TNSN06308A1 - Macrocyclic compounds as inhibitors of viral replication - Google Patents

Macrocyclic compounds as inhibitors of viral replication

Info

Publication number
TNSN06308A1
TNSN06308A1 TNP2006000308A TNSN06308A TNSN06308A1 TN SN06308 A1 TNSN06308 A1 TN SN06308A1 TN P2006000308 A TNP2006000308 A TN P2006000308A TN SN06308 A TNSN06308 A TN SN06308A TN SN06308 A1 TNSN06308 A1 TN SN06308A1
Authority
TN
Tunisia
Prior art keywords
methods
inhibitors
viral replication
macrocyclic compounds
subject compound
Prior art date
Application number
TNP2006000308A
Other languages
French (fr)
Inventor
Steven M Wenglowsky
Steven W Andrews
Kevin R Condroski
Yutong Jiang
April L Kennedy
George A Doherty
John A Josey
Peter J Stengel
Benjamin T Woodard
Machender R Madduru
Lawrence M Blatt
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/010494 external-priority patent/WO2005095403A2/en
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of TNSN06308A1 publication Critical patent/TNSN06308A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
TNP2006000308A 2004-03-30 2006-09-27 Macrocyclic compounds as inhibitors of viral replication TNSN06308A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
PCT/US2005/010494 WO2005095403A2 (en) 2004-03-30 2005-03-29 Macrocyclic compounds as inhibitors of viral replication

Publications (1)

Publication Number Publication Date
TNSN06308A1 true TNSN06308A1 (en) 2007-12-03

Family

ID=37955155

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000308A TNSN06308A1 (en) 2004-03-30 2006-09-27 Macrocyclic compounds as inhibitors of viral replication

Country Status (5)

Country Link
CN (1) CN1938311A (en)
CU (1) CU20090112A6 (en)
TN (1) TNSN06308A1 (en)
UA (1) UA91677C2 (en)
ZA (1) ZA200608798B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101821629A (en) * 2007-09-10 2010-09-01 诺瓦提斯研究基金会弗里德里克·米谢尔生物医学研究所 Method for predicting the response of subject suffering from viral infection of the liver to antiviral therapy
JP5503655B2 (en) 2008-09-22 2014-05-28 アレイ バイオファーマ、インコーポレイテッド Substituted imidazo [1,2B] pyridazine compounds as TRK kinase inhibitors
EP2725028B1 (en) 2008-10-22 2016-05-25 Array Biopharma, Inc. Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors
WO2010097229A2 (en) 2009-02-27 2010-09-02 Ortho-Mcneil-Janssen Pharmaceuticals Inc Amorphous salt of a macrocyclic inhibitor of hcv
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
WO2011038283A1 (en) * 2009-09-28 2011-03-31 Hoffmann-La Roche Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
JP5833022B2 (en) * 2010-01-27 2015-12-16 エービー・ファーマ・リミテッド Polyheterocyclic compounds as hepatitis C virus inhibitors
US8933084B2 (en) 2010-05-20 2015-01-13 Array Biopharma Inc. Macrocyclic compounds as Trk kinase inhibitors
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
PT3699181T (en) 2014-11-16 2023-04-05 Array Biopharma Inc Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
SG11201803438XA (en) 2015-10-26 2018-05-30 Univ Colorado Regents Point mutations in trk inhibitor-resistant cancer and methods relating to the same
CN107043405B (en) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
RU2751767C2 (en) 2016-04-04 2021-07-16 Локсо Онколоджи, Инк. Liquid compositions (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidine-1-yl)pyrazolo[1,5-a]pyrimidine-3-yl)-3-hydroxypyrrolidine-1-arboxamide
EP3800189B1 (en) 2016-05-18 2023-06-28 Loxo Oncology, Inc. Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors

Also Published As

Publication number Publication date
ZA200608798B (en) 2008-06-25
CN1938311A (en) 2007-03-28
CU20090112A6 (en) 2012-03-15
UA91677C2 (en) 2010-08-25

Similar Documents

Publication Publication Date Title
WO2005095403A3 (en) Macrocyclic compounds as inhibitors of viral replication
TNSN06308A1 (en) Macrocyclic compounds as inhibitors of viral replication
SG166791A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
TN2009000457A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
WO2007047146A3 (en) Inhibitors of viral replication
WO2008005511A3 (en) Novel inhibitors of hepatitis c virus replication
TN2009000481A1 (en) Novel peptide inhibitors of hepatitis c virus replication
WO2009142842A3 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
MY144593A (en) Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
MX2012003171A (en) Novel macrocyclic inhibitors of hepatitis c virus replication.
WO2006039488A3 (en) Hcv ns3-ns4a protease inhibition
WO2008100867A3 (en) Novel inhibitors hepatitis c virus replication
WO2008106058A3 (en) Inhibitors of serine proteases
WO2009134616A8 (en) Novel inhibitors of hepatitis c virus replication
TNSN06103A1 (en) Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
TW200611905A (en) Macrocyclic compounds as inhibitors of viral replication
UA95455C2 (en) Macrocyclic inhibitors of hepatitis c virus replication
UA84579C2 (en) Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hepatitis c virus replication
TN2010000468A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
CU23602A3 (en) MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION