noncausative

The expected data from this effort would be thousands of genetic alterations (point mutations, insertions/deletions, chromosomal rearrangements, and copy number variations) that may be "passengers" (vast majority, noncausative) or "drivers" (very few, causative).

Much of current genetic testing deals with complex interpretations of sequence data where variants unique to the individual patient have to be judged as causative, noncausative, or of unknown significance.

Changes in test volume over time would result in misclassification bias (as noncausative pathogens will be detected as well).

In a noncausative situation, the initial agent ([Agent.sub.2]) is also the agent of the main action.