MX360554B - Composiciones que comprenden y metodos que utilizan inhibidores de co-transportadores de glucosa-sodio 1 y 2. - Google Patents
Composiciones que comprenden y metodos que utilizan inhibidores de co-transportadores de glucosa-sodio 1 y 2.Info
- Publication number
- MX360554B MX360554B MX2013007826A MX2013007826A MX360554B MX 360554 B MX360554 B MX 360554B MX 2013007826 A MX2013007826 A MX 2013007826A MX 2013007826 A MX2013007826 A MX 2013007826A MX 360554 B MX360554 B MX 360554B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- inhibitors
- compositions
- sodium
- glucose cotransporters
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000000070 Sodium-Glucose Transport Proteins Human genes 0.000 title 1
- 108010080361 Sodium-Glucose Transport Proteins Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000036996 cardiovascular health Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010034 metabolic health Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Formas de dosis farmacéuticas útiles para mejorar la salud cardiovascular y/o metabólica de pacientes, particularmente aquellos que sufren de diabetes tipo 2, se describen así como métodos para su fabricación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161430027P | 2011-01-05 | 2011-01-05 | |
PCT/US2012/020042 WO2012094293A1 (en) | 2011-01-05 | 2012-01-03 | Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013007826A MX2013007826A (es) | 2013-09-06 |
MX360554B true MX360554B (es) | 2018-11-07 |
Family
ID=45507917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007826A MX360554B (es) | 2011-01-05 | 2012-01-03 | Composiciones que comprenden y metodos que utilizan inhibidores de co-transportadores de glucosa-sodio 1 y 2. |
Country Status (22)
Country | Link |
---|---|
US (6) | US20120172320A1 (es) |
EP (1) | EP2661256B1 (es) |
JP (3) | JP2014501780A (es) |
KR (1) | KR102024204B1 (es) |
CN (1) | CN103458875A (es) |
AR (1) | AR084781A1 (es) |
AU (1) | AU2012204567B9 (es) |
BR (1) | BR112013017314B1 (es) |
CA (1) | CA2823736C (es) |
DK (1) | DK2661256T3 (es) |
ES (1) | ES2710341T3 (es) |
HU (1) | HUE041364T2 (es) |
IL (1) | IL295438A (es) |
MX (1) | MX360554B (es) |
PL (1) | PL2661256T3 (es) |
PT (1) | PT2661256T (es) |
RU (1) | RU2669921C2 (es) |
SG (2) | SG191865A1 (es) |
TR (1) | TR201901262T4 (es) |
TW (1) | TWI631963B (es) |
WO (1) | WO2012094293A1 (es) |
ZA (1) | ZA201304694B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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HUE043868T2 (hu) * | 2012-11-20 | 2019-09-30 | Lexicon Pharmaceuticals Inc | Nátrium-glükóz kotranszporter 1 inhibitorai |
US10626135B2 (en) | 2016-05-25 | 2020-04-21 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal forms of sodium-glucose co-transporter inhibitor, processes for preparation and use thereof |
US11723929B2 (en) | 2017-06-13 | 2023-08-15 | The Regents Of The University Of California | Methods of improving cell-based therapy |
CN107540685B (zh) * | 2017-09-04 | 2020-05-05 | 杭州科巢生物科技有限公司 | 一种Sotagliflozin的制备方法及其中间体 |
EP3456320A1 (de) * | 2017-09-15 | 2019-03-20 | Stada Arzneimittel Ag | Dpp-4-inhibitor-mono-zusammensetzung |
CN111372930B (zh) | 2018-01-05 | 2021-08-10 | 山东丹红制药有限公司 | 一种SGLTs抑制剂及其应用 |
CN110117304A (zh) * | 2018-04-23 | 2019-08-13 | 中国科学院成都生物研究所 | 一种钠-葡萄糖协同转运蛋白1和2抑制剂的药物用途 |
CN110818722B (zh) * | 2018-08-14 | 2022-12-02 | 苏州鹏旭医药科技有限公司 | 三种化合物及其制备方法和在合成索格列净中的用途 |
WO2021004388A1 (zh) | 2019-07-05 | 2021-01-14 | 山东丹红制药有限公司 | 一种SGLTs抑制剂的晶型及其应用 |
EP4005568B1 (en) | 2019-07-26 | 2024-07-10 | Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. | Sglts/dpp4 inhibitor and application thereof |
CA3156136A1 (en) * | 2019-11-07 | 2021-05-14 | Michael Hadd | Sodium-glucose linked transporter inhibitors for the management of chronic kidney disease, hypertension, and heart failure in companion animals |
WO2022144465A1 (en) | 2021-01-04 | 2022-07-07 | Charité-Universitätsmedizin Berlin | Sotagliflozin for improving left atrial function |
WO2022155303A1 (en) | 2021-01-14 | 2022-07-21 | Lexicon Pharmaceuticals, Inc. | Sotagliflozin for treating or preventing cardiovascular diseases |
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