. PMID 8655576.
- Chen B, Leverette RD, Schwinn DA, Kwatra MM (1996). "Human G(alpha q): cDNA and tissue distribution". Biochim. Biophys. Acta. 1281 (2): 125–8. doi:10.1016/0005-2736(96)00039-9. PMID 8664309.
- Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences". Biochem. J. 318. ( Pt 3) (3): 1023–31. doi:10.1042/bj3181023. PMC 1217719. PMID 8836152.
- Gomeza J, Mary S, Brabet I, Parmentier ML, Restituito S, Bockaert J, Pin JP (1996). "Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists". Mol. Pharmacol. 50 (4): 923–30. PMID 8863838.
- Petit A, Geoffroy P, Bélisle S (1997). "Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta". J. Soc. Gynecol. Investig. 3 (6): 316–21. doi:10.1016/S1071-5576(96)00035-4. PMID 8923415. S2CID 210868588.
- Petit A, Geoffroy P, Bélisle S (1997). "Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension". Life Sci. 60 (12): 953–60. doi:10.1016/S0024-3205(96)00654-6. PMID 9061052.
- Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.
- Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association". FEBS Lett. 407 (3): 257–60. doi:10.1016/S0014-5793(97)00300-1. PMID 9175863. S2CID 85622146.
- Gabbeta J, Yang X, Kowalska MA, Sun L, Dhanasekaran N, Rao AK (1997). "Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8750–5. Bibcode:1997PNAS...94.8750G. doi:10.1073/pnas.94.16.8750. PMC 23110. PMID 9238049.
PDB 갤러리 | |
|---|---|
|
