MX363110B - Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos. - Google Patents
Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos.Info
- Publication number
- MX363110B MX363110B MX2015001310A MX2015001310A MX363110B MX 363110 B MX363110 B MX 363110B MX 2015001310 A MX2015001310 A MX 2015001310A MX 2015001310 A MX2015001310 A MX 2015001310A MX 363110 B MX363110 B MX 363110B
- Authority
- MX
- Mexico
- Prior art keywords
- deuterated
- synthesis
- oligonucleotides
- nucleosides
- protected phosphoramidites
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3531—Hydrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a la síntesis de azúcares deuterados de alta pureza, fosforamiditas deuteradas, nucleobases deuteradas, nucleósidos deuterados, oligonucleótidos deuterados, y ARNs deuterados de secuencias definidas que pueden exhibir propiedades bioquímicamente útiles y biológicamente valiosas, teniendo de esta manera potencial para usos terapéuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/563,343 US8859754B2 (en) | 2012-07-31 | 2012-07-31 | Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides |
PCT/US2013/053035 WO2014022566A2 (en) | 2012-07-31 | 2013-07-31 | Synthesis of deuterated ribo nucleosides, n-protected phosphoramidites, and oligonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015001310A MX2015001310A (es) | 2016-02-03 |
MX363110B true MX363110B (es) | 2019-03-08 |
Family
ID=49326829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015001310A MX363110B (es) | 2012-07-31 | 2013-07-31 | Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US8859754B2 (es) |
EP (1) | EP2882769A2 (es) |
JP (1) | JP6799918B2 (es) |
CN (2) | CN104812770B (es) |
AU (1) | AU2013296508B2 (es) |
CA (1) | CA2880496C (es) |
IL (1) | IL236902B (es) |
MX (1) | MX363110B (es) |
SG (1) | SG11201500614XA (es) |
WO (1) | WO2014022566A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017532982A (ja) * | 2014-10-17 | 2017-11-09 | セルジーン アルパイン インベストメント カンパニー Ii, エルエルシー | Smad7アンチセンスオリゴヌクレオチドの同位体置換体 |
WO2016073756A1 (en) * | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Deuterated nucleoside/tide derivatives |
US9732110B2 (en) | 2014-12-05 | 2017-08-15 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
US9430443B1 (en) * | 2015-05-08 | 2016-08-30 | Norwegian University Of Science And Technology | Systematic coding technique |
KR20230175313A (ko) | 2016-07-05 | 2023-12-29 | 바이오마린 테크놀로지스 비.브이. | 유전적 장애 치료를 위한, 특징이 개선된, 비사이클릭 스캐폴드 모이어티를 포함하는 프리-mrna 스플라이스 스위칭 또는 조정 올리고뉴클레오티드 |
WO2019158583A1 (en) | 2018-02-13 | 2019-08-22 | Ethris Gmbh | Polyribonucleotide containing deuterated nucleotides |
CN109134570B (zh) * | 2018-09-20 | 2021-08-24 | 南开大学 | C4′-氟代尿苷亚磷酰胺单体和c4′-氟代尿苷修饰rna的制备方法 |
CA3118167A1 (en) | 2018-11-02 | 2020-05-07 | Biomarin Technologies B.V. | Bispecific antisense oligonucleotides for dystrophin exon skipping |
CN115894458A (zh) * | 2022-08-31 | 2023-04-04 | 合肥华纳生物医药科技有限公司 | 一种新型修饰核苷及其在核酸药物中的应用 |
GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
WO2024110565A1 (en) | 2022-11-24 | 2024-05-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of hereditary hfe-hemochromatosis |
GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
WO2024121373A1 (en) | 2022-12-09 | 2024-06-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of cardiovascular disease |
GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
WO2024175550A1 (en) | 2023-02-20 | 2024-08-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
WO2024206175A1 (en) | 2023-03-24 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
WO2024200472A1 (en) | 2023-03-27 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2872377T3 (es) * | 2008-05-26 | 2021-11-02 | Univ Zuerich | Nanopartículas de protamina/ARN para inmunoestimulación |
WO2011034072A1 (ja) * | 2009-09-16 | 2011-03-24 | 株式会社キラルジェン | Rna及びその誘導体合成のための新規保護基 |
US20120184724A1 (en) * | 2009-09-22 | 2012-07-19 | Agilent Technologies, Inc. | Protected monomers and methods of deprotection for rna synthesis |
-
2012
- 2012-07-31 US US13/563,343 patent/US8859754B2/en active Active
-
2013
- 2013-07-31 EP EP13774532.9A patent/EP2882769A2/en not_active Withdrawn
- 2013-07-31 CA CA2880496A patent/CA2880496C/en active Active
- 2013-07-31 JP JP2015525560A patent/JP6799918B2/ja active Active
- 2013-07-31 WO PCT/US2013/053035 patent/WO2014022566A2/en active Application Filing
- 2013-07-31 CN CN201380042886.XA patent/CN104812770B/zh active Active
- 2013-07-31 MX MX2015001310A patent/MX363110B/es unknown
- 2013-07-31 SG SG11201500614XA patent/SG11201500614XA/en unknown
- 2013-07-31 CN CN201810056471.2A patent/CN108659081A/zh active Pending
- 2013-07-31 AU AU2013296508A patent/AU2013296508B2/en active Active
-
2014
- 2014-10-10 US US14/511,775 patent/US9493773B2/en active Active
-
2015
- 2015-01-25 IL IL236902A patent/IL236902B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU2013296508B2 (en) | 2017-08-31 |
JP2015524820A (ja) | 2015-08-27 |
SG11201500614XA (en) | 2015-02-27 |
US20150119565A1 (en) | 2015-04-30 |
US9493773B2 (en) | 2016-11-15 |
EP2882769A2 (en) | 2015-06-17 |
IL236902B (en) | 2019-02-28 |
WO2014022566A2 (en) | 2014-02-06 |
CN104812770B (zh) | 2018-02-16 |
MX2015001310A (es) | 2016-02-03 |
US20140039175A1 (en) | 2014-02-06 |
CA2880496A1 (en) | 2014-02-06 |
AU2013296508A1 (en) | 2015-02-19 |
JP6799918B2 (ja) | 2020-12-16 |
CA2880496C (en) | 2023-10-17 |
WO2014022566A3 (en) | 2014-03-20 |
US8859754B2 (en) | 2014-10-14 |
CN108659081A (zh) | 2018-10-16 |
CN104812770A (zh) | 2015-07-29 |
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