Alfa-metilhistamin

α-Metilhistamin
	1-(3H-Imidazol-4-il)propan-2-amin
Naziv po klasifikaciji	1-(1H-Imidazol-4-il)propan-2-amin
Identifikacija
CAS registarski broj	6986-90-9 , 75614-87-8 (R) , 75614-93-6 (S)
PubChem	3615, ; 156615 (R), ; 6603865 (S)
ChemSpider	3489
MeSH	Alpha-methylhistamine
ChEBI	295965
ChEMBL	CHEMBL116655
IUPHAR ligand	1239
Jmol-3D slike	Slika 1; Slika 2; Slika 3
SMILES
	CC(N)CC1=CNC=N1 CC(CC1=CN=CN1)N n1cc(nc1)CC(N)C
InChI
	InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9) ; Kod: XNQIOISZPFVUFG-UHFFFAOYSA-N InChI=1/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9); Kod: XNQIOISZPFVUFG-UHFFFAOYAW
Svojstva
Molekulska formula	C6H11N3
Molarna masa	125.17 g mol−1
log P	-0,346
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

α-Metilhistamin je histaminski agonist koji je selektivan za histaminski H₃ receptor. On uzrokuje snižavanje krvnog pritiska i usporavanje brzine otkucaja srca u životinjskim modelima.^[6]

Reference

↑ Compound Name and Classification
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ McLeod, RL; Gertner, SB; Hey, JA (1993). „Production by R-alpha-methylhistamine of a histamine H3 receptor-mediated decrease in basal vascular resistance in guinea-pigs”. Br J Pharmacol 110 (2): 553–558. PMC 2175947. PMID 7902173.

Vanjske veze

Portal Hemija

[1] Compound Name and Classification

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] McLeod, RL; Gertner, SB; Hey, JA (1993). „Production by R-alpha-methylhistamine of a histamine H3 receptor-mediated decrease in basal vascular resistance in guinea-pigs”. Br J Pharmacol 110 (2): 553–558. PMC 2175947. PMID 7902173.

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