ZA864023B - N-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents - Google Patents

N-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents

Info

Publication number
ZA864023B
ZA864023B ZA864023A ZA864023A ZA864023B ZA 864023 B ZA864023 B ZA 864023B ZA 864023 A ZA864023 A ZA 864023A ZA 864023 A ZA864023 A ZA 864023A ZA 864023 B ZA864023 B ZA 864023B
Authority
ZA
South Africa
Prior art keywords
carboxamidines
piperazine
phenyl
related compounds
antiarrhythmic agents
Prior art date
Application number
ZA864023A
Other languages
English (en)
Inventor
Jean-Claude Pascal
Original Assignee
Syntex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Lab filed Critical Syntex Lab
Publication of ZA864023B publication Critical patent/ZA864023B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA864023A 1985-05-30 1986-05-29 N-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents ZA864023B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/739,393 US4713382A (en) 1985-05-30 1985-05-30 N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents

Publications (1)

Publication Number Publication Date
ZA864023B true ZA864023B (en) 1988-01-27

Family

ID=24972082

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA864023A ZA864023B (en) 1985-05-30 1986-05-29 N-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents

Country Status (16)

Country Link
US (1) US4713382A (es)
EP (1) EP0204265A1 (es)
JP (1) JPS61280486A (es)
KR (1) KR860008999A (es)
CN (1) CN86103798A (es)
AU (1) AU5805086A (es)
DD (1) DD247452A5 (es)
DK (1) DK253586A (es)
ES (1) ES8708132A1 (es)
FI (1) FI862279A (es)
GR (1) GR861370B (es)
HU (1) HU195201B (es)
IL (1) IL78963A0 (es)
NO (1) NO862138L (es)
PT (1) PT82675B (es)
ZA (1) ZA864023B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1231208A3 (en) * 1991-08-14 2003-12-10 Procter & Gamble Pharmaceuticals 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
JP6397407B2 (ja) 2012-07-19 2018-09-26 ドレクセル ユニバーシティ 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA574981A (en) * 1959-04-28 H. Brown Edwin Fluid pressure bearing and seal for centrifugal pump
GB948766A (en) * 1959-10-20 1964-02-05 May & Baker Ltd Trifluoromethylphenylpiperazine derivatives
US3655667A (en) * 1968-04-04 1972-04-11 Smith Kline French Lab 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines
PH12016A (en) * 1972-09-22 1978-10-06 Rorer Inc William H Amidinoureas
US3793322A (en) * 1972-12-15 1974-02-19 Usv Pharma Corp 1,4-disubstituted piperazines
US3976643A (en) * 1973-07-13 1976-08-24 William H. Rorer, Inc. Guanidines
US3961056A (en) * 1974-02-11 1976-06-01 The Upjohn Company Substituted morpholine guanidines for the treatment of arrhythmic conditions
GB1514907A (en) * 1975-05-30 1978-06-21 Rorer Inc William H Process for the preparation of substituted phenylguanidines and substituted phenylguanidines when thus prepared
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
EP0005385B1 (fr) * 1978-04-27 1982-09-01 LAROCHE NAVARRON S.A. Société dite: Dérivés de la pipérazine méthanimine, leur procédé de préparation et leurs applications en thérapeutique
CH643549A5 (de) * 1979-08-25 1984-06-15 Merz & Co N-(trimethoxybenzyl)-n'-phenylpiperazine.
ZA81160B (en) * 1980-01-31 1982-02-24 Laroche Navarron Sa Piperazine derivatives of theophylline

Also Published As

Publication number Publication date
FI862279A0 (fi) 1986-05-29
IL78963A0 (en) 1986-09-30
NO862138L (no) 1986-12-01
GR861370B (en) 1986-09-17
ES555440A0 (es) 1987-10-16
DK253586A (da) 1986-12-01
ES8708132A1 (es) 1987-10-16
AU5805086A (en) 1986-12-04
FI862279A (fi) 1986-12-01
US4713382A (en) 1987-12-15
KR860008999A (ko) 1986-12-19
EP0204265A1 (en) 1986-12-10
HU195201B (en) 1988-04-28
DD247452A5 (de) 1987-07-08
DK253586D0 (da) 1986-05-29
CN86103798A (zh) 1987-06-10
PT82675B (en) 1987-09-29
PT82675A (en) 1986-06-01
JPS61280486A (ja) 1986-12-11
HUT41016A (en) 1987-03-30

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