WO2004052313A3 - Anti-infectives - Google Patents

Anti-infectives Download PDF

Info

Publication number
WO2004052313A3
WO2004052313A3 PCT/US2003/039983 US0339983W WO2004052313A3 WO 2004052313 A3 WO2004052313 A3 WO 2004052313A3 US 0339983 W US0339983 W US 0339983W WO 2004052313 A3 WO2004052313 A3 WO 2004052313A3
Authority
WO
WIPO (PCT)
Prior art keywords
infectives
disclosed
formula
making
methods
Prior art date
Application number
PCT/US2003/039983
Other languages
French (fr)
Other versions
WO2004052313A2 (en
Inventor
Deping Chai
Kevin J Duffy
Duke M Fitch
Antony N Shaw
Rosanna Tedesco
Kenneth J Wiggall
Michael N Zimmerman
Original Assignee
Smithkline Beecham Corp
Deping Chai
Kevin J Duffy
Duke M Fitch
Antony N Shaw
Rosanna Tedesco
Kenneth J Wiggall
Michael N Zimmerman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Deping Chai, Kevin J Duffy, Duke M Fitch, Antony N Shaw, Rosanna Tedesco, Kenneth J Wiggall, Michael N Zimmerman filed Critical Smithkline Beecham Corp
Priority to AU2003300957A priority Critical patent/AU2003300957A1/en
Publication of WO2004052313A2 publication Critical patent/WO2004052313A2/en
Publication of WO2004052313A3 publication Critical patent/WO2004052313A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds useful as HCV anti-infectives having the formula (I) wherein the formula variables are as defined herein, are disclosed. Also disclosed are methods of making and using the same.
PCT/US2003/039983 2002-12-11 2003-12-11 Anti-infectives WO2004052313A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003300957A AU2003300957A1 (en) 2002-12-11 2003-12-11 Anti-infectives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43246202P 2002-12-11 2002-12-11
US60/432,462 2002-12-11

Publications (2)

Publication Number Publication Date
WO2004052313A2 WO2004052313A2 (en) 2004-06-24
WO2004052313A3 true WO2004052313A3 (en) 2004-09-02

Family

ID=32507933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/039983 WO2004052313A2 (en) 2002-12-11 2003-12-11 Anti-infectives

Country Status (2)

Country Link
AU (1) AU2003300957A1 (en)
WO (1) WO2004052313A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327764T3 (en) 2004-08-23 2009-11-03 F. Hoffmann-La Roche Ag ANTIVIRICAL HETEROCICLIC COMPOUNDS.
ATE409179T1 (en) 2004-12-21 2008-10-15 Hoffmann La Roche TETRALIN AND INDANDE DERIVATIVES AND THEIR APPLICATIONS AS 5-HT ANTAGONISTS
MX2007013415A (en) 2005-05-04 2008-01-15 Hoffmann La Roche Heterocyclic antiviral compounds.
NZ567285A (en) 2005-11-03 2010-06-25 Hoffmann La Roche Arylsulfonylchromans as 5-HT6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors
BRPI0708067A2 (en) 2006-02-17 2011-05-17 Hoffmann La Roche heterocyclic antiviral compounds
EA018935B1 (en) 2006-10-10 2013-11-29 Медивир Аб Hcv nucleoside inhibitor
CA2752443A1 (en) 2009-03-06 2010-09-10 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
JP2012524752A (en) 2009-04-25 2012-10-18 エフ．ホフマン−ラ ロシュ アーゲー Heterocyclic antiviral compounds
CN102803212A (en) 2009-06-24 2012-11-28 弗·哈夫曼-拉罗切有限公司 Heterocyclic Antiviral Compound
BR112012005616A2 (en) 2009-09-21 2016-06-21 Hoffmann La Roche heterocyclic antiviral compounds
CN102713630A (en) 2009-11-14 2012-10-03 弗·哈夫曼-拉罗切有限公司 Biomarkers for predicting rapid response to HCV treatment
BR112012012085A2 (en) 2009-11-21 2016-05-17 Hoffmann La Roche heterocyclic antiviral compounds
RU2012127201A (en) 2009-12-02 2014-01-20 Ф.Хоффманн-Ля Рош Аг BIOMARKERS FOR FORECASTING A SUSTAINABLE RESPONSE TO THE TREATMENT OF HEPATITIS C VIRUS
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
RU2534613C2 (en) 2013-03-22 2014-11-27 Александр Васильевич Иващенко Alkyl2-{[(2r,3s,5r)-5-(4-amino-2-oxo-2h-pyrimidine-1-yl)- -hydroxy- tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino}-proptonates, nucleoside inhibitors of rna-polymerase hcv ns5b, methods for producing and using them
CN105294648B (en) * 2015-11-30 2017-11-28 山东罗欣药业集团股份有限公司 A kind of preparation method of sitafloxacin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085172A1 (en) * 2000-05-10 2001-11-15 Smithkline Beecham Corporation Novel anti-infectives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085172A1 (en) * 2000-05-10 2001-11-15 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
WO2004052313A2 (en) 2004-06-24
AU2003300957A1 (en) 2004-06-30
AU2003300957A8 (en) 2004-06-30

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