NO940109D0 - Ketorolac-derivater med betydelig redusert gastrointestinal irrit asjon og ulcerasjon - Google Patents

Ketorolac-derivater med betydelig redusert gastrointestinal irrit asjon og ulcerasjon

Info

Publication number: NO940109D0
Authority: NO; Norway
Prior art keywords: ulceration; ketorolac; significantly reduced; gastrointestinal irritation; reduced gastrointestinal
Prior art date: 1993-01-13

Application number

NO940109A

Other languages

English (en)

Other versions

NO940109L (no

NO301013B1 (no

Inventor

Carlos Ernesto Antonio Monti

Gustavo Enrique Aldoma

Original Assignee

Roemmers Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-13

Filing date

1994-01-12

Publication date

1994-01-12

1994-01-12 Application filed by Roemmers Sa filed Critical Roemmers Sa

1994-01-12 Publication of NO940109D0 publication Critical patent/NO940109D0/no

1994-07-14 Publication of NO940109L publication Critical patent/NO940109L/no

1997-09-01 Publication of NO301013B1 publication Critical patent/NO301013B1/no

Links

206010070840 Gastrointestinal tract irritation Diseases 0.000 title abstract 2
208000025865 Ulcer Diseases 0.000 title abstract 2
OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical class OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 title abstract 2
230000036269 ulceration Effects 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
125000004494 ethyl ester group Chemical group 0.000 abstract 1
229960004752 ketorolac Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
-1 trometamole salt Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO940109A 1993-01-13 1994-01-12 Ketorolac-derivater med betydelig redusert gastrointestinal irritasjon og ulcerasjon NO301013B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4300697A DE4300697C1 (de)	1993-01-13	1993-01-13	Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration

Publications (3)

Publication Number	Publication Date
NO940109D0 true NO940109D0 (no)	1994-01-12
NO940109L NO940109L (no)	1994-07-14
NO301013B1 NO301013B1 (no)	1997-09-01

Family

ID=6478109

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO940109A NO301013B1 (no)	1993-01-13	1994-01-12	Ketorolac-derivater med betydelig redusert gastrointestinal irritasjon og ulcerasjon

Country Status (14)

Country	Link
US (2)	US5508301A (no)
EP (1)	EP0606657B1 (no)
JP (1)	JPH06316577A (no)
KR (1)	KR940018387A (no)
AT (1)	ATE144775T1 (no)
CA (1)	CA2113226A1 (no)
DE (2)	DE4300697C1 (no)
DK (1)	DK0606657T3 (no)
ES (1)	ES2094454T3 (no)
FI (1)	FI105919B (no)
GR (1)	GR3021717T3 (no)
HU (1)	HU216841B (no)
NO (1)	NO301013B1 (no)
ZA (1)	ZA94183B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20020050188A (ko) *	2002-03-19	2002-06-26	에코바이오젠주식회사	경피흡수제로서의 용도를 위해 지용성이 부가된케토로락의 에스테르 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4089969A (en) *	1976-07-14	1978-05-16	Syntex (U.S.A.) Inc.	5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) *	1976-07-14	1978-01-28	Syntex Inc	55aloyll122dihydroo3hh pyroro 122a pyroll11 carboxylic acid derivative
JPS6452742A (en) *	1987-04-27	1989-02-28	Syntex Pharma Int	Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory
DK0519983T3 (da) *	1990-03-16	1996-10-14	Procter & Gamble	Anvendelse af ketorolac til behandling af periodontal sygdom

1993
- 1993-01-13 DE DE4300697A patent/DE4300697C1/de not_active Expired - Fee Related
- 1993-12-30 EP EP93121130A patent/EP0606657B1/de not_active Expired - Lifetime
- 1993-12-30 ES ES93121130T patent/ES2094454T3/es not_active Expired - Lifetime
- 1993-12-30 AT AT93121130T patent/ATE144775T1/de active
- 1993-12-30 DE DE59304359T patent/DE59304359D1/de not_active Expired - Fee Related
- 1993-12-30 DK DK93121130.4T patent/DK0606657T3/da active
1994
- 1994-01-03 HU HU9400006A patent/HU216841B/hu not_active IP Right Cessation
- 1994-01-07 US US08/178,541 patent/US5508301A/en not_active Expired - Fee Related
- 1994-01-11 CA CA002113226A patent/CA2113226A1/en not_active Abandoned
- 1994-01-12 ZA ZA94183A patent/ZA94183B/xx unknown
- 1994-01-12 JP JP6013935A patent/JPH06316577A/ja active Pending
- 1994-01-12 NO NO940109A patent/NO301013B1/no unknown
- 1994-01-12 KR KR1019940000417A patent/KR940018387A/ko not_active Application Discontinuation
- 1994-01-13 FI FI940171A patent/FI105919B/fi active
1995
- 1995-06-06 US US08/468,648 patent/US5574170A/en not_active Expired - Fee Related
1996
- 1996-11-20 GR GR960403112T patent/GR3021717T3/el unknown

Also Published As

Publication number	Publication date
ES2094454T3 (es)	1997-01-16
FI940171A (fi)	1994-07-14
KR940018387A (ko)	1994-08-16
JPH06316577A (ja)	1994-11-15
DK0606657T3 (da)	1997-04-14
HU216841B (hu)	1999-09-28
EP0606657A1 (de)	1994-07-20
FI105919B (fi)	2000-10-31
FI940171A0 (fi)	1994-01-13
HUT70410A (en)	1995-10-30
DE59304359D1 (de)	1996-12-05
DE4300697C1 (de)	1994-05-19
GR3021717T3 (en)	1997-02-28
ATE144775T1 (de)	1996-11-15
CA2113226A1 (en)	1994-07-14
NO940109L (no)	1994-07-14
EP0606657B1 (de)	1996-10-30
NO301013B1 (no)	1997-09-01
ZA94183B (en)	1994-08-18
US5508301A (en)	1996-04-16
HU9400006D0 (en)	1994-05-30
US5574170A (en)	1996-11-12

Publication	Publication Date	Title
ES2120728T3 (es)	1998-11-01	Inhibidores de la agregacion de plaquetas.
MX9203551A (es)	1992-09-01	Derivados de fenil amidinas utiles como inhibidores de agregacion de plaquetas.
EA200500814A1 (ru)	2006-02-24	Производные пирролопиримидина
ATE204873T1 (de)	2001-09-15	Naphthyridinderivate als angiotensin-ii- antagonist-inhibitoren
NO944162L (no)	1995-05-03	Substituerte heterosykliske karboksylsyreamider, deres fremstilling og deres anvendelse som legemiddel
MY123908A (en)	2006-06-30	Meta-azacyclic amino benzoic acid compounds and derivatives thereof
DE69709493D1 (de)	2002-02-14	Substituierte Indazolderivate
WO2003049690A3 (en)	2004-01-22	Hiv integrase inhibitors
ES2110115T3 (es)	1998-02-01	Inhibidores de la agregacion de plaquetas.
NO923200L (no)	1993-02-16	Piperidin-derivater
DE69202166D1 (de)	1995-06-01	Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.
DK0804418T3 (da)	2003-07-07	Platelataggregationshæmmere
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
NO940109D0 (no)	1994-01-12	Ketorolac-derivater med betydelig redusert gastrointestinal irrit asjon og ulcerasjon
DK1303307T3 (da)	2007-07-16	Kombinationsterapi mod tumorer omfattende substituerede acryloyldistamycinderivater og alkyleringsmidler
ATE222583T1 (de)	2002-09-15	Derivate substituierter amidinonaphthylester
ATE243219T1 (de)	2003-07-15	9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin