호모 사피엔스 종의 단백질 코드 유전자
글로뮬린 은 인간 의 GLMN [5] [6] 단백질 이다.
이 유전자는 Skp1-Cullin-F-box 유사 복합체의 구성원인 인산화 단백질을 암호화한다. 그 단백질은 혈관 구조의 정상적인 발달에 필수적이며 이 유전자의 돌연변이는 사구체 변형이라고도 불리는 사구체 기형과 연관되어 왔다. 다른 단백질 아이소폼을 코드하는 대체 스플라이스 변형이 설명되었지만, 단 하나의 전장 성질이 [6]
상호 작용 GLMN은 FKBP4 ,[5] [7] C-Met [8] FKBP1A 와 [5] [7] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000174842 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029276 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Chambraud B, Radanyi C, Camonis JH, Shazand K, Rajkowski K, Baulieu EE (Jan 1997). "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin" . J Biol Chem . 271 (51): 32923–9. doi :10.1074/jbc.271.51.32923 PMID 8955134 . ^ a b "Entrez Gene: GLMN glomulin, FKBP associated protein" .^ a b Neye, H (Mar 2001). "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52". Regul. Pept . Netherlands. 97 (2–3): 147–52. doi :10.1016/S0167-0115(00)00206-8 . ISSN 0167-0115 . PMID 11164950 . S2CID 20617551 . ^ Grisendi, S; Chambraud B; Gout I; Comoglio P M; Crepaldi T (Dec 2001). "Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor" . J. Biol. Chem . United States. 276 (49): 46632–8. doi :10.1074/jbc.M104323200 ISSN 0021-9258 . PMID 11571281 .
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