RS50853B - Derivati n-(1h-indolil)-1h-indol-2-karboksamida, njihova priprema i njihova primena u terapiji - Google Patents
Derivati n-(1h-indolil)-1h-indol-2-karboksamida, njihova priprema i njihova primena u terapijiInfo
- Publication number
- RS50853B RS50853B RSP-2009/0089A RSP20090089A RS50853B RS 50853 B RS50853 B RS 50853B RS P20090089 A RSP20090089 A RS P20090089A RS 50853 B RS50853 B RS 50853B
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- group
- cycloalkyl
- aryl
- fluoroalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Jedinjenje koje Odgovara formuli (I)u kojojX1, X2, X3, X4, Z1, Z2, Z3, Z4 i Z5 predstavljaju, nezavisno jedan od drugog, jedan atom vodonika ili halogeni atom ili grupu C1-C6-alkil, C3-C7-cikloalkil, C1-C6-fluoroalkil, C1-C6-alkoksi, C1-C6-fluoroalkoksi, cijano, C(O)NR1R2, nitro, NR1R2,C1-C6-tioalkil, -S(O)-C1-C6-alkil, -S(O)2-C1-C6-alkil, SO2NR1R2, NR3COR4, NR3SO2R5 ili aril;X5 predstavlja atom vodonika ili halogena ili grupu C1-C6-alkil, C1-C6-fluoroalkil; R predstavlja grupu 4-, 5-, 6- ili 7-indolil,R je eventualno supstituisan u poziciji 1, 2 i/ili 3 sa jednom ili više grupa izabranih između grupa C1-C6-alkil i C1-C6-fluoroalkil;R je eventualno supstituisan u poziciji 4, 5, 6 i/ili 7 sa jednom ili više grupa izabranih među atomima halogena, grupama C1-C6-alkil, C1-C6-fluoroalkil, C1-C6-alkoksi, C1-C6-fluoroalkoksi ;Y predstavlja atom vodonika ili grupu C1-C6-alkil;n je jednako 0, 1, 2 ili 3 ;R1 i R2, predstavljaju, nezavisno jedan od drugoga, jedan vodonikov atom ili grupu C1-C6-alkil, C3-C7-cikloalkil, C3-C7-cikloalkil-C1-C3-alkil, ili aril ; ili R1 i R2 čine zajedno, sa atomom azota koji ih nosi, azetidin, pirolidin, piperidin, azepin, morfolin, tiomorfolin, piperazin, homopiperazin grupu, ova grupa je eventualno supstituisana sa jednom grupom C1-C6-alkil, C3-C7-cikloalkil, C3-C7-cikloalkil-C1-C3-alkil ili aril;R3 i R4, predstavljaju, nezavisno jedan od drugoga, jedan vodonikov atom ili grupu C1-C6-alkil ili aril;R5 predstavlja grupu C1-C6-alkil ili aril;u obliku baze ili adicione soli kiseline, kao i u obliku hidrata ili solvata.Prijava sadrži još 17 patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0408652A FR2874015B1 (fr) | 2004-08-05 | 2004-08-05 | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| PCT/FR2005/002014 WO2006024776A1 (fr) | 2004-08-05 | 2005-08-02 | Derives de n-(1 h-indolyl)-i h-ind0le-2-carb0xamides, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS50853B true RS50853B (sr) | 2010-08-31 |
Family
ID=34950701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2009/0089A RS50853B (sr) | 2004-08-05 | 2005-08-02 | Derivati n-(1h-indolil)-1h-indol-2-karboksamida, njihova priprema i njihova primena u terapiji |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US7384969B2 (sr) |
| EP (1) | EP1776340B1 (sr) |
| JP (1) | JP5100381B2 (sr) |
| KR (1) | KR101215162B1 (sr) |
| CN (1) | CN101010297B (sr) |
| AR (1) | AR050283A1 (sr) |
| AT (1) | ATE416160T1 (sr) |
| AU (1) | AU2005279085B2 (sr) |
| BR (1) | BRPI0513087A (sr) |
| CA (1) | CA2576727C (sr) |
| CR (1) | CR8889A (sr) |
| CY (1) | CY1108816T1 (sr) |
| DE (1) | DE602005011450D1 (sr) |
| DK (1) | DK1776340T3 (sr) |
| EA (1) | EA011714B1 (sr) |
| EC (1) | ECSP077215A (sr) |
| ES (1) | ES2318542T3 (sr) |
| FR (1) | FR2874015B1 (sr) |
| HK (1) | HK1110308A1 (sr) |
| HR (1) | HRP20090101T3 (sr) |
| IL (1) | IL180911A (sr) |
| MA (1) | MA28845B1 (sr) |
| ME (1) | ME01663B (sr) |
| MX (1) | MX2007001436A (sr) |
| MY (1) | MY139286A (sr) |
| NO (1) | NO340060B1 (sr) |
| NZ (1) | NZ552924A (sr) |
| PE (1) | PE20060557A1 (sr) |
| PL (1) | PL1776340T3 (sr) |
| PT (1) | PT1776340E (sr) |
| RS (1) | RS50853B (sr) |
| SI (1) | SI1776340T1 (sr) |
| TN (1) | TNSN07041A1 (sr) |
| TW (1) | TWI360538B (sr) |
| UA (1) | UA90483C2 (sr) |
| UY (1) | UY29046A1 (sr) |
| WO (1) | WO2006024776A1 (sr) |
| ZA (1) | ZA200700999B (sr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2874015B1 (fr) * | 2004-08-05 | 2006-09-15 | Sanofi Synthelabo | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2880625B1 (fr) | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2888847B1 (fr) * | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| PE20080145A1 (es) * | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| FR2910473B1 (fr) | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
| FR2911604B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| AU2008286946B2 (en) * | 2007-08-10 | 2013-11-21 | H. Lundbeck A/S | Heteroaryl amide analogues |
| CL2008003749A1 (es) | 2007-12-17 | 2010-01-15 | Janssen Pharmaceutica Nv | Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras. |
| FR2926555B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| US20100210682A1 (en) * | 2009-02-19 | 2010-08-19 | Abbott Laboratories | Repeated Dosing of TRPV1 Antagonists |
| FR3007850B1 (fr) | 2013-06-28 | 2015-07-17 | Probayes | Systeme de prediction de temperature |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| PT885215E (pt) * | 1996-02-13 | 2006-08-31 | Abbott Lab | Novos derivados de pirrolidina substituidos com benzo-1,3-dioxolilo e benzofuranilo como antagonistas de endotelina |
| HUP0003484A3 (en) * | 1997-08-04 | 2002-02-28 | Abbott Lab | Pyrrolidine-3-crboxylic acid derivatives and their use as endothelin antagonists |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| CA2468544A1 (en) * | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands |
| ES2355472T3 (es) * | 2002-05-22 | 2011-03-28 | Amgen Inc. | Derivados de aminopirimidina para su uso como ligandos del receptor vaniloide para el tratamiento del dolor. |
| WO2004056768A2 (en) * | 2002-12-20 | 2004-07-08 | Bayer Healthcare Ag | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases |
| US7531558B2 (en) | 2003-02-14 | 2009-05-12 | Glaxo Group Limited | Carboxamide derivatives |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| FR2874015B1 (fr) * | 2004-08-05 | 2006-09-15 | Sanofi Synthelabo | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
-
2004
- 2004-08-05 FR FR0408652A patent/FR2874015B1/fr not_active Expired - Lifetime
-
2005
- 2005-02-08 UA UAA200702276A patent/UA90483C2/uk unknown
- 2005-08-02 ES ES05793766T patent/ES2318542T3/es active Active
- 2005-08-02 UY UY29046A patent/UY29046A1/es not_active Application Discontinuation
- 2005-08-02 NZ NZ552924A patent/NZ552924A/en not_active IP Right Cessation
- 2005-08-02 EP EP05793766A patent/EP1776340B1/fr active Active
- 2005-08-02 PL PL05793766T patent/PL1776340T3/pl unknown
- 2005-08-02 DE DE602005011450T patent/DE602005011450D1/de active Active
- 2005-08-02 KR KR1020077002714A patent/KR101215162B1/ko not_active IP Right Cessation
- 2005-08-02 CN CN2005800296989A patent/CN101010297B/zh not_active Expired - Fee Related
- 2005-08-02 AT AT05793766T patent/ATE416160T1/de active
- 2005-08-02 EA EA200700400A patent/EA011714B1/ru not_active IP Right Cessation
- 2005-08-02 PT PT05793766T patent/PT1776340E/pt unknown
- 2005-08-02 WO PCT/FR2005/002014 patent/WO2006024776A1/fr active Application Filing
- 2005-08-02 ZA ZA200700999A patent/ZA200700999B/xx unknown
- 2005-08-02 SI SI200530600T patent/SI1776340T1/sl unknown
- 2005-08-02 BR BRPI0513087-5A patent/BRPI0513087A/pt not_active Application Discontinuation
- 2005-08-02 AU AU2005279085A patent/AU2005279085B2/en not_active Ceased
- 2005-08-02 MX MX2007001436A patent/MX2007001436A/es active IP Right Grant
- 2005-08-02 ME MEP-2009-366A patent/ME01663B/me unknown
- 2005-08-02 DK DK05793766T patent/DK1776340T3/da active
- 2005-08-02 JP JP2007524371A patent/JP5100381B2/ja not_active Expired - Fee Related
- 2005-08-02 CA CA2576727A patent/CA2576727C/fr active Active
- 2005-08-02 RS RSP-2009/0089A patent/RS50853B/sr unknown
- 2005-08-03 PE PE2005000900A patent/PE20060557A1/es not_active Application Discontinuation
- 2005-08-03 MY MYPI20053619A patent/MY139286A/en unknown
- 2005-08-04 TW TW094126541A patent/TWI360538B/zh not_active IP Right Cessation
- 2005-08-04 AR ARP050103236A patent/AR050283A1/es not_active Application Discontinuation
-
2007
- 2007-01-18 US US11/624,406 patent/US7384969B2/en not_active Expired - Fee Related
- 2007-01-23 IL IL180911A patent/IL180911A/en not_active IP Right Cessation
- 2007-01-29 EC EC2007007215A patent/ECSP077215A/es unknown
- 2007-02-01 CR CR8889A patent/CR8889A/es unknown
- 2007-02-05 TN TNP2007000041A patent/TNSN07041A1/fr unknown
- 2007-03-02 NO NO20071198A patent/NO340060B1/no not_active IP Right Cessation
- 2007-03-02 MA MA29730A patent/MA28845B1/fr unknown
-
2008
- 2008-01-18 HK HK08100693.2A patent/HK1110308A1/xx not_active IP Right Cessation
- 2008-04-25 US US12/109,388 patent/US7582671B2/en not_active Expired - Fee Related
-
2009
- 2009-02-17 HR HR20090101T patent/HRP20090101T3/xx unknown
- 2009-02-19 CY CY20091100191T patent/CY1108816T1/el unknown
- 2009-07-21 US US12/506,322 patent/US7781477B2/en not_active Expired - Fee Related
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