MX363110B - Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos. - Google Patents

Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos.

Info

Publication number
MX363110B
MX363110B MX2015001310A MX2015001310A MX363110B MX 363110 B MX363110 B MX 363110B MX 2015001310 A MX2015001310 A MX 2015001310A MX 2015001310 A MX2015001310 A MX 2015001310A MX 363110 B MX363110 B MX 363110B
Authority
MX
Mexico
Prior art keywords
deuterated
synthesis
oligonucleotides
nucleosides
protected phosphoramidites
Prior art date
Application number
MX2015001310A
Other languages
English (en)
Other versions
MX2015001310A (es
Inventor
C Srivastava Suresh
Yasko Amy
Original Assignee
Ased Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ased Llc filed Critical Ased Llc
Publication of MX2015001310A publication Critical patent/MX2015001310A/es
Publication of MX363110B publication Critical patent/MX363110B/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/353Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3531Hydrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a la síntesis de azúcares deuterados de alta pureza, fosforamiditas deuteradas, nucleobases deuteradas, nucleósidos deuterados, oligonucleótidos deuterados, y ARNs deuterados de secuencias definidas que pueden exhibir propiedades bioquímicamente útiles y biológicamente valiosas, teniendo de esta manera potencial para usos terapéuticos.
MX2015001310A 2012-07-31 2013-07-31 Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos. MX363110B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/563,343 US8859754B2 (en) 2012-07-31 2012-07-31 Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
PCT/US2013/053035 WO2014022566A2 (en) 2012-07-31 2013-07-31 Synthesis of deuterated ribo nucleosides, n-protected phosphoramidites, and oligonucleotides

Publications (2)

Publication Number Publication Date
MX2015001310A MX2015001310A (es) 2016-02-03
MX363110B true MX363110B (es) 2019-03-08

Family

ID=49326829

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001310A MX363110B (es) 2012-07-31 2013-07-31 Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos.

Country Status (10)

Country Link
US (2) US8859754B2 (es)
EP (1) EP2882769A2 (es)
JP (1) JP6799918B2 (es)
CN (2) CN104812770B (es)
AU (1) AU2013296508B2 (es)
CA (1) CA2880496C (es)
IL (1) IL236902B (es)
MX (1) MX363110B (es)
SG (1) SG11201500614XA (es)
WO (1) WO2014022566A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170247695A1 (en) 2014-10-17 2017-08-31 Celgene Corporation Isotopologues of smad7 antisense oligonucleotides
WO2016073756A1 (en) * 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Deuterated nucleoside/tide derivatives
US9732110B2 (en) 2014-12-05 2017-08-15 Enanta Pharmaceuticals, Inc. Nucleoside and nucleotide derivatives
US9430443B1 (en) * 2015-05-08 2016-08-30 Norwegian University Of Science And Technology Systematic coding technique
BR112019000061A2 (pt) 2016-07-05 2019-11-26 Biomarin Tech Bv comutação e modulação de splicing de pré-mrna compreendendo porções de arcabouço bicíclico, com características melhoradas para o tratamento de distúrbios genéticos
US20210009995A1 (en) 2018-02-13 2021-01-14 Ethris Gmbh Polyribonucleotide containing deuterated nucleotides
CN109134570B (zh) * 2018-09-20 2021-08-24 南开大学 C4′-氟代尿苷亚磷酰胺单体和c4′-氟代尿苷修饰rna的制备方法
US20220025368A1 (en) 2018-11-02 2022-01-27 Biomarin Technologies B.V. Bispecific antisense oligonucleotides for dystrophin exon skipping
CN115894458A (zh) * 2022-08-31 2023-04-04 合肥华纳生物医药科技有限公司 一种新型修饰核苷及其在核酸药物中的应用
GB202215614D0 (en) 2022-10-21 2022-12-07 Proqr Therapeutics Ii Bv Heteroduplex rna editing oligonucleotide complexes
WO2024110565A1 (en) 2022-11-24 2024-05-30 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of hereditary hfe-hemochromatosis
GB202218090D0 (en) 2022-12-01 2023-01-18 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency
WO2024121373A1 (en) 2022-12-09 2024-06-13 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of cardiovascular disease
GB202300865D0 (en) 2023-01-20 2023-03-08 Proqr Therapeutics Ii Bv Delivery of oligonucleotides
WO2024175550A1 (en) 2023-02-20 2024-08-29 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease
GB202304363D0 (en) 2023-03-24 2023-05-10 Proqr Therapeutics Ii Bv Chemically modified antisense oligonucleotides for use in RNA editing
WO2024206175A1 (en) 2023-03-24 2024-10-03 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of neurological disorders
WO2024200472A1 (en) 2023-03-27 2024-10-03 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of liver disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009253160B2 (en) * 2008-05-26 2015-03-05 Universitat Zurich Protamine/RNA nanoparticles for immunostimulation
EP2479182B8 (en) * 2009-09-16 2016-07-13 Wave Life Sciences Japan, Inc. Novel protecting group for synthesizing rna and derivative thereof
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis

Also Published As

Publication number Publication date
JP2015524820A (ja) 2015-08-27
AU2013296508A1 (en) 2015-02-19
CN104812770A (zh) 2015-07-29
CA2880496C (en) 2023-10-17
US9493773B2 (en) 2016-11-15
JP6799918B2 (ja) 2020-12-16
WO2014022566A2 (en) 2014-02-06
EP2882769A2 (en) 2015-06-17
CN108659081A (zh) 2018-10-16
SG11201500614XA (en) 2015-02-27
US20140039175A1 (en) 2014-02-06
CA2880496A1 (en) 2014-02-06
US8859754B2 (en) 2014-10-14
MX2015001310A (es) 2016-02-03
WO2014022566A3 (en) 2014-03-20
AU2013296508B2 (en) 2017-08-31
CN104812770B (zh) 2018-02-16
US20150119565A1 (en) 2015-04-30
IL236902B (en) 2019-02-28

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