PL2814587T3 - Chromatografia powinowactwa oparta na receptorze Fc - Google Patents
Chromatografia powinowactwa oparta na receptorze FcInfo
- Publication number
- PL2814587T3 PL2814587T3 PL13704599T PL13704599T PL2814587T3 PL 2814587 T3 PL2814587 T3 PL 2814587T3 PL 13704599 T PL13704599 T PL 13704599T PL 13704599 T PL13704599 T PL 13704599T PL 2814587 T3 PL2814587 T3 PL 2814587T3
- Authority
- PL
- Poland
- Prior art keywords
- affinity chromatography
- based affinity
- receptor based
- receptor
- chromatography
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
- B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient, chromatofocusing, i.e. separation according to the isoelectric point pI
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Inorganic Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12155630 | 2012-02-15 | ||
| PCT/EP2013/052932 WO2013120929A1 (en) | 2012-02-15 | 2013-02-14 | Fc-receptor based affinity chromatography |
| EP13704599.3A EP2814587B1 (en) | 2012-02-15 | 2013-02-14 | Fc-receptor based affinity chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2814587T3 true PL2814587T3 (pl) | 2018-10-31 |
Family
ID=47720509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13704599T PL2814587T3 (pl) | 2012-02-15 | 2013-02-14 | Chromatografia powinowactwa oparta na receptorze Fc |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20150018241A1 (pl) |
| EP (1) | EP2814587B1 (pl) |
| JP (3) | JP6152120B2 (pl) |
| KR (1) | KR102069397B1 (pl) |
| CN (1) | CN104125852B9 (pl) |
| BR (1) | BR112014018005B1 (pl) |
| CA (2) | CA3159061A1 (pl) |
| ES (1) | ES2676031T3 (pl) |
| HK (1) | HK1203435A1 (pl) |
| HR (1) | HRP20180966T1 (pl) |
| MX (1) | MX360352B (pl) |
| PL (1) | PL2814587T3 (pl) |
| RU (1) | RU2624128C2 (pl) |
| SI (1) | SI2814587T1 (pl) |
| TR (1) | TR201808458T4 (pl) |
| WO (1) | WO2013120929A1 (pl) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2726496B1 (en) | 2011-07-01 | 2018-04-04 | F.Hoffmann-La Roche Ag | Method for separation of monomeric polypeptides from aggregated polypeptides |
| CA2931986A1 (en) * | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
| EP3119490B1 (en) * | 2014-03-21 | 2021-09-08 | F. Hoffmann-La Roche AG | In vitro prediction of in vivo half-life of antibodies |
| CN106574261B (zh) | 2014-06-27 | 2021-02-05 | 东曹株式会社 | 改良Fc结合蛋白、及制造方法、使用该蛋白的抗体吸附剂和使用该吸附剂的抗体分离方法 |
| UY36287A (es) | 2014-09-03 | 2016-04-29 | Macrogenics Inc | COMPUESTO DE OBJETIVO A IL-23A y TNF-ALFA Y USO DEL MISMO |
| LT3215528T (lt) | 2014-11-06 | 2019-10-25 | Hoffmann La Roche | Fc srities variantai su modifikuota fcrn jungtimi ir naudojimo būdai |
| MX2018000959A (es) | 2015-07-23 | 2018-06-06 | Boehringer Ingelheim Int | Compuesto que se dirige a il-23a y al factor de activacion de linfocitos b (baff) y usos de estos. |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| EP3371202A1 (en) | 2015-11-04 | 2018-09-12 | Biogen MA Inc. | Conjugation methods for modifying or immobilizing proteins |
| JP2018039735A (ja) * | 2016-09-05 | 2018-03-15 | 東ソー株式会社 | 補体依存性細胞傷害活性が異なる抗体の分離方法 |
| CN109689682B (zh) | 2016-09-19 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 基于补体因子的亲和层析 |
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| KR102692708B1 (ko) | 2016-12-20 | 2024-08-07 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법 |
| ES2955852T3 (es) | 2017-04-03 | 2023-12-07 | Hoffmann La Roche | Anticuerpos de unión a STEAP-1 |
| CN117003887A (zh) | 2017-04-03 | 2023-11-07 | 豪夫迈·罗氏有限公司 | 抗pd-1抗体与突变体il-2或与il-15的免疫缀合物 |
| EP3606947B1 (en) | 2017-04-03 | 2022-12-21 | F. Hoffmann-La Roche AG | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
| HUE060019T2 (hu) | 2017-04-05 | 2023-01-28 | Hoffmann La Roche | Anti-LAG3 antitestek |
| WO2018189220A1 (en) | 2017-04-13 | 2018-10-18 | F. Hoffmann-La Roche Ag | An interleukin-2 immunoconjugate, a cd40 agonist, and optionally a pd-1 axis binding antagonist for use in methods of treating cancer |
| CN110573626B (zh) * | 2017-04-28 | 2024-05-03 | 豪夫迈·罗氏有限公司 | 抗体选择方法 |
| GB201717446D0 (en) * | 2017-10-24 | 2017-12-06 | Evox Therapeutics Ltd | Affinity purification of engineering extracellular vesicles |
| JP6977536B2 (ja) * | 2017-12-19 | 2021-12-08 | 東ソー株式会社 | ゲル濾過クロマトグラフィを用いた抗体の変性度合評価方法 |
| MA51302A (fr) | 2017-12-21 | 2021-03-31 | Hoffmann La Roche | Anticorps se liant à hla-a2/wt1 |
| CN111479588A (zh) | 2017-12-29 | 2020-07-31 | 豪夫迈·罗氏有限公司 | 用于改善抗vegf抗体的vegf受体阻断选择性的方法 |
| TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
| EP3765489B1 (en) | 2018-03-13 | 2024-10-16 | F. Hoffmann-La Roche AG | Therapeutic combination of 4-1bb agonists with anti-cd20 antibodies |
| JP2021519073A (ja) | 2018-03-29 | 2021-08-10 | ジェネンテック， インコーポレイテッド | 哺乳動物細胞におけるラクトジェニック活性の制御 |
| AR115052A1 (es) | 2018-04-18 | 2020-11-25 | Hoffmann La Roche | Anticuerpos multiespecíficos y utilización de los mismos |
| JP7469584B2 (ja) | 2018-06-20 | 2024-04-17 | 東ソー株式会社 | 抗体の分離方法および疾患の検査方法 |
| JP7159642B2 (ja) * | 2018-06-26 | 2022-10-25 | 東ソー株式会社 | カラムの抗体に対する保持力の測定方法 |
| MA50586A (fr) | 2018-08-09 | 2020-09-16 | Regeneron Pharma | Procédés d'évaluation de l'affinité de liaison d'une variante d'anticorps au récepteur fc néonatal |
| CN112955240B (zh) * | 2018-10-25 | 2022-09-16 | 豪夫迈·罗氏有限公司 | 抗体FcRn结合的修饰 |
| TWI829831B (zh) | 2018-12-21 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合cd3之抗體 |
| CN113195531A (zh) | 2018-12-21 | 2021-07-30 | 豪夫迈·罗氏有限公司 | 与VEGF和IL-1β结合的抗体及其使用方法 |
| CN109725159B (zh) * | 2018-12-28 | 2021-10-08 | 江苏众红生物工程创药研究院有限公司 | 人β2-微球蛋白的定量检测试纸卡与临床应用 |
| EP3903102B1 (en) | 2018-12-30 | 2023-04-12 | F. Hoffmann-La Roche AG | Ph-gradient spr-based binding assay |
| JP7250950B2 (ja) * | 2019-03-29 | 2023-04-03 | エフ． ホフマン－ラ ロシュ アーゲー | 所定の構成の複数の発現カセットを標的指向組込みすることによってＦｃＲｎ発現細胞を作製するための方法 |
| WO2021001289A1 (en) | 2019-07-02 | 2021-01-07 | F. Hoffmann-La Roche Ag | Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| WO2021018925A1 (en) | 2019-07-31 | 2021-02-04 | F. Hoffmann-La Roche Ag | Antibodies binding to gprc5d |
| SG11202112491WA (en) | 2019-07-31 | 2021-12-30 | Hoffmann La Roche | Antibodies binding to gprc5d |
| JP2022549087A (ja) | 2019-09-18 | 2022-11-24 | ジェネンテック， インコーポレイテッド | 抗ｋｌｋ７抗体、抗ｋｌｋ５抗体、多重特異性抗ｋｌｋ５／ｋｌｋ７抗体および使用方法 |
| KR20220100963A (ko) | 2019-12-18 | 2022-07-18 | 에프. 호프만-라 로슈 아게 | Hla-a2/mage-a4에 결합하는 항체 |
| WO2021123173A1 (en) | 2019-12-20 | 2021-06-24 | F. Hoffmann-La Roche Ag | Il-37 fusion proteins and uses thereof |
| WO2021195464A2 (en) | 2020-03-26 | 2021-09-30 | Genentech, Inc. | Modified mammalian cells |
| WO2021198034A1 (en) | 2020-03-30 | 2021-10-07 | F. Hoffmann-La Roche Ag | Antibody that binds to vegf and pdgf-b and methods of use |
| US20230192795A1 (en) | 2020-04-15 | 2023-06-22 | Hoffmann-La Roche Inc. | Immunoconjugates |
| WO2021249990A2 (en) | 2020-06-08 | 2021-12-16 | Hoffmann-La Roche Inc. | Anti-hbv antibodies and methods of use |
| MX2022015887A (es) | 2020-06-19 | 2023-01-24 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y folr1. |
| WO2021255142A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 |
| CN115916825A (zh) | 2020-06-19 | 2023-04-04 | 豪夫迈·罗氏有限公司 | 与cd3和cd19结合的抗体 |
| WO2021255146A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cea |
| CA3184747A1 (en) | 2020-06-24 | 2021-12-30 | Genentech, Inc. | Apoptosis resistant cell lines |
| WO2022008688A1 (en) | 2020-07-10 | 2022-01-13 | F. Hoffmann-La Roche Ag | Antibodies which bind to cancer cells and target radionuclides to said cells |
| CN116406377A (zh) | 2020-07-17 | 2023-07-07 | 基因泰克公司 | 抗notch2抗体及其使用方法 |
| WO2022047222A2 (en) | 2020-08-28 | 2022-03-03 | Genentech, Inc. | Crispr/cas9 multiplex knockout of host cell proteins |
| JP7158626B1 (ja) | 2020-09-04 | 2022-10-21 | エフ．ホフマン－ラ ロシュ アーゲー | Ｖｅｇｆ－ａ及びａｎｇ２に結合する抗体及び使用方法 |
| AR123855A1 (es) | 2020-10-20 | 2023-01-18 | Genentech Inc | Anticuerpos anti-mertk conjugados con peg y métodos de uso |
| US20220196651A1 (en) * | 2020-12-06 | 2022-06-23 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
| MX2023007133A (es) | 2020-12-17 | 2023-06-27 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de estos. |
| WO2022148853A1 (en) | 2021-01-11 | 2022-07-14 | F. Hoffmann-La Roche Ag | Immunoconjugates |
| MX2023008084A (es) | 2021-01-12 | 2023-07-13 | Hoffmann La Roche | Anticuerpos split que se unen a celulas cancerosas y dirigen radionuclidos a dichas celulas. |
| CA3204291A1 (en) | 2021-01-13 | 2022-07-21 | F. Hoffmann-La Roche Ag | Combination therapy |
| JP2024509695A (ja) | 2021-02-03 | 2024-03-05 | ジェネンテック， インコーポレイテッド | 多重特異性結合タンパク質分解プラットフォームおよび使用方法 |
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| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| LT2691417T (lt) * | 2011-03-29 | 2018-10-25 | Roche Glycart Ag | Antikūno fc variantai |
| CN103827134A (zh) * | 2011-07-20 | 2014-05-28 | 泽普泰恩股份有限公司 | 多肽分离方法 |
| EP2791171A1 (en) | 2011-12-16 | 2014-10-22 | Synthon Biopharmaceuticals B.V. | EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED |
| SI3495387T1 (sl) | 2012-07-13 | 2021-12-31 | Roche Glycart Ag | Bispecifična protitelesa proti VEGF/proti ANG-2 in njihova uporaba pri zdravljenju bolezni očesnih žil |
| SI2961771T1 (sl) | 2013-02-26 | 2020-04-30 | Roche Glycart Ag | Bispecifične molekule, ki aktivirajo celice T in vežejo antigene, specifične za CD3 in CEA |
| EP3119490B1 (en) | 2014-03-21 | 2021-09-08 | F. Hoffmann-La Roche AG | In vitro prediction of in vivo half-life of antibodies |
| US20170267780A1 (en) | 2014-05-16 | 2017-09-21 | Medimmune, Llc | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
| LT3215528T (lt) | 2014-11-06 | 2019-10-25 | Hoffmann La Roche | Fc srities variantai su modifikuota fcrn jungtimi ir naudojimo būdai |
| JP6288332B2 (ja) * | 2017-03-06 | 2018-03-07 | 東洋紡株式会社 | 新規なグルコース脱水素酵素 |
-
2013
- 2013-02-14 PL PL13704599T patent/PL2814587T3/pl unknown
- 2013-02-14 TR TR2018/08458T patent/TR201808458T4/tr unknown
- 2013-02-14 CA CA3159061A patent/CA3159061A1/en active Pending
- 2013-02-14 CN CN201380009724.6A patent/CN104125852B9/zh active Active
- 2013-02-14 KR KR1020147022694A patent/KR102069397B1/ko active IP Right Grant
- 2013-02-14 EP EP13704599.3A patent/EP2814587B1/en active Active
- 2013-02-14 MX MX2014009622A patent/MX360352B/es active IP Right Grant
- 2013-02-14 RU RU2014136223A patent/RU2624128C2/ru active
- 2013-02-14 CA CA2860600A patent/CA2860600C/en active Active
- 2013-02-14 SI SI201331082T patent/SI2814587T1/en unknown
- 2013-02-14 JP JP2014557032A patent/JP6152120B2/ja active Active
- 2013-02-14 US US14/378,808 patent/US20150018241A1/en not_active Abandoned
- 2013-02-14 BR BR112014018005-9A patent/BR112014018005B1/pt active IP Right Grant
- 2013-02-14 ES ES13704599.3T patent/ES2676031T3/es active Active
- 2013-02-14 WO PCT/EP2013/052932 patent/WO2013120929A1/en active Application Filing
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2015
- 2015-04-27 HK HK15104045.0A patent/HK1203435A1/xx unknown
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2017
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2018
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- 2018-06-26 HR HRP20180966TT patent/HRP20180966T1/hr unknown
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2019
- 2019-01-25 US US16/258,294 patent/US11814409B2/en active Active
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2023
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Also Published As
| Publication number | Publication date |
|---|---|
| HK1203435A1 (en) | 2015-10-30 |
| MX360352B (es) | 2018-10-30 |
| BR112014018005A2 (pt) | 2018-06-26 |
| TR201808458T4 (tr) | 2018-07-23 |
| CA2860600C (en) | 2022-07-26 |
| BR112014018005B1 (pt) | 2021-06-29 |
| HRP20180966T1 (hr) | 2018-08-10 |
| JP2018188442A (ja) | 2018-11-29 |
| US11814409B2 (en) | 2023-11-14 |
| CA2860600A1 (en) | 2013-08-22 |
| JP6360232B2 (ja) | 2018-07-18 |
| CN104125852B (zh) | 2017-03-22 |
| ES2676031T3 (es) | 2018-07-16 |
| US20150018241A1 (en) | 2015-01-15 |
| EP2814587A1 (en) | 2014-12-24 |
| JP6152120B2 (ja) | 2017-06-21 |
| KR102069397B1 (ko) | 2020-01-22 |
| CN104125852B9 (zh) | 2017-05-17 |
| SI2814587T1 (en) | 2018-08-31 |
| US20240124519A1 (en) | 2024-04-18 |
| CA3159061A1 (en) | 2013-08-22 |
| CN104125852A (zh) | 2014-10-29 |
| KR20140127251A (ko) | 2014-11-03 |
| EP2814587B1 (en) | 2018-05-02 |
| WO2013120929A1 (en) | 2013-08-22 |
| RU2624128C2 (ru) | 2017-06-30 |
| MX2014009622A (es) | 2014-11-10 |
| RU2014136223A (ru) | 2016-04-10 |
| JP6713020B2 (ja) | 2020-06-24 |
| JP2015512034A (ja) | 2015-04-23 |
| US20190276492A1 (en) | 2019-09-12 |
| JP2017207494A (ja) | 2017-11-24 |
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