RU2008119689A - Человеческие антитела к il-13 и их терапевтическое применение - Google Patents

Человеческие антитела к il-13 и их терапевтическое применение Download PDF

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RU2008119689A
RU2008119689A RU2008119689/13A RU2008119689A RU2008119689A RU 2008119689 A RU2008119689 A RU 2008119689A RU 2008119689/13 A RU2008119689/13 A RU 2008119689/13A RU 2008119689 A RU2008119689 A RU 2008119689A RU 2008119689 A RU2008119689 A RU 2008119689A
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БУХЛЕР Джой (US)
БУХЛЕР Джой
Мишелл КАМПБЕЛЛ Эмма (GB)
Мишелл КАМПБЕЛЛ Эмма
ПАРВИН София (GB)
ПАРВИН София
ВАЛКИРС Гунарс (US)
ВАЛКИРС Гунарс
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Новартис АГ (CH)
Новартис Аг
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Abstract

1. Выделенный антигенсвязывающий участок антитела или его функционально активный фрагмент, содержащий H-CDR3-участок, который имеет аминокислотную последовательность, выбранную из SEQ ID NO: 9 и SEQ ID NO: 10, и их консервативных вариантов. ! 2. Выделенный антигенсвязывающий участок по п.1, H-CDR1-, H-CDR2- и H-CDR3- и L-CDR1-, L-CDR2- и L-CDR3-участки которого имеют аминокислотные последовательности, выбранные вместе из (I)-(III): ! (I) SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 9 и SEQ ID NO: 16, SEQ ID NO: 19, SEQ ID NO: 20; ! (II) SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10 и SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21; и ! (III) SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10 и SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 22; и их консервативных вариантов. ! 3. Выделенный антигенсвязывающий участок, последовательность CDR-участков которого по меньшей мере на 60, 70, 80, 90 или 95% идентична последовательности CDR-участков по одному из пп.1 и 2. ! 4. Выделенное человеческое или гуманизированное антитело к IL13, содержащее выделенный антигенсвязывающий участок по пп.1-3. ! 5. Антитело по п.4, которое содержит антигенсвязывающий центр, несущий область НС, которая имеет аминокислотную последовательность, выбранную из любой из SEQ ID NO: 23, 27, 31 и 35, или последовательность, идентичную ей по меньшей мере на 60, 70, 80, 90 или 95%. ! 6. Антитело по п.4, которое содержит по меньшей мере один антигенсвязывающий центр, несущий область LC, которая имеет аминокислотную последовательность, выбранную из любой из SEQ ID NO: 25, 29, 33 и 37, или последовательность, идентичную ей по меньшей мере на 60, 70, 80, 90 или 95%. ! 7. Антитело, которое содержит по меньшей мере один антигенсвязывающий центр, несущий первую область НС, выбранную из аминокислотной последовательности по п.5, и вторую область LC, выбранную из аминокислотной последовательности по п.6, или последо�

Claims (15)

1. Выделенный антигенсвязывающий участок антитела или его функционально активный фрагмент, содержащий H-CDR3-участок, который имеет аминокислотную последовательность, выбранную из SEQ ID NO: 9 и SEQ ID NO: 10, и их консервативных вариантов.
2. Выделенный антигенсвязывающий участок по п.1, H-CDR1-, H-CDR2- и H-CDR3- и L-CDR1-, L-CDR2- и L-CDR3-участки которого имеют аминокислотные последовательности, выбранные вместе из (I)-(III):
(I) SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 9 и SEQ ID NO: 16, SEQ ID NO: 19, SEQ ID NO: 20;
(II) SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10 и SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21; и
(III) SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10 и SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 22; и их консервативных вариантов.
3. Выделенный антигенсвязывающий участок, последовательность CDR-участков которого по меньшей мере на 60, 70, 80, 90 или 95% идентична последовательности CDR-участков по одному из пп.1 и 2.
4. Выделенное человеческое или гуманизированное антитело к IL13, содержащее выделенный антигенсвязывающий участок по пп.1-3.
5. Антитело по п.4, которое содержит антигенсвязывающий центр, несущий область НС, которая имеет аминокислотную последовательность, выбранную из любой из SEQ ID NO: 23, 27, 31 и 35, или последовательность, идентичную ей по меньшей мере на 60, 70, 80, 90 или 95%.
6. Антитело по п.4, которое содержит по меньшей мере один антигенсвязывающий центр, несущий область LC, которая имеет аминокислотную последовательность, выбранную из любой из SEQ ID NO: 25, 29, 33 и 37, или последовательность, идентичную ей по меньшей мере на 60, 70, 80, 90 или 95%.
7. Антитело, которое содержит по меньшей мере один антигенсвязывающий центр, несущий первую область НС, выбранную из аминокислотной последовательности по п.5, и вторую область LC, выбранную из аминокислотной последовательности по п.6, или последовательность, идентичную им по меньшей мере на 60, 70, 80, 90 или 95%.
8. Антитело по п.4, содержащее вариабельную область НС, которая имеет последовательность SEQ ID NO: 23, и вариабельную область LC, которая имеет последовательность SEQ ID NO: 25, или последовательность, идентичную им по меньшей мере на 60, 70, 80, 90 или 95%.
9. Антитело по п.4, содержащее вариабельную область НС, которая имеет последовательность SEQ ID NO: 27, и вариабельную область LC, которая имеет последовательность SEQ ID NO: 29, или последовательность, идентичную им по меньшей мере на 60, 70, 80, 90 или 95%.
10. Антитело по п.4, содержащее вариабельную область НС, которая имеет последовательность SEQ ID NO: 31, и вариабельную область LC, которая имеет последовательность SEQ ID NO: 33, или последовательность, идентичную им по меньшей мере на 60, 70, 80, 90 или 95%.
11. Антитело по п.4, содержащее вариабельную область НС, которая имеет последовательность SEQ ID NO: 35, и вариабельную область LC, которая имеет последовательность SEQ ID NO: 37, или последовательность, идентичную им по меньшей мере на 60, 70, 80, 90 или 95%.
12. Антитело по одному из пп.4-11, представляющее IgGI или IgG4.
13. Фармацевтическая композиция, содержащая антитело или его функционально активный фрагмент по одному из пп.4-12 и фармацевтически приемлемый носитель или эксципиент.
14. Способ лечения нарушения или состояния, которое ассоциировано с присутствием клеточного рецептора IL-13-мишени, заключающийся в том, что индивидууму, который нуждается в этом, вводят в эффективном количестве фармацевтическую композицию по п.13.
15. Способ по п.14, в котором нарушение или состояние представляет собой астму.
RU2008119689/10A 2005-10-21 2006-10-19 Человеческие антитела к il-13 и их терапевтическое применение RU2421464C2 (ru)

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GB0616666A GB0616666D0 (en) 2006-08-22 2006-08-22 Organic compounds
GB0616666.4 2006-08-22

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