SI1212320T1 - Phenylpiperazines as serotonin reuptake inhibitors - Google Patents

Phenylpiperazines as serotonin reuptake inhibitors

Info

Publication number
SI1212320T1
SI1212320T1 SI200030720T SI200030720T SI1212320T1 SI 1212320 T1 SI1212320 T1 SI 1212320T1 SI 200030720 T SI200030720 T SI 200030720T SI 200030720 T SI200030720 T SI 200030720T SI 1212320 T1 SI1212320 T1 SI 1212320T1
Authority
SI
Slovenia
Prior art keywords
phenylpiperazines
serotonin reuptake
reuptake inhibitors
serotonin
inhibitors
Prior art date
Application number
SI200030720T
Other languages
English (en)
Slovenian (sl)
Inventor
Hes Roelof Van
Der Heijden Johannes A. M. Van
Cornelis G. Kruse
Jacobus Tipker
Martinus T. M. Tulp
Gerben M. Visser
Vliet Bernard J. Van
Original Assignee
Solvay Pharmaceuticals B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals B.V. filed Critical Solvay Pharmaceuticals B.V.
Publication of SI1212320T1 publication Critical patent/SI1212320T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI200030720T 1999-08-23 2000-08-22 Phenylpiperazines as serotonin reuptake inhibitors SI1212320T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99202710 1999-08-23
NL1012888 1999-08-23
PCT/EP2000/008190 WO2001014330A2 (en) 1999-08-23 2000-08-22 Phenylpiperazines as serotonin reuptake inhibitors
EP00962355A EP1212320B1 (de) 1999-08-23 2000-08-22 Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme

Publications (1)

Publication Number Publication Date
SI1212320T1 true SI1212320T1 (en) 2005-10-31

Family

ID=26153354

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030720T SI1212320T1 (en) 1999-08-23 2000-08-22 Phenylpiperazines as serotonin reuptake inhibitors

Country Status (30)

Country Link
US (3) US7067513B1 (de)
EP (1) EP1212320B1 (de)
JP (1) JP4919565B2 (de)
KR (1) KR100634039B1 (de)
CN (1) CN1155596C (de)
AR (1) AR031526A1 (de)
AT (1) ATE299142T1 (de)
AU (1) AU772189B2 (de)
BR (1) BR0013498A (de)
CA (1) CA2379021C (de)
CZ (1) CZ298533B6 (de)
DE (1) DE60021194T2 (de)
DK (1) DK1212320T3 (de)
ES (1) ES2244469T3 (de)
HK (1) HK1051199A1 (de)
HU (1) HUP0203194A3 (de)
IL (2) IL148218A0 (de)
MX (1) MXPA02001919A (de)
NO (1) NO321887B1 (de)
NZ (1) NZ517900A (de)
PL (1) PL201178B1 (de)
PT (1) PT1212320E (de)
RU (1) RU2246494C2 (de)
SI (1) SI1212320T1 (de)
SK (1) SK287018B6 (de)
TR (1) TR200200460T2 (de)
TW (1) TWI286136B (de)
UA (1) UA74160C2 (de)
WO (1) WO2001014330A2 (de)
ZA (1) ZA200201829B (de)

Families Citing this family (25)

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DE60021194T2 (de) 1999-08-23 2005-12-22 Solvay Pharmaceuticals B.V. Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR032711A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
AU2002258971A1 (en) * 2001-04-24 2002-11-05 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
EP1336406A1 (de) * 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität
CN100429206C (zh) * 2002-05-13 2008-10-29 弗·哈夫曼-拉罗切有限公司 作为5－ht6调节剂的苯并嗪衍生物及其用途
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
PL377770A1 (pl) * 2002-11-08 2006-02-20 F. Hoffmann-La Roche Ag Podstawione benzoksazynony i ich zastosowanie
US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
SA05260390B1 (ar) * 2004-12-07 2009-04-01 سولفاي فارماسوتيكالز بي . في مشتقات بنزدايوكسان ببرازين ذات الفة مشتركة تجاه مستقبلات دوبامين - d2 ومواقع إعادة امتصاص السيروتونين
CN101072765A (zh) * 2004-12-07 2007-11-14 索尔瓦药物有限公司 同时对多巴胺－d2受体和5－羟色胺重摄取部位具有亲合力的苯基哌嗪
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
EP1824480A1 (de) * 2004-12-08 2007-08-29 Solvay Pharmaceuticals B.V. Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung
US20060122247A1 (en) 2004-12-08 2006-06-08 Solvay Pharmaceuticals B.V. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
GT200600416A (es) 2005-09-12 2007-09-20 Sales salicilato y gentisato de un compuesto de piperazina
GT200600414A (es) * 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
TW200800306A (en) * 2005-09-12 2008-01-01 Wyeth Corp Sustained-release formulation and uses thereof
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
AU2010266040B2 (en) * 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
US9598401B2 (en) 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

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EP1007523B9 (de) * 1997-07-25 2004-09-08 H. Lundbeck A/S Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung
EP0900792B1 (de) 1997-09-02 2003-10-29 Duphar International Research B.V Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
DE69819266T2 (de) * 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EA004248B1 (ru) * 1998-06-19 2004-02-26 Х.Лундбекк А/С Производные 4-, 5-, 6- и 7-замещенного индола и индолина, их получение и применение
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AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
DE60021194T2 (de) 1999-08-23 2005-12-22 Solvay Pharmaceuticals B.V. Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR032711A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
EP1336406A1 (de) 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität

Also Published As

Publication number Publication date
SK287018B6 (sk) 2009-09-07
BR0013498A (pt) 2002-05-14
US20060293313A1 (en) 2006-12-28
DK1212320T3 (da) 2005-08-08
WO2001014330A3 (en) 2001-08-02
UA74160C2 (uk) 2005-11-15
KR20020057949A (ko) 2002-07-12
CZ298533B6 (cs) 2007-10-31
KR100634039B1 (ko) 2006-10-17
PL201178B1 (pl) 2009-03-31
US20090143406A1 (en) 2009-06-04
SK2492002A3 (en) 2002-09-10
ES2244469T3 (es) 2005-12-16
EP1212320A2 (de) 2002-06-12
US7456182B2 (en) 2008-11-25
AU7411800A (en) 2001-03-19
IL148218A (en) 2007-05-15
CA2379021C (en) 2009-10-27
CN1390214A (zh) 2003-01-08
NZ517900A (en) 2003-08-29
AU772189B2 (en) 2004-04-08
TR200200460T2 (tr) 2002-06-21
NO20020810L (no) 2002-02-19
PT1212320E (pt) 2005-11-30
AR031526A1 (es) 2003-09-24
DE60021194T2 (de) 2005-12-22
TWI286136B (en) 2007-09-01
HUP0203194A2 (hu) 2003-01-28
HUP0203194A3 (en) 2004-01-28
EP1212320B1 (de) 2005-07-06
MXPA02001919A (es) 2003-07-21
CN1155596C (zh) 2004-06-30
JP4919565B2 (ja) 2012-04-18
WO2001014330A2 (en) 2001-03-01
RU2246494C2 (ru) 2005-02-20
IL148218A0 (en) 2002-09-12
NO321887B1 (no) 2006-07-17
HK1051199A1 (en) 2003-07-25
ZA200201829B (en) 2003-08-27
US7605162B2 (en) 2009-10-20
DE60021194D1 (de) 2005-08-11
NO20020810D0 (no) 2002-02-19
CZ2002619A3 (cs) 2002-08-14
JP2003507454A (ja) 2003-02-25
US7067513B1 (en) 2006-06-27
CA2379021A1 (en) 2001-03-01
PL364821A1 (en) 2004-12-13
ATE299142T1 (de) 2005-07-15

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