NO973482L - Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider - Google Patents

Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider

Info

Publication number
NO973482L
NO973482L NO973482A NO973482A NO973482L NO 973482 L NO973482 L NO 973482L NO 973482 A NO973482 A NO 973482A NO 973482 A NO973482 A NO 973482A NO 973482 L NO973482 L NO 973482L
Authority
NO
Norway
Prior art keywords
parathyroid hormone
analogues
synthesis
related peptides
hormone related
Prior art date
Application number
NO973482A
Other languages
English (en)
Other versions
NO973482D0 (no
Inventor
Humberto Arzeno
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO973482D0 publication Critical patent/NO973482D0/no
Publication of NO973482L publication Critical patent/NO973482L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO973482A 1996-07-30 1997-07-29 Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider NO973482L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2332296P 1996-07-30 1996-07-30

Publications (2)

Publication Number Publication Date
NO973482D0 NO973482D0 (no) 1997-07-29
NO973482L true NO973482L (no) 1998-02-02

Family

ID=21814418

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973482A NO973482L (no) 1996-07-30 1997-07-29 Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider

Country Status (30)

Country Link
US (1) US6849710B1 (no)
EP (1) EP0822200B1 (no)
JP (1) JP4229992B2 (no)
KR (1) KR100518982B1 (no)
CN (1) CN1293096C (no)
AR (2) AR008094A1 (no)
AT (1) ATE277080T1 (no)
AU (1) AU731160B2 (no)
BR (1) BR9704138A (no)
CA (1) CA2206008C (no)
CO (1) CO4650046A1 (no)
CZ (1) CZ239697A3 (no)
DE (1) DE69730787T2 (no)
DK (1) DK0822200T3 (no)
ES (1) ES2227639T3 (no)
HR (1) HRP970416A2 (no)
HU (1) HUP9701277A3 (no)
IL (1) IL121391A0 (no)
MA (1) MA24353A1 (no)
MX (1) MX9705719A (no)
NO (1) NO973482L (no)
NZ (1) NZ328411A (no)
PE (1) PE91998A1 (no)
PL (1) PL321391A1 (no)
SG (1) SG67408A1 (no)
TR (1) TR199700714A2 (no)
TW (1) TW505654B (no)
UY (1) UY24651A1 (no)
YU (1) YU32197A (no)
ZA (1) ZA976555B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003059291A2 (en) 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US7378495B2 (en) * 2002-10-21 2008-05-27 Pevion Biotech, Ltd. PTH-rP related peptide cancer therapeutics
WO2007059470A2 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
ATE461208T1 (de) * 2006-01-17 2010-04-15 Organon Nv Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
CN101578093B (zh) 2006-10-03 2011-09-14 半径健康公司 骨合成代谢蛋白质的药物递送方法
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
CN102993293B (zh) * 2012-12-05 2014-05-07 深圳翰宇药业股份有限公司 一种特立帕肽醋酸盐的纯化方法
MX363522B (es) 2013-03-21 2019-03-26 Sanofi Aventis Deutschland Síntesis de productos peptídicos que contienen hidantoína.
ES2624961T3 (es) 2013-03-21 2017-07-18 Sanofi-Aventis Deutschland Gmbh Síntesis de productos de péptido que contienen imida cíclica
CN104530198B (zh) * 2014-12-09 2017-09-15 兰州大学 一种片段缩合制备醋酸去氨加压素的方法
KR20240110098A (ko) 2015-04-29 2024-07-12 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
CN117417263A (zh) 2017-01-05 2024-01-19 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
WO2019175173A1 (en) * 2018-03-12 2019-09-19 Fresenius Kabi Ipsum S.R.L. Process for the manufacture of pthrp analogue
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
CN111057139B (zh) * 2018-10-17 2023-12-22 南京华威医药科技集团有限公司 一种制备特立帕肽的新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
WO1992000753A1 (en) * 1990-07-13 1992-01-23 The Regents Of The University Of California PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

Also Published As

Publication number Publication date
CO4650046A1 (es) 1998-09-03
HUP9701277A2 (hu) 1998-11-30
YU32197A (sh) 1999-07-28
PL321391A1 (en) 1998-02-02
ZA976555B (en) 1998-01-30
CZ239697A3 (cs) 1998-04-15
CA2206008C (en) 2008-09-23
JP4229992B2 (ja) 2009-02-25
CA2206008A1 (en) 1998-01-30
DK0822200T3 (da) 2005-01-31
HUP9701277A3 (en) 2001-02-28
DE69730787T2 (de) 2005-10-13
AR016981A2 (es) 2001-08-01
BR9704138A (pt) 1998-12-29
HRP970416A2 (en) 1998-08-31
TR199700714A2 (xx) 1998-02-21
AU731160B2 (en) 2001-03-22
ATE277080T1 (de) 2004-10-15
US6849710B1 (en) 2005-02-01
UY24651A1 (es) 2000-12-29
EP0822200B1 (en) 2004-09-22
ES2227639T3 (es) 2005-04-01
NO973482D0 (no) 1997-07-29
HU9701277D0 (en) 1997-09-29
EP0822200A1 (en) 1998-02-04
CN1293096C (zh) 2007-01-03
PE91998A1 (es) 1998-12-31
TW505654B (en) 2002-10-11
NZ328411A (en) 1998-12-23
JPH1077295A (ja) 1998-03-24
CN1174845A (zh) 1998-03-04
MA24353A1 (fr) 1998-07-01
KR100518982B1 (ko) 2006-05-29
KR980009282A (ko) 1998-04-30
AU3236297A (en) 1998-02-05
SG67408A1 (en) 1999-09-21
MX9705719A (es) 1998-02-28
IL121391A0 (en) 1998-01-04
AR008094A1 (es) 1999-12-09
DE69730787D1 (de) 2004-10-28

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