WO2001077320A3 - Regulation of human hm74-like g protein coupled receptor - Google Patents

Regulation of human hm74-like g protein coupled receptor Download PDF

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Publication number
WO2001077320A3
WO2001077320A3 PCT/EP2001/003811 EP0103811W WO0177320A3 WO 2001077320 A3 WO2001077320 A3 WO 2001077320A3 EP 0103811 W EP0103811 W EP 0103811W WO 0177320 A3 WO0177320 A3 WO 0177320A3
Authority
WO
WIPO (PCT)
Prior art keywords
asthma
coupled receptor
disease
protein coupled
diseases
Prior art date
Application number
PCT/EP2001/003811
Other languages
French (fr)
Other versions
WO2001077320A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2001246526A priority Critical patent/AU2001246526A1/en
Priority to EP01919423A priority patent/EP1272631A2/en
Publication of WO2001077320A2 publication Critical patent/WO2001077320A2/en
Publication of WO2001077320A3 publication Critical patent/WO2001077320A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents which regulate human HM74-like G protein coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, CNS diseases such as Parkinson's disease, cardiovascular diseases such as acute heart failure, hypotension, hypertension, angina pectoris, and myocardial infarction, urinary retention, osteoporosis, ulcers, asthma, inflammation, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
PCT/EP2001/003811 2000-04-05 2001-04-04 Regulation of human hm74-like g protein coupled receptor WO2001077320A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001246526A AU2001246526A1 (en) 2000-04-05 2001-04-04 Regulation of human hm74-like g protein coupled receptor
EP01919423A EP1272631A2 (en) 2000-04-05 2001-04-04 Regulation of human hm74-like g protein coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19470100P 2000-04-05 2000-04-05
US60/194,701 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077320A2 WO2001077320A2 (en) 2001-10-18
WO2001077320A3 true WO2001077320A3 (en) 2002-03-14

Family

ID=22718593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003811 WO2001077320A2 (en) 2000-04-05 2001-04-04 Regulation of human hm74-like g protein coupled receptor

Country Status (3)

Country Link
EP (1) EP1272631A2 (en)
AU (1) AU2001246526A1 (en)
WO (1) WO2001077320A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
CA2404541A1 (en) * 2000-03-31 2001-10-11 Curagen Corporation G-protein coupled receptors and nucleic acids encoding same
US20020052022A1 (en) * 2000-05-30 2002-05-02 Nabil Elshourbagy Molecular cloning of a chemokine like 7TMR (AXOR87)
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
US7189524B1 (en) 2002-11-25 2007-03-13 Amgen, Inc. Receptor ligands and methods of modulating receptors
EP1597586A2 (en) * 2003-02-13 2005-11-23 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with hm74
NZ555320A (en) 2004-12-03 2010-11-26 Schering Corp Substituted piperazines as CB1 antagonists
SI1901731T1 (en) 2005-06-28 2011-07-29 Merck Sharp & Dohme Niacin receptor agonists, compositions containing such compounds and methods of treatment
WO2008063321A2 (en) 2006-10-13 2008-05-29 Janssen Pharmaceutica N.V. Gpr81-ligand complexes and their preparation and use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578962A2 (en) * 1992-07-17 1994-01-19 American Cyanamid Company Receptor identification method
WO1998056820A1 (en) * 1997-06-12 1998-12-17 Smithkline Beecham Corporation Hm74a receptor
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2404541A1 (en) * 2000-03-31 2001-10-11 Curagen Corporation G-protein coupled receptors and nucleic acids encoding same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578962A2 (en) * 1992-07-17 1994-01-19 American Cyanamid Company Receptor identification method
WO1998056820A1 (en) * 1997-06-12 1998-12-17 Smithkline Beecham Corporation Hm74a receptor
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 23 March 2000 (2000-03-23), MUZNY, D.M., ET AL.: "Homo sapiens chromosome 12 clone RP11-324E6, WORKING DRAFT SEQUENCE, 13 unordered pieces.", XP002180536 *
DATABASE EMBL 23 March 2000 (2000-03-23), MUZNY, D.M., ET AL.: "Homo sapiens chromosome 12 clone RP11-507N20, WORKING DRAFT SEQUENCE, 10 unordered pieces.", XP002180537 *
DATABASE EMBL 3 April 2001 (2001-04-03), WANG, Y., ET AL.: "Homo sapiens putative chemokine receptor (FKSG80) mRNA, complete cds.", XP002180538 *
See also references of EP1272631A2 *

Also Published As

Publication number Publication date
EP1272631A2 (en) 2003-01-08
WO2001077320A2 (en) 2001-10-18
AU2001246526A1 (en) 2001-10-23

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