neural tube

(redirected from neural tubes)
Also found in: Thesaurus, Medical, Encyclopedia.

neural tube

A dorsal tubular structure in the vertebrate embryo that is formed by longitudinal folding of the neural plate and that differentiates into the brain and spinal cord.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

neural tube

(Anatomy) the structure in mammalian embryos that develops into the brain and spinal cord. Incomplete development results in neural-tube defects, such as spina bifida, in a newborn baby

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

neu′ral tube′

a tube formed in the early embryo by the closure of ectodermal tissue and later developing into the spinal cord and brain.

neural tube

Embryonic tissue that gives rise to the brain and spinal cord.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Switch to new thesaurus

Noun

neural tube - a tube of ectodermal tissue in the embryo from which the brain and spinal cord develop

ectoblast, ectoderm, exoderm - the outer germ layer that develops into skin and nervous tissue

Translations

tubo neural

References in periodicals archive ?

Spinal defects encompass mouse mutants with spina bifida (without any other NTD phenotype, e.g., exencephaly and/or craniorachischisis) and abnormal spinal neural tubes with no spina bifida.

Abnormal and ectopic spinal neural tubes may be regarded as variant forms of NTDs as it may be possible that the neural tube reopens after closure due to various reasons.

Development of the central nervous system including the brain and spinal cord is a complex process beginning with a flat sheet of cells which undergoes sequential thickening, elevation, mediolateral convergence accompanied by rostro-caudal extension, and finally adhesion to form the neural tube (NT) which is the precursor of the brain and the spinal cord.

More recent efforts by our group ("Spina Bifida: A 10-Year Retrospective Study at University of Malaya Medical Centre, Malaysia," manuscript in submission), however, have found that the lower rate of NTDs may not be completely representative as in our hospital alone from the years 2003 to 2012 we have had over 10 cases of neural tube defects per year (spina bifida and anencephaly).

Myelomeningocele is when the spinal cord protrudes from the spinal canal into a fluid-filled sac resulting from incomplete closure of the primary neural tube. Myeloschisis is when the incomplete closure of the primary neural plate results in a cleft spinal cord with the edges flush with the defect.

Most of human neural tube defects are nonsyndromic with NTD being the only defect.

Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans

According to the (https://www.mayoclinic.com/health/spina-bifida/DS00417) Mayo Clinic , spina bifida is a birth defect that occurs when a portion of the baby's neural tubes (the structure that forms in the embryo and develops into the brain and spine) don't develop properly or fully close.

What Is Spina Bifida? Mother Of Xiao Wei, Baby Born With 3-Inch 'Tail', Begs Doctors For Help

"The discovery that the mutation of a single gene could prevent neural tubes developing normally in the mouse - by stopping the closure of the brain and spinal cord - is important and could offer a potential target for new treatment."

Spina bifida, which affects one in 1,000 pregnancies, belongs to a group of disorders called neural tube defects.

It arises in early pregnancy when the part of the foetus that forms the brain and spinal cord - the neural tube - fails to close properly.

Prof Copp said, "Our identification of the loop-tail gene is a key finding which will aid in understanding the developmental pathway that regulates neural tube closure.

By working out the pattern of DNA components, 12 candidate genes were identified and 11 were shown to be involved in neural tube formation.