ZA912782B - An improved process for the preparation of substituted indolone derivatives - Google Patents

An improved process for the preparation of substituted indolone derivatives

Info

Publication number: ZA912782B
Authority: ZA; South Africa
Prior art keywords: preparation; improved process; indolone derivatives; substituted indolone; substituted
Prior art date: 1990-04-17

Application number

ZA912782A

Other languages

English (en)

Inventor

Robert Giles

Giles Robert

Timothy Charles Walsgrove

Charles Walsgrove Timothy

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-17

Filing date

1991-04-15

Publication date

1992-11-25

1991-04-15 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1992-11-25 Publication of ZA912782B publication Critical patent/ZA912782B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/40—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups and esterified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

ZA912782A 1990-04-17 1991-04-15 An improved process for the preparation of substituted indolone derivatives ZA912782B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909008605A GB9008605D0 (en)	1990-04-17	1990-04-17	Process

Publications (1)

Publication Number	Publication Date
ZA912782B true ZA912782B (en)	1992-11-25

Family

ID=10674534

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA912782A ZA912782B (en)	1990-04-17	1991-04-15	An improved process for the preparation of substituted indolone derivatives

Country Status (29)

Country	Link
US (1)	US5336781A (xx)
EP (1)	EP0526529B1 (xx)
JP (2)	JP2788548B2 (xx)
KR (1)	KR0180215B1 (xx)
CN (1)	CN1027892C (xx)
AP (1)	AP184A (xx)
AT (1)	ATE144251T1 (xx)
AU (2)	AU640006B2 (xx)
CA (1)	CA2080221C (xx)
CY (1)	CY1981A (xx)
DE (1)	DE69122753T2 (xx)
DK (1)	DK0526529T3 (xx)
ES (1)	ES2094812T3 (xx)
FI (1)	FI101148B (xx)
GB (1)	GB9008605D0 (xx)
GR (1)	GR3022261T3 (xx)
HK (1)	HK3097A (xx)
HU (1)	HU214822B (xx)
IE (1)	IE911262A1 (xx)
IL (7)	IL97867A (xx)
MA (1)	MA22133A1 (xx)
MY (1)	MY109628A (xx)
NO (2)	NO178396C (xx)
NZ (1)	NZ237819A (xx)
PL (1)	PL166736B1 (xx)
PT (1)	PT97375B (xx)
SA (1)	SA91110352B1 (xx)
WO (1)	WO1991016306A1 (xx)
ZA (1)	ZA912782B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9008605D0 (en) *	1990-04-17	1990-06-13	Smith Kline French Lab	Process
WO1992005785A1 (en) *	1990-09-28	1992-04-16	Smithkline Beecham Corporation	Water soluble camptothecin analogues, processes and methods
GB9300309D0 (en) *	1993-01-08	1993-03-03	Smithkline Beecham Plc	Process
US6218421B1 (en) *	1999-07-01	2001-04-17	Smithkline Beecham P.L.C.	Method of promoting smoking cessation
AR030557A1 (es)	2000-04-14	2003-08-27	Jagotec Ag	Una tableta en multicapa de liberacion controlada y metodo de tratamiento
WO2005074387A2 (en) *	2003-12-30	2005-08-18	Sun Pharmaceutical Industries Limited	Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
US7378439B2 (en) *	2004-01-20	2008-05-27	Usv, Ltd.	Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
WO2005105741A1 (en) *	2004-02-11	2005-11-10	Sun Pharmaceutical Industries Limited	Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
WO2005080333A1 (en) *	2004-02-19	2005-09-01	Torrent Pharmaceuticals Ltd	Process for purification of ropinirole
US20070254941A1 (en) *	2006-04-21	2007-11-01	Glenmark Pharmaceuticals Limited	Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
CN103130704B (zh) *	2013-03-11	2019-03-22	上海奥博生物医药技术有限公司	一种制备4-(2-羟乙基)-1，3-二氢-2h-吲哚-2-酮的新方法
CN103145604A (zh) *	2013-03-19	2013-06-12	上海奥博生物医药技术有限公司	一种制备罗匹尼罗关键中间体的方法
CN105418482A (zh) *	2015-11-23	2016-03-23	东南大学	一种改进的盐酸罗匹尼罗的制备方法
CN108440376B (zh) *	2018-05-08	2020-06-05	中国科学院成都生物研究所	一种盐酸罗匹尼罗的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1154976A (en) *	1967-02-21	1969-06-11	Pfizer Ltd	N-Phenyl Indoline Derivatives
JPS53101333A (en) *	1977-02-14	1978-09-04	Sagami Chem Res Center	3-acyloxymethyl-3,4:5,6-diepoxycyclohexane-1,2-diol and
IT1171624B (it) *	1980-11-12	1987-06-10	Thomae Gmbh Dr K	Indolinoni dotati di proprieta' farmaceutiche e procedimento per la loro produzione
US4588790A (en) *	1982-03-24	1986-05-13	Union Carbide Corporation	Method for fluidized bed polymerization
US4452808A (en) *	1982-12-07	1984-06-05	Smithkline Beckman Corporation	4-Aminoalkyl-2(3H)-indolones
US4593033A (en) *	1985-04-24	1986-06-03	Merck & Co., Inc.	Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
GB8712073D0 (en) *	1987-05-21	1987-06-24	Smith Kline French Lab	Medicament
GB8714371D0 (en) *	1987-06-19	1987-07-22	Smith Kline French Lab	Process
FR2635104B1 (fr) *	1988-08-03	1992-04-30	Synthelabo	Derives d'indolone, leur preparation et leur application en therapeutique
GB9008605D0 (en) *	1990-04-17	1990-06-13	Smith Kline French Lab	Process

1990
- 1990-04-17 GB GB909008605A patent/GB9008605D0/en active Pending
1991
- 1991-04-09 MY MYPI91000591A patent/MY109628A/en unknown
- 1991-04-15 CA CA002080221A patent/CA2080221C/en not_active Expired - Lifetime
- 1991-04-15 US US07/934,492 patent/US5336781A/en not_active Expired - Lifetime
- 1991-04-15 HU HU9203261A patent/HU214822B/hu unknown
- 1991-04-15 ZA ZA912782A patent/ZA912782B/xx unknown
- 1991-04-15 DK DK91908508.4T patent/DK0526529T3/da active
- 1991-04-15 DE DE69122753T patent/DE69122753T2/de not_active Expired - Lifetime
- 1991-04-15 KR KR1019920702578A patent/KR0180215B1/ko not_active IP Right Cessation
- 1991-04-15 ES ES91908508T patent/ES2094812T3/es not_active Expired - Lifetime
- 1991-04-15 NZ NZ237819A patent/NZ237819A/xx unknown
- 1991-04-15 MA MA22402A patent/MA22133A1/fr unknown
- 1991-04-15 PL PL91296387A patent/PL166736B1/pl unknown
- 1991-04-15 EP EP91908508A patent/EP0526529B1/en not_active Expired - Lifetime
- 1991-04-15 AT AT91908508T patent/ATE144251T1/de not_active IP Right Cessation
- 1991-04-15 JP JP3507509A patent/JP2788548B2/ja not_active Expired - Lifetime
- 1991-04-15 AU AU76562/91A patent/AU640006B2/en not_active Expired
- 1991-04-15 WO PCT/GB1991/000587 patent/WO1991016306A1/en active IP Right Grant
- 1991-04-16 AP APAP/P/1991/000251A patent/AP184A/en active
- 1991-04-16 IE IE126291A patent/IE911262A1/en not_active IP Right Cessation
- 1991-04-16 IL IL9786791A patent/IL97867A/en not_active IP Right Cessation
- 1991-04-16 IL IL11102891A patent/IL111028A/en not_active IP Right Cessation
- 1991-04-16 IL IL11102991A patent/IL111029A/en not_active IP Right Cessation
- 1991-04-16 CN CN91102564A patent/CN1027892C/zh not_active Expired - Lifetime
- 1991-04-16 PT PT97375A patent/PT97375B/pt not_active IP Right Cessation
- 1991-04-16 IL IL11103091A patent/IL111030A/en not_active IP Right Cessation
- 1991-05-13 SA SA91110352A patent/SA91110352B1/ar unknown
1992
- 1992-10-15 FI FI924674A patent/FI101148B/fi active
- 1992-10-16 NO NO924028A patent/NO178396C/no not_active IP Right Cessation
1993
- 1993-04-01 AU AU35669/93A patent/AU646771B2/en not_active Expired
1994
- 1994-09-22 IL IL11102894A patent/IL111028A0/xx unknown
- 1994-09-22 IL IL11102994A patent/IL111029A0/xx unknown
- 1994-09-22 IL IL11103094A patent/IL111030A0/xx unknown
1997
- 1997-01-02 HK HK3097A patent/HK3097A/xx not_active IP Right Cessation
- 1997-01-09 GR GR970400030T patent/GR3022261T3/el unknown
- 1997-09-05 CY CY198197A patent/CY1981A/xx unknown
1998
- 1998-02-19 JP JP10037427A patent/JP3044013B2/ja not_active Expired - Lifetime
1999
- 1999-06-18 NO NO1999012C patent/NO1999012I1/no unknown

Also Published As

Publication number	Publication date
DE69122753T2 (de)	1997-05-07
FI924674A (fi)	1992-10-15
PT97375B (pt)	1998-08-31
HU9203261D0 (en)	1992-12-28
MA22133A1 (fr)	1991-12-31
JP3044013B2 (ja)	2000-05-22
IL111028A (en)	1995-11-27
CA2080221C (en)	2000-11-14
FI101148B (fi)	1998-04-30
EP0526529A1 (en)	1993-02-10
PT97375A (pt)	1992-01-31
HUT64742A (en)	1994-02-28
IL111030A0 (en)	1994-11-28
CY1981A (en)	1997-09-05
NZ237819A (en)	1993-05-26
KR0180215B1 (ko)	1999-03-20
IL111029A (en)	1995-11-27
AU646771B2 (en)	1994-03-03
AU3566993A (en)	1993-06-03
FI924674A0 (fi)	1992-10-15
GR3022261T3 (en)	1997-04-30
NO924028D0 (no)	1992-10-16
DK0526529T3 (da)	1996-11-18
PL166736B1 (pl)	1995-06-30
IL97867A0 (en)	1992-06-21
JP2788548B2 (ja)	1998-08-20
CN1056686A (zh)	1991-12-04
US5336781A (en)	1994-08-09
ES2094812T3 (es)	1997-02-01
WO1991016306A1 (en)	1991-10-31
ATE144251T1 (de)	1996-11-15
CA2080221A1 (en)	1991-10-18
NO178396B (no)	1995-12-11
HU214822B (hu)	1998-06-29
AU640006B2 (en)	1993-08-12
GB9008605D0 (en)	1990-06-13
AU7656291A (en)	1991-11-11
AP9100251A0 (en)	1991-04-30
DE69122753D1 (de)	1996-11-21
NO178396C (no)	1996-03-20
JPH10251205A (ja)	1998-09-22
EP0526529B1 (en)	1996-10-16
IL111028A0 (en)	1994-11-28
AP184A (en)	1992-06-30
NO924028L (no)	1992-10-16
IE911262A1 (en)	1991-10-23
IL111029A0 (en)	1994-11-28
MY109628A (en)	1997-03-31
JPH05506029A (ja)	1993-09-02
CN1027892C (zh)	1995-03-15
IL97867A (en)	1995-11-27
NO1999012I1 (no)	1999-06-18
IL111030A (en)	1995-11-27
HK3097A (en)	1997-01-10
SA91110352B1 (ar)	2001-11-12

Publication	Publication Date	Title
ZA918636B (en)	1992-08-26	Process for the preparation of piperazine derivatives
ZA912782B (en)	1992-11-25	An improved process for the preparation of substituted indolone derivatives
IL99801A0 (en)	1992-08-18	Process for the preparation of nitroguanidine derivatives
ZA915567B (en)	1992-07-29	Process for the manufacture of quinoline derivatives
HU895959D0 (en)	1990-02-28	Process for the preparation of substituted oxa-diaminebutane derivatives
AU8251891A (en)	1992-02-20	Process for the preparation of 1-alkylisoquinoline derivatives
EP0476649A3 (en)	1992-09-16	Process for the preparation of carbapeneme compounds
FI953361A (fi)	1995-07-07	Menetelmä substituoitujen indolonijohdannaisten valmistamiseksi
HU885893D0 (en)	1990-02-28	Process for the preparation of substituted azaciclohexyl derivatives
EP0439745A3 (en)	1991-10-16	Process for the preparation of 2-chloro-5-methyl-pyridine
ZA915396B (en)	1992-04-29	Process for the preparation of 1-hydroxymethylpyrazoles
EP0449778A3 (en)	1991-11-27	Process for the preparation of hydroxyphenylepropionates
EP0444460A3 (en)	1991-09-25	Process for the preparation of acrolin
IL97512A0 (en)	1992-06-21	Process for the preparation of 1-hydroxyalkyl-5-nitro-imidazoles
GB9200653D0 (en)	1992-03-11	Novel process for the preparation of 3-unsubstituted indoles
IL98877A0 (en)	1992-07-15	Process for the preparation of n-alkylsulfonylamino-sulfonylureas
EP0486900A3 (en)	1992-08-19	Process for the preparation of indoles
EP0450180A3 (en)	1992-01-02	Process for the preparation of aminoethanol derivatives
GB9205920D0 (en)	1992-04-29	Process for the preparation of pyrethroide derivatives
ZA915630B (en)	1992-03-25	Process for the preparation of n-alkylsulfonylaminosulfonylureas
EP0459242A3 (en)	1992-07-08	Process for the preparation of phenolethers
ZW8288A1 (en)	1989-01-18	Improved process for the preparation of substituted indolines derivatives
NZ233012A (en)	1991-02-26	Process for the preparation of thieno-triazolo-diazepine derivatives
HU903050D0 (en)	1990-09-28	Process for the preparation of 3-amino-propyl-chloride derivatives
ZA915762B (en)	1992-04-29	Process for the preparation of 6-(3-substitutedamino-propionyl)-7-deacetylforskolin derivatives