KEGG   PATHWAY: syun00260
Entry
syun00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces yunnanensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
syun00260  Glycine, serine and threonine metabolism
syun00260

Module
syun_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:syun00260]
syun_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:syun00260]
syun_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:syun00260]
syun_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:syun00260]
syun_M00555  Betaine biosynthesis, choline => betaine [PATH:syun00260]
syun_M00621  Glycine cleavage system [PATH:syun00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces yunnanensis [GN:syun]
Gene
MOV08_00975  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MOV08_19820  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MOV08_27220  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MOV08_00980  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MOV08_19815  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MOV08_14675  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MOV08_14665  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
MOV08_14670  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MOV08_18070  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MOV08_33850  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
MOV08_38810  threonine aldolase family protein [KO:K01620] [EC:4.1.2.48]
MOV08_41540  hypothetical protein [KO:K00600] [EC:2.1.2.1]
MOV08_14145  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MOV08_14625  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MOV08_17045  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MOV08_10560  glycerate kinase [KO:K00865] [EC:2.7.1.165]
MOV08_18270  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
MOV08_08130  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MOV08_13890  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MOV08_17775  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
MOV08_31220  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
MOV08_21225  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
MOV08_35910  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
MOV08_35905  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
MOV08_02885  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
MOV08_11565  NAD(P)/FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
MOV08_34675  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MOV08_14135  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
MOV08_29510  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MOV08_38980  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MOV08_11515  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MOV08_14140  gcvH; glycine cleavage system protein GcvH [KO:K02437]
MOV08_08870  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
MOV08_15915  FAD-binding oxidoreductase [KO:K00273] [EC:1.4.3.3]
MOV08_03770  serine/threonine protein kinase [KO:K00613] [EC:2.1.4.1]
MOV08_10555  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MOV08_09180  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
MOV08_09170  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
MOV08_13260  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MOV08_13285  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MOV08_17165  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
MOV08_36310  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
MOV08_36315  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
MOV08_43510  class I SAM-dependent methyltransferase [KO:K18896] [EC:2.1.1.156]
MOV08_29300  class I SAM-dependent methyltransferase [KO:K18897] [EC:2.1.1.157]
MOV08_25260  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MOV08_07250  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
MOV08_20950  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
MOV08_14150  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MOV08_16500  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
MOV08_38925  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
MOV08_30220  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
MOV08_30215  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
MOV08_30915  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
MOV08_35450  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
MOV08_12605  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
MOV08_30920  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
MOV08_30910  ectoine synthase [KO:K06720] [EC:4.2.1.108]
MOV08_30900  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
MOV08_31345  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
MOV08_35455  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
MOV08_30335  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
syun00010  Glycolysis / Gluconeogenesis
syun00020  Citrate cycle (TCA cycle)
syun00230  Purine metabolism
syun00250  Alanine, aspartate and glutamate metabolism
syun00270  Cysteine and methionine metabolism
syun00290  Valine, leucine and isoleucine biosynthesis
syun00300  Lysine biosynthesis
syun00330  Arginine and proline metabolism
syun00460  Cyanoamino acid metabolism
syun00470  D-Amino acid metabolism
syun00564  Glycerophospholipid metabolism
syun00600  Sphingolipid metabolism
syun00620  Pyruvate metabolism
syun00630  Glyoxylate and dicarboxylate metabolism
syun00640  Propanoate metabolism
syun00680  Methane metabolism
syun00860  Porphyrin metabolism
syun00920  Sulfur metabolism
KO pathway
ko00260   
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