NO781896L - 4-fenyl-8-amino-tetrahydroisokinoliner, farmasoeytiske preparater som inneholder disse, fremgangsmaate til fremstilling av disse preparater og deres anvendelse som antidepresjonsmidler - Google Patents

4-fenyl-8-amino-tetrahydroisokinoliner, farmasoeytiske preparater som inneholder disse, fremgangsmaate til fremstilling av disse preparater og deres anvendelse som antidepresjonsmidler

Info

Publication number: NO781896L
Authority: NO; Norway
Prior art keywords: preparations; amino; phenyl; acid; preparation
Prior art date: 1977-06-01

Application number

NO78781896A

Other languages

English (en)

Norwegian (no)

Inventor

Karl Schmitt

Irmgard Hoffmann

Ulrich Schacht

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-01

Filing date

1978-05-31

Publication date

1978-12-04

1978-05-31 Application filed by Hoechst Ag filed Critical Hoechst Ag

1978-12-04 Publication of NO781896L publication Critical patent/NO781896L/no

Links

238000002360 preparation method Methods 0.000 title claims description 7
238000000034 method Methods 0.000 title claims description 6
239000000825 pharmaceutical preparation Substances 0.000 title claims 3
150000001875 compounds Chemical class 0.000 claims description 15
229910052739 hydrogen Inorganic materials 0.000 claims description 9
239000001257 hydrogen Substances 0.000 claims description 9
239000002253 acid Substances 0.000 claims description 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
-1 N-(2-amino-benzyl)-α-methyl-amino-methyl-benzyl Chemical group 0.000 claims description 4
230000001430 anti-depressive effect Effects 0.000 claims description 4
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
229910052794 bromium Inorganic materials 0.000 claims description 4
229910052801 chlorine Inorganic materials 0.000 claims description 4
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
150000007513 acids Chemical class 0.000 claims description 3
239000000935 antidepressant agent Substances 0.000 claims description 3
229940005513 antidepressants Drugs 0.000 claims description 3
239000000460 chlorine Substances 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
230000003001 depressive effect Effects 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
239000000969 carrier Substances 0.000 claims 1
239000003381 stabilizer Substances 0.000 claims 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
150000002431 hydrogen Chemical class 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
238000003756 stirring Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
WXPTXMBRTPQBEN-UHFFFAOYSA-N 4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine Chemical class C1NCC=2C(N)=CC=CC=2C1C1=CC=CC=C1 WXPTXMBRTPQBEN-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
238000001816 cooling Methods 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
239000003814 drug Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
239000011976 maleic acid Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
238000007363 ring formation reaction Methods 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
230000013275 serotonin uptake Effects 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
WYECURVXVYPVAT-UHFFFAOYSA-N 1-(4-bromophenyl)ethanone Chemical compound CC(=O)C1=CC=C(Br)C=C1 WYECURVXVYPVAT-UHFFFAOYSA-N 0.000 description 1
FWWOWPGPERBCNJ-UHFFFAOYSA-N 2-hydroxy-4-(2-hydroxyethoxy)-4-oxobutanoic acid Chemical compound OCCOC(=O)CC(O)C(O)=O FWWOWPGPERBCNJ-UHFFFAOYSA-N 0.000 description 1
WGILVXQNSFDASI-UHFFFAOYSA-N 2-nitro-n-methylbenzylamine Chemical compound CNCC1=CC=CC=C1[N+]([O-])=O WGILVXQNSFDASI-UHFFFAOYSA-N 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
101100387923 Caenorhabditis elegans dos-1 gene Proteins 0.000 description 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-diisopropylethylamine Substances CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 1
OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 1
239000007868 Raney catalyst Substances 0.000 description 1
NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
229910000564 Raney nickel Inorganic materials 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
150000008062 acetophenones Chemical class 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
125000001309 chloro group Chemical group Cl* 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
229950006191 gluconic acid Drugs 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000002440 hydroxy compounds Chemical class 0.000 description 1
230000008517 inhibition of serotonin uptake Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000000155 melt Substances 0.000 description 1
230000003340 mental effect Effects 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000004540 pour-on Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO78781896A 1977-06-01 1978-05-31 4-fenyl-8-amino-tetrahydroisokinoliner, farmasoeytiske preparater som inneholder disse, fremgangsmaate til fremstilling av disse preparater og deres anvendelse som antidepresjonsmidler NO781896L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19772724610 DE2724610A1 (de)	1977-06-01	1977-06-01	4-phenyl-8-amino-tetrahydroisochinoline

Publications (1)

Publication Number	Publication Date
NO781896L true NO781896L (no)	1978-12-04

Family

ID=6010350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO78781896A NO781896L (no)	1977-06-01	1978-05-31	4-fenyl-8-amino-tetrahydroisokinoliner, farmasoeytiske preparater som inneholder disse, fremgangsmaate til fremstilling av disse preparater og deres anvendelse som antidepresjonsmidler

Country Status (17)

Country	Link
US (1)	US4185105A (xx)
EP (1)	EP0000013B1 (xx)
JP (1)	JPS543078A (xx)
AT (1)	AT361482B (xx)
AU (1)	AU517664B2 (xx)
CA (1)	CA1093079A (xx)
DE (2)	DE2724610A1 (xx)
DK (1)	DK242278A (xx)
EG (1)	EG13777A (xx)
ES (1)	ES470226A1 (xx)
FI (1)	FI781717A (xx)
HU (1)	HU176978B (xx)
IL (1)	IL54810A0 (xx)
IT (1)	IT1094899B (xx)
NO (1)	NO781896L (xx)
PT (1)	PT68123A (xx)
ZA (1)	ZA783122B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4340600A (en) *	1980-05-22	1982-07-20	Smithkline Corporation	Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
PH19604A (en) *	1982-06-04	1986-05-27	Egyt Gyogyszervegyeszeti Gyar	Isoquinoline derivatives and pharmaceutical compositions containing the same
DE3310878A1 (de) *	1983-03-25	1984-09-27	Hoechst Ag, 6230 Frankfurt	Optische antipoden von 8-amino-4-phenyl-1,2,3,4-tetrahydroisochinolin, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit antidepressiver wirkung
BG45572A1 (en) *	1986-10-23	1989-07-14	Druzhestven N Izsledovatelski	Antiulcer means
CN101850147B (zh) *	2003-06-10	2012-11-21	雷斯梅德有限公司	多级吹风机及其外壳

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3384640A (en) *	1966-03-15	1968-05-21	Bristol Myers Co	Amino isoquinolinium salts
DE1670694B2 (de) *	1966-05-05	1976-07-22	Hoechst Ag, 6000 Frankfurt	Verfahren zur herstellung von tetrahydroisochinolinen

1977
- 1977-06-01 DE DE19772724610 patent/DE2724610A1/de not_active Withdrawn
1978
- 1978-05-26 ES ES470226A patent/ES470226A1/es not_active Expired
- 1978-05-29 EG EG343/78A patent/EG13777A/xx active
- 1978-05-30 US US05/910,781 patent/US4185105A/en not_active Expired - Lifetime
- 1978-05-30 ZA ZA00783122A patent/ZA783122B/xx unknown
- 1978-05-30 FI FI781717A patent/FI781717A/fi not_active Application Discontinuation
- 1978-05-30 IL IL54810A patent/IL54810A0/xx unknown
- 1978-05-30 IT IT23996/78A patent/IT1094899B/it active
- 1978-05-31 CA CA304,518A patent/CA1093079A/en not_active Expired
- 1978-05-31 AT AT395078A patent/AT361482B/de not_active IP Right Cessation
- 1978-05-31 PT PT68123A patent/PT68123A/pt unknown
- 1978-05-31 AU AU36705/78A patent/AU517664B2/en not_active Expired
- 1978-05-31 HU HU78HO2078A patent/HU176978B/hu unknown
- 1978-05-31 DK DK242278A patent/DK242278A/da not_active Application Discontinuation
- 1978-05-31 NO NO78781896A patent/NO781896L/no unknown
- 1978-06-01 JP JP6499278A patent/JPS543078A/ja active Pending
- 1978-06-01 DE DE7878100025T patent/DE2860212D1/de not_active Expired
- 1978-06-01 EP EP78100025A patent/EP0000013B1/de not_active Expired

Also Published As

Publication number	Publication date
HU176978B (hu)	1981-06-28
EP0000013A1 (de)	1978-12-20
IT1094899B (it)	1985-08-10
US4185105A (en)	1980-01-22
EG13777A (en)	1982-03-31
JPS543078A (en)	1979-01-11
IT7823996A0 (it)	1978-05-30
PT68123A (en)	1978-06-01
DK242278A (da)	1978-12-02
ATA395078A (de)	1980-08-15
ES470226A1 (es)	1979-01-01
IL54810A0 (en)	1978-07-31
DE2860212D1 (en)	1981-01-22
CA1093079A (en)	1981-01-06
AT361482B (de)	1981-03-10
AU517664B2 (en)	1981-08-20
EP0000013B1 (de)	1980-10-15
DE2724610A1 (de)	1978-12-14
AU3670578A (en)	1979-12-06
FI781717A (fi)	1978-12-02
ZA783122B (en)	1979-06-27

Publication	Publication Date	Title
NO781935L (no)	1978-12-05	Fremgangsmaate ved fremstilling av fthalazinderivater
NO130878B (xx)	1974-11-18
NO137177B (no)	1977-10-10	Fremgangsm}te og apparat for hurtigkoking av levnedsmidler
NO120686B (xx)	1970-11-23
MXPA02006499A (es)	2002-11-29	Derivados de fenilpiperazinilo.
AU8108187A (en)	1988-05-25	Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids
Cook et al.	1995	Structure-activity studies of 2, 3, 4, 4a, 5, 9b-hexahydroindeno [1, 2-c] pyridines as antispermatogenic agents for male contraception
NO782108L (no)	1978-12-19	Nye hexahydropyrimidiner, fremgangsmaate til deres fremstilling og legemidler som inneholder disse forbindelser
JPS6341910B2 (xx)	1988-08-19
NO781896L (no)	1978-12-04	4-fenyl-8-amino-tetrahydroisokinoliner, farmasoeytiske preparater som inneholder disse, fremgangsmaate til fremstilling av disse preparater og deres anvendelse som antidepresjonsmidler
NO773300L (no)	1978-03-29	Fremgangsmaate for fremstilling av nye eddiksyrederivater
US4767862A (en)	1988-08-30	Substituted tetrahydro isoquinoline intermediates
NO151387B (no)	1984-12-17	Innstillingsinnretning for en elektronisk digitalindikator
FI57747B (fi)	1980-06-30	Foerfarande foer framstaellning av nya isoindolin-1-on-derivat vilka aer anvaendbara saosom medel mot arytmi
JPS60132962A (ja)	1985-07-16	Ｎ−置換イソキノリン誘導体
CA1243033A (en)	1988-10-11	Process for preparing 4-¬2- (dialkylamino)ethyl\|isatins
US4054659A (en)	1977-10-18	5,7 Dihydroxy-1-(trimethoxybenzyl)-1,2,3,H-tetrahydroisoquinolines and use thereof
NO132478B (xx)	1975-08-11
Marion et al.	1944	The Synthesis of l-Roemerine1
SU1329620A3 (ru)	1987-08-07	Способ получени производных изохинолина или их фармацевтически пригодных аддитивных кислых солей
NO121584B (xx)	1971-03-15
US3413294A (en)	1968-11-26	Tetrahydro-1, 4-ethano-isoquinolines
KR820001081B1 (ko)	1982-06-21	모라노린 유도체의 제법
NO179041B (no)	1996-04-15	Analogifremgangsmåte for fremstilling av terapeutisk aktive, racemiske eller optisk aktive isokinolinderivater
US4150227A (en)	1979-04-17	Process for the production of basic substituted alkyl theophylline