MX366596B - Compuestos y sus sales especificas de receptores de ppar y egf y su uso en el campo medico. - Google Patents

Compuestos y sus sales especificas de receptores de ppar y egf y su uso en el campo medico.

Info

Publication number
MX366596B
MX366596B MX2013012753A MX2013012753A MX366596B MX 366596 B MX366596 B MX 366596B MX 2013012753 A MX2013012753 A MX 2013012753A MX 2013012753 A MX2013012753 A MX 2013012753A MX 366596 B MX366596 B MX 366596B
Authority
MX
Mexico
Prior art keywords
receptors
compounds
medical field
ppar
egf
Prior art date
Application number
MX2013012753A
Other languages
English (en)
Inventor
Baroni Sergio
Naccari Giancarlo
Original Assignee
Nogra Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37579831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX366596(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nogra Pharma Ltd filed Critical Nogra Pharma Ltd
Publication of MX366596B publication Critical patent/MX366596B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se refiere a los compuestos que comprenden la formula general (I), en la cual R1 y R2, los cuales pueden ser idénticos o diferentes, son seleccionados del grupo que comprende -H o un grupo de alquilo lineal o ramificado que tiene desde 1 a 6 átomos de carbono o juntos forman un anillo aromático o alifático con 5 o 6 átomos; Y e Z, los cuales pueden ser idénticos o diferentes, son seleccionados del grupo que comprende -H, -OH, -COOH, -0R3, -CH(OR3)COOH, en el cual R3 es seleccionado de H, fenilo, bencilo, -CF3 o -CF2CF3, vinilo, alilo y un grupo de alquilo lineal o ramificado que tiene desde 1 a 6 átomos de carbono.
MX2013012753A 2005-07-22 2006-07-24 Compuestos y sus sales especificas de receptores de ppar y egf y su uso en el campo medico. MX366596B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000389A ITRM20050389A1 (it) 2005-07-22 2005-07-22 Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
PCT/IE2006/000078 WO2007010516A2 (en) 2005-07-22 2006-07-24 Compounds and their salts specific to the ppar receptors and the egf receptors and their use in the medical field

Publications (1)

Publication Number Publication Date
MX366596B true MX366596B (es) 2019-07-15

Family

ID=37579831

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012753A MX366596B (es) 2005-07-22 2006-07-24 Compuestos y sus sales especificas de receptores de ppar y egf y su uso en el campo medico.

Country Status (23)

Country Link
US (6) US8153841B2 (es)
EP (1) EP1910270B3 (es)
JP (1) JP5312026B2 (es)
KR (1) KR101317519B1 (es)
CN (2) CN102020577B (es)
AU (1) AU2006271165C1 (es)
CA (1) CA2616146C (es)
CY (1) CY1114294T1 (es)
DK (1) DK1910270T6 (es)
EA (2) EA014665B3 (es)
ES (1) ES2421260T7 (es)
HR (1) HRP20130549T4 (es)
IL (2) IL188878A (es)
IT (1) ITRM20050389A1 (es)
MX (1) MX366596B (es)
NO (1) NO340680B1 (es)
NZ (2) NZ566045A (es)
PL (1) PL1910270T6 (es)
PT (1) PT1910270E (es)
SI (1) SI1910270T1 (es)
UA (1) UA100359C2 (es)
WO (1) WO2007010516A2 (es)
ZA (2) ZA200801671B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20050390A1 (it) * 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
IE20070129A1 (en) * 2007-02-28 2008-12-24 Giuliani Int Ltd Ppar-gamma agonists stimulate enteric defensin expression
ITMI20072429A1 (it) 2007-12-24 2009-06-25 Giuliani Int Ltd Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
EP2396081B1 (en) * 2009-02-16 2017-04-05 Nogra Pharma Limited Alkylamido compounds and uses thereof
CA2800521A1 (en) 2010-05-24 2011-12-01 Toa Eiyo Ltd. Fused imidazole derivative
US9682923B2 (en) * 2012-02-09 2017-06-20 Nogra Pharma Limited Methods of treating fibrosis
MX2014012652A (es) * 2012-04-18 2014-11-25 Nogra Pharma Ltd Metodo de tratamiento de la intolerancia a la lactosa.
FR2996545B1 (fr) 2012-10-08 2016-03-25 Ecole Polytech Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant.
WO2015141851A1 (ja) * 2014-03-20 2015-09-24 京セラ株式会社 ユーザ端末、通信制御方法及び基地局
WO2017093444A1 (en) * 2015-12-01 2017-06-08 Nogra Pharma Limited Compositions for oral administration in the treatment of inflammatory bowel disease
US20220000818A1 (en) 2019-01-25 2022-01-06 Nogra Pharma Limited Compositions for use in preventing acne
BR112021015609A2 (pt) * 2019-02-08 2021-10-05 Nogra Pharma Limited Processo de fabricação de ácido 3-(4?-aminofenil)-2-metoxipropiônico, e análogos e intermediários do mesmo

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB767788A (en) 1953-12-28 1957-02-06 Schering Corp Polyiodinated phenyl fatty acid compounds and process for their manufacture
US3211610A (en) * 1961-09-29 1965-10-12 Merck & Co Inc Benzoic acid ester derivatives for treating coccidiosis and method of using same
US3444232A (en) * 1966-05-18 1969-05-13 Squibb & Sons Inc O-alkyl or phenylalkyl benzohydroxamic acids
GB1359560A (en) 1972-02-25 1974-07-10 Merck & Co Inc Preparation of pyrrylsalicylic acid
US4036951A (en) * 1973-03-12 1977-07-19 Synergistics, Inc. Ultra-violet filtration with certain aminosalicylic acid esters
FR2440353A1 (fr) * 1978-11-03 1980-05-30 Science Union & Cie Nouveaux arylethanols, leurs procedes d'obtention et leur emploi comme medicament
US4348223A (en) * 1980-12-05 1982-09-07 Ppg Industries, Inc. N-Alkyl-N-[3-(alkoxyalkyl)phenyl]-2-haloacetamide herbicides
DE3164618D1 (en) * 1980-12-22 1984-08-09 Schering Ag 3-substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them
JPS58194814A (ja) 1982-05-11 1983-11-12 Nippon Shinyaku Co Ltd 免疫調節作用を有する薬剤
IL69282A (en) 1982-09-02 1988-06-30 Euro Celtique Sa Method for the carboxylation of potassium phenoxide with carbon dioxide
DE3786452T2 (de) * 1987-02-05 1993-10-21 Kureha Chemical Ind Co Ltd Benzylether-Verbindungen und Verfahren zu ihrer Herstellung.
NZ224087A (en) 1987-04-01 1990-08-28 Dak Lab As Topical pharmaceutical compositions containing 4- or 5- amino salicylic acid or a functional derivative thereof
EP0352826B1 (en) 1988-05-05 1994-10-26 Tillotts Pharma Ag Use of 5-aminosalicylic acid in the treatment of dermatological disorders
WO1992006690A1 (en) 1990-10-22 1992-04-30 Borody Thomas J Treatment of non-inflammatory and non-infectious bowel disorders
US5519014A (en) * 1990-10-22 1996-05-21 Borody; Thomas J. Treatment of non-inflammatory and non-infectious bowel disorders
US5262549A (en) * 1991-05-30 1993-11-16 Polaroid Corporation Benzpyrylium dyes, and processes for their preparation and use
US5302751A (en) 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
EP0604641B1 (en) 1992-06-30 2002-03-20 SHAPIRO, Howard, K. Use of a combination containing an amine or amine-related derivative of benzoic acid and an amino-polysaccharide in the manufacture of a medicament for the treatment of inflammatory diseases
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
CA2190107A1 (en) 1994-05-11 1995-11-23 Howard K. Shapiro Compositions for treatment of chronic inflammatory diseases
US5594015A (en) 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
JPH10511097A (ja) 1995-03-28 1998-10-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 低薬用量リドグレル調合物および炎症性腸疾患の処置のためのそれらの使用
US5939442A (en) * 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
GB9600464D0 (en) * 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
GB9617001D0 (en) 1996-08-13 1996-09-25 Tillotts Pharma Ag Oral composition
DE19647582A1 (de) 1996-11-18 1998-05-20 Hoechst Ag Verfahren zur Herstellung von aromatischen Olefinen mittels Katalyse durch Palladaphosphacyclobutane
AU6773598A (en) 1997-03-26 1998-10-20 Institut Pasteur Treatment of gastrointestinal disease with ppar modulators
US7098025B1 (en) * 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
WO1999015520A1 (fr) * 1997-09-19 1999-04-01 Ono Pharmaceutical Co., Ltd. Composes de benzene fusionnes ou non fusionnes
FR2773075B1 (fr) 1997-12-31 2000-05-05 Cird Galderma Utilisation d'activateurs de ppar-gamma en dermatologie
US6114382A (en) 1998-11-11 2000-09-05 Moretti; Itagiba G. Methods for treating inflammatory bowel disease
US6326364B1 (en) * 1999-02-08 2001-12-04 Cedars-Sinai Medical Center Use of 5-aminosalicylates as antimicrobial agents
FR2791671B1 (fr) 1999-04-01 2001-05-11 Oreal Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation
GB9908647D0 (en) 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel compounds
US20040034067A1 (en) * 1999-04-15 2004-02-19 Macphee Colin Houston Novel method of treatment
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
JP3854154B2 (ja) 2000-04-19 2006-12-06 ニューロテック カンパニー リミテッド 中枢神経系の急性及び慢性的損傷に起因した神経変性を防止するための化合物、組成物及び方法
DK1285908T3 (da) * 2000-05-29 2008-12-01 Kyorin Seiyaku Kk Substituerede phenylpropionsyrederivater
US7049342B2 (en) 2000-05-29 2006-05-23 Kyorin Pharmaceutical Co., Ltd. Substituted phenylpropionic acid derivatives
EP1642885B1 (en) * 2000-08-29 2009-11-11 Biocon Limited Use of a pharmaceutical composition containing a para-aminophenyl acetic acid derivative for treating inflammatory conditions of the gastrointestinal tract
CA2430846A1 (en) 2000-12-05 2002-06-13 Kyorin Pharmaceutical Co., Ltd. Substituted carboxylic acid derivatives
FR2822955B1 (fr) 2001-03-27 2003-10-03 Chru Lille Methode de diagnostic de maladies inflammatoires chroniques de l'intestin
CA2443935A1 (en) 2001-04-18 2002-10-31 Merck & Co., Inc. Ppar-alpha-gamma ligands or agonists for the treatment of inflammation
CA2354921A1 (en) 2001-05-24 2002-11-24 Yasuo Konishi Drug evolution: drug design at hot spots
HUP0401647A3 (en) * 2001-10-16 2008-05-28 Reddys Lab Ltd Dr Novel betha-phenyl-alpha-oxy propionic acid derivatives, processes for their preparation and their use in the preparation of pharmaceutically important compounds
GB0127916D0 (en) 2001-11-21 2002-01-16 Rowett Res Inst Method
UA82835C2 (en) * 2001-12-03 2008-05-26 Reddys Lab Ltd Dr ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
US20030113815A1 (en) * 2001-12-19 2003-06-19 Pfizer Inc. Canine peroxisome proliferator activated receptor gamma
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20040115127A1 (en) * 2002-04-12 2004-06-17 Wright Samuel D. Ppar-alpha-gamma ligands or agonists for the treatment of inflammation
US20060159648A1 (en) 2003-02-17 2006-07-20 Davis Adrian F Novel therapeutic method and compositions for topical administration
GB0303609D0 (en) 2003-02-17 2003-03-19 Glaxo Group Ltd Novel therapeutic method and compositions
JPWO2004082715A1 (ja) * 2003-03-20 2006-06-22 エーザイ株式会社 炎症性腸疾患治療剤としての併用医薬
WO2005012280A1 (en) 2003-07-21 2005-02-10 Applied Research Systems Ars Holding N.V. Alkynyl aryl carboxamides
US7749980B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Non-nucleotide compositions and method for treating pain
WO2005040102A2 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd. Novel compounds and their use as antidiabetic and hypolipidemic agents, process for their preparation and pharmaceutical compositions containing them
JP2007513173A (ja) 2003-12-03 2007-05-24 スミスクライン・ビーチャム・コーポレイション ロシグリタゾンを用いる乾癬の治療
CA2553775A1 (en) 2004-01-20 2005-08-11 Richard F. Harty Compositions and methods of treatment for inflammatory diseases
WO2005084658A1 (en) 2004-03-04 2005-09-15 Arakis Ltd. Derivatives of actarit and their therapeutic use
US20060286046A1 (en) 2005-01-05 2006-12-21 Haber C Andrew Skin care compositions
US20060270635A1 (en) * 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid
ITRM20050390A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
ITRM20050389A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
DE102005061472A1 (de) 2005-12-22 2007-07-05 Saltigo Gmbh Verfahren zur Herstellung von enantiomerenangereicherten 2-Alkoxy-3-phenylpropionsäuren
WO2007096148A1 (en) 2006-02-23 2007-08-30 Lipid Nutrition B.V. Immunoregulation
US7645801B2 (en) 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
IE20070129A1 (en) 2007-02-28 2008-12-24 Giuliani Int Ltd Ppar-gamma agonists stimulate enteric defensin expression
US20090054312A1 (en) 2007-08-22 2009-02-26 Wolf Dieter A SMIPs: Small molecule inhibitors of p27 depletion in cancers and other proliferative diseases
ITMI20072429A1 (it) 2007-12-24 2009-06-25 Giuliani Int Ltd Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca
US8030520B2 (en) 2008-03-31 2011-10-04 Saltigo Gmbh Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide
UA107562C2 (uk) 2008-12-05 2015-01-26 Спосіб лікування псоріазу
EP2396081B1 (en) 2009-02-16 2017-04-05 Nogra Pharma Limited Alkylamido compounds and uses thereof
EP2298321A1 (en) 2009-08-26 2011-03-23 Nordic Pharma Novel pharmaceutical compositions for treating IBD
US20140256661A1 (en) 2011-07-15 2014-09-11 David Nigel Armstrong Pharmaceutical compositions for rectal administration
ES2602075T3 (es) 2011-10-31 2017-02-17 Larsen, Claus Selch Profármacos de agentes antiinflamatorios no esteroideos (AINE)
US9682923B2 (en) 2012-02-09 2017-06-20 Nogra Pharma Limited Methods of treating fibrosis
MX2014012652A (es) 2012-04-18 2014-11-25 Nogra Pharma Ltd Metodo de tratamiento de la intolerancia a la lactosa.
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
MX2014014657A (es) 2012-06-01 2015-08-10 Nogra Pharma Ltd Heterociclos bicíclicos capaces de modular las respuestas de los linfocitos t, y métodos de uso de los mismos.
TR201809219T4 (tr) 2012-09-13 2018-07-23 Nogra Pharma Ltd Saç i̇le bağlantili durumlarin tedavi̇ edi̇lmesi̇ yöntemleri̇.
EP2897603A1 (en) 2012-09-13 2015-07-29 Nogra Pharma Limited Methods of inhibiting hair growth
US20180193361A1 (en) 2015-04-02 2018-07-12 University Health Network Gut anti-inflammatory agents for regulation of high blood glucose levels
MX2017016424A (es) 2015-06-15 2019-08-01 Nmd Pharma Aps Compuestos para su uso en el tratamiento de trastornos neuromusculares.

Also Published As

Publication number Publication date
JP2009502777A (ja) 2009-01-29
NO340680B1 (no) 2017-05-29
NZ592228A (en) 2012-10-26
DK1910270T6 (en) 2016-08-29
EA014665B1 (ru) 2010-12-30
ES2421260T3 (es) 2013-08-30
US20170312239A1 (en) 2017-11-02
US9345680B2 (en) 2016-05-24
PL1910270T6 (pl) 2017-05-31
US20150265563A1 (en) 2015-09-24
UA100359C2 (uk) 2012-12-25
KR20080039428A (ko) 2008-05-07
CN101243039B (zh) 2013-04-03
ITRM20050389A1 (it) 2007-01-23
HRP20130549T4 (hr) 2016-07-15
CN101243039A (zh) 2008-08-13
KR101317519B1 (ko) 2013-10-15
HRP20130549T1 (en) 2013-07-31
AU2006271165A1 (en) 2007-01-25
CN102020577A (zh) 2011-04-20
AU2006271165C1 (en) 2016-11-17
SI1910270T1 (sl) 2013-08-30
EP1910270A2 (en) 2008-04-16
BRPI0613396A2 (pt) 2011-01-11
ZA200801671B (en) 2011-02-23
WO2007010516A3 (en) 2007-03-29
NZ566045A (en) 2012-04-27
IL205992A (en) 2014-05-28
US9561202B2 (en) 2017-02-07
NO20080325L (no) 2008-04-16
JP5312026B2 (ja) 2013-10-09
US8710100B2 (en) 2014-04-29
US10016381B2 (en) 2018-07-10
CA2616146A1 (en) 2007-01-25
BRPI0613396A8 (pt) 2017-12-26
DK1910270T3 (da) 2013-07-01
CN102020577B (zh) 2013-03-13
EA017566B1 (ru) 2013-01-30
ES2421260T7 (es) 2016-10-11
EA200800372A1 (ru) 2008-06-30
EA014665B3 (ru) 2016-09-30
AU2006271165B2 (en) 2012-01-19
US20090048343A1 (en) 2009-02-19
EP1910270B3 (en) 2016-05-11
US20150265562A1 (en) 2015-09-24
US20130005813A1 (en) 2013-01-03
EA201000708A1 (ru) 2010-10-29
EP1910270B1 (en) 2013-05-08
CY1114294T1 (el) 2016-08-31
US20150045436A1 (en) 2015-02-12
ZA201008268B (en) 2012-04-25
WO2007010516A2 (en) 2007-01-25
IL188878A (en) 2013-04-30
CA2616146C (en) 2015-06-30
US8153841B2 (en) 2012-04-10
PL1910270T3 (pl) 2013-09-30
US9133099B2 (en) 2015-09-15
IL188878A0 (en) 2008-04-13
PT1910270E (pt) 2013-07-17

Similar Documents

Publication Publication Date Title
MX366596B (es) Compuestos y sus sales especificas de receptores de ppar y egf y su uso en el campo medico.
WO2007010514A3 (en) Compounds and their salts specific to the ppar receptors and the egf receptors and their use in the medical field
PH12015501098A1 (en) Antituberculous composition comprising oxazole compounds
GEP20125523B (en) Metabolites of (thio) carbamoyl-cyclohexane derivatives
MX2010001773A (es) Metodo para preparar derivados de 5-haloalquil-4,5-dihidroisoxasol .
TW200708605A (en) Aqueous abrasives dispersion medium composition
EA201100875A1 (ru) Новые пиразол-4-n-алкоксикарбоксамиды в качестве микробиоцидов
SG161302A1 (en) DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE ss2 ADRENERGIC RECEPTOR
MX2007010404A (es) Hidrazinometilo, hidrazonometilo y compuestos heterociclicos de 5 miembros que actuan como inhibidores de mtor y su uso como agentes anti-cancer.
TN2010000064A1 (en) Novel herbicides
CY1109835T1 (el) Πυρανονες χρησιμες ως αναστολεις της atm
RS54047B1 (en) PROCEDURE FOR OBTAINING 4-OXOCHINOLINE COMPOUNDS
MX2010001364A (es) Derivados de ciclopentandiona puenteados triciclicos como herbicidas.
UY29388A1 (es) Derivados del (1,5-difenil-h-pirazol-3-il)oxadiazol, su preparación y su aplicacion en terapéutica.
UA96947C2 (ru) Производные циннамоил-пиперазина и их применение как антагонистов par-1
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
AR075777A1 (es) Derivados de benzotiazina, su preparacion y aplicacion como farmacos para la inhibicion de 11beta-hidroxiesteroide deshidrogenasa tipo i (11betahsd1)
MX2009006552A (es) Derivados de 4-(1-amino-etil)-ciclohexilamina.
UA86077C2 (en) Cetp inhibitors
MX2010002246A (es) Nuevos herbicidas.
AR061628A1 (es) Composicion herbicida de fenoxialcanoato y metodo de preparacion y uso
MX2009005366A (es) Derivados de pirrol, su preparacion y su utilizacion en terapeutica.
MX2007010787A (es) Derivados de 1,2,4-triazinas, su preparacion y su aplicacion en terapia humana.
TW200606163A (en) Imidazopyridine compound
DK1023273T3 (da) Cyclohexanderivater, som er difunktionaliserede i 1,4, som ligander for 5-HT1A-receptorer