NO148290C - Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive polyenforbindelser - Google Patents

Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive polyenforbindelser

Info

Publication number: NO148290C
Authority: NO; Norway
Prior art keywords: preparation; therapeutically active; polyene compounds; new therapeutically; analogy procedure
Prior art date: 1977-05-04

Application number

NO781586A

Other languages

English (en)

Other versions

NO781586L (no

NO148290B (no

Inventor

Peter Loeliger

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-05-04

Filing date

1978-05-03

Publication date

1983-09-14

1978-05-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1978-11-07 Publication of NO781586L publication Critical patent/NO781586L/no

1983-06-06 Publication of NO148290B publication Critical patent/NO148290B/no

1983-09-14 Publication of NO148290C publication Critical patent/NO148290C/no

Links

-1 POLYENE COMPOUNDS Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO781586A 1977-05-04 1978-05-03 Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive polyenforbindelser NO148290C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
LU77254A LU77254A1 (no)	1977-05-04	1977-05-04

Publications (3)

Publication Number	Publication Date
NO781586L NO781586L (no)	1978-11-07
NO148290B NO148290B (no)	1983-06-06
NO148290C true NO148290C (no)	1983-09-14

Family

ID=19728555

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO781586A NO148290C (no)	1977-05-04	1978-05-03	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive polyenforbindelser

Country Status (32)

Country	Link
US (1)	US4193931A (no)
JP (1)	JPS53137940A (no)
AR (1)	AR220704A1 (no)
AT (1)	AT356647B (no)
AU (1)	AU522598B2 (no)
BE (1)	BE866651A (no)
BR (1)	BR7802807A (no)
CA (1)	CA1114830A (no)
CH (2)	CH641755A5 (no)
CS (1)	CS214853B2 (no)
CU (1)	CU21105A (no)
DE (1)	DE2819213A1 (no)
DK (1)	DK155730C (no)
ES (2)	ES469394A1 (no)
FI (1)	FI66587C (no)
FR (1)	FR2390428A1 (no)
GB (2)	GB1600914A (no)
GR (1)	GR74426B (no)
HU (1)	HU183088B (no)
IE (1)	IE46946B1 (no)
IL (2)	IL54590A (no)
IT (1)	IT1096278B (no)
LU (1)	LU77254A1 (no)
MC (1)	MC1193A1 (no)
MY (1)	MY8500250A (no)
NL (1)	NL7804773A (no)
NO (1)	NO148290C (no)
NZ (1)	NZ187114A (no)
PH (1)	PH14216A (no)
PT (1)	PT67988B (no)
SE (1)	SE436644B (no)
ZA (1)	ZA782415B (no)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4216312A (en)	1978-08-24	1980-08-05	Hoffmann-La Roche Inc.	Furyl substituted polyenes
FI67386C (fi) *	1979-06-21	1985-03-11	Hoffmann La Roche	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat
CH651007A5 (de) *	1982-06-24	1985-08-30	Hoffmann La Roche	Polyenverbindungen.
DK158947C (da) *	1982-07-06	1991-01-21	Hoffmann La Roche	Tetrahydronaphthalin-,benzofuran- og benzothiophenderivater, fremstilling og anvendelse deraf samt rodenticid indeholdende saadanne derivater
US4529600A (en) *	1982-09-09	1985-07-16	Sri International	Pentadeuterioretinoids
US4439614A (en) *	1982-09-22	1984-03-27	Sri International	5,6-Methano-5,6-dihydroretinoids
US4464389A (en) *	1982-10-20	1984-08-07	Sri International	Esters of retinoic acid and pentaerythritol and monobenzal acetals thereof
US4539154A (en) *	1983-06-15	1985-09-03	Hoffmann-La Roche Inc.	Polyene compounds
CH661516A5 (de) *	1983-12-08	1987-07-31	Hoffmann La Roche	Phenylnonatetraenoylzuckerderivate.
CH667868A5 (fr) *	1984-09-05	1988-11-15	Oreal	Derives du benzonorbornene, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant.
FR2580277B1 (fr) *	1985-04-15	1988-06-10	Oreal	Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant
US5030765A (en) *	1986-05-23	1991-07-09	Hoffmann-La Roche Inc.	Novel tetrahydronaphthalene and indane derivatives
ZW7487A1 (en) *	1986-05-23	1987-12-16	Hoffmann La Roche	Tetrahydronaphthaline and indane derivatives
US5030764A (en) *	1986-05-23	1991-07-09	Hoffmann-La Roche Inc.	Novel tetrahydronaphthalene and indane derivatives
AT388728B (de) *	1987-03-17	1989-08-25	Hoffmann La Roche	Neue tetrahydronaphthalin- und indanderivate
US5250562A (en) *	1988-02-24	1993-10-05	Hoffmann-La Roche Inc.	Stilbene derivatives
US5248696A (en) *	1991-04-18	1993-09-28	World Research Institute For Science And Technology, Inc.	Composition and method for treating tumors
US7655699B1 (en)	1992-04-22	2010-02-02	Eisai Inc.	Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) *	1992-04-22	1998-07-14	Ligand Pharmaceuticals Incorporated	Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
CA2129773C (en) *	1993-09-02	2007-05-01	Michael Klaus	Aromatic carboxylic acid derivatives
FR2719041B1 (fr) *	1994-04-26	1996-05-31	Cird Galderma	Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
ATE192731T1 (de) *	1994-12-30	2000-05-15	Ligand Pharm Inc	Retinoid trienverbindungen und verfahren
US7115728B1 (en) *	1995-01-30	2006-10-03	Ligand Pharmaceutical Incorporated	Human peroxisome proliferator activated receptor γ
PT873295E (pt)	1995-10-06	2003-08-29	Ligand Pharm Inc	Moduladores de rxr selectivos para dimeros para a sua utilizacao
US6112489A (en) *	1995-12-12	2000-09-05	Monotech International, Inc.	Monocoque concrete structures
AU4080597A (en) *	1996-08-23	1998-03-06	Board Of Regents For Oklahoma State University, The	Heteroarotinoids-anticancer agents with receptor specificity and tgase activity
FR2752837B1 (fr) *	1996-09-02	1999-11-12	Cird Galderma	Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie
AU8588798A (en)	1997-07-25	1999-02-16	Institut Pasteur	Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor
US6534545B1 (en)	1997-09-25	2003-03-18	Galderma Research & Development	Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics
FR2768731B1 (fr) *	1997-09-25	1999-12-10	Cird Galderma	Derives insatures en position -4 du 6-tert-butyl-1,1- dimethylindane et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
WO1999063980A1 (en) *	1998-06-12	1999-12-16	Ligand Pharmaceuticals Inc.	Treatment of anti-estrogen resistant breast cancer using rxr modulators
US6566372B1 (en) *	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
CZ2002711A3 (cs)	1999-08-27	2003-11-12	Ligand Pharmaceuticals Incorporated	Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití
JP2003508397A (ja)	1999-08-27	2003-03-04	リガンド・ファーマシューティカルズ・インコーポレイテッド	アンドロゲンレセプターモジュレーターとしての８−置換−６−トリフルオロメチル−９−ピリド［３，２−ｇ］キノリン化合物
EP1216221A2 (en)	1999-09-14	2002-06-26	Ligand Pharmaceuticals Incorporated	Rxr modulators with improved pharmacologic profile
US7312247B2 (en)	2001-03-27	2007-12-25	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US6495719B2 (en)	2001-03-27	2002-12-17	Circagen Pharmaceutical	Histone deacetylase inhibitors
US7057057B2 (en) *	2002-05-22	2006-06-06	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
US8026280B2 (en)	2001-03-27	2011-09-27	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7842727B2 (en) *	2001-03-27	2010-11-30	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US6586460B1 (en)	2001-04-02	2003-07-01	The Board Of Regents For Oklahoma State University	Heteroarotinoids containing urea or thiourea linker
WO2004046104A2 (en) *	2002-11-20	2004-06-03	Errant Gene Therapeutics, Llc	Treatment of lung cells with histone deacetylase inhibitors
US9050310B2 (en) *	2004-06-25	2015-06-09	Minas Theodore Coroneo	Treatment of ocular lesions
US20060160902A1 (en) *	2004-11-08	2006-07-20	Wiech Norbert L	Histone deacetylase inhibitors
US20060204474A1 (en) *	2005-02-25	2006-09-14	Coroneo Minas T	Treatment of epithelial layer lesions
WO2012076842A1 (en) *	2010-12-09	2012-06-14	University Of Durham	Synthetic retinoids for control of cell differentiation
US11045441B2 (en)	2015-10-13	2021-06-29	Wisconsin Alumni Research Foundation	Use of retinoic acid and analogs thereof to treat central neural apneas
US10980725B2 (en) *	2017-09-28	2021-04-20	Johnson & Johnson Consumer Inc.	Cosmetic compositions and method of treating the skin
US10966948B2 (en)	2019-07-23	2021-04-06	Johnson & Johnson Surgical Vision, Inc.	Compositions and methods for treating the eye
CA3107707A1 (en)	2018-07-27	2020-01-30	Johnson & Johnson Surgical Vision, Inc.	Compositions and methods for treating the eye
US11197841B2 (en)	2019-07-23	2021-12-14	Johnson & Johnson Surgical Vision, Inc.	Compositions and methods for treating the eye
US11969454B2 (en)	2019-11-19	2024-04-30	Johnson & Johnson Surgical Vision, Inc.	Compositions and methods for treating the eye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3452085A (en) *	1966-02-11	1969-06-24	Carbo Erba Spa	Alpha-(5-indanyl)-butyric acid
US3781314A (en) *	1971-07-14	1973-12-25	Hoffmann La Roche	Polyene compounds
BE793108A (fr) *	1971-12-22	1973-06-21	Hoffmann La Roche	Derives polyeniques
US3957836A (en) *	1973-07-02	1976-05-18	Takeda Chemical Industries, Ltd.	Quinone derivatives
CH582668A5 (no) *	1973-08-10	1976-12-15	Hoffmann La Roche
CH585709A5 (no) *	1973-08-24	1977-03-15	Hoffmann La Roche
CH592598A5 (no) *	1973-10-30	1977-10-31	Hexachimie
AR206620A1 (es) *	1974-02-07	1976-08-06	Hexachimie	Procedimiento para preparar acidos 5-indanilaceticos
FR2276035A1 (fr) *	1974-06-28	1976-01-23	Lipha	Nouveaux derives de l'indane
US4054589A (en) *	1974-09-26	1977-10-18	Hoffmann-La Roche Inc.	Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters
JPS51125235A (en) *	1974-09-26	1976-11-01	Hoffmann La Roche	Preparation of polyene compounds

1977
- 1977-05-04 LU LU77254A patent/LU77254A1/xx unknown
1978
- 1978-03-30 CH CH340578A patent/CH641755A5/de not_active IP Right Cessation
- 1978-04-13 CA CA301,052A patent/CA1114830A/en not_active Expired
- 1978-04-20 FI FI781227A patent/FI66587C/fi not_active IP Right Cessation
- 1978-04-24 US US05/899,427 patent/US4193931A/en not_active Expired - Lifetime
- 1978-04-27 IL IL54590A patent/IL54590A/xx unknown
- 1978-04-27 ZA ZA00782415A patent/ZA782415B/xx unknown
- 1978-04-28 NZ NZ187714A patent/NZ187114A/xx unknown
- 1978-05-01 IE IE864/78A patent/IE46946B1/en unknown
- 1978-05-02 JP JP5241878A patent/JPS53137940A/ja active Granted
- 1978-05-02 DE DE19782819213 patent/DE2819213A1/de active Granted
- 1978-05-02 MC MC781300A patent/MC1193A1/xx unknown
- 1978-05-02 FR FR7812933A patent/FR2390428A1/fr active Granted
- 1978-05-03 GB GB17478/78A patent/GB1600914A/en not_active Expired
- 1978-05-03 NO NO781586A patent/NO148290C/no unknown
- 1978-05-03 AT AT320478A patent/AT356647B/de not_active IP Right Cessation
- 1978-05-03 PT PT67988A patent/PT67988B/pt unknown
- 1978-05-03 ES ES469394A patent/ES469394A1/es not_active Expired
- 1978-05-03 NL NL7804773A patent/NL7804773A/xx not_active Application Discontinuation
- 1978-05-03 PH PH21098A patent/PH14216A/en unknown
- 1978-05-03 GB GB5961/80A patent/GB1600915A/en not_active Expired
- 1978-05-03 HU HU78HO2072A patent/HU183088B/hu not_active IP Right Cessation
- 1978-05-03 DK DK195378A patent/DK155730C/da not_active IP Right Cessation
- 1978-05-03 SE SE7805136A patent/SE436644B/sv not_active IP Right Cessation
- 1978-05-03 BE BE187341A patent/BE866651A/xx not_active IP Right Cessation
- 1978-05-04 CS CS782858A patent/CS214853B2/cs unknown
- 1978-05-04 AU AU35762/78A patent/AU522598B2/en not_active Expired
- 1978-05-04 GR GR56136A patent/GR74426B/el unknown
- 1978-05-04 CU CU7834913A patent/CU21105A/es unknown
- 1978-05-04 BR BR7802807A patent/BR7802807A/pt unknown
- 1978-05-04 AR AR272036A patent/AR220704A1/es active
- 1978-05-04 IT IT23003/78A patent/IT1096278B/it active
- 1978-11-20 ES ES475240A patent/ES475240A1/es not_active Expired
1980
- 1980-12-12 IL IL61697A patent/IL61697A0/xx unknown
1983
- 1983-02-11 CH CH78683A patent/CH642380A5/de not_active IP Right Cessation
1985
- 1985-12-30 MY MY250/85A patent/MY8500250A/xx unknown

Also Published As

Publication number	Publication date
IL54590A (en)	1982-02-28
CH642380A5 (de)	1984-04-13
DK155730B (da)	1989-05-08
IE46946B1 (en)	1983-11-16
GB1600915A (en)	1981-10-21
HU183088B (en)	1984-04-28
IE780864L (en)	1978-11-04
BR7802807A (pt)	1979-01-02
CS214853B2 (en)	1982-06-25
DK195378A (da)	1978-11-05
GR74426B (no)	1984-06-28
AT356647B (de)	1980-05-12
CA1114830A (en)	1981-12-22
PT67988A (en)	1978-06-01
US4193931A (en)	1980-03-18
NO781586L (no)	1978-11-07
AU522598B2 (en)	1982-06-17
LU77254A1 (no)	1979-01-18
NO148290B (no)	1983-06-06
MC1193A1 (fr)	1979-02-23
ES475240A1 (es)	1979-05-16
JPS6332777B2 (no)	1988-07-01
SE436644B (sv)	1985-01-14
FI781227A (fi)	1978-11-05
NL7804773A (nl)	1978-11-07
NZ187114A (en)	1980-11-14
IT7823003A0 (it)	1978-05-04
PT67988B (en)	1980-05-05
CH641755A5 (de)	1984-03-15
ES469394A1 (es)	1979-02-01
CU21105A (es)	1981-12-04
FR2390428A1 (fr)	1978-12-08
IL54590A0 (en)	1978-07-31
BE866651A (fr)	1978-11-03
ZA782415B (en)	1979-04-25
JPS53137940A (en)	1978-12-01
FR2390428B1 (no)	1983-03-04
IL61697A0 (en)	1981-01-30
FI66587C (fi)	1984-11-12
DE2819213C2 (no)	1987-09-24
DE2819213A1 (de)	1978-11-16
IT1096278B (it)	1985-08-26
GB1600914A (en)	1981-10-21
DK155730C (da)	1989-10-02
MY8500250A (en)	1985-12-31
FI66587B (fi)	1984-07-31
PH14216A (en)	1981-04-02
AU3576278A (en)	1979-11-08
AR220704A1 (es)	1980-11-28
SE7805136L (sv)	1978-11-05
ATA320478A (de)	1979-10-15

Publication	Publication Date	Title
NO148290C (no)	1983-09-14	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive polyenforbindelser
NO149174C (no)	1984-02-29	Analogifremgangsmaate ved fremstilling av nye terapeutisk virksomme tiazinderivater
NO147148C (no)	1983-02-09	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive fenyletanolaminderivater
NO151085C (no)	1985-02-06	Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive peptidylargininaldehydderivater
NO149962C (no)	1984-07-25	Analogifremgangsmaate ved fremstilling av terapeutisk aktive imidazolderivater
NO149662C (no)	1984-05-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive c-076-forbindelser
NO153136C (no)	1986-01-22	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive naftyridinderivater.
NO150206C (no)	1984-09-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive hoeyredreiende spiro-hydantoinforbindelser
NO150800C (no)	1984-12-27	Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser
NO160211C (no)	1989-03-22	Analogifremgangsmaate til fremstilling av nye terapeutisk virksomme cefemderivater.
NO152841C (no)	1985-11-27	Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye 4-aroylimidazol-2-oner.
NO145307C (no)	1982-02-24	Analogifremgangsmaate ved fremstilling av nye terapeutisk virksomme nucleosider
NO148848C (no)	1983-12-28	Analogifremgangsmaate ved fremstilling av nye antibiotisk aktive spiroimidazolidin-rifamyciner
NO149733C (no)	1984-06-13	Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive acylderivater av carnitin
NO146392C (no)	1982-09-22	Analogifremgangsmaate ved fremstilling av nye analgesisk aktive n-acetyl-para-aminofenyl-n`-acetyl-aminoalkansyreester-derivater
NO147560C (no)	1983-05-04	Analogifremgangsmaate ved fremstilling av terapeutisk aktive indanyl-derivater
NO148642C (no)	1983-11-16	Analogifremgangsmaate ved fremstilling av terapeutisk aktive, nye prostacyclinderivater
NO147953C (no)	1983-07-20	Analogifremgangsmaate ved fremstilling av terapeutisk aktive antracyklinglukosider
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