EA201591611A1 - Конъюгаты антитело-лекарственное средство - Google Patents

Конъюгаты антитело-лекарственное средство

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Publication number
EA201591611A1
EA201591611A1 EA201591611A EA201591611A EA201591611A1 EA 201591611 A1 EA201591611 A1 EA 201591611A1 EA 201591611 A EA201591611 A EA 201591611A EA 201591611 A EA201591611 A EA 201591611A EA 201591611 A1 EA201591611 A1 EA 201591611A1
Authority
EA
Eurasian Patent Office
Prior art keywords
medicine
conjugates antibody
antibody
conjugates
fgfr4
Prior art date
Application number
EA201591611A
Other languages
English (en)
Inventor
Сет Эттенберг
Николь Хаубст
Тяньцэнь Ху
Дэвид Дженкинс
Энджин Токсоз
Ребекка Мошер
Мэттью Джон Мейер
Константин Петропоулос
Дэвид Брайант Батт (умер)
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201591611A1 publication Critical patent/EA201591611A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/3015—Breast
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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Abstract

Настоящее изобретение относится к антителам против FGFR2 и FGFR4, фрагментам антител, конъюгатам антитело-лекарственное средство и их использованию для лечения рака.
EA201591611A 2013-03-13 2014-03-13 Конъюгаты антитело-лекарственное средство EA201591611A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361780299P 2013-03-13 2013-03-13
PCT/US2014/025944 WO2014160160A2 (en) 2013-03-13 2014-03-13 Antibody drug conjugates

Publications (1)

Publication Number Publication Date
EA201591611A1 true EA201591611A1 (ru) 2016-03-31

Family

ID=50897870

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591611A EA201591611A1 (ru) 2013-03-13 2014-03-13 Конъюгаты антитело-лекарственное средство

Country Status (14)

Country Link
US (2) US9498532B2 (ru)
EP (1) EP2968592A2 (ru)
JP (2) JP2016518332A (ru)
KR (1) KR20150130333A (ru)
CN (1) CN105188763B (ru)
AR (1) AR096015A1 (ru)
AU (2) AU2014244060B2 (ru)
BR (1) BR112015023418A8 (ru)
CA (1) CA2904090A1 (ru)
EA (1) EA201591611A1 (ru)
MX (1) MX2015012122A (ru)
TW (1) TW201444574A (ru)
UY (1) UY35399A (ru)
WO (1) WO2014160160A2 (ru)

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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
JP6188681B2 (ja) 2012-04-09 2017-08-30 第一三共株式会社 抗ｆｇｆｒ２抗体
NZ702747A (en) 2012-06-13 2017-03-31 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9415118B2 (en) 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
EP2986610B9 (en) 2013-04-19 2018-10-17 Incyte Holdings Corporation Bicyclic heterocycles as fgfr inhibitors
DK3027651T3 (en) * 2013-08-01 2019-04-15 Five Prime Therapeutics Inc AFUCOSYLED ANTI-FGFR2IIIB ANTIBODIES
TWI541022B (zh) * 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
EA201691765A1 (ru) 2014-03-14 2016-12-30 Новартис Аг Молекулы антител против lag-3 и их применения
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AU2017202150B2 (en) 2018-12-20
JP2016518332A (ja) 2016-06-23
AU2014244060A1 (en) 2015-10-01
WO2014160160A3 (en) 2015-01-08
BR112015023418A8 (pt) 2018-01-23
AU2017202150A1 (en) 2017-04-20
US20170106095A1 (en) 2017-04-20
KR20150130333A (ko) 2015-11-23
MX2015012122A (es) 2016-11-08
EP2968592A2 (en) 2016-01-20
JP2019193626A (ja) 2019-11-07
AU2014244060B2 (en) 2017-04-20
US20140301946A1 (en) 2014-10-09
AR096015A1 (es) 2015-12-02
WO2014160160A2 (en) 2014-10-02
CN105188763A (zh) 2015-12-23
CN105188763B (zh) 2019-02-19
TW201444574A (zh) 2014-12-01
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CA2904090A1 (en) 2014-10-02
BR112015023418A2 (pt) 2017-11-28

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