BG108166A - Imidazo-pyrimidine derivatives as liigands for gaba receptors - Google Patents

Imidazo-pyrimidine derivatives as liigands for gaba receptors

Info

Publication number: BG108166A
Authority: BG; Bulgaria
Prior art keywords: pyrimidine derivatives; liigands; imidazo; substituted; phenyl ring
Prior art date: 2001-03-21

Application number

BG108166A

Other languages

Bulgarian (bg)

English (en)

Inventor

Mark S. Chambers

Simon C. Goodacre

David J. Hallett

Andrew Jennings

Philip Jones

Richard T. Lewis

Kevin W. Moore

Leslie J. Street

Helen J. Szekeres

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-21

Filing date

2003-09-09

Publication date

2004-09-30

2001-03-21 Priority claimed from GB0107134A external-priority patent/GB0107134D0/en

2001-11-21 Priority claimed from GB0127938A external-priority patent/GB0127938D0/en

2003-09-09 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

2004-09-30 Publication of BG108166A publication Critical patent/BG108166A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG108166A 2001-03-21 2003-09-09 Imidazo-pyrimidine derivatives as liigands for gaba receptors BG108166A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0107134A GB0107134D0 (en)	2001-03-21	2001-03-21	Therapeutic agents
GB0127938A GB0127938D0 (en)	2001-11-21	2001-11-21	Therapeutic agents
PCT/GB2002/001351 WO2002074772A1 (en)	2001-03-21	2002-03-19	Imidazo-pyrimidine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
BG108166A true BG108166A (en)	2004-09-30

Family

ID=26245875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108166A BG108166A (en)	2001-03-21	2003-09-09	Imidazo-pyrimidine derivatives as liigands for gaba receptors

Country Status (24)

Country	Link
EP (1)	EP1381606B1 (xx)
JP (1)	JP4409174B2 (xx)
KR (1)	KR20030083001A (xx)
CN (1)	CN1294133C (xx)
AT (1)	ATE299882T1 (xx)
AU (1)	AU2002241138B2 (xx)
BG (1)	BG108166A (xx)
BR (1)	BR0207994A (xx)
CA (1)	CA2461426C (xx)
CZ (1)	CZ20032539A3 (xx)
DE (1)	DE60205101T2 (xx)
EA (1)	EA006234B1 (xx)
EE (1)	EE200300455A (xx)
ES (1)	ES2244752T3 (xx)
HU (1)	HUP0303630A3 (xx)
IL (1)	IL157641A0 (xx)
MX (1)	MXPA03008572A (xx)
NO (1)	NO20034170L (xx)
NZ (1)	NZ527901A (xx)
PE (1)	PE20020970A1 (xx)
PL (1)	PL363804A1 (xx)
SK (1)	SK11672003A3 (xx)
TW (1)	TWI248936B (xx)
WO (2)	WO2002074772A1 (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0117277D0 (en)	2001-07-16	2001-09-05	Merck Sharp & Dohme	Therapeutic agents
GB0128499D0 (en) *	2001-11-28	2002-01-23	Merck Sharp & Dohme	Therapeutic agents
GB0226462D0 (en) *	2002-11-13	2002-12-18	Merck Sharp & Dohme	Therapeutic agents
PT1648899E (pt) *	2003-07-25	2007-03-30	Neurogen Corp	Imidazo-pirimidinas e triazolo-pirimidinas: ligandos do receptor de benzodiazepina
PL2121687T3 (pl)	2006-12-22	2016-03-31	Astex Therapeutics Ltd	Pochodne amin tricyklicznych jako inhibitory białkowej kinazy tyrozynowej
JP5442448B2 (ja)	2006-12-22	2014-03-12	アステックス、セラピューティックス、リミテッド	Ｆｇｆｒインヒビターとしての二環式ヘテロ環式化合物
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
NZ623384A (en) *	2009-10-16	2016-06-24	Melinta Therapeutics Inc	Antimicrobial compounds and methods of making and using the same
DK2488532T3 (en)	2009-10-16	2018-08-13	Melinta Therapeutics Inc	ANTIMICROBIAL COMPOUNDS AND PROCEDURES FOR PREPARING AND USING THE SAME
CA2777741A1 (en)	2009-10-16	2011-04-21	Rib-X Pharmaceuticals, Inc.	Antimicrobial compounds and methods of making and using the same
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
CN102898315B (zh) *	2012-11-05	2015-01-28	上海毕得医药科技有限公司	3-乙炔基-4-氟苯胺的制备方法
SG11201601654TA (en)	2013-09-09	2016-04-28	Melinta Therapeutics Inc	Antimicrobial compunds and methods of making and using the same
CA2923179A1 (en)	2013-09-09	2015-03-12	Melinta Therapeutics, Inc.	Antimicrobial compounds and methods of making and using the same
AU2016228584A1 (en)	2015-03-11	2017-10-05	Melinta Therapeutics, Inc.	Antimicrobial compounds and methods of making and using the same
WO2017098367A1 (en) *	2015-12-10	2017-06-15	Pfizer Limited	4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
EP3407886A1 (en)	2016-01-27	2018-12-05	Universität Zürich	Use of gabaa receptor modulators for treatment of itch
JP2019515041A (ja)	2016-05-06	2019-06-06	メリンタセラピューティクス、インコーポレイテッドＭｅｌｉｎｔａＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	抗菌剤ならびにそれを作製および使用する方法
BR112020021104A2 (pt) *	2018-04-18	2021-02-23	Neurocycle Therapeutics, Inc	compostos moduladores alostéricos positivos gabaa, métodos de produção e usos dos mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5185446A (en) *	1990-09-04	1993-02-09	Neurogen Corporation	Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
CA2218552C (en) *	1995-04-21	2002-04-16	Neurosearch A/S	Benzimidazole compounds and their use as modulators of the gabaa receptor complex
PA8535601A1 (es) *	2000-12-21	2002-11-28	Pfizer	Derivados benzimidazol y piridilimidazol como ligandos para gabaa

2002
- 2002-03-12 TW TW091104588A patent/TWI248936B/zh active
- 2002-03-19 EE EEP200300455A patent/EE200300455A/xx unknown
- 2002-03-19 DE DE60205101T patent/DE60205101T2/de not_active Expired - Lifetime
- 2002-03-19 AU AU2002241138A patent/AU2002241138B2/en not_active Ceased
- 2002-03-19 PE PE2002000211A patent/PE20020970A1/es not_active Application Discontinuation
- 2002-03-19 BR BR0207994-1A patent/BR0207994A/pt not_active IP Right Cessation
- 2002-03-19 SK SK1167-2003A patent/SK11672003A3/sk not_active Application Discontinuation
- 2002-03-19 JP JP2002573781A patent/JP4409174B2/ja not_active Expired - Fee Related
- 2002-03-19 MX MXPA03008572A patent/MXPA03008572A/es unknown
- 2002-03-19 CA CA2461426A patent/CA2461426C/en not_active Expired - Fee Related
- 2002-03-19 CN CNB028070577A patent/CN1294133C/zh not_active Expired - Fee Related
- 2002-03-19 PL PL02363804A patent/PL363804A1/xx not_active Application Discontinuation
- 2002-03-19 KR KR10-2003-7012252A patent/KR20030083001A/ko not_active Application Discontinuation
- 2002-03-19 NZ NZ527901A patent/NZ527901A/en unknown
- 2002-03-19 EA EA200301037A patent/EA006234B1/ru not_active IP Right Cessation
- 2002-03-19 EP EP02706976A patent/EP1381606B1/en not_active Expired - Lifetime
- 2002-03-19 IL IL15764102A patent/IL157641A0/xx unknown
- 2002-03-19 HU HU0303630A patent/HUP0303630A3/hu unknown
- 2002-03-19 AT AT02706976T patent/ATE299882T1/de not_active IP Right Cessation
- 2002-03-19 WO PCT/GB2002/001351 patent/WO2002074772A1/en not_active Application Discontinuation
- 2002-03-19 WO PCT/GB2002/001352 patent/WO2002074773A1/en not_active Application Discontinuation
- 2002-03-19 ES ES02706976T patent/ES2244752T3/es not_active Expired - Lifetime
- 2002-03-19 CZ CZ20032539A patent/CZ20032539A3/cs unknown
2003
- 2003-09-09 BG BG108166A patent/BG108166A/xx unknown
- 2003-09-19 NO NO20034170A patent/NO20034170L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2004523584A (ja)	2004-08-05
AU2002241138B2 (en)	2007-09-20
TWI248936B (en)	2006-02-11
EP1381606A1 (en)	2004-01-21
EE200300455A (et)	2003-12-15
DE60205101D1 (de)	2005-08-25
BR0207994A (pt)	2004-03-02
WO2002074772A1 (en)	2002-09-26
HUP0303630A2 (hu)	2004-03-01
EP1381606B1 (en)	2005-07-20
PE20020970A1 (es)	2002-11-01
EA006234B1 (ru)	2005-10-27
CZ20032539A3 (en)	2004-03-17
PL363804A1 (en)	2004-11-29
NO20034170L (no)	2003-11-19
DE60205101T2 (de)	2006-05-24
MXPA03008572A (es)	2003-12-08
KR20030083001A (ko)	2003-10-23
CN1498218A (zh)	2004-05-19
CA2461426A1 (en)	2002-09-26
JP4409174B2 (ja)	2010-02-03
CN1294133C (zh)	2007-01-10
NZ527901A (en)	2005-09-30
WO2002074773A1 (en)	2002-09-26
CA2461426C (en)	2010-08-03
ATE299882T1 (de)	2005-08-15
IL157641A0 (en)	2004-03-28
SK11672003A3 (sk)	2004-05-04
HUP0303630A3 (en)	2005-06-28
EA200301037A1 (ru)	2004-04-29
ES2244752T3 (es)	2005-12-16
NO20034170D0 (no)	2003-09-19

Publication	Publication Date	Title
BG108166A (en)	2004-09-30	Imidazo-pyrimidine derivatives as liigands for gaba receptors
AU1253002A (en)	2002-05-21	Imidazo-triazine derivatives as ligands for gaba receptors
WO2001038326A3 (en)	2002-05-10	Imidazo-pyridine derivatives as ligands for gaba receptors
ATE310002T1 (de)	2005-12-15	Imidazotriazin-derivate als gaba-rezeptor- liganden
GB0212048D0 (en)	2002-07-03	Therapeutic agents
ATE338758T1 (de)	2006-09-15	Imidazopyrimidin-derivate als liganden für gaba- rezeptoren
BG103112A (en)	1999-09-30	Substituted triazolo-pyuridazin derivatives as ligands for gaba receptors
DE60307462D1 (de)	2006-09-21	8-fluorimidazo(1,2-a)pyridin derivative als liganden für gaba rezeptoren
CA2410037A1 (en)	2001-11-29	3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
EA200000783A1 (ru)	2000-12-25	Производные триазолопиридазина в качестве лигандов для гамк рецепторов
ATE253066T1 (de)	2003-11-15	Imidazotriazinderivate als gaba rezeptor-liganden
DE69911374D1 (de)	2003-10-23	Triazolopiridazinederivate als gaba rezeptor-liganden
ATE420867T1 (de)	2009-01-15	Phenylpyridazin derivative als liganden für gaba- rezeptoren
TW200609218A (en)	2006-03-16	Bicyclic compounds
JO2312B1 (en)	2005-09-12	Imidazo-pyrimidine derivatives as associative groups of JABA receptors
WO2005021562A3 (en)	2005-06-16	Phospinite-imidazolines and metal complexes thereof
EA200200378A2 (ru)	2002-10-31	НОВЫЙ СПОСОБ СИНТЕЗА (3aS)-5,5-ДИОКСО-2,3,3а,4-ТЕТРАГИДРО-1H-ПИРРОЛО[2,1-c][1,2,4]БЕНЗОТИАДИАЗИНА
CA2260774A1 (en)	1998-02-05	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
PE44299A1 (es)	1999-05-06	Derivados sustituidos de triazolo-piridacina como ligandos para receptores gaba
DK0746556T3 (da)	2002-12-16	Tricycliske forbindelser med affinitet for 5-HT1A-receptoren
MXPA03006718A (es)	2004-05-31	Nuevos polimeros basados en ligandos de n-carbamil-n'- dimetilsilil metil-piperacina sin trazas para sintesis en fase solida de bibliotecas basadas en fenilo.
CO5050329A1 (es)	2001-06-27	Nuevos derivados de tetrahidroisoquinoleina y procedimientos para su preparacion