MX2009006552A - Derivados de 4-(1-amino-etil)-ciclohexilamina. - Google Patents

Derivados de 4-(1-amino-etil)-ciclohexilamina.

Info

Publication number
MX2009006552A
MX2009006552A MX2009006552A MX2009006552A MX2009006552A MX 2009006552 A MX2009006552 A MX 2009006552A MX 2009006552 A MX2009006552 A MX 2009006552A MX 2009006552 A MX2009006552 A MX 2009006552A MX 2009006552 A MX2009006552 A MX 2009006552A
Authority
MX
Mexico
Prior art keywords
sup
compounds
represent
ethyl
amino
Prior art date
Application number
MX2009006552A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Cornelia Zumbrunn Acklin
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39480472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009006552(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2009006552A publication Critical patent/MX2009006552A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se refiere a compuestos de fórmula I (ver fórmula (I)) en donde R0 representa H o OH; R1 representa alcoxi; U y W representan N, V representa CH y R2 representa H o F, o U y V representan CH, W representa N y R2 representa H o F, o U y V representan N, W representa CH y R2 representa H, o U representa N, V representa CH, W representa CRa y R2 representa H; Ra representa CH2OH o alcoxicarbonilo; A representa el grupo CH=CH-B o un sistema D heterocíclico binuclear, representando B un grupo fenilo mono- o di-sustituido en donde los sustituyentes son átomos de halógeno y D representa uno de los siguientes grupos (ver fórmula (II)) en donde Z representa CH o N, y Q representa O o S; (ver fórmula (III)) y a las sales de tales compuestos. Estos compuestos son útiles como agentes antibacterianos.
MX2009006552A 2006-12-22 2007-12-21 Derivados de 4-(1-amino-etil)-ciclohexilamina. MX2009006552A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2006055026 2006-12-22
IB2007052805 2007-07-13
PCT/IB2007/055281 WO2008078305A2 (en) 2006-12-22 2007-12-21 4-(1-amino-ethyl)-cyclohexylamine derivatives

Publications (1)

Publication Number Publication Date
MX2009006552A true MX2009006552A (es) 2009-06-26

Family

ID=39480472

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006552A MX2009006552A (es) 2006-12-22 2007-12-21 Derivados de 4-(1-amino-etil)-ciclohexilamina.

Country Status (15)

Country Link
US (1) US8044044B2 (es)
EP (1) EP2094267B1 (es)
JP (1) JP5755409B2 (es)
KR (1) KR101496894B1 (es)
CN (1) CN101563084B (es)
AR (1) AR064488A1 (es)
AU (1) AU2007337673B2 (es)
BR (1) BRPI0720684A8 (es)
CA (1) CA2670763C (es)
CL (1) CL2007003693A1 (es)
ES (1) ES2542148T3 (es)
MX (1) MX2009006552A (es)
RU (1) RU2460723C2 (es)
TW (1) TWI395584B (es)
WO (1) WO2008078305A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009104147A2 (en) 2008-02-20 2009-08-27 Actelion Pharmaceuticals Ltd Azatricyclic antibiotic compounds
JP5639581B2 (ja) * 2008-06-03 2014-12-10 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌剤としての［４−（１−アミノ−エチル）−シクロヘキシル］−メチル−アミン及び［６−（１−アミノ−エチル）−テトラヒドロ−ピラン−３−イル］−メチル−アミン誘導体
TWI415853B (zh) 2008-10-07 2013-11-21 Actelion Pharmaceuticals Ltd 三環唑啶酮抗生素化合物
TW201022279A (en) * 2008-11-14 2010-06-16 Astrazeneca Ab Chemical compounds
KR101322496B1 (ko) 2008-11-17 2013-10-29 에프. 호프만-라 로슈 아게 나프틸아세트산
WO2017019487A1 (en) 2015-07-24 2017-02-02 Celgene Corporation Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536725A (en) * 1993-08-25 1996-07-16 Fmc Corporation Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines
GB9821977D0 (en) 1998-10-08 1998-12-02 Smithkline Beecham Plc Compounds
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
DE10161940A1 (de) 2001-12-17 2003-07-03 Nad Ag N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
PL375525A1 (en) * 2002-10-10 2005-11-28 Morphochem Aktiengesellschaft Für Kombinatorischechemie Novel compounds with antibacterial activity
TW200427688A (en) * 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
CA2580621A1 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
JP5314244B2 (ja) * 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
ES2351613T3 (es) 2005-03-03 2011-02-08 Santen Pharmaceutical Co., Ltd. Nuevo compuesto cíclico que tiene un grupo quinolilalquiltio.
UA46692U (ru) * 2009-10-22 2009-12-25 Игорь Борисович Буркинский Способ предотвращения образования песочных пробок в нефтяных и газовых скважинах

Also Published As

Publication number Publication date
ES2542148T3 (es) 2015-07-31
KR20090104024A (ko) 2009-10-05
WO2008078305A2 (en) 2008-07-03
JP2010513468A (ja) 2010-04-30
RU2460723C2 (ru) 2012-09-10
CA2670763C (en) 2015-02-17
CN101563084A (zh) 2009-10-21
US8044044B2 (en) 2011-10-25
RU2009127852A (ru) 2011-01-27
TWI395584B (zh) 2013-05-11
US20100029623A1 (en) 2010-02-04
CA2670763A1 (en) 2008-07-03
AU2007337673A1 (en) 2008-07-03
BRPI0720684A8 (pt) 2017-12-26
TW200843754A (en) 2008-11-16
CN101563084B (zh) 2013-02-20
BRPI0720684A2 (pt) 2016-03-15
AR064488A1 (es) 2009-04-08
WO2008078305A3 (en) 2008-08-21
EP2094267A2 (en) 2009-09-02
JP5755409B2 (ja) 2015-07-29
CL2007003693A1 (es) 2008-06-27
AU2007337673B2 (en) 2013-06-20
EP2094267B1 (en) 2015-04-22
KR101496894B1 (ko) 2015-03-03

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