KR830009106A - 퓨로-(3,4-C)-피리딘[Furo-3,4-C)-Pyridine] 유도체의 제조방법 - Google Patents

퓨로-(3,4-C)-피리딘[Furo-3,4-C)-Pyridine] 유도체의 제조방법 Download PDF

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Publication number
KR830009106A
KR830009106A KR1019820000536A KR820000536A KR830009106A KR 830009106 A KR830009106 A KR 830009106A KR 1019820000536 A KR1019820000536 A KR 1019820000536A KR 820000536 A KR820000536 A KR 820000536A KR 830009106 A KR830009106 A KR 830009106A
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KR
South Korea
Prior art keywords
carbon atoms
group
alkoxy groups
pyridine
isopropylidene
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Application number
KR1019820000536A
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English (en)
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KR870000206B1 (ko
Inventor
에싸뉘 앙드레
Original Assignee
알베르 보프르
쏘씨에떼 드 꽁쎄이 드 르세르슈에 다쁠리까씨용 싸이엔-띠피끄 쏘씨에떼 아노님
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Application filed by 알베르 보프르, 쏘씨에떼 드 꽁쎄이 드 르세르슈에 다쁠리까씨용 싸이엔-띠피끄 쏘씨에떼 아노님 filed Critical 알베르 보프르
Publication of KR830009106A publication Critical patent/KR830009106A/ko
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Publication of KR870000206B1 publication Critical patent/KR870000206B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

내용 없음

Description

퓨로-(3,4-C)-피리딘[Furo-3,4-C]-Pyridine] 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. α4, -3-0-이소프로필리덴-피리독살과 일반식 X-A-R의 화합물을 디에틸에테르 내의 마그네슘존재하에 환류시켜서, 생성된 상응하는 2차 알콜α4, 3-0-이소프로필리덴-α-하이드록시 0-5-치환-피리독신을 산성화하여 이소프로필리덴 환을 끊은후, 3,4-환화(環化)를 촉진시키는 것으로 구성된 하기일반식(1)의 1,3-디하이드로-6-메틸-7-하이드록시-퓨로-(3,4-C)-피리딘 유도체를 제조하는 방법.
    식중,
    A < 는 일반식-(CH2)n-(n은 1에서 5사이의 정수)의 기(基)이거나 단원소 혹은 복원소환기를 뜻하며
    R은 수소, 염소 또는 불소원자, 트리플루오로메틸기, 1 내지 5탄소원자를 가진 알킬기 ｜ 1 내지 5탄소원자를 가진 알콕시기, 1 내지 5탄소원자를 가진 티오알킬기, 1 내지 5탄소원자의 알킬기와 1 내지 5탄소원자의 알콕시기로 된 디알킬아미노 알콕시기 혹은 1 내지 5탄소원자의 알콕시기로 된 N-피롤리디닐-알콕시기를 나타내며
    X는 브롬 혹은 요오드 원자를 뜻한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8200536A 1981-02-10 1982-02-09 퓨로-(3,4-c)-피리딘 유도체의 제조방법 KR870000206B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB04072/81 1981-02-10
GB8104072 1981-02-10

Publications (2)

Publication Number Publication Date
KR830009106A true KR830009106A (ko) 1983-12-17
KR870000206B1 KR870000206B1 (ko) 1987-02-16

Family

ID=10519587

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8200536A KR870000206B1 (ko) 1981-02-10 1982-02-09 퓨로-(3,4-c)-피리딘 유도체의 제조방법

Country Status (34)

Country Link
US (1) US4383998A (ko)
JP (1) JPS57150688A (ko)
KR (1) KR870000206B1 (ko)
AR (1) AR230284A1 (ko)
AU (1) AU545876B2 (ko)
BE (1) BE891797A (ko)
CA (1) CA1175837A (ko)
CH (1) CH649554A5 (ko)
DE (1) DE3204596A1 (ko)
DK (1) DK157551C (ko)
DZ (1) DZ376A1 (ko)
ES (1) ES509449A0 (ko)
FI (1) FI75347C (ko)
FR (2) FR2499406A1 (ko)
GB (1) GB2092586B (ko)
GR (1) GR75905B (ko)
HK (1) HK22485A (ko)
HU (1) HU185088B (ko)
IE (1) IE52376B1 (ko)
IL (1) IL64759A (ko)
IN (1) IN156817B (ko)
IT (1) IT1157252B (ko)
LU (1) LU83886A1 (ko)
MA (1) MA19378A1 (ko)
MX (1) MX6983E (ko)
NL (1) NL186697C (ko)
NO (1) NO156373C (ko)
NZ (1) NZ199528A (ko)
OA (1) OA07003A (ko)
PT (1) PT74408B (ko)
SE (1) SE456994B (ko)
SG (1) SG85384G (ko)
YU (1) YU44000B (ko)
ZA (1) ZA82158B (ko)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735950A (en) * 1983-04-05 1988-04-05 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same
IN160104B (ko) * 1983-04-05 1987-06-27 Scras
GB8327817D0 (en) * 1983-10-18 1983-11-16 Scras 4-halo-furo-(3 4-c)-pyridine derivatives
GB8330517D0 (en) * 1983-11-16 1983-12-21 Scras 6-vinyl-furo-(3,4-c)pyridine derivatives
GB8330658D0 (en) * 1983-11-17 1983-12-29 Scras 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives
GB8402740D0 (en) * 1984-02-02 1984-03-07 Scras Furo-(3 4-c)-pyridine derivatives
GB8414559D0 (en) * 1984-06-07 1984-07-11 Scras Pyridine derivatives
GB8422379D0 (en) * 1984-09-05 1984-10-10 Scras Derivatives
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
DE3519693A1 (de) * 1985-06-01 1987-01-02 Basf Ag Pyridin-derivate, ihre herstellung und verwendung
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
GB8907480D0 (en) * 1989-04-03 1989-05-17 Scaras Societe De Conseils De Separation of insomers of furo(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
GB0221494D0 (en) * 2002-09-16 2002-10-23 Generics Uk Ltd Novel processes for the preparation of 1.3-dihydro-6-methylfuro (3,4-c) pyndin derivatives
HUP0300990A2 (hu) * 2003-04-15 2005-05-30 SynoSens Kutató és Fejlesztő Kft. Szinergista gyógyszer-kombináció a diabetesz megelőzésére vagy kezelésére
WO2005009446A1 (en) * 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
US20060089374A1 (en) * 2003-07-17 2006-04-27 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
WO2006034510A2 (en) * 2004-09-22 2006-03-30 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US20060153934A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and magnesium
US20060154959A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and carvedilol
US20070141174A1 (en) * 2005-01-13 2007-06-21 Navitas Pharma, Inc. Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
US20070105817A1 (en) * 2005-11-09 2007-05-10 Jim Page Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
JP2010514841A (ja) * 2007-01-03 2010-05-06 グレン ブイ． コルネット， 肺疾患および心疾患の処置におけるシクレタニンおよびｐｋｃ阻害剤
AR073259A1 (es) * 2008-07-29 2010-10-28 Merck & Co Inc Derivados de furosemida utiles como diureticos
US8214941B2 (en) 2008-10-02 2012-07-10 Kohler Co. Slip-fit clamping system for mounting a fitting on a wall
EP2485734B1 (en) * 2009-10-09 2014-07-02 Merck Sharp & Dohme Corp. Diuretics
US8354394B2 (en) 2009-10-29 2013-01-15 Merck Sharp & Dohme Corp. Diuretics
US9522138B2 (en) * 2013-12-31 2016-12-20 Don C. Rockey Systems, methods, techniques, and compounds in research and treatment of portal hypertension and other conditions

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ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use

Also Published As

Publication number Publication date
PT74408B (en) 1983-07-07
JPH0261477B2 (ko) 1990-12-20
JPS57150688A (en) 1982-09-17
LU83886A1 (fr) 1982-06-30
NO156373B (no) 1987-06-01
FI75347B (fi) 1988-02-29
IL64759A0 (en) 1982-03-31
IE820288L (en) 1982-08-10
FI75347C (fi) 1988-06-09
FR2499574A1 (fr) 1982-08-13
US4383998A (en) 1983-05-17
FR2499574B1 (ko) 1984-03-30
BE891797A (fr) 1982-04-30
SE8200744L (sv) 1982-08-11
DK157551C (da) 1990-06-11
PT74408A (en) 1982-03-01
DK157551B (da) 1990-01-22
SG85384G (en) 1985-06-07
DE3204596C2 (ko) 1991-07-04
YU44000B (en) 1990-02-28
NO820253L (no) 1982-08-11
GR75905B (ko) 1984-08-02
ES8302714A1 (es) 1983-01-16
NZ199528A (en) 1984-02-03
OA07003A (fr) 1983-08-31
IE52376B1 (en) 1987-09-30
FR2499406A1 (fr) 1982-08-13
FR2499406B1 (ko) 1984-03-30
AR230284A1 (es) 1984-03-01
KR870000206B1 (ko) 1987-02-16
CA1175837A (en) 1984-10-09
SE456994B (sv) 1988-11-21
ZA82158B (en) 1982-11-24
IL64759A (en) 1985-09-29
DE3204596A1 (de) 1982-09-09
AU8029482A (en) 1982-08-19
DK54382A (da) 1982-08-11
NL186697B (nl) 1990-09-03
GB2092586A (en) 1982-08-18
IT1157252B (it) 1987-02-11
FI820353L (fi) 1982-08-11
HU185088B (en) 1984-11-28
CH649554A5 (fr) 1985-05-31
DZ376A1 (fr) 2004-09-13
ES509449A0 (es) 1983-01-16
YU25382A (en) 1984-08-31
NL186697C (nl) 1991-02-01
NO156373C (no) 1987-09-09
IN156817B (ko) 1985-11-09
HK22485A (en) 1985-03-29
AU545876B2 (en) 1985-08-01
GB2092586B (en) 1984-09-26
IT8219502A0 (it) 1982-02-08
NL8200180A (nl) 1982-09-01
MX6983E (es) 1987-01-19
MA19378A1 (fr) 1982-10-01

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