NO323853B1 - Renset og isolert hamster-EF-1alpha-transkripsjonsregulatorisk DNA, kimaert polynukleotid omfattende dette, vertceller og plasmid omfattende disse og fremgangsmate for okning av transkripsjon av et gen av interesse i en vertcelle - Google Patents

Renset og isolert hamster-EF-1alpha-transkripsjonsregulatorisk DNA, kimaert polynukleotid omfattende dette, vertceller og plasmid omfattende disse og fremgangsmate for okning av transkripsjon av et gen av interesse i en vertcelle Download PDF

Info

Publication number
NO323853B1
NO323853B1 NO19990025A NO990025A NO323853B1 NO 323853 B1 NO323853 B1 NO 323853B1 NO 19990025 A NO19990025 A NO 19990025A NO 990025 A NO990025 A NO 990025A NO 323853 B1 NO323853 B1 NO 323853B1
Authority
NO
Norway
Prior art keywords
dna
plasmid
seq
gene
fragment
Prior art date
Application number
NO19990025A
Other languages
English (en)
Norwegian (no)
Other versions
NO990025D0 (no
NO990025L (no
Inventor
Daniell S Allison
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO990025D0 publication Critical patent/NO990025D0/no
Publication of NO990025L publication Critical patent/NO990025L/no
Publication of NO323853B1 publication Critical patent/NO323853B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
NO19990025A 1997-05-01 1999-01-04 Renset og isolert hamster-EF-1alpha-transkripsjonsregulatorisk DNA, kimaert polynukleotid omfattende dette, vertceller og plasmid omfattende disse og fremgangsmate for okning av transkripsjon av et gen av interesse i en vertcelle NO323853B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/847,218 US5888809A (en) 1997-05-01 1997-05-01 Hamster EF-1α transcriptional regulatory DNA
PCT/US1998/008906 WO1998049289A1 (en) 1997-05-01 1998-05-01 HAMSTER EF-1α TRANSCRIPTIONAL REGULATORY DNA

Publications (3)

Publication Number Publication Date
NO990025D0 NO990025D0 (no) 1999-01-04
NO990025L NO990025L (no) 1999-03-01
NO323853B1 true NO323853B1 (no) 2007-07-16

Family

ID=25300098

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990025A NO323853B1 (no) 1997-05-01 1999-01-04 Renset og isolert hamster-EF-1alpha-transkripsjonsregulatorisk DNA, kimaert polynukleotid omfattende dette, vertceller og plasmid omfattende disse og fremgangsmate for okning av transkripsjon av et gen av interesse i en vertcelle

Country Status (20)

Country Link
US (1) US5888809A (da)
EP (2) EP0920498B1 (da)
JP (1) JP2000513948A (da)
CN (2) CN101570753A (da)
AT (1) ATE318900T1 (da)
AU (1) AU742561B2 (da)
BR (1) BR9804896B1 (da)
CZ (1) CZ296544B6 (da)
DE (1) DE69833649T2 (da)
DK (1) DK0920498T3 (da)
ES (1) ES2263206T3 (da)
HK (1) HK1022719A1 (da)
HU (1) HU225764B1 (da)
IL (1) IL127897A (da)
NO (1) NO323853B1 (da)
PL (1) PL195604B1 (da)
PT (1) PT920498E (da)
RU (2) RU2249617C2 (da)
SK (1) SK285664B6 (da)
WO (1) WO1998049289A1 (da)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183344B2 (en) * 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
US6479256B1 (en) 1998-03-04 2002-11-12 Icos Corporation Lectomedin materials and methods
KR20000046969A (ko) * 1998-12-31 2000-07-25 이선경 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더
US20030088061A1 (en) * 2000-10-12 2003-05-08 Staunton Donald E. Materials and methods to modulate ligand binding/enzymatic activity of alpha/beta proteins containing an allosteric regulatory site
AU2002230773A1 (en) * 2000-12-18 2002-07-01 Wyeth Promoters and recombinant expression constructs
DK1806407T3 (da) * 2001-07-04 2010-08-16 Chromagenics Bv DNA-sekvenser med anti-repressoraktivitet
DK1513937T3 (da) * 2002-06-14 2011-05-16 Chromagenics Bv Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved
AU2003243059A1 (en) * 2002-06-14 2003-12-31 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
EP1573058B1 (en) * 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) * 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
US7687233B2 (en) 2003-09-23 2010-03-30 The University Of North Carolina At Chapel Hill Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
US8039230B2 (en) * 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
CN101090968B (zh) 2004-11-08 2011-10-26 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
US8999667B2 (en) * 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
PL1809750T3 (pl) * 2004-11-08 2012-08-31 Chromagenics Bv Selekcja komórki gospodarza eksprymującej białko na wysokich poziomach
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
EP1819829A1 (en) * 2004-12-08 2007-08-22 ICOS Corporation Recombinant method for making multimeric proteins
JP2008532544A (ja) * 2005-03-15 2008-08-21 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 活性ビタミンk依存性タンパク質を生産するための方法及び組成物
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
ES2708763T3 (es) 2005-07-07 2019-04-11 Seattle Genetics Inc Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
AR056138A1 (es) 2005-10-21 2007-09-19 Hoffmann La Roche Procedimiento para la expresion recombinante de un polipeptido
CN101341252B (zh) 2005-10-28 2011-08-17 弗·哈夫曼-拉罗切有限公司 啮齿动物细胞中的蛋白质表达
ES2503365T5 (es) * 2005-12-21 2017-10-31 Cnj Holdings, Inc Método para producir proteínas dependientes de vitamina K biológicamente activas por métodos recombinantes
WO2007081336A1 (en) * 2006-01-13 2007-07-19 Five Prime Therapeutics, Inc. Mammalian vectors for high-level expression of recombinant proteins
ES2543629T3 (es) 2006-05-17 2015-08-20 Hoffmann-La Roche Ag Células productoras de polipéptidos
EP2520586A1 (en) 2006-06-30 2012-11-07 The Regents of the University of Michigan Method of producing factor VIII proteins by recombinant methods
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
TW200902544A (en) 2007-03-13 2009-01-16 Hoffmann La Roche Peptide-complement conjugates
EP1975228A1 (en) 2007-03-28 2008-10-01 Fachhochschule Mannheim Polynucleotides for enhancing expression of a polynucleotide of interest
CA2683423C (en) 2007-04-26 2020-10-27 Inspiration Biopharmaceuticals, Inc. Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
LT2167540T (lt) * 2007-06-29 2018-04-25 F. Hoffmann-La Roche Ag Sunkioji grandinė mutantė, pagerinanti imunoglobulino gamybą
BRPI0818165B8 (pt) 2007-10-12 2021-05-25 Hoffmann La Roche método de produção recombinante de uma imunoglobulina heteróloga em células cho que é secretada para o meio de cultura
CA2705486C (en) 2007-11-19 2019-04-02 Celera Corporation Lung cancer markers and uses thereof
ES2466340T3 (es) 2008-04-24 2014-06-10 Cantab Biopharmaceuticals Patents Limited Conjugados de Factor IX con semividas extendidas
PL2282773T3 (pl) 2008-05-02 2014-08-29 Seattle Genetics Inc Sposoby i kompozycje do wytwarzania przeciwciał i pochodnych przeciwciał o obniżonej fukozylacji rdzeniowej
PL2462237T3 (pl) 2009-08-06 2016-06-30 Cmc Icos Biologics Inc Sposoby polepszania wyrażania białka rekombinowanego
DK2478107T3 (da) 2009-09-15 2019-01-02 Medimmune Ltd Celler til transient ekspression og anvendelser deraf
EP2494040B1 (en) * 2009-10-30 2018-08-29 Aptevo BioTherapeutics LLC Method of producing recombinant vitamin k dependent proteins
EP2339009A1 (en) 2009-12-22 2011-06-29 Sandoz Ag Cold inducible promoter sequences
SI3178851T1 (sl) 2010-03-31 2020-09-30 Boehringer Inhelheim International Gmbh Anti-CD40 protitelesa
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
KR101931591B1 (ko) 2010-11-04 2018-12-24 베링거 인겔하임 인터내셔날 게엠베하 항-il-23 항체
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
US20150158934A1 (en) 2011-09-09 2015-06-11 Ucl Business Plc Broadly neutralizing vhh against hiv-1
LT2771031T (lt) 2011-10-28 2018-08-27 Prothena Biosciences Limited Humanizuoti antikūnai, kurie atpažįsta alfa sinukleiną
UA115540C2 (uk) 2011-11-16 2017-11-27 Бьорінгер Інгельхайм Інтернаціональ Гмбх Антитіло до il-36r
BR112014013035A2 (pt) 2011-12-22 2018-10-09 Hoffmann La Roche métodos de seleção de células, conjuntos de expressão bicistrônica, células eucarióticas, vetores lentivirais, uso de vetor lentiviral, bibliotecas de ventores lentivirais e de células eucarióticas, métodos de seleção de células, fluxos de trabalho e uso de célula
RU2756106C2 (ru) 2011-12-22 2021-09-28 Ф. Хоффманн-Ля Рош Аг Строение экспрессионного вектора, новые способы получения клеток-продуцентов и их применение для рекомбинантного получения полипептидов
CA3149402A1 (en) 2011-12-22 2013-06-27 F. Hoffman-La Roche Ag Expression vector element combinations, novel production cell generation methods and their use for the recombinant production of polypeptides
DK2807188T3 (da) 2012-01-27 2019-10-07 Prothena Biosciences Ltd Humaniserede antistoffer, der genkender alpha-synuclein
CN108324943B (zh) 2012-02-10 2024-03-08 思进股份有限公司 Cd30+癌症的检测和治疗
JP2015507929A (ja) * 2012-02-14 2015-03-16 ポートラ ファーマシューティカルズ, インコーポレイテッド 第Xa因子阻害剤に対する組み換え拮抗剤を製作するためのプロセス
CA2871985C (en) 2012-05-03 2023-10-10 Boehringer Ingelheim International Gmbh Anti-il-23p19 antibodies
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
ES2744903T3 (es) 2012-11-20 2020-02-26 Univ North Carolina Chapel Hill Métodos y composiciones para proteínas del factor IX modificadas
AU2014248936B2 (en) 2013-03-12 2020-07-09 Cmc Icos Biologics, Inc. Improved recombinant protein expression using a hybrid CHEF1 promoter
KR102313513B1 (ko) 2013-03-13 2021-10-15 프로테나 바이오사이언시즈 리미티드 Tau 면역치료제
US10513555B2 (en) 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
RU2535871C1 (ru) * 2013-07-10 2014-12-20 Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") Плазмида для экспрессии в клетке китайского хомячка, клетка китайского хомячка - продуцент белка с Gla-доменом и способ получения белка с Gla-доменом
WO2015004632A1 (en) 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize iapp
WO2015004633A1 (en) 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize islet-amyloid polypeptide (iapp)
WO2015075635A2 (en) 2013-11-19 2015-05-28 Prothena Biosciences Limited Monitoring immunotherapy of lewy body disease from constipation symptoms
KR20160113715A (ko) 2014-01-31 2016-09-30 베링거 인겔하임 인터내셔날 게엠베하 신규한 항-baff 항체
PT3116911T (pt) 2014-03-12 2019-09-04 Prothena Biosciences Ltd Anticorpos anti-mcam e métodos de utilização associados
KR20160131082A (ko) 2014-03-12 2016-11-15 프로테나 바이오사이언시즈 리미티드 Lg1-3에 특이적인 항-라미닌4 항체
TW201623331A (zh) 2014-03-12 2016-07-01 普羅帝納生物科學公司 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法
JP2017514458A (ja) 2014-03-12 2017-06-08 プロセナ バイオサイエンシーズ リミテッド Lg4−5に対して特異的な抗−ラミニン4抗体
EP3129051A1 (en) 2014-04-08 2017-02-15 Prothena Biosciences Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
EP3708679A1 (en) 2014-07-24 2020-09-16 Boehringer Ingelheim International GmbH Biomarkers useful in the treatment of il-23a related diseases
TWI718122B (zh) 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
TWI718121B (zh) 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
TWI711631B (zh) 2015-01-28 2020-12-01 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
EP3253786A4 (en) 2015-02-06 2018-10-17 The University of North Carolina at Chapel Hill Optimized human clotting factor viii gene expression cassettes and their use
BR112017018574A2 (pt) 2015-04-14 2018-04-17 Boehringer Ingelheim International Gmbh métodos para o tratamento de doenças
CN108025066B (zh) 2015-05-12 2022-04-12 Synt免疫公司 人源化亲和力成熟的抗FcRn抗体
CA2998716A1 (en) 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
WO2017046774A2 (en) 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
TWI733695B (zh) 2015-09-18 2021-07-21 德商百靈佳殷格翰國際股份有限公司 治療發炎性疾病之方法
US11560418B2 (en) 2015-10-20 2023-01-24 The University Of North Carolina At Chapel Hill Methods and compositions for modified factor IX fusion proteins
WO2017149513A1 (en) 2016-03-03 2017-09-08 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
WO2017153953A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
WO2017153955A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
JP6728392B2 (ja) 2016-04-15 2020-07-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性疾患の処置法
EP3448429B1 (en) 2016-04-25 2021-01-13 Syntimmune Inc. Humanized affinity matured anti-fcrn antibodies
SG11201808434WA (en) 2016-05-02 2018-10-30 Prothena Biosciences Ltd Antibodies recognizing tau
PT3452507T (pt) 2016-05-02 2022-12-20 Prothena Biosciences Ltd Imunoterapia anti-tau
CN109415434B (zh) 2016-05-02 2022-12-30 普罗塞纳生物科学有限公司 识别tau的抗体
WO2017208210A1 (en) 2016-06-03 2017-12-07 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
JP7016470B2 (ja) 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
EP3478716A2 (en) 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7076711B2 (ja) 2016-07-02 2022-05-30 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
WO2018060239A1 (en) 2016-09-29 2018-04-05 F. Hoffmann-La Roche Ag Improved method for selecting polypeptide producing cells
EP3848390A1 (en) 2016-10-14 2021-07-14 Boehringer Ingelheim International GmbH Methods of treating diseases
EP3601350A1 (en) 2017-03-27 2020-02-05 Boehringer Ingelheim International GmbH Anti il-36r antibodies combination therapy
KR20200030029A (ko) 2017-05-02 2020-03-19 프로테나 바이오사이언시즈 리미티드 타우 인식 항체
US10793634B2 (en) 2017-06-09 2020-10-06 Boehringer Ingelheim International Gmbh Anti-TrkB antibodies
WO2019064053A1 (en) 2017-09-28 2019-04-04 Prothena Biosciences Limited DOSAGE REGIMES FOR THE TREATMENT OF SYNUCLEINOPATHIES
AU2019206443A1 (en) 2018-01-10 2020-07-23 Cmc Icos Biologics, Inc. Bidirectional CHEFl vectors
CN112004826B (zh) 2018-02-05 2024-06-14 自由大学基金会 反向激动性抗us28抗体
WO2019156566A1 (en) 2018-02-12 2019-08-15 Umc Utrecht Holding B.V. Bispecific molecules comprising gamma-delta tcr and t-cell or nk cell binding domain
WO2019226050A2 (en) 2018-05-24 2019-11-28 Wageningen Universiteit Novel viral anti-infective reagents
WO2019235923A1 (en) 2018-06-04 2019-12-12 Erasmus University Medical Center Rotterdam Role for low density lipoprotein receptor-related protein 10 in progressive brain diseases
MX2020013885A (es) 2018-06-29 2021-03-09 Boehringer Ingelheim Int Anticuerpos anti-cd40 para su uso en el tratamiento de enfermedades autoinmunes.
CN110904127B (zh) 2018-09-18 2024-09-20 瓦赫宁恩研究基金会 非洲猪瘟病毒疫苗
WO2020080941A1 (en) 2018-10-16 2020-04-23 Umc Utrecht Holding B.V. Anti- low-density lipoprotein receptor-related protein 5/6 antibodies
AU2019386976B2 (en) 2018-11-26 2024-05-30 Forty Seven, Inc. Humanized antibodies against c-Kit
WO2020130838A2 (en) 2018-12-21 2020-06-25 Qvq Holding B.V. Antibodies for preventing or treating candidiasis
CA3131531A1 (en) 2019-03-03 2020-09-10 Prothena Biosciences Limited Antibodies recognizing tau
MX2021010783A (es) 2019-03-08 2021-09-30 Boehringer Ingelheim Int Formulaciones de anticuerpo anti-il-36r.
CN114173809A (zh) 2019-04-02 2022-03-11 伊缪纯有限公司 免疫刺激组合物及其用途
TWI836069B (zh) 2019-05-09 2024-03-21 德商百靈佳殷格翰國際股份有限公司 抗-sema3a抗體及其用於治療眼或眼部疾病之用途
TW202115112A (zh) 2019-06-27 2021-04-16 德商百靈佳殷格翰國際股份有限公司 抗-angpt2抗體
AU2020355599A1 (en) 2019-09-24 2022-04-07 Boehringer Ingelheim International Gmbh Anti-NRP1a antibodies and their uses for treating eye or ocular diseases
WO2021242663A1 (en) 2020-05-26 2021-12-02 Boehringer Ingelheim International Gmbh Anti-pd-1 antibodies
JP2023533458A (ja) 2020-06-24 2023-08-03 プロシーナ バイオサイエンシーズ リミテッド ソルチリンを認識する抗体
US20240317868A1 (en) 2021-02-05 2024-09-26 Boehringer Ingelheim International Gmbh Anti-il1rap antibodies
AR128065A1 (es) 2021-12-22 2024-03-20 Cdr Life Ag Anticuerpos anti-c3 y fragmentos de unión al antígeno de estos y sus usos para tratar enfermedades oftálmicas u oculares
CN114540352A (zh) * 2022-02-16 2022-05-27 艾瑞生命科学技术(常州)有限公司 一种多核苷酸、载体元件及表达载体和宿主细胞及应用
WO2024096735A1 (en) 2022-10-31 2024-05-10 Stichting Amsterdam UMC Single domain anti-cd169 antibodies
WO2024101989A1 (en) 2022-11-08 2024-05-16 Stichting Amsterdam UMC Activation inducible antigen receptors for adoptive immunotherapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3051411B2 (ja) * 1989-03-14 2000-06-12 持田製薬株式会社 新規dnaならびにそれを含有する発現プラスミド
US5266491A (en) * 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
WO1991009955A1 (en) * 1989-12-22 1991-07-11 Applied Research Systems Ars Holding N.V. Endogenous gene expression modification with regulatory element
US5650294A (en) * 1990-06-25 1997-07-22 Basf Aktiengesellschaft Isolated promoter and terminator of elongation factor 1-α
WO1992020808A1 (en) * 1991-05-15 1992-11-26 Cell Genesys, Inc. Genomic modifications with homologous dna targeting
CA2051085C (en) * 1991-09-10 2001-08-21 Shigekazu Nagata Expression plasmids
TW402639B (en) * 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery

Also Published As

Publication number Publication date
US5888809A (en) 1999-03-30
HUP0004137A3 (en) 2003-08-28
ES2263206T3 (es) 2006-12-01
RU2249617C2 (ru) 2005-04-10
CZ28099A3 (cs) 2000-02-16
SK11899A3 (en) 2000-05-16
HU225764B1 (en) 2007-08-28
NO990025D0 (no) 1999-01-04
PL195604B1 (pl) 2007-10-31
WO1998049289A1 (en) 1998-11-05
AU742561B2 (en) 2002-01-03
BR9804896B1 (pt) 2013-11-26
NO990025L (no) 1999-03-01
EP0920498B1 (en) 2006-03-01
EP1676916A1 (en) 2006-07-05
DE69833649D1 (de) 2006-04-27
DE69833649T2 (de) 2006-12-28
EP0920498A1 (en) 1999-06-09
RU2004136574A (ru) 2006-05-27
AU7277098A (en) 1998-11-24
HK1022719A1 (en) 2000-08-18
IL127897A (en) 2005-12-18
IL127897A0 (en) 1999-11-30
CZ296544B6 (cs) 2006-04-12
CN1230991A (zh) 1999-10-06
CN100430477C (zh) 2008-11-05
JP2000513948A (ja) 2000-10-24
CN101570753A (zh) 2009-11-04
BR9804896A (pt) 1999-08-31
PL331005A1 (en) 1999-06-21
DK0920498T3 (da) 2006-07-10
HUP0004137A2 (en) 2001-03-28
ATE318900T1 (de) 2006-03-15
PT920498E (pt) 2006-08-31
SK285664B6 (sk) 2007-05-03

Similar Documents

Publication Publication Date Title
NO323853B1 (no) Renset og isolert hamster-EF-1alpha-transkripsjonsregulatorisk DNA, kimaert polynukleotid omfattende dette, vertceller og plasmid omfattende disse og fremgangsmate for okning av transkripsjon av et gen av interesse i en vertcelle
KR102085189B1 (ko) 일시적인 유전자 발현을 통한 정교한 식물 변형 방법
AU2023270322A1 (en) Compositions and methods for modifying genomes
JP5684445B2 (ja) 部位特異的セリンリコンビナーゼ及びそれらの使用方法
SG182847A1 (en) Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes
CN101827938A (zh) 涉及rt1基因、相关的构建体和方法的具有改变的根构造的植物
KR20180084135A (ko) 감소된 clr2 활성을 갖는 사상 진균에서 단백질을 생산하는 방법
PT1984512T (pt) Sistema de expressão génica utilizando excisão-união em insetos
CS267192A3 (en) Expression systems
JP2001500009A (ja) 植物レトロウイルスポリヌクレオチドおよびその使用のための方法
EP1274854B1 (en) Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
KR20060052865A (ko) 비당화 인간의 알파페토프로테인과 이의 생산방법 및 이의용도
BRPI0616533A2 (pt) polinucleotìdeo isolado, fragmento de ácido nucléico isolado, construções de dna recombinante, plantas, sementes, células vegetais, tecidos vegetais, método de isolamento de fragmentos de ácidos nucléico, método de mapeamento de variações genéticas, método de cultivo molecular, plantas de milho, métodos de alteração do transporte de nitrogênio das plantas e variantes de hat de plantas alteradas
JP2001515724A (ja) 分泌されたβ−グルクロニダーゼの微生物遺伝子、遺伝子産物およびそれらの使用
WO2005054463A1 (ja) レトロトランスポゾンを用いた哺乳動物のゲノム改変技術の開発
JP2010522549A (ja) 目的のポリヌクレオチドの発現を増強するためのポリヌクレオチド
Grippo et al. Cell‐specific transgene expression from a widely transcribed promoter using Cre/lox in mice
KR19990076627A (ko) 재조합 배큘로바이러스의 제조
JP2003235575A (ja) 哺乳動物において機能的なトランスポゾン
CA2259145C (en) Hamster ef-1.alpha. transcriptional regulatory dna
JP2006262875A (ja) 鳥類の卵管内でタンパク質を発現させるための遺伝子構築物、およびこれを用いたタンパク質の生産方法
EP1404842A2 (en) Perv screening method and use thereof
US20040231006A1 (en) Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
JPH05115283A (ja) プロテインホスフアターゼ阻害物質−1の遺伝子及びその発現
NZ503901A (en) Transgenic avians containing replication-defective retroviral vectors and methods for tissue specific synthesis of protein in eggs laid by the avian or female progeny thereof.

Legal Events

Date Code Title Description
MK1K Patent expired