KEGG   PATHWAY: syun00020
Entry
syun00020                   Pathway                                
Name
Citrate cycle (TCA cycle) - Streptomyces yunnanensis
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
syun00020  Citrate cycle (TCA cycle)
syun00020

Module
syun_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:syun00020]
syun_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:syun00020]
syun_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:syun00020]
syun_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:syun00020]
syun_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:syun00020]
Other DBs
GO: 0006099
Organism
Streptomyces yunnanensis [GN:syun]
Gene
MOV08_26840  citrate synthase [KO:K01647] [EC:2.3.3.1]
MOV08_17660  citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
MOV08_11835  acnA; aconitate hydratase AcnA [KO:K27802] [EC:4.2.1.3 4.2.1.99]
MOV08_33470  NADP-dependent isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
MOV08_17205  NADP-dependent isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
MOV08_14830  multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MOV08_29510  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MOV08_38980  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MOV08_11515  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MOV08_23440  2-oxoacid:acceptor oxidoreductase subunit alpha [KO:K00174] [EC:1.2.7.3 1.2.7.11]
MOV08_23435  2-oxoacid:ferredoxin oxidoreductase subunit beta [KO:K00175] [EC:1.2.7.3 1.2.7.11]
MOV08_17255  sucD; succinate--CoA ligase subunit alpha [KO:K01902] [EC:6.2.1.5]
MOV08_17260  sucC; ADP-forming succinate--CoA ligase subunit beta [KO:K01903] [EC:6.2.1.5]
MOV08_30155  fumarate reductase/succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
MOV08_15775  fumarate reductase/succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
MOV08_16975  sdhA; succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
MOV08_30150  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
MOV08_15780  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
MOV08_16980  succinate dehydrogenase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
MOV08_30160  succinate dehydrogenase [KO:K00241]
MOV08_16965  sdhC; succinate dehydrogenase, cytochrome b556 subunit [KO:K00241]
MOV08_16970  succinate dehydrogenase hydrophobic membrane anchor subunit [KO:K00242]
MOV08_16020  fumarate hydratase [KO:K01676] [EC:4.2.1.2]
MOV08_16060  class II fumarate hydratase [KO:K01679] [EC:4.2.1.2]
MOV08_17200  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
MOV08_16305  phosphoenolpyruvate carboxykinase (GTP) [KO:K01596] [EC:4.1.1.32]
MOV08_28440  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
MOV08_29495  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
MOV08_29505  sucB; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
syun00010  Glycolysis / Gluconeogenesis
syun00053  Ascorbate and aldarate metabolism
syun00061  Fatty acid biosynthesis
syun00071  Fatty acid degradation
syun00190  Oxidative phosphorylation
syun00220  Arginine biosynthesis
syun00250  Alanine, aspartate and glutamate metabolism
syun00280  Valine, leucine and isoleucine degradation
syun00350  Tyrosine metabolism
syun00470  D-Amino acid metabolism
syun00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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