SE0301998D0 - Quil A fraction with low toxicity and use thereof - Google Patents
Quil A fraction with low toxicity and use thereofInfo
- Publication number
- SE0301998D0 SE0301998D0 SE0301998A SE0301998A SE0301998D0 SE 0301998 D0 SE0301998 D0 SE 0301998D0 SE 0301998 A SE0301998 A SE 0301998A SE 0301998 A SE0301998 A SE 0301998A SE 0301998 D0 SE0301998 D0 SE 0301998D0
- Authority
- SE
- Sweden
- Prior art keywords
- quil
- fraction
- adjuvant
- lps
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301998A SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Quil A fraction with low toxicity and use thereof |
CA2529363A CA2529363C (en) | 2003-07-07 | 2004-07-07 | Quil a fraction with low toxicity and use thereof |
DE602004023089T DE602004023089D1 (de) | 2003-07-07 | 2004-07-07 | Quil a fraktion mit geringer toxizität und ihre verwendung |
PL04749076T PL1648505T3 (pl) | 2003-07-07 | 2004-07-07 | Frakcja Quil A o niskiej toksyczności i jej zastosowanie |
PCT/SE2004/001038 WO2005002620A1 (en) | 2003-07-07 | 2004-07-07 | Quil a fraction with low toxicity and use thereof |
ES04749076T ES2331952T3 (es) | 2003-07-07 | 2004-07-07 | Fraccion de quil a con baja toxicidad y su uso. |
AT04749076T ATE442164T1 (de) | 2003-07-07 | 2004-07-07 | Quil a fraktion mit geringer toxizität und ihre verwendung |
JP2006518582A JP4731475B2 (ja) | 2003-07-07 | 2004-07-07 | 毒性の低いQuilA画分およびその使用 |
EP04749076A EP1648505B1 (en) | 2003-07-07 | 2004-07-07 | Quil a fraction with low toxicity and use thereof |
DK04749076T DK1648505T3 (da) | 2003-07-07 | 2004-07-07 | Quil A-fraktion med lav toksicitet og anvendelse deraf |
BRPI0412444A BRPI0412444B8 (pt) | 2003-07-07 | 2004-07-07 | fração de quil a com baixa toxidez e seu uso |
US10/562,866 US8821881B2 (en) | 2003-07-07 | 2004-07-07 | Quil A fraction with low toxicity and use thereof |
AU2004254152A AU2004254152B2 (en) | 2003-07-07 | 2004-07-07 | Quil a fraction with low toxicity and use thereof |
NZ544299A NZ544299A (en) | 2003-07-07 | 2004-07-07 | Quil A fraction A for the enhancement of immune activities and immunomodulating activities |
ZA200600151A ZA200600151B (en) | 2003-07-07 | 2006-01-06 | Quil A fraction with low toxicity and use thereof |
US14/445,690 US20140335049A1 (en) | 2003-07-07 | 2014-07-29 | Quil a fraction with low toxicity and use thereof |
US14/714,664 US20150320858A1 (en) | 2003-07-07 | 2015-05-18 | Quil a fraction with low toxicity and use thereof |
US15/054,801 US20160184427A1 (en) | 2003-07-07 | 2016-02-26 | Quil a fraction with low toxicity and use thereof |
US15/874,262 US20180369368A1 (en) | 2003-07-07 | 2018-01-18 | Quil a fraction with low toxicity and use thereof |
US16/701,948 US20200345840A1 (en) | 2003-07-07 | 2019-12-03 | Quil a fraction with low toxicity and use thereof |
US17/477,739 US20220241408A1 (en) | 2003-07-07 | 2021-09-17 | Quil a fraction with low toxicity and use thereof |
US18/376,666 US20240024468A1 (en) | 2003-07-07 | 2023-10-04 | Quil a fraction with low toxicity and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301998A SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Quil A fraction with low toxicity and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0301998D0 true SE0301998D0 (sv) | 2003-07-07 |
Family
ID=27731119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0301998A SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Quil A fraction with low toxicity and use thereof |
Country Status (15)
Country | Link |
---|---|
US (8) | US8821881B2 (sv) |
EP (1) | EP1648505B1 (sv) |
JP (1) | JP4731475B2 (sv) |
AT (1) | ATE442164T1 (sv) |
AU (1) | AU2004254152B2 (sv) |
BR (1) | BRPI0412444B8 (sv) |
CA (1) | CA2529363C (sv) |
DE (1) | DE602004023089D1 (sv) |
DK (1) | DK1648505T3 (sv) |
ES (1) | ES2331952T3 (sv) |
NZ (1) | NZ544299A (sv) |
PL (1) | PL1648505T3 (sv) |
SE (1) | SE0301998D0 (sv) |
WO (1) | WO2005002620A1 (sv) |
ZA (1) | ZA200600151B (sv) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU773204C (en) * | 1998-08-10 | 2005-05-19 | Antigenics Llc | Compositions of CPG and saponin adjuvants and methods thereof |
SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
EP1838341B1 (en) | 2005-01-20 | 2013-08-14 | Isconova AB | Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide |
EP1764369A1 (de) * | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
WO2009030978A2 (en) | 2006-06-09 | 2009-03-12 | Novartis Ag | Conformers of bacterial adhesins |
WO2008031878A1 (en) * | 2006-09-15 | 2008-03-20 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | A composition for therapy and/or for prophylaxis of hbv-infections and hbv-mediated diseases |
EP1902727A1 (de) * | 2006-09-22 | 2008-03-26 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
EP2094278B1 (en) * | 2006-11-20 | 2017-04-05 | Duecom | Use of lipid containing particles comprising quillaja saponins for the treatment of cancer |
BRPI0813866A2 (pt) | 2007-06-27 | 2015-01-06 | Novartis Ag | Vacinas contra influenza com baixo teor de aditivos |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
CA2723786C (en) | 2008-06-27 | 2020-04-28 | Pfizer Inc. | Novel saponin-containing adjuvants |
AU2010269148A1 (en) * | 2009-07-10 | 2012-01-19 | Isconova Ab | New composition |
EP2618838A1 (en) | 2010-09-20 | 2013-07-31 | Crucell Holland B.V. | Therapeutic vaccination against active tuberculosis |
PT2750683T (pt) | 2011-10-03 | 2018-06-26 | Mx Adjuvac Ab | Nanopartículas, processo de preparação e seu uso como transportadores para moléculas hidrofóbicas anfipáticas no domínio da medicina, incluindo tratamento de cancro e compostos relacionados a alimentos |
AU2012343981B2 (en) | 2011-11-28 | 2017-09-07 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
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US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
AU2013237424B2 (en) | 2012-03-22 | 2017-07-06 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
AU2014214844B2 (en) | 2013-02-07 | 2017-12-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
CN105007936B (zh) | 2013-03-08 | 2018-10-02 | 扬森疫苗与预防公司 | 无细胞百日咳疫苗 |
AR095962A1 (es) | 2013-04-01 | 2015-11-25 | Moreinx Ab | Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos |
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US10806779B2 (en) | 2013-07-02 | 2020-10-20 | Janssen Vaccines & Prevention B.V. | Method for preparing virosomes |
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DE102014005771A1 (de) | 2014-04-23 | 2015-10-29 | Clariant International Ltd. | Verwendung von wässrigen driftreduzierenden Zusammensetzungen |
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CN114699519A (zh) | 2015-09-03 | 2022-07-05 | 诺瓦瓦克斯股份有限公司 | 具有改进的稳定性和免疫原性的疫苗组合物 |
SG11201804148TA (en) | 2015-12-23 | 2018-07-30 | Pfizer | Rsv f protein mutants |
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EA201892250A1 (ru) | 2016-04-05 | 2019-03-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
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DE112017005577T5 (de) | 2016-11-04 | 2019-08-29 | Cabot Corporation | Nanokomposite, enthaltend kristallinen Polyester und Organosiliciumdioxid |
JP6721797B2 (ja) | 2017-02-09 | 2020-07-15 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 異種遺伝子発現のための強力で短いプロモーター |
US11229692B2 (en) | 2017-05-17 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
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KR20200053518A (ko) | 2017-09-15 | 2020-05-18 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 면역의 안전한 유도를 위한 방법 |
KR20200113226A (ko) | 2018-01-23 | 2020-10-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 인플루엔자 바이러스 백신 및 이의 용도 |
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JP2021524449A (ja) | 2018-05-23 | 2021-09-13 | アーデーセー セラピューティクス ソシエテ アノニム | 分子アジュバント |
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JP2022532742A (ja) | 2019-05-15 | 2022-07-19 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | アデノウイルスベースのワクチンによる呼吸器合胞体ウイルス感染の予防的処置 |
BR112021022087A2 (pt) | 2019-05-15 | 2021-12-28 | Janssen Vaccines & Prevention Bv | Coadministração de vacina sazonal contra influenza e vacina contra vírus respiratório sincicial à base de adenovírus |
MX2022002766A (es) | 2019-09-05 | 2022-04-06 | Janssen Vaccines & Prevention Bv | Vacunas contra el virus de la gripe y usos de las mismas. |
US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
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US20210347828A1 (en) | 2020-05-11 | 2021-11-11 | Janssen Pharmaceuticals, Inc. | RNA Replicon Encoding a Stabilized Corona Virus Spike Protein |
MX2022014162A (es) | 2020-05-11 | 2023-02-23 | Janssen Pharmaceuticals Inc | Proteínas de fusión de la proteína de la espícula del coronavirus estabilizadas. |
JP2023524860A (ja) | 2020-05-11 | 2023-06-13 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | SARS-CoV-2ワクチン |
BR112022026408A2 (pt) | 2020-06-29 | 2023-01-17 | Janssen Vaccines & Prevention Bv | Combinação vacinal contra infecção pelo vírus sincicial respiratório |
JP2023532369A (ja) | 2020-07-06 | 2023-07-27 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | 安定化されたコロナウイルススパイクタンパク質融合タンパク質 |
JP2022060169A (ja) | 2020-10-02 | 2022-04-14 | ファイザー・インク | Rsv fタンパク質生産のための細胞培養工程 |
WO2022175477A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv fb antigens |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
WO2022175479A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Vaccine combinations against respiratory syncytial virus strain a and b infections |
EP4314019A2 (en) | 2021-04-01 | 2024-02-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2023047348A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
EP4448802A1 (en) | 2021-12-16 | 2024-10-23 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2023196634A2 (en) | 2022-04-08 | 2023-10-12 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
WO2023217988A1 (en) | 2022-05-12 | 2023-11-16 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2024017682A1 (en) | 2022-07-18 | 2024-01-25 | Janssen Vaccines & Prevention B.V. | Rsv immunogens |
WO2024030856A2 (en) | 2022-08-01 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory proteins and related methods |
WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
WO2024061759A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized coronavirus s proteins |
WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2024104947A2 (en) | 2022-11-14 | 2024-05-23 | Janssen Vaccines & Prevention B.V. | Influenza b virus vaccines and uses thereof |
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WO2024167885A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
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JPS5839376B2 (ja) * | 1978-10-30 | 1983-08-30 | 富士通株式会社 | イオン注入法 |
SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
DK166762B1 (da) | 1986-01-14 | 1993-07-12 | Nederlanden Staat | Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser |
CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
NL9002314A (nl) | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
SE9600647D0 (sv) * | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
US6231859B1 (en) | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
US6558670B1 (en) * | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
-
2003
- 2003-07-07 SE SE0301998A patent/SE0301998D0/sv unknown
-
2004
- 2004-07-07 ES ES04749076T patent/ES2331952T3/es not_active Expired - Lifetime
- 2004-07-07 NZ NZ544299A patent/NZ544299A/en not_active IP Right Cessation
- 2004-07-07 AU AU2004254152A patent/AU2004254152B2/en not_active Expired
- 2004-07-07 PL PL04749076T patent/PL1648505T3/pl unknown
- 2004-07-07 WO PCT/SE2004/001038 patent/WO2005002620A1/en active Application Filing
- 2004-07-07 AT AT04749076T patent/ATE442164T1/de not_active IP Right Cessation
- 2004-07-07 US US10/562,866 patent/US8821881B2/en active Active
- 2004-07-07 DE DE602004023089T patent/DE602004023089D1/de not_active Expired - Lifetime
- 2004-07-07 CA CA2529363A patent/CA2529363C/en not_active Expired - Lifetime
- 2004-07-07 DK DK04749076T patent/DK1648505T3/da active
- 2004-07-07 JP JP2006518582A patent/JP4731475B2/ja not_active Expired - Lifetime
- 2004-07-07 EP EP04749076A patent/EP1648505B1/en not_active Expired - Lifetime
- 2004-07-07 BR BRPI0412444A patent/BRPI0412444B8/pt active IP Right Grant
-
2006
- 2006-01-06 ZA ZA200600151A patent/ZA200600151B/en unknown
-
2014
- 2014-07-29 US US14/445,690 patent/US20140335049A1/en not_active Abandoned
-
2015
- 2015-05-18 US US14/714,664 patent/US20150320858A1/en not_active Abandoned
-
2016
- 2016-02-26 US US15/054,801 patent/US20160184427A1/en not_active Abandoned
-
2018
- 2018-01-18 US US15/874,262 patent/US20180369368A1/en not_active Abandoned
-
2019
- 2019-12-03 US US16/701,948 patent/US20200345840A1/en not_active Abandoned
-
2021
- 2021-09-17 US US17/477,739 patent/US20220241408A1/en not_active Abandoned
-
2023
- 2023-10-04 US US18/376,666 patent/US20240024468A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DK1648505T3 (da) | 2009-12-21 |
US20180369368A1 (en) | 2018-12-27 |
US20140335049A1 (en) | 2014-11-13 |
EP1648505B1 (en) | 2009-09-09 |
BRPI0412444B8 (pt) | 2021-05-25 |
US20160184427A1 (en) | 2016-06-30 |
WO2005002620A1 (en) | 2005-01-13 |
NZ544299A (en) | 2009-03-31 |
US20150320858A1 (en) | 2015-11-12 |
ATE442164T1 (de) | 2009-09-15 |
AU2004254152B2 (en) | 2009-10-29 |
ZA200600151B (en) | 2007-01-31 |
US20060239963A1 (en) | 2006-10-26 |
US8821881B2 (en) | 2014-09-02 |
BRPI0412444A (pt) | 2006-09-19 |
AU2004254152A1 (en) | 2005-01-13 |
CA2529363A1 (en) | 2005-01-13 |
US20220241408A1 (en) | 2022-08-04 |
CA2529363C (en) | 2013-04-02 |
EP1648505A1 (en) | 2006-04-26 |
US20200345840A1 (en) | 2020-11-05 |
JP4731475B2 (ja) | 2011-07-27 |
JP2007527386A (ja) | 2007-09-27 |
BRPI0412444B1 (pt) | 2016-06-14 |
US20240024468A1 (en) | 2024-01-25 |
ES2331952T3 (es) | 2010-01-21 |
PL1648505T3 (pl) | 2010-02-26 |
DE602004023089D1 (de) | 2009-10-22 |
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