PL2599778T3 - Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2 - Google Patents

Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2

Info

Publication number: PL2599778T3
Authority: PL; Poland
Prior art keywords: beta; agonist activity; diamide compounds; receptor antagonist; receptor agonist
Prior art date: 2009-04-23

Application number

PL13151470T

Other languages

English (en)

Inventor

Adam Hughes

Daniel Byun

Yan Chen

Melissa Fleury

John Jacobsen

Eric Strangeland

Richard Wilson

Rose Yen

Original Assignee

Theravance Respiratory Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-04-23

Filing date

2010-04-16

Publication date

2018-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42272140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2599778(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-04-16 Application filed by Theravance Respiratory Co Llc filed Critical Theravance Respiratory Co Llc

2018-01-31 Publication of PL2599778T3 publication Critical patent/PL2599778T3/pl

Links

102100039705 Beta-2 adrenergic receptor Human genes 0.000 title 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
239000000048 adrenergic agonist Substances 0.000 title 1
229940126157 adrenergic receptor agonist Drugs 0.000 title 1
108010014499 beta-2 Adrenergic Receptors Proteins 0.000 title 1
150000001470 diamides Chemical class 0.000 title 1
230000000694 effects Effects 0.000 title 1
239000003149 muscarinic antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

PL13151470T 2009-04-23 2010-04-16 Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2 PL2599778T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17203909P	2009-04-23	2009-04-23
EP13151470.5A EP2599778B1 (en)	2009-04-23	2010-04-16	Diamide Compounds having Muscarinic Receptor Antagonist and Beta 2 Adrenergic Receptor Agonist Activity
EP10715058A EP2421849B1 (en)	2009-04-23	2010-04-16	Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity

Publications (1)

Publication Number	Publication Date
PL2599778T3 true PL2599778T3 (pl)	2018-01-31

Family

ID=42272140

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL17164740T PL3210981T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące działanie jako antagonista receptora muskarynowego i agonista antagonista receptora beta 2 adrenergicznego
PL10715058T PL2421849T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące aktywność antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta2
PL13151470T PL2599778T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
PL17164740T PL3210981T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące działanie jako antagonista receptora muskarynowego i agonista antagonista receptora beta 2 adrenergicznego
PL10715058T PL2421849T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące aktywność antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta2

Country Status (32)

Country	Link
US (14)	US8138345B2 (pl)
EP (3)	EP2421849B1 (pl)
JP (3)	JP5671006B2 (pl)
KR (1)	KR101769061B1 (pl)
CN (2)	CN103936716B (pl)
AR (1)	AR076412A1 (pl)
AU (1)	AU2010239522B2 (pl)
BR (1)	BRPI1014877B8 (pl)
CA (1)	CA2758505C (pl)
CL (1)	CL2011002637A1 (pl)
CO (1)	CO6440584A2 (pl)
CY (2)	CY1119008T1 (pl)
DK (3)	DK2599778T3 (pl)
ES (3)	ES2417339T3 (pl)
HK (1)	HK1165799A1 (pl)
HR (3)	HRP20130468T1 (pl)
HU (2)	HUE035049T2 (pl)
IL (1)	IL215554A (pl)
LT (2)	LT2599778T (pl)
MX (1)	MX2011011156A (pl)
MY (1)	MY158339A (pl)
NZ (1)	NZ595850A (pl)
PL (3)	PL3210981T3 (pl)
PT (3)	PT2421849E (pl)
RU (2)	RU2543716C2 (pl)
SG (1)	SG175330A1 (pl)
SI (3)	SI2421849T1 (pl)
SM (1)	SMT201300060B (pl)
TR (1)	TR201903556T4 (pl)
TW (2)	TWI570115B (pl)
WO (1)	WO2010123766A1 (pl)
ZA (1)	ZA201107743B (pl)

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WO2010123766A1 (en)	2009-04-23	2010-10-28	Theravance, Inc.	DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
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EP2386555A1 (en)	2010-05-13	2011-11-16	Almirall, S.A.	New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
AR083115A1 (es) *	2010-09-30	2013-01-30	Theravance Inc	Sales oxalato cristalinas de un compuesto diamida
KR101906630B1 (ko)	2011-06-10	2018-10-10	키에시 파르마슈티시 엣스. 피. 에이.	무스카린 수용체 길항제 및 베타2 아드레날린 수용체 작용제 효능을 갖는 화합물
PT2718280E (pt)	2011-06-10	2015-11-25	Chiesi Farma Spa	Compostos possuindo uma atividade antagonista de um recetor muscarínico e agonista de um recetor beta2 adrenérgico
EP2592078A1 (en)	2011-11-11	2013-05-15	Almirall, S.A.	New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
RU2661877C2 (ru)	2012-12-06	2018-07-20	КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.	Соединения, обладающие активностью антагонистов мускариновых рецепторов и агонистов бета-2-адренергических рецепторов
SG10201704032RA (en)	2012-12-06	2017-06-29	Chiesi Farm Spa	Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
JP6307091B2 (ja)	2012-12-18	2018-04-04	アルミラル・ソシエダッド・アノニマＡｌｍｉｒａｌｌ，Ｓ．Ａ．	β２アドレナリンアゴニスト活性およびＭ３ムスカリンアンタゴニスト活性を有する新規のシクロヘキシルおよびキヌクリジニルカルバメート誘導体
TWI643853B (zh)	2013-02-27	2018-12-11	阿爾米雷爾有限公司	同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh)	2013-07-25	2015-05-16	Almirall Sa	含有ｍａｂａ化合物和皮質類固醇之組合
TWI641373B (zh)	2013-07-25	2018-11-21	阿爾米雷爾有限公司	具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
CN104030933A (zh) *	2014-05-16	2014-09-10	烟台恒迪克能源科技有限公司	一种β-异烷醇基氨基戊酸环己胺的合成方法
TW201617343A (zh)	2014-09-26	2016-05-16	阿爾米雷爾有限公司	具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
TWI703138B (zh)	2015-02-12	2020-09-01	義大利商吉斯藥品公司	具有蕈毒鹼受體拮抗劑及β２腎上腺素受體促效劑活性之化合物
WO2016155573A1 (zh) *	2015-03-27	2016-10-06	四川海思科制药有限公司	一种杂环衍生物及其制备方法和在医药上的用途
WO2016180349A1 (zh) *	2015-05-14	2016-11-17	四川海思科制药有限公司	具有β2受体激动及M受体拮抗活性的联苯衍生物及其在医药上的用途
TW201702225A (zh) *	2015-05-14	2017-01-16	Sichuan Haisco Pharmaceutical Co Ltd	具有β２受體激動及Ｍ受體拮抗活性的含氮雜螺環衍生物及其在醫藥上的用途
AR104828A1 (es)	2015-06-01	2017-08-16	Chiesi Farm Spa	COMPUESTOS CON ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES MUSCARÍNICOS Y ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO
WO2017093208A1 (en)	2015-12-03	2017-06-08	Chiesi Farmaceutici S.P.A.	Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
BR112018015018A2 (pt) *	2016-01-22	2018-12-18	Sichuan Haisco Pharmaceutical Co Ltd	derivado de amido azaciclo, método de preparação deste, e aplicação farmacêutica
EP3484879B1 (en)	2016-07-13	2020-12-30	Chiesi Farmaceutici S.p.A.	Hydroxyquinolinone compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
RU2722720C1 (ru)	2016-12-14	2020-06-03	Бейджинг Шоубай Фармасьютикэл Ко., Лтд.	Класс бифункциональных соединений со структурой соли четвертичного аммония
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2010
- 2010-04-16 WO PCT/US2010/031356 patent/WO2010123766A1/en active Application Filing
- 2010-04-16 MY MYPI2011004779A patent/MY158339A/en unknown
- 2010-04-16 SI SI201030228T patent/SI2421849T1/sl unknown
- 2010-04-16 SG SG2011077765A patent/SG175330A1/en unknown
- 2010-04-16 MX MX2011011156A patent/MX2011011156A/es active IP Right Grant
- 2010-04-16 CN CN201410175377.0A patent/CN103936716B/zh not_active Expired - Fee Related
- 2010-04-16 EP EP10715058A patent/EP2421849B1/en active Active
- 2010-04-16 EP EP13151470.5A patent/EP2599778B1/en active Active
- 2010-04-16 ES ES10715058T patent/ES2417339T3/es active Active
- 2010-04-16 PT PT107150583T patent/PT2421849E/pt unknown
- 2010-04-16 KR KR1020117027797A patent/KR101769061B1/ko active IP Right Grant
- 2010-04-16 PT PT17164740T patent/PT3210981T/pt unknown
- 2010-04-16 ES ES17164740T patent/ES2715965T3/es active Active
- 2010-04-16 DK DK13151470.5T patent/DK2599778T3/en active
- 2010-04-16 LT LTEP13151470.5T patent/LT2599778T/lt unknown
- 2010-04-16 CN CN201080017581.XA patent/CN102405218B/zh not_active Expired - Fee Related
- 2010-04-16 EP EP17164740.7A patent/EP3210981B1/en active Active
- 2010-04-16 NZ NZ595850A patent/NZ595850A/xx not_active IP Right Cessation
- 2010-04-16 RU RU2011147374/04A patent/RU2543716C2/ru active
- 2010-04-16 DK DK10715058.3T patent/DK2421849T3/da active
- 2010-04-16 CA CA2758505A patent/CA2758505C/en not_active Expired - Fee Related
- 2010-04-16 HU HUE13151470A patent/HUE035049T2/en unknown
- 2010-04-16 PL PL17164740T patent/PL3210981T3/pl unknown
- 2010-04-16 SI SI201031866T patent/SI3210981T1/sl unknown
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EP2421849B1 (en)	2013-04-03
US9682957B2 (en)	2017-06-20
JP5965440B2 (ja)	2016-08-03
AU2010239522B2 (en)	2015-07-02
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JP5671006B2 (ja)	2015-02-18
US20130137665A1 (en)	2013-05-30
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SG175330A1 (en)	2011-11-28
US20140323733A1 (en)	2014-10-30
US10590107B2 (en)	2020-03-17
EP2421849A1 (en)	2012-02-29
BRPI1014877A2 (pt)	2016-04-12
US20170096412A1 (en)	2017-04-06
ES2635358T3 (es)	2017-10-03
TR201903556T4 (tr)	2019-04-22
US20200165223A1 (en)	2020-05-28
US20210024493A1 (en)	2021-01-28
US20130331364A1 (en)	2013-12-12
HRP20130468T1 (en)	2013-06-30
HK1165799A1 (en)	2012-10-12
TWI570115B (zh)	2017-02-11
DK3210981T3 (en)	2019-04-01
RU2543716C2 (ru)	2015-03-10
CN103936716B (zh)	2016-09-07
HRP20190417T1 (hr)	2019-04-19
EP2599778A1 (en)	2013-06-05
LT2599778T (lt)	2017-08-25
BRPI1014877B8 (pt)	2021-05-25
CN102405218B (zh)	2014-06-04
ZA201107743B (en)	2012-06-27
PT2421849E (pt)	2013-05-27
RU2676686C2 (ru)	2019-01-10
KR20110138292A (ko)	2011-12-26
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EP3210981B1 (en)	2019-01-02
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PL3210981T3 (pl)	2019-06-28
CO6440584A2 (es)	2012-05-15
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ES2417339T3 (es)	2013-08-07
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CY1121601T1 (el)	2020-05-29
BRPI1014877B1 (pt)	2020-11-10
CN103936716A (zh)	2014-07-23
US9975875B2 (en)	2018-05-22
SI2599778T1 (sl)	2017-08-31
JP2012524783A (ja)	2012-10-18
WO2010123766A1 (en)	2010-10-28
US9771350B2 (en)	2017-09-26
TW201546057A (zh)	2015-12-16
ES2715965T3 (es)	2019-06-07
JP2015147807A (ja)	2015-08-20
KR101769061B1 (ko)	2017-08-17
PT3210981T (pt)	2019-04-01
SI2421849T1 (sl)	2013-07-31
US8816088B2 (en)	2014-08-26
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US20160361304A1 (en)	2016-12-15
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MY158339A (en)	2016-09-30
TWI513693B (zh)	2015-12-21
DK2599778T3 (en)	2017-06-26
US9000173B2 (en)	2015-04-07
US20100273755A1 (en)	2010-10-28
CN102405218A (zh)	2012-04-04
US20170226082A1 (en)	2017-08-10
RU2011147374A (ru)	2013-05-27
EP2599778B1 (en)	2017-04-12

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