EA201190178A1 - Замещённые нуклеозидные и нуклеотидные аналоги - Google Patents

Замещённые нуклеозидные и нуклеотидные аналоги

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Publication number
EA201190178A1
EA201190178A1 EA201190178A EA201190178A EA201190178A1 EA 201190178 A1 EA201190178 A1 EA 201190178A1 EA 201190178 A EA201190178 A EA 201190178A EA 201190178 A EA201190178 A EA 201190178A EA 201190178 A1 EA201190178 A1 EA 201190178A1
Authority
EA
Eurasian Patent Office
Prior art keywords
analogues
nucleotic
nucleoside
replaced
nucleotide analogues
Prior art date
Application number
EA201190178A
Other languages
English (en)
Inventor
Леонид Бейгельман
Лоуренс Блатт
Гуани Ван
Original Assignee
Алиос Биофарма, Инк.
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Publication date
Application filed by Алиос Биофарма, Инк. filed Critical Алиос Биофарма, Инк.
Publication of EA201190178A1 publication Critical patent/EA201190178A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Pulmonology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Представлены нуклеотидные аналоги с защищенными фосфатами, способы синтеза нуклеотидных аналогов с защищенными фосфатами и способы лечения заболеваний и/или состояний, таких как вирусные инфекции, рак и/или паразитарные инфекции с помощью нуклеотидных аналогов с защищенными фосфатами.
EA201190178A 2009-03-20 2010-03-19 Замещённые нуклеозидные и нуклеотидные аналоги EA201190178A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16219809P 2009-03-20 2009-03-20
US22481509P 2009-07-10 2009-07-10
US23416909P 2009-08-14 2009-08-14
PCT/US2010/028046 WO2010108140A1 (en) 2009-03-20 2010-03-19 Substituted nucleoside and nucleotide analogs

Publications (1)

Publication Number Publication Date
EA201190178A1 true EA201190178A1 (ru) 2012-06-29

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ID=42740025

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EA201190178A EA201190178A1 (ru) 2009-03-20 2010-03-19 Замещённые нуклеозидные и нуклеотидные аналоги

Country Status (16)

Country Link
US (1) US20100249068A1 (ru)
EP (2) EP2623104A1 (ru)
JP (1) JP2012521359A (ru)
KR (1) KR20110128947A (ru)
CN (1) CN102421293A (ru)
AP (1) AP2011005929A0 (ru)
AU (1) AU2010226466A1 (ru)
BR (1) BRPI1009324A2 (ru)
CA (1) CA2755642A1 (ru)
CL (1) CL2011002286A1 (ru)
EA (1) EA201190178A1 (ru)
IL (1) IL215156A0 (ru)
MX (1) MX2011009728A (ru)
SG (1) SG174364A1 (ru)
WO (1) WO2010108140A1 (ru)
ZA (1) ZA201106827B (ru)

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KR20110128947A (ko) 2011-11-30
CL2011002286A1 (es) 2012-02-17
AU2010226466A1 (en) 2011-10-20
EP2408306A1 (en) 2012-01-25
EP2408306A4 (en) 2012-11-07
CN102421293A (zh) 2012-04-18
MX2011009728A (es) 2011-10-14
IL215156A0 (en) 2011-12-29
JP2012521359A (ja) 2012-09-13
SG174364A1 (en) 2011-10-28

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