NO20034170L - Imidazo-pyrimidinderivater som ligander for GABA-reseptorer - Google Patents

Imidazo-pyrimidinderivater som ligander for GABA-reseptorer

Info

Publication number
NO20034170L
NO20034170L NO20034170A NO20034170A NO20034170L NO 20034170 L NO20034170 L NO 20034170L NO 20034170 A NO20034170 A NO 20034170A NO 20034170 A NO20034170 A NO 20034170A NO 20034170 L NO20034170 L NO 20034170L
Authority
NO
Norway
Prior art keywords
pyrimidine derivatives
ligands
imidazo
phenyl ring
gaba receptors
Prior art date
Application number
NO20034170A
Other languages
English (en)
Other versions
NO20034170D0 (no
Inventor
Mark Stuart Chambers
Simon Charles Goodacre
David James Hallett
Andrew Jennings
Philip Jones
Richard Thomas Lewis
Kevin William Moore
Leslie Joseph Street
Helen Jane Szekeres
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0107134A external-priority patent/GB0107134D0/en
Priority claimed from GB0127938A external-priority patent/GB0127938D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NO20034170D0 publication Critical patent/NO20034170D0/no
Publication of NO20034170L publication Critical patent/NO20034170L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20034170A 2001-03-21 2003-09-19 Imidazo-pyrimidinderivater som ligander for GABA-reseptorer NO20034170L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0107134A GB0107134D0 (en) 2001-03-21 2001-03-21 Therapeutic agents
GB0127938A GB0127938D0 (en) 2001-11-21 2001-11-21 Therapeutic agents
PCT/GB2002/001351 WO2002074772A1 (en) 2001-03-21 2002-03-19 Imidazo-pyrimidine derivatives as ligands for gaba receptors

Publications (2)

Publication Number Publication Date
NO20034170D0 NO20034170D0 (no) 2003-09-19
NO20034170L true NO20034170L (no) 2003-11-19

Family

ID=26245875

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034170A NO20034170L (no) 2001-03-21 2003-09-19 Imidazo-pyrimidinderivater som ligander for GABA-reseptorer

Country Status (24)

Country Link
EP (1) EP1381606B1 (no)
JP (1) JP4409174B2 (no)
KR (1) KR20030083001A (no)
CN (1) CN1294133C (no)
AT (1) ATE299882T1 (no)
AU (1) AU2002241138B2 (no)
BG (1) BG108166A (no)
BR (1) BR0207994A (no)
CA (1) CA2461426C (no)
CZ (1) CZ20032539A3 (no)
DE (1) DE60205101T2 (no)
EA (1) EA006234B1 (no)
EE (1) EE200300455A (no)
ES (1) ES2244752T3 (no)
HU (1) HUP0303630A3 (no)
IL (1) IL157641A0 (no)
MX (1) MXPA03008572A (no)
NO (1) NO20034170L (no)
NZ (1) NZ527901A (no)
PE (1) PE20020970A1 (no)
PL (1) PL363804A1 (no)
SK (1) SK11672003A3 (no)
TW (1) TWI248936B (no)
WO (2) WO2002074772A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
GB0226462D0 (en) * 2002-11-13 2002-12-18 Merck Sharp & Dohme Therapeutic agents
PT1648899E (pt) * 2003-07-25 2007-03-30 Neurogen Corp Imidazo-pirimidinas e triazolo-pirimidinas: ligandos do receptor de benzodiazepina
PL2121687T3 (pl) 2006-12-22 2016-03-31 Astex Therapeutics Ltd Pochodne amin tricyklicznych jako inhibitory białkowej kinazy tyrozynowej
JP5442448B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド Ｆｇｆｒインヒビターとしての二環式ヘテロ環式化合物
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
NZ623384A (en) * 2009-10-16 2016-06-24 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
DK2488532T3 (en) 2009-10-16 2018-08-13 Melinta Therapeutics Inc ANTIMICROBIAL COMPOUNDS AND PROCEDURES FOR PREPARING AND USING THE SAME
CA2777741A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN102898315B (zh) * 2012-11-05 2015-01-28 上海毕得医药科技有限公司 3-乙炔基-4-氟苯胺的制备方法
SG11201601654TA (en) 2013-09-09 2016-04-28 Melinta Therapeutics Inc Antimicrobial compunds and methods of making and using the same
CA2923179A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
AU2016228584A1 (en) 2015-03-11 2017-10-05 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2017098367A1 (en) * 2015-12-10 2017-06-15 Pfizer Limited 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
EP3407886A1 (en) 2016-01-27 2018-12-05 Universität Zürich Use of gabaa receptor modulators for treatment of itch
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗菌剤ならびにそれを作製および使用する方法
BR112020021104A2 (pt) * 2018-04-18 2021-02-23 Neurocycle Therapeutics, Inc compostos moduladores alostéricos positivos gabaa, métodos de produção e usos dos mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185446A (en) * 1990-09-04 1993-02-09 Neurogen Corporation Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
CA2218552C (en) * 1995-04-21 2002-04-16 Neurosearch A/S Benzimidazole compounds and their use as modulators of the gabaa receptor complex
PA8535601A1 (es) * 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa

Also Published As

Publication number Publication date
BG108166A (en) 2004-09-30
JP2004523584A (ja) 2004-08-05
AU2002241138B2 (en) 2007-09-20
TWI248936B (en) 2006-02-11
EP1381606A1 (en) 2004-01-21
EE200300455A (et) 2003-12-15
DE60205101D1 (de) 2005-08-25
BR0207994A (pt) 2004-03-02
WO2002074772A1 (en) 2002-09-26
HUP0303630A2 (hu) 2004-03-01
EP1381606B1 (en) 2005-07-20
PE20020970A1 (es) 2002-11-01
EA006234B1 (ru) 2005-10-27
CZ20032539A3 (en) 2004-03-17
PL363804A1 (en) 2004-11-29
DE60205101T2 (de) 2006-05-24
MXPA03008572A (es) 2003-12-08
KR20030083001A (ko) 2003-10-23
CN1498218A (zh) 2004-05-19
CA2461426A1 (en) 2002-09-26
JP4409174B2 (ja) 2010-02-03
CN1294133C (zh) 2007-01-10
NZ527901A (en) 2005-09-30
WO2002074773A1 (en) 2002-09-26
CA2461426C (en) 2010-08-03
ATE299882T1 (de) 2005-08-15
IL157641A0 (en) 2004-03-28
SK11672003A3 (sk) 2004-05-04
HUP0303630A3 (en) 2005-06-28
EA200301037A1 (ru) 2004-04-29
ES2244752T3 (es) 2005-12-16
NO20034170D0 (no) 2003-09-19

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