PE20120902A1 - Anticuerpos anti-egfl7 humanizados - Google Patents

Anticuerpos anti-egfl7 humanizados

Info

Publication number
PE20120902A1
PE20120902A1 PE2011001927A PE2011001927A PE20120902A1 PE 20120902 A1 PE20120902 A1 PE 20120902A1 PE 2011001927 A PE2011001927 A PE 2011001927A PE 2011001927 A PE2011001927 A PE 2011001927A PE 20120902 A1 PE20120902 A1 PE 20120902A1
Authority
PE
Peru
Prior art keywords
humanized anti
seq
nos
egfl7
antibody
Prior art date
Application number
PE2011001927A
Other languages
English (en)
Inventor
Weilan Ye
Mark Dennis
Jill Fredrickson
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20120902A1 publication Critical patent/PE20120902A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K31/282—Platinum compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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Abstract

SE REFIERE A UN ANTICUERPO BIESPECIFICO ANTI-EGFL7 QUE COMPRENDE UN DOMINIO VARIABLE QUE COMPRENDE: (A) UNA REGION HIPERVARIABLE DE CADENA LIGERA SELECCIONADA DE SEC ID NºS 193, 194, 210, 211, 212, 222, 223, 224 Y 201, 202, 203 Y 204; (B) UNA REGION HIPERVARIABLE DE CADENA PESADA SELECCIONADA DE SEC ID NºS 213, 214, 215, 225, 226, 227 Y 195, 196, 197, 198, 200, 220, 216, 217, 218 Y 219. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHO ANTICUERPO Y ES UTIL EN EL TRATAMIENTO DEL CANCER, UN TUMOR O UN TRANSTORNO PROLIFERATIVO CELULAR
PE2011001927A 2009-05-08 2010-05-07 Anticuerpos anti-egfl7 humanizados PE20120902A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17681709P 2009-05-08 2009-05-08

Publications (1)

Publication Number Publication Date
PE20120902A1 true PE20120902A1 (es) 2012-08-08

Family

ID=42333507

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001927A PE20120902A1 (es) 2009-05-08 2010-05-07 Anticuerpos anti-egfl7 humanizados

Country Status (24)

Country Link
US (8) US8404811B2 (es)
EP (1) EP2427493A1 (es)
JP (2) JP5383905B2 (es)
KR (1) KR20120005021A (es)
CN (3) CN103772500A (es)
AR (1) AR076662A1 (es)
AU (1) AU2010245739B2 (es)
BR (1) BRPI1007706A2 (es)
CA (2) CA2760246A1 (es)
CL (1) CL2011002784A1 (es)
CO (1) CO6450619A2 (es)
CR (1) CR20110576A (es)
EC (1) ECSP11011430A (es)
IL (1) IL216115A0 (es)
MA (1) MA33551B1 (es)
MX (1) MX2011010570A (es)
NZ (1) NZ595641A (es)
PE (1) PE20120902A1 (es)
RU (1) RU2011149798A (es)
SG (1) SG175891A1 (es)
TW (2) TW201422237A (es)
UA (1) UA105386C2 (es)
WO (1) WO2010129904A1 (es)
ZA (1) ZA201207484B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1464702A4 (en) * 2001-12-28 2005-09-21 Chugai Pharmaceutical Co Ltd METHOD FOR PROTEIN STABILIZATION
KR20170027711A (ko) 2009-06-12 2017-03-10 사이나프서스 쎄라퓨틱스, 아이엔씨. 설하 아포모르핀
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