TNSN06308A1 - Macrocyclic compounds as inhibitors of viral replication - Google Patents

Macrocyclic compounds as inhibitors of viral replication

Info

Publication number
TNSN06308A1
TNSN06308A1 TNP2006000308A TNSN06308A TNSN06308A1 TN SN06308 A1 TNSN06308 A1 TN SN06308A1 TN P2006000308 A TNP2006000308 A TN P2006000308A TN SN06308 A TNSN06308 A TN SN06308A TN SN06308 A1 TNSN06308 A1 TN SN06308A1
Authority
TN
Tunisia
Prior art keywords
methods
inhibitors
viral replication
macrocyclic compounds
subject compound
Prior art date
Application number
TNP2006000308A
Other languages
English (en)
Inventor
Steven M Wenglowsky
Steven W Andrews
Kevin R Condroski
Yutong Jiang
April L Kennedy
George A Doherty
John A Josey
Peter J Stengel
Benjamin T Woodard
Machender R Madduru
Lawrence M Blatt
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/010494 external-priority patent/WO2005095403A2/fr
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of TNSN06308A1 publication Critical patent/TNSN06308A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
TNP2006000308A 2004-03-30 2006-09-27 Macrocyclic compounds as inhibitors of viral replication TNSN06308A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
PCT/US2005/010494 WO2005095403A2 (fr) 2004-03-30 2005-03-29 Composes macrocycliques inhibiteurs de replication virale

Publications (1)

Publication Number Publication Date
TNSN06308A1 true TNSN06308A1 (en) 2007-12-03

Family

ID=37955155

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000308A TNSN06308A1 (en) 2004-03-30 2006-09-27 Macrocyclic compounds as inhibitors of viral replication

Country Status (5)

Country Link
CN (1) CN1938311A (fr)
CU (1) CU20090112A6 (fr)
TN (1) TNSN06308A1 (fr)
UA (1) UA91677C2 (fr)
ZA (1) ZA200608798B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101821629A (zh) * 2007-09-10 2010-09-01 诺瓦提斯研究基金会弗里德里克·米谢尔生物医学研究所 用于预测患有肝脏病毒性感染的受试者针对抗病毒疗法的应答的方法
JP5503655B2 (ja) 2008-09-22 2014-05-28 アレイ バイオファーマ、インコーポレイテッド Ｔｒｋキナーゼ阻害剤としての置換イミダゾ［１，２ｂ］ピリダジン化合物
EP2725028B1 (fr) 2008-10-22 2016-05-25 Array Biopharma, Inc. Composés de pyrazolo[1,5-a] pyrimidine substitués en tant qu'intermédiare pour la synthese d'inhibiteurs de kinases TRK
WO2010097229A2 (fr) 2009-02-27 2010-09-02 Ortho-Mcneil-Janssen Pharmaceuticals Inc Sel amorphe d'un inhibiteur macrocyclique du vhc
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2011038283A1 (fr) * 2009-09-28 2011-03-31 Hoffmann-La Roche Inc. Nouveaux inhibiteurs macrocycliques de réplication du virus de l'hépatite c
JP5833022B2 (ja) * 2010-01-27 2015-12-16 エービー・ファーマ・リミテッド Ｃ型肝炎ウィルス阻害剤としてのポリ複素環式化合物
US8933084B2 (en) 2010-05-20 2015-01-13 Array Biopharma Inc. Macrocyclic compounds as Trk kinase inhibitors
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
PT3699181T (pt) 2014-11-16 2023-04-05 Array Biopharma Inc Forma cristalina de hidrogenossulfato de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
SG11201803438XA (en) 2015-10-26 2018-05-30 Univ Colorado Regents Point mutations in trk inhibitor-resistant cancer and methods relating to the same
CN107043405B (zh) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 多环杂环化合物的晶型、其制备方法、应用及组合物
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
RU2751767C2 (ru) 2016-04-04 2021-07-16 Локсо Онколоджи, Инк. Жидкие составы (s)-n-(5-((r)-2-(2,5-дифторфенил)пирролидин-1-ил)пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида
EP3800189B1 (fr) 2016-05-18 2023-06-28 Loxo Oncology, Inc. Préparation de (s)-n-(5-((r)-2-(2,5-difluorophényl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1

Also Published As

Publication number Publication date
ZA200608798B (en) 2008-06-25
CN1938311A (zh) 2007-03-28
CU20090112A6 (es) 2012-03-15
UA91677C2 (ru) 2010-08-25

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