RU97117083A - POLYPHENOLIC FACTIONS OF TEA, THEIR APPLICATION AND CONTAINING THEIR COMPOSITIONS - Google Patents

POLYPHENOLIC FACTIONS OF TEA, THEIR APPLICATION AND CONTAINING THEIR COMPOSITIONS

Info

Publication number
RU97117083A
RU97117083A RU97117083/13A RU97117083A RU97117083A RU 97117083 A RU97117083 A RU 97117083A RU 97117083/13 A RU97117083/13 A RU 97117083/13A RU 97117083 A RU97117083 A RU 97117083A RU 97117083 A RU97117083 A RU 97117083A
Authority
RU
Russia
Prior art keywords
paragraphs
stage
volume
aqueous
extraction
Prior art date
Application number
RU97117083/13A
Other languages
Russian (ru)
Other versions
RU2185070C2 (en
Inventor
Бомбарделли Эдзио
Морадзони Паоло
Мустик Джузеппе
Original Assignee
Индена С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95MI000493A external-priority patent/IT1275905B1/en
Application filed by Индена С.П.А. filed Critical Индена С.П.А.
Publication of RU97117083A publication Critical patent/RU97117083A/en
Application granted granted Critical
Publication of RU2185070C2 publication Critical patent/RU2185070C2/en

Links

Claims (21)

1. Способ экстракции полифенольных фракций Camellia sinensis, содержащих не более, чем 0.2% по весу кофеина, включающий: а) экстракцию растительной биомассы водно-спиртовыми или водно-кетонными смесями; б) полное или частичное упаривание растворителя экстракции; в) суспендирование остатка в водной смеси 30-60% по объему метанола; г) экстракцию гидрометанольной суспензии хлорированными растворителями; д) фильтрование нерастворимых остатков и концентрирование гидрометанольной фазы; е) подкисление при необходимости органическими кислотами; ж) экстракцию концентрированной гидрометанольной фазы и при необходимости подкисление растворителями, выбранными из алифатических сложных эфиров, спиртов или кетонов при условии, что они не смешиваются с гидрометанольной смесью; з) добавление при необходимости ароматического или алифатического углеводорода с последующим промыванием разбавленными водными растворами минеральных кислот; и) концентрирование несмешивающейся водно-органической фазы и ее разбавление хлорированными растворителями; к) при отсутствии стадий е) и з) обработка сульфоновыми смолами в сухих алифатических кетонах или спиртах.1. A method for the extraction of Camellia sinensis polyphenolic fractions containing not more than 0.2% by weight of caffeine, including: a) extraction of plant biomass with water-alcohol or water-ketone mixtures; b) complete or partial evaporation of the extraction solvent; c) suspension of the residue in an aqueous mixture of 30-60% by volume of methanol; d) extraction of the hydromethanol suspension with chlorinated solvents; e) filtering insoluble residues and concentrating the hydromethanol phase; e) acidification, if necessary, with organic acids; g) extraction of the concentrated hydromethanol phase and, if necessary, acidification with solvents selected from aliphatic esters, alcohols or ketones, provided that they are not mixed with the hydromethanol mixture; h) adding, if necessary, an aromatic or aliphatic hydrocarbon, followed by washing with dilute aqueous solutions of mineral acids; i) the concentration of immiscible aqueous-organic phase and its dilution with chlorinated solvents; k) in the absence of stages e) and h) treatment with sulfonic resins in dry aliphatic ketones or alcohols. 2. Способ по п. 1, отличающийся тем, что на стадии а) используют 40-90% по объему водный ацетон. 2. The method according to p. 1, characterized in that at the stage a) use 40-90% by volume aqueous acetone. 3. Способ по п. 2, отличающийся тем, что используют 70% по объему водный ацетон. 3. The method according to p. 2, characterized in that use 70% by volume of aqueous acetone. 4. Способ по любому из пп. 2, 3, отличающийся тем, что на стадии в) используют 50% по объему водный метанол. 4. The method according to any one of paragraphs. 2, 3, characterized in that in stage c) use 50% by volume aqueous methanol. 5. Способ по любому из пп. 1-4, отличающийся тем, что на стадии г) используют хлористый метилен. 5. The method according to any one of paragraphs. 1-4, characterized in that at the stage d) use methylene chloride. 6. Способ по любому из пп. 1-5, отличающийся тем, что на стадии е) используют лимонную кислоту в присутствии цитрата аммония. 6. The method according to any one of paragraphs. 1-5, characterized in that in stage e) use citric acid in the presence of ammonium citrate. 7. Способ по любому из пп. 1-6, отличающийся тем, что на стадии ж) растворители выбирают из этилацетата, этилформиата, метилэтилкетона, 1-бутанола, трет-бутанола, 2-бутанола. 7. The method according to any one of paragraphs. 1-6, characterized in that in step g) the solvents are selected from ethyl acetate, ethyl formate, methyl ethyl ketone, 1-butanol, tert-butanol, 2-butanol. 8. Способ по п. 7, отличающийся тем, что используют растворитель, представляющий собой этилацетат. 8. The method according to p. 7, characterized in that the solvent is an ethyl acetate. 9. Способ по любому из пп. 1-8, отличающийся тем, что на стадии з) используют толуол в количестве 5% по объему от общего объема органической фазы и 1% по объему водной серной кислоты. 9. The method according to any one of paragraphs. 1-8, characterized in that in stage h) use toluene in an amount of 5% by volume of the total volume of the organic phase and 1% by volume of aqueous sulfuric acid. 10. Способ по любому из пп. 1-9, отличающийся тем, что на стадии и) используют хлористый метилен. 10. The method according to any one of paragraphs. 1-9, characterized in that at the stage and) use methylene chloride. 11. Способ по любому из пп. 1-10, отличающийся тем, что проводят стадии от а) до д), ж), и) и к). 11. The method according to any one of paragraphs. 1-10, characterized in that stage from a) to e), g), i) and k) are carried out. 12. Способ по любому из пп. 1-10, отличающийся тем, что проводят стадии от а) до и). 12. The method according to any one of paragraphs. 1-10, characterized in that carry out stage a) to and). 13. Полифенольные фракции Camellia sinensis, содержащие не более 0,2% кофеина, получаемые по способу по пп. 1-12. 13. Polyphenolic fractions of Camellia sinensis containing not more than 0.2% caffeine, obtained by the method according to PP. 1-12. 14. Полифенольные фракции зеленого чая, содержащие 50-65% эпигаллокатехин-3-0-галлата, 13-20% эпикатехин-3-0-галлата, 2-4% эпикатехина и 1,5-3% эпигаллокатехина и не более, чем 0,2% кофеина. 14. Polyphenolic fractions of green tea containing 50-65% epigallocatechin-3-0-gallate, 13-20% epicatechin-3-0-gallate, 2-4% epicatechin and 1.5-3% epigallocatechin and not more than 0.2% caffeine. 15. Фармацевтические композиции, содержащие эффективное количество полифенольной фракции по п. 13 или 14 в смеси с фармацевтически приемлемым носителем или эксципиентом. 15. Pharmaceutical compositions containing an effective amount of a polyphenol fraction according to claim 13 or 14 in admixture with a pharmaceutically acceptable carrier or excipient. 16. Фармацевтические композиции по п. 15 в форме таблеток, желатиновых капсул, саше, сиропов, ампул. 16. The pharmaceutical compositions of claim 15 in the form of tablets, gelatine capsules, sachets, syrups, ampoules. 17. Фармацевтические композиции по п. 15 или 16, дополнительно содержащие антрациклин или цис-платину и их производные, по выбору в форме, пригодной для последовательного или отдельного введения. 17. The pharmaceutical compositions of claim 15 or 16, further comprising anthracycline or cis-platinum and derivatives thereof, optionally in a form suitable for sequential or separate administration. 18. Косметические композиции, содержащие эффективное количество полифенольных фракций по п. 13 или 14 в смеси с приемлемыми носителями или эксципиентами. 18. Cosmetic compositions containing an effective amount of polyphenolic fractions according to claim 13 or 14 in a mixture with acceptable carriers or excipients. 19. Диетические композиции, содержащие эффективное количество полифенольных фракций по п. 13 или 14 в смеси с приемлемыми носителями или эксципиентами. 19. Dietary compositions containing an effective amount of polyphenolic fractions according to claim 13 or 14 in a mixture with acceptable carriers or excipients. 20. Применение полифенольных фракций по п. 13 или 14 для получения лекарственных средств, обладающих дифференциальной цитотоксичной и антиокислительной активностями. 20. The use of polyphenolic fractions according to claim 13 or 14 for the production of drugs with differential cytotoxic and antioxidant activities. 21. Применение полифенольных фракций по п. 13 или 14 для получения лекарственных средств для лечения опухолевых форм, хронико-дегенеративных состояний сердечно-сосудистой системы, артрозных состояний, атеросклероза. 21. The use of polyphenolic fractions according to claim 13 or 14 for the manufacture of medicines for the treatment of tumor forms, chronic and degenerative conditions of the cardiovascular system, arthritic conditions, atherosclerosis.
RU97117083/13A 1995-03-14 1996-03-07 Tea polyphenolic fractions, their use and compositions comprising thereof RU2185070C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI95A000493 1995-03-14
IT95MI000493A IT1275905B1 (en) 1995-03-14 1995-03-14 POLYPHENOLIC FRACTIONS OF TEA, THEIR USE AND FORMULATIONS THAT CONTAIN THEM

Publications (2)

Publication Number Publication Date
RU97117083A true RU97117083A (en) 1999-10-10
RU2185070C2 RU2185070C2 (en) 2002-07-20

Family

ID=11370887

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97117083/13A RU2185070C2 (en) 1995-03-14 1996-03-07 Tea polyphenolic fractions, their use and compositions comprising thereof

Country Status (16)

Country Link
US (2) US5989557A (en)
EP (1) EP0814823B1 (en)
JP (2) JP3264934B2 (en)
KR (1) KR100301678B1 (en)
CN (1) CN1138552C (en)
AT (1) ATE222113T1 (en)
AU (1) AU696676B2 (en)
CA (1) CA2215210C (en)
DE (1) DE69622998T2 (en)
DK (1) DK0814823T3 (en)
ES (1) ES2181873T3 (en)
IT (1) IT1275905B1 (en)
NO (1) NO326762B1 (en)
PT (1) PT814823E (en)
RU (1) RU2185070C2 (en)
WO (1) WO1996028178A1 (en)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
US5968973A (en) * 1996-11-18 1999-10-19 Cancer Institute (Hospital), Chinese Academy Of Medical Sciences Method for treating hyperplasia
US6197808B1 (en) 1996-11-18 2001-03-06 Cancer Instititute (Hospital), Chinese Academy Of Medical Sciences Methods for treating hyperplasia
JP3213557B2 (en) * 1996-11-18 2001-10-02 三井農林株式会社 A remedy for condyloma acuminatum containing tea catechin as an active ingredient
EP1003535A1 (en) * 1997-08-14 2000-05-31 Joel Howard Glass Method for extracting synergistic and biological activity maintaining compound from camellia sinensis; an extracted compound and use of said compound in the food processing or pharmaceutical industry
DE19754940A1 (en) * 1997-12-12 1999-06-17 Siedler Siegfried Preparation and administration of plant extracts
DE19824727A1 (en) * 1998-06-03 1999-12-09 Beiersdorf Ag Cosmetic or dermatological preparations containing catechins or green tea extract
JP4507027B2 (en) * 1998-12-04 2010-07-21 明治乳業株式会社 MMP inhibitor
US6210679B1 (en) 1999-01-07 2001-04-03 Hauser, Inc. Method for isolation of caffeine-free catechins from green tea
US6576275B1 (en) * 1999-02-02 2003-06-10 Archer-Daniels-Midland Company Process for extracting polyphenolic antioxidants from purine-containing plants
WO2000046183A1 (en) * 1999-02-08 2000-08-10 Checkpoint Genetics, Inc. N-substituted amino acids, antioxidant pharmaceutical compositions containing same and methods using same
SE9900473D0 (en) * 1999-02-12 1999-02-12 Karolinska Innovations Ab Inhibitor of endothelial cell proliferation
US6428818B1 (en) 1999-03-30 2002-08-06 Purdue Research Foundation Tea catechin formulations and processes for making same
US6410052B1 (en) 1999-03-30 2002-06-25 Purdue Research Foundation Tea catechins in sustained release formulations as cancer specific proliferation inhibitors
AU4043900A (en) 1999-03-30 2000-10-16 Purdue Research Foundation Compositions containing tea catechins as cancer specific proliferation inhibitors
US8372454B2 (en) * 1999-04-19 2013-02-12 Pom Wonderful Llc Methods of making pomegranate compounds for the treatment of erectile dysfunction
US7611738B2 (en) * 2005-05-24 2009-11-03 Pom Wonderful, Llc Processes for extracting phytochemicals from pomegranate solids and compositions and methods of use thereof
JP2003501381A (en) * 1999-06-07 2003-01-14 ユニバーシティ・オブ・シェフィールド Arthritis treatment
US6299925B1 (en) * 1999-06-29 2001-10-09 Xel Herbaceuticals, Inc. Effervescent green tea extract formulation
CN1089006C (en) * 1999-08-13 2002-08-14 中国科学院生态环境研究中心 Method of extracting activated hemagglutination factor and inhibitor component (ATI) from tea
DE60031921T2 (en) 1999-08-16 2007-09-20 Dsm Ip Assets B.V. Process for the preparation of epigallocatechin gallate
US6562864B1 (en) * 1999-09-02 2003-05-13 Drake Larson Catechin multimers as therapeutic drug delivery agents
FR2798561B1 (en) * 1999-09-21 2001-11-02 Jean Morelle COMPOSITIONS FOR FOOD AND COSMETIC USE, CHARACTERIZED BY THEIR ANTILIPOPEROXIDE PROPERTIES
US6248341B1 (en) 2000-01-14 2001-06-19 Color Access, Inc. Method of treating topical angiogenesis-related disorders
IL146010A0 (en) * 2000-02-18 2002-07-25 Arch Dev Corp Polyhydroxylated benzene-containing compounds
KR100379323B1 (en) * 2000-02-29 2003-04-08 삼아약품 주식회사 Pharmaceutical composition for preventing and treating coronary restenosis comprising catechine
EP1262543B1 (en) * 2000-03-10 2012-10-24 Kabushiki Kaisha Yakult Honsha Alpha-amylase activity inhibitors
US6497887B1 (en) * 2000-04-13 2002-12-24 Color Access, Inc. Membrane delivery system
US6509054B1 (en) * 2000-05-05 2003-01-21 American Fruits And Flavors Food additives having enlarged concentration of phenolics extracted from fruits, and process of obtaining the same
US6620452B1 (en) 2000-05-05 2003-09-16 American Fruit And Flavors Food additives having enlarged concentration of phenolics extracted from fruits and vegetables and process of obtaining the same
US6254898B1 (en) * 2000-05-25 2001-07-03 Protective Factors, Inc. Nutraceutical composition for protection against solar radiation
CA2431196C (en) * 2000-11-15 2012-01-24 Rutgers, The State University Of New Jersey Black tea extract for prevention of disease
US7192612B2 (en) * 2001-02-22 2007-03-20 Purdue Research Foundation Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
AU2002254007B2 (en) 2001-02-22 2006-09-21 Purdue Research Foundation Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer
WO2002067965A1 (en) * 2001-02-22 2002-09-06 Purdue Research Foundation Compositions based on proanthocyanadin-catechin synergies for prevention and treatment of cancer
ATE555807T1 (en) * 2001-03-15 2012-05-15 Proteotech Inc CATECHINES FOR THE TREATMENT OF FIBRILLOGENESIS IN ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, SYSTEMIC AA AMYLOIDOSIS AND OTHER AMYLOID DISORDERS
EP1448186B1 (en) * 2001-11-19 2008-12-17 MediGene AG Medicament for the treatment of viral skin and tumour diseases
US20040142048A1 (en) * 2002-02-22 2004-07-22 Morre Dorothy M. Compositions based on proanthocyanadin-catechin synergies for prevention and treatment of cancer
KR20030087566A (en) * 2002-05-07 2003-11-14 액세스 비지니스 그룹 인터내셔날 엘엘씨 Phytonutrient Nutritional Supplement
US20040097432A1 (en) * 2002-11-04 2004-05-20 Access Business Group International Llc. Method of reducing cholesterol
US7115283B2 (en) * 2003-05-06 2006-10-03 Access Business Group International Llc Preparations for sustained release of nutraceuticals and methods of controllably releasing nutraceuticals
ES2373663T3 (en) 2003-09-08 2012-02-07 Genyous Biomed International Inc. COMPOSITIONS OF BOTANICAL EXTRACTS FOR CANCER THERAPY.
EP1667528A4 (en) * 2003-09-22 2007-10-24 Genyous Biomed Internat Inc Hippophae rhamnoides compositions for cancer therapy
US20090017078A1 (en) * 2003-09-23 2009-01-15 Origin Biomedicinals, Inc. Anhydrous topical formulation for polyphenols
BRPI0415215B8 (en) 2003-10-09 2021-05-25 Medigene Ag use of polyphenol in drug preparation
US20050079235A1 (en) * 2003-10-09 2005-04-14 Eggert Stockfleth Use of a polyphenol for the treatment of actinic keratosis
MXPA06007942A (en) * 2004-01-12 2007-02-16 Integrated Botan Technologies Bioactive compositions from theacea.
CN1319527C (en) * 2004-01-17 2007-06-06 栾德刚 Use of tea polyphenol for preparing medicine for preventing and treating lipsotrichia induced from chemotherapy
US7232585B2 (en) * 2004-06-24 2007-06-19 Xel Herbaceuticals, Inc. Green tea formulations and methods of preparation
EP1618793A1 (en) * 2004-07-20 2006-01-25 Cognis IP Management GmbH Extracts of Camellia sinensis with low alkaloid content
JP4702824B2 (en) * 2004-07-22 2011-06-15 三井農林株式会社 Tea polyphenol composition and method for producing the same
US7666452B2 (en) * 2006-01-25 2010-02-23 Ito En, Ltd. Beverage comprising cathechins and caffeine
FR2876905B1 (en) * 2004-10-22 2007-01-12 Silab Sa PROCESS FOR OBTAINING ACTIVE INGREDIENT WITH HAIR PROTECTIVE EFFECT, ACTIVE ACTIVE PRINCIPLE AND COMPOSITIONS THEREOF
WO2006049258A1 (en) * 2004-11-04 2006-05-11 University Of Tsukuba Polymeric polyphenol extracted from fermented tea, therapeutic agent for mitochondrial disease, preventive/therapeutic agent for diabetes mellitus, and food or beverage
CN100413858C (en) * 2004-11-23 2008-08-27 三达膜科技（厦门）有限公司 Method for producing high pure tea polyphenol with low caffeine
ITMI20042414A1 (en) 2004-12-17 2005-03-17 Indena Spa FORMULATION FOR THE TREATMENT OF AFFECTIONS OF THE FIRST RESPIRATORY ROUTES
US8895084B2 (en) 2004-12-23 2014-11-25 Colgate-Palmolive Company Oral care composition containing extract of unoxidized Camellia
US8609152B2 (en) * 2005-05-24 2013-12-17 Mohammad Madjid Compositions and methods for extracting and using phytochemicals for the treatment of influenza
KR100757175B1 (en) 2005-08-23 2007-09-07 (주)아모레퍼시픽 Skin compositions for external application for improving wrinkle and enhancing skin elasticity comprising kaempferol from green tea
MY147363A (en) * 2005-09-20 2012-11-30 Nestec Sa Water dispersible composition and method for preparing same
CN1939296B (en) * 2005-09-29 2011-04-13 中国人民解放军军事医学科学院毒物药物研究所 Theapolyphenol composition and its preparation
KR101351674B1 (en) * 2005-09-30 2014-01-14 디에스엠 아이피 어셋츠 비.브이. Novel compositions containing polyphenols
CN100364985C (en) * 2005-11-22 2008-01-30 三达膜科技（厦门）有限公司 Method of preparing tea polyphenol by resin adsorption method
EP2001493A4 (en) * 2006-03-15 2010-03-03 Pom Wonderful Llc Method of using pomegranate extracts for increasing prostate specific antigen doubling time
US10131727B2 (en) * 2006-03-31 2018-11-20 Council Of Scientific And Industrial Research Solid state matrix, process of preparation thereof, and process of preparation of theaflavins
EP1913821A1 (en) * 2006-10-20 2008-04-23 Kraft Foods R & D, Inc. Zweigniederlassung München Polyphenol-rich extract from plant material
US20110117121A1 (en) * 2006-10-27 2011-05-19 James Dao Compositions for treatment and inhibition of pain
US20080138481A1 (en) * 2006-12-07 2008-06-12 Chi-Tang Ho Methods of reducing reactive carbonyl species
US8383175B2 (en) * 2006-12-12 2013-02-26 Firmenich Sa Active ingredient delivery system with an amorphous metal salt as carrier
CN101284022B (en) * 2007-06-01 2011-06-15 山西省农业科学院农产品综合利用研究所 Complexation extraction method of plant polyphenols substances
US20090048187A1 (en) * 2007-07-30 2009-02-19 Luigi Ricciardiello Chemopreventive, Anticancer and Anti-Inflammatory Effects of Pinoresinol-Rich Olives
CN101121705B (en) * 2007-09-21 2010-12-08 江苏德和生物科技有限公司 Technique for preparing tea polyphenols
EP2070429A1 (en) 2007-12-13 2009-06-17 Cognis IP Management GmbH Oxidative stabilisation of sterols and sterol esters
US20110082071A1 (en) * 2008-05-15 2011-04-07 Amal Elabbadi Delivery system for an active ingredient
RU2395281C2 (en) * 2008-09-04 2010-07-27 Всеволод Иванович Киселев Pharmaceutical composition for treatment of dysplastic processes of cervix
JP4565219B2 (en) * 2008-12-26 2010-10-20 アサヒビール株式会社 Polyphenol-containing granule or polyphenol-containing chewable tablet and method for producing the same
KR101171832B1 (en) 2009-10-30 2012-08-14 박경식 Tea compositions for long term dose of without side effects, its' components
RU2569822C2 (en) * 2010-10-13 2015-11-27 Интерконтинентал Грейт Брэндс ЛЛС Coffee extracts as ingredients of food products, medications, cosmetic products, food additives and biopharmaceuticals
US20120121721A1 (en) * 2010-11-16 2012-05-17 Michael James Skin care products and compositions
MX2013010616A (en) * 2011-03-21 2014-08-18 Coloright Ltd Systems for custom coloration.
US9316580B2 (en) 2011-03-21 2016-04-19 Coloright Ltd. Systems for custom coloration
CA2858211C (en) 2011-12-09 2018-08-21 Mary Kay Inc. Skin care formulation
CN107148560A (en) 2013-09-26 2017-09-08 卡拉莱特有限公司 Hair reader, distributor and related System and method for
EP3137876B1 (en) 2014-04-27 2023-06-07 Coloright Ltd. Method for customized hair-coloring
KR102021652B1 (en) 2014-04-27 2019-09-16 콜로라이트 리미티드 Apparatus and method for analyzing hair and/or predicting an outcome of a hair-coloring treatment
JP6730788B2 (en) * 2015-08-31 2020-07-29 花王株式会社 Method for producing purified catechin-containing composition
FR3061176B1 (en) * 2016-12-22 2020-09-11 Antofenol PREPARATION OF A DRIED BIOMASS EXTRACT RICH IN POLYPHENOLS
US10292482B2 (en) 2017-01-06 2019-05-21 Coloright Ltd. Hair-holder, hair-reader comprising the same, and methods for optically acquiring data from hair
CN106626941A (en) * 2017-03-22 2017-05-10 王培彪 Compound tea mud and interior decoration artwork made of compound tea mud
US10543158B2 (en) 2017-04-17 2020-01-28 W Skincare, LLC Autophagy activating complex, compositions and methods
KR20190048502A (en) * 2017-10-31 2019-05-09 (주)아모레퍼시픽 Composition for improving circulatory diseases comprising tea extraction which has modified amount of ingredients
KR20210015827A (en) * 2018-05-28 2021-02-10 아넬로테크, 인코퍼레이티드 Bio-based medicines and methods to improve patient compliance
CN112090402A (en) * 2020-08-13 2020-12-18 咖法科技(上海)有限公司 Tea leaf residue mixed silica gel and preparation method thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2637197C2 (en) * 1976-08-18 1983-01-27 Hag Ag, 2800 Bremen Process for the removal of caffeine from natural substances containing caffeine with a supercritical extractant
US4315036A (en) * 1978-01-12 1982-02-09 Societe D'assistance Technique Pour Produits Nestle S.A. Process for decaffeinating tea
US4331694A (en) * 1978-12-26 1982-05-25 Union Carbide Corporation Removal of caffeine by selective adsorption using zeolite adsorbents
JPS55105677A (en) * 1979-02-07 1980-08-13 Norin Suisansyo Chiyagiyou Shikenjo Production of catechins
JPS59219384A (en) * 1983-05-30 1984-12-10 Mitsui Norin Kk Preparation of natural antioxidant
US4521438A (en) * 1983-09-29 1985-06-04 General Foods Corporation Coffee extract decaffeination method
EP0167399A3 (en) * 1984-07-06 1987-08-26 General Foods Corporation Decaffeination of fermented unfired tea
JPS63214183A (en) * 1987-03-03 1988-09-06 Mitsui Norin Kk Inhibitor of enzyme transforming angiotensin
JPH0327248A (en) * 1989-06-22 1991-02-05 Itouen:Kk Production of decaffeinated green tea liquid
JPH03228664A (en) * 1990-02-02 1991-10-09 Meiji Seika Kaisha Ltd Food having function of suppressing lipid digestion and absorption
JP3027248B2 (en) 1991-10-02 2000-03-27 沖電気工業株式会社 Ashing method and apparatus
WO1994022321A1 (en) * 1993-04-01 1994-10-13 Kalamazoo Holdings, Inc. Lipid-soluble green tea catechin antioxidant solutions
US5443709A (en) * 1993-12-17 1995-08-22 Imsco, Inc. Apparatus for separating caffeine from a liquid containing the same
JP3504309B2 (en) * 1993-12-22 2004-03-08 三井農林株式会社 Method for producing low-caffeine-containing tea polyphenols
CN1097411A (en) * 1994-05-19 1995-01-18 浙江医科大学 A kind of production method of tea-polyphenol of caffein-free
US5674477A (en) * 1995-02-28 1997-10-07 Ahluwalia; Gurpreet S. Reduction of hair growth
JP3228664B2 (en) * 1995-09-04 2001-11-12 株式会社東芝 Vehicle control device
US6063428A (en) * 1996-02-26 2000-05-16 The Procter & Gamble Company Green tea extract subjected to cation exchange treatment and nanofiltration to improve clarity and color
US5910308A (en) * 1997-03-19 1999-06-08 Sante International Inc. Herbal extract composition containing gynostemma pentaphyllum, crataegus pinnatifida and camellia sinensis

Similar Documents

Publication Publication Date Title
RU97117083A (en) POLYPHENOLIC FACTIONS OF TEA, THEIR APPLICATION AND CONTAINING THEIR COMPOSITIONS
RU2185070C2 (en) Tea polyphenolic fractions, their use and compositions comprising thereof
US4925870A (en) Therapeutic use of proanthocyanidine A2 as a cytoprotective agent
KR19980024298A (en) Process for preparing a stable and homogeneous extract with little or no secondary reaction products
US5296224A (en) Kava-kava extract, process for the production thereof and use thereof
KR101393359B1 (en) Grape seeds extracts obtainable by fractioning on a resin
CA1337973C (en) Extracts of ginkgo biloba and their methods of preparation
AU2007227384A1 (en) Extracts and methods comprising green tea species
JPS59219384A (en) Preparation of natural antioxidant
KR101788099B1 (en) Improved method for producing ginkgo extracts
US5108750A (en) Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation
US20190022159A1 (en) Novel method for preparing purified extracts of harpagophytum procumbens
NZ238069A (en) Process for extracting catechin complexes from leaves of plants; catechin complexes when so produced
US4906471A (en) Pharmaceutical composition for the reducing both hyperlipidemia and platelet-aggregation (PHP)
JP2011021033A (en) Anti-fatigue agent
KR100703242B1 (en) Extraction method of a compound from vegetable material
KR930701968A (en) Anti-neoplastic agents extracted from plants and preparation method thereof
CN100528855C (en) Process for producing kuh-seng total flavone and flavone salt by kuh-seng
JPS63277628A (en) Antitumor agent
Nnamani et al. Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
CN114394931B (en) Monoterpene alkaloid with vasodilation activity and extraction method and application thereof
RU2116797C1 (en) Method of preparing the dried extract from plant raw
KR100558930B1 (en) Purified extracts obtained from Harpagopitum procumbens and / or Harpagopitum J. heidens, preparation methods thereof and uses thereof
US9131723B2 (en) Substantially coumarin-free extract of cinnamon and its production method
KR960000244A (en) Extract of Philiostigma Tonninji, Method of Use thereof, and Composition Comprising the Same