PT82675B - Process for preparing n-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrythmic agents - Google Patents

Process for preparing n-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrythmic agents

Info

Publication number
PT82675B
PT82675B PT82675A PT8267586A PT82675B PT 82675 B PT82675 B PT 82675B PT 82675 A PT82675 A PT 82675A PT 8267586 A PT8267586 A PT 8267586A PT 82675 B PT82675 B PT 82675B
Authority
PT
Portugal
Prior art keywords
phenyl
piperazinecarboxamidines
preparing
related compounds
antiarrythmic agents
Prior art date
Application number
PT82675A
Other languages
English (en)
Other versions
PT82675A (en
Inventor
Jean-Claude Pascal
Original Assignee
Syntex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Lab filed Critical Syntex Lab
Publication of PT82675A publication Critical patent/PT82675A/pt
Publication of PT82675B publication Critical patent/PT82675B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT82675A 1985-05-30 1986-05-28 Process for preparing n-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrythmic agents PT82675B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/739,393 US4713382A (en) 1985-05-30 1985-05-30 N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents

Publications (2)

Publication Number Publication Date
PT82675A PT82675A (en) 1986-06-01
PT82675B true PT82675B (en) 1987-09-29

Family

ID=24972082

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82675A PT82675B (en) 1985-05-30 1986-05-28 Process for preparing n-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrythmic agents

Country Status (16)

Country Link
US (1) US4713382A (pt)
EP (1) EP0204265A1 (pt)
JP (1) JPS61280486A (pt)
KR (1) KR860008999A (pt)
CN (1) CN86103798A (pt)
AU (1) AU5805086A (pt)
DD (1) DD247452A5 (pt)
DK (1) DK253586A (pt)
ES (1) ES8708132A1 (pt)
FI (1) FI862279A (pt)
GR (1) GR861370B (pt)
HU (1) HU195201B (pt)
IL (1) IL78963A0 (pt)
NO (1) NO862138L (pt)
PT (1) PT82675B (pt)
ZA (1) ZA864023B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1231208A3 (en) * 1991-08-14 2003-12-10 Procter & Gamble Pharmaceuticals 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
JP6397407B2 (ja) 2012-07-19 2018-09-26 ドレクセル ユニバーシティ 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA574981A (en) * 1959-04-28 H. Brown Edwin Fluid pressure bearing and seal for centrifugal pump
GB948766A (en) * 1959-10-20 1964-02-05 May & Baker Ltd Trifluoromethylphenylpiperazine derivatives
US3655667A (en) * 1968-04-04 1972-04-11 Smith Kline French Lab 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines
PH12016A (en) * 1972-09-22 1978-10-06 Rorer Inc William H Amidinoureas
US3793322A (en) * 1972-12-15 1974-02-19 Usv Pharma Corp 1,4-disubstituted piperazines
US3976643A (en) * 1973-07-13 1976-08-24 William H. Rorer, Inc. Guanidines
US3961056A (en) * 1974-02-11 1976-06-01 The Upjohn Company Substituted morpholine guanidines for the treatment of arrhythmic conditions
GB1514907A (en) * 1975-05-30 1978-06-21 Rorer Inc William H Process for the preparation of substituted phenylguanidines and substituted phenylguanidines when thus prepared
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
EP0005385B1 (fr) * 1978-04-27 1982-09-01 LAROCHE NAVARRON S.A. Société dite: Dérivés de la pipérazine méthanimine, leur procédé de préparation et leurs applications en thérapeutique
CH643549A5 (de) * 1979-08-25 1984-06-15 Merz & Co N-(trimethoxybenzyl)-n'-phenylpiperazine.
ZA81160B (en) * 1980-01-31 1982-02-24 Laroche Navarron Sa Piperazine derivatives of theophylline

Also Published As

Publication number Publication date
FI862279A0 (fi) 1986-05-29
IL78963A0 (en) 1986-09-30
NO862138L (no) 1986-12-01
GR861370B (en) 1986-09-17
ES555440A0 (es) 1987-10-16
ZA864023B (en) 1988-01-27
DK253586A (da) 1986-12-01
ES8708132A1 (es) 1987-10-16
AU5805086A (en) 1986-12-04
FI862279A (fi) 1986-12-01
US4713382A (en) 1987-12-15
KR860008999A (ko) 1986-12-19
EP0204265A1 (en) 1986-12-10
HU195201B (en) 1988-04-28
DD247452A5 (de) 1987-07-08
DK253586D0 (da) 1986-05-29
CN86103798A (zh) 1987-06-10
PT82675A (en) 1986-06-01
JPS61280486A (ja) 1986-12-11
HUT41016A (en) 1987-03-30

Similar Documents

Publication Publication Date Title
GB2159823B (en) Polymer-fibre mixture process
EP0199997A3 (en) Process for preparing diaryl-pentaerythritol
DE3661343D1 (en) Castings and process for their preparation
HUT37932A (en) Process for preparing 4-hydroxy-2h-1-benzo-thiopyrane-2-one-derivatives and for preparing rhodenticide preparations comprising such compounds
HUT43573A (en) Process for producing azolyl-cyclopropyl-ethanol derivatives and compositions containing them as active agents
PT83293B (en) Process for preparing dihidropyridine-2-hydroxyamines useful asmedicaments
PT83154A (en) Process for preparing quinolizinesulphonamides
HUT42766A (en) Process for preparing n-sulfamyl-3-(2-guanidino-thiazolyl-4-methyl-thio)-propionamidine
ZA863454B (en) Process for preparing benzothiazolesulphenamides
PT84441B (en) Process for preparing benzylpyrimidine derivatives and compositions containing them
YU218086A (en) Process for preparing herbicidically effective imidazolynones
GB8800425D0 (en) Process for preparing 4 4-dialkyl-2-azetidinones
PT82675B (en) Process for preparing n-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrythmic agents
CS435886A2 (en) Process for preparing 2-brom-alfa-ergokryptine
HUT43022A (en) Process for preparing monochloro-pinacolone
PT82643A (en) Process for preparing substituted hexanydro arylquinolizines
GB2155478B (en) 1a-hydroxyvitamin d2 analogs and process for preparing same
HUT43039A (en) Process for preparing 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetamide
HUT42769A (en) Process for preparing pyridazodiazepines
HUT42438A (en) Process for preparing novel 4-alkoxy-2-oxo-pyrrolidin-1-yl-acetic acid-alkylesters
ZA858865B (en) Process for preparing mixtures
EP0191401A3 (en) Novel antiallergic agents and process for their preparation
DE3662097D1 (en) 4-mercaptobenzonitriles and process for their preparation
PL249198A1 (en) Process for preparing n-phosphonmethylglycine and its derivatives
DE3661635D1 (en) Ketosultams and process for their preparation