MX2009003542A - Metodos y composiciones con opalescencia reducida. - Google Patents
Metodos y composiciones con opalescencia reducida.Info
- Publication number
- MX2009003542A MX2009003542A MX2009003542A MX2009003542A MX2009003542A MX 2009003542 A MX2009003542 A MX 2009003542A MX 2009003542 A MX2009003542 A MX 2009003542A MX 2009003542 A MX2009003542 A MX 2009003542A MX 2009003542 A MX2009003542 A MX 2009003542A
- Authority
- MX
- Mexico
- Prior art keywords
- ionic strength
- aggregates
- antibody
- modification
- solutions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se describen métodos para reducir la apariencia opalescente de una preparación proteínica que modifica la fuerza iónica de la preparación, así como composiciones, por ejemplo, composiciones farmacéuticas, de una proteína concentrada con una opalescencia disminuida. También se describen métodos de purificación que monitorizan y/o reducen las concentraciones de sal durante las etapas seleccionadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85165106P | 2006-10-12 | 2006-10-12 | |
PCT/US2007/021904 WO2008045563A2 (en) | 2006-10-12 | 2007-10-12 | Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003542A true MX2009003542A (es) | 2009-04-15 |
Family
ID=39205011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003542A MX2009003542A (es) | 2006-10-12 | 2007-10-12 | Metodos y composiciones con opalescencia reducida. |
Country Status (12)
Country | Link |
---|---|
US (1) | US7744890B2 (es) |
EP (1) | EP2076287A2 (es) |
JP (1) | JP2010506839A (es) |
KR (1) | KR20090069330A (es) |
CN (1) | CN101522219A (es) |
AU (1) | AU2007308145A1 (es) |
BR (1) | BRPI0719250A2 (es) |
CA (1) | CA2665423A1 (es) |
IL (1) | IL197778A0 (es) |
MX (1) | MX2009003542A (es) |
RU (1) | RU2009111138A (es) |
WO (1) | WO2008045563A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009003542A (es) | 2006-10-12 | 2009-04-15 | Wyeth Corp | Metodos y composiciones con opalescencia reducida. |
EP2020240A1 (en) * | 2007-07-30 | 2009-02-04 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Methods and substances for the treatment of Alzheimer's |
KR20110039218A (ko) | 2008-06-30 | 2011-04-15 | 노보 노르디스크 에이/에스 | 항-인간 인터루킨-20 항체 |
CN102395597A (zh) * | 2009-03-11 | 2012-03-28 | 惠氏有限责任公司 | 纯化小模块免疫药物蛋白的方法 |
US8454956B2 (en) | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
US20130004976A1 (en) * | 2009-12-25 | 2013-01-03 | Sekisui Medical Co., Ltd. | Human insulin assay and assay reagent |
SI3409289T1 (sl) | 2010-02-26 | 2020-12-31 | Novo Nordisk A/S | Stabilni sestavki, ki vsebujejo protitelo |
SG10201502587SA (en) | 2010-03-01 | 2015-06-29 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
US9221904B2 (en) | 2012-07-19 | 2015-12-29 | National Cheng Kung University | Treatment of osteoarthritis using IL-20 antagonists |
US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
TWI650125B (zh) * | 2016-05-19 | 2019-02-11 | 長弘生物科技股份有限公司 | 用於延緩肺纖維化之發病及/或治療肺纖維化之藥劑 |
ES2974961T3 (es) | 2016-08-18 | 2024-07-02 | Regeneron Pharma | Ensayo para determinar la capacidad de autoasociación de una proteína usando espectroscopía de autointeracción de nanopartículas dependiente de la concentración |
CN107236038B (zh) * | 2017-06-20 | 2020-11-27 | 华兰生物工程股份有限公司 | 微晶纤维素提高蛋白质澄清度的方法及其产品和应用 |
JP7233980B2 (ja) * | 2019-03-08 | 2023-03-07 | キオクシア株式会社 | 粒子計測方法及び検出液 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704362A (en) * | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) * | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) * | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4396608A (en) * | 1981-08-24 | 1983-08-02 | Cutter Laboratories | Intravenously injectable immune serum globulin |
US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4510245A (en) * | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
US4968615A (en) * | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB8628104D0 (en) * | 1986-11-25 | 1986-12-31 | Connaught Lab | Pasteurization of immunoglobin solutions |
EP0832981A1 (en) * | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
WO1989007947A1 (en) | 1988-03-04 | 1989-09-08 | Cancer Research Campaign Technology Limited | Improvements relating to antigens |
EP1892296A1 (en) | 1988-09-02 | 2008-02-27 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5549892A (en) * | 1988-12-23 | 1996-08-27 | Genzyme Corporation | Enhanced in vivo uptake of glucocerebrosidase |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
JPH0396383A (ja) | 1989-09-08 | 1991-04-22 | Riso Kagaku Corp | 画像形成装置 |
DK0939121T4 (da) | 1989-09-12 | 2008-02-04 | Ahp Mfg B V | TNF-bindende proteiner |
US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ATE185601T1 (de) | 1990-07-10 | 1999-10-15 | Cambridge Antibody Tech | Verfahren zur herstellung von spezifischen bindungspaargliedern |
GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
DK1279731T3 (da) | 1991-03-01 | 2007-09-24 | Dyax Corp | Fremgangsmåde til udvikling af bindende miniproteiner |
DE69233367T2 (de) | 1991-04-10 | 2005-05-25 | The Scripps Research Institute, La Jolla | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
DE122004000008I1 (de) * | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
US6607884B1 (en) * | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
JPH09502089A (ja) * | 1993-08-27 | 1997-03-04 | ダナ−ファーバー キャンサー インスティチュート インコーポレイテッド | ナチュラルキラー細胞特異性抗原およびこの抗原を識別する抗体 |
US5827690A (en) * | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5516964A (en) * | 1994-01-21 | 1996-05-14 | Sun Company, Inc. (R&M) | Hydrocarbon isomerization using solid superacid catalysts comprising platinum metal |
ES2304786T3 (es) | 1995-04-27 | 2008-10-16 | Amgen Fremont Inc. | Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados. |
WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
PT859841E (pt) * | 1995-08-18 | 2002-11-29 | Morphosys Ag | Bibliotecas de proteinas/ (poli) peptidos |
GB9524973D0 (en) * | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
WO1998024893A2 (en) * | 1996-12-03 | 1998-06-11 | Abgenix, Inc. | TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM |
EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
JP2002507117A (ja) * | 1997-06-04 | 2002-03-05 | オックスフォード・バイオメディカ・(ユーケイ)・リミテッド | ベクター |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
EP0917879B1 (de) * | 1997-11-22 | 2002-07-17 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Stabilisierung von Proteinen |
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7198789B2 (en) * | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
ES2421736T3 (es) * | 1998-06-09 | 2013-09-05 | Csl Behring Ag | Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos |
GB2347932B (en) | 1998-11-18 | 2003-05-07 | Oxford Biomedica Ltd | Vectors for the delivery of 5T4 antigen |
JP2002534959A (ja) | 1998-12-08 | 2002-10-22 | バイオベーション リミテッド | 免疫原性タンパク質の改変方法 |
US6939545B2 (en) * | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
US7307161B1 (en) * | 1999-04-28 | 2007-12-11 | Genetics Institute, Llc | Human Gil-19/AE289 polynucleotides |
CA2391925A1 (en) | 1999-11-18 | 2001-05-25 | Oxford Biomedica (Uk) Limited | Antibodies |
ATE279442T1 (de) | 2000-02-24 | 2004-10-15 | Univ St Louis | Humanisierte antikörper, die amyloid beta peptid sequestrieren |
PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US7638604B2 (en) * | 2001-02-23 | 2009-12-29 | Genetics Institute, Llc | Monoclonal antibodies against interleukin-22 |
ES2437875T3 (es) | 2001-04-30 | 2014-01-14 | Eli Lilly And Company | Anticuerpos humanizados que reconocen el péptido beta-amiloide |
ATE409047T1 (de) | 2001-04-30 | 2008-10-15 | Lilly Co Eli | Humanisierte antikörper |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
BRPI0309868B8 (pt) * | 2002-05-02 | 2021-05-25 | Wyeth Corp | métodos de preparação de uma composição de reduzida fração conjugada inferior |
GB0215287D0 (en) * | 2002-07-02 | 2002-08-14 | Oxford Biomedica Ltd | 5T4 antigen expression |
US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
BRPI0403964B8 (pt) * | 2003-04-04 | 2021-05-25 | Genentech Inc | formulações líquidas estáveis, artigo manufaturado e uso dessas formulações para o tratamento de disfunção mediada por ige |
PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
US7501121B2 (en) * | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
SV2007002227A (es) * | 2004-09-10 | 2007-03-20 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637 |
MX2009003542A (es) | 2006-10-12 | 2009-04-15 | Wyeth Corp | Metodos y composiciones con opalescencia reducida. |
-
2007
- 2007-10-12 MX MX2009003542A patent/MX2009003542A/es not_active Application Discontinuation
- 2007-10-12 AU AU2007308145A patent/AU2007308145A1/en not_active Abandoned
- 2007-10-12 EP EP07852729A patent/EP2076287A2/en not_active Withdrawn
- 2007-10-12 JP JP2009532451A patent/JP2010506839A/ja active Pending
- 2007-10-12 CN CNA2007800368948A patent/CN101522219A/zh active Pending
- 2007-10-12 CA CA002665423A patent/CA2665423A1/en not_active Abandoned
- 2007-10-12 RU RU2009111138/15A patent/RU2009111138A/ru not_active Application Discontinuation
- 2007-10-12 KR KR1020097009757A patent/KR20090069330A/ko not_active Application Discontinuation
- 2007-10-12 BR BRPI0719250-9A patent/BRPI0719250A2/pt not_active IP Right Cessation
- 2007-10-12 WO PCT/US2007/021904 patent/WO2008045563A2/en active Application Filing
- 2007-10-12 US US11/974,312 patent/US7744890B2/en not_active Expired - Fee Related
-
2009
- 2009-03-24 IL IL197778A patent/IL197778A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008045563A9 (en) | 2008-08-14 |
RU2009111138A (ru) | 2010-11-20 |
BRPI0719250A2 (pt) | 2015-06-16 |
US20080154023A1 (en) | 2008-06-26 |
CA2665423A1 (en) | 2008-04-17 |
EP2076287A2 (en) | 2009-07-08 |
AU2007308145A1 (en) | 2008-04-17 |
WO2008045563A3 (en) | 2008-06-19 |
WO2008045563A2 (en) | 2008-04-17 |
KR20090069330A (ko) | 2009-06-30 |
CN101522219A (zh) | 2009-09-02 |
IL197778A0 (en) | 2011-08-01 |
JP2010506839A (ja) | 2010-03-04 |
US7744890B2 (en) | 2010-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |