JPS5721375A - 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation - Google Patents

2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation

Info

Publication number
JPS5721375A
JPS5721375A JP9609280A JP9609280A JPS5721375A JP S5721375 A JPS5721375 A JP S5721375A JP 9609280 A JP9609280 A JP 9609280A JP 9609280 A JP9609280 A JP 9609280A JP S5721375 A JPS5721375 A JP S5721375A
Authority
JP
Japan
Prior art keywords
formula
tert
butyl
compound
heterocyclic substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9609280A
Other languages
Japanese (ja)
Inventor
Kazuo Kubo
Tokuki Ito
Yasuo Isomura
Shuichi Sakamoto
Hiroshige Honma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP9609280A priority Critical patent/JPS5721375A/en
Publication of JPS5721375A publication Critical patent/JPS5721375A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative of formula I (ring A is benzene ring or pyridine ring; R is H or lower alkanoyl; R1, R2 and R3 are H, halogen, nitro, amino, hydroxyl group, lower alkyl, lower alkoxyl or mono- or di-lower alkylamino; X is O, S or formula II; R4 is H or lower alkyl) or a salt thereof.
EXAMPLE: 2-(3,5-Di-tert-butyl-4-hydroxyphenyl)benzoxazole.
USE: Useful as a medicine having anti-inflammatory, analgesic and antipyretic, antarthritic and regulating action on immunological functions, and orally administrable.
PROCESS: A compound of formula III is reacted with a compound of formula IV (Y is H or halogen) in an organic solvent at room temperature or under heating to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP9609280A 1980-07-14 1980-07-14 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation Pending JPS5721375A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9609280A JPS5721375A (en) 1980-07-14 1980-07-14 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9609280A JPS5721375A (en) 1980-07-14 1980-07-14 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5721375A true JPS5721375A (en) 1982-02-04

Family

ID=14155748

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9609280A Pending JPS5721375A (en) 1980-07-14 1980-07-14 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5721375A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582837A (en) * 1982-07-01 1986-04-15 Dr. Karl Thomae Gmbh Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic activity
US4808620A (en) * 1986-07-22 1989-02-28 Yoshitomi Pharmaceutical Industries, Ltd. Pyrazolopyridine compounds, their preparation and use as platelet aggregation inhibitors
WO1995006469A1 (en) * 1993-08-28 1995-03-09 Cancer Research Campaign Technology Limited Benzazole compounds for use in therapy
WO1996011917A1 (en) * 1994-10-12 1996-04-25 Euro-Celtique, S.A. Novel benzoxazoles
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5874431A (en) * 1993-08-28 1999-02-23 Cancer Research Campaign Technology Limited Benzazole compounds
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582837A (en) * 1982-07-01 1986-04-15 Dr. Karl Thomae Gmbh Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic activity
US4808620A (en) * 1986-07-22 1989-02-28 Yoshitomi Pharmaceutical Industries, Ltd. Pyrazolopyridine compounds, their preparation and use as platelet aggregation inhibitors
WO1995006469A1 (en) * 1993-08-28 1995-03-09 Cancer Research Campaign Technology Limited Benzazole compounds for use in therapy
US5874431A (en) * 1993-08-28 1999-02-23 Cancer Research Campaign Technology Limited Benzazole compounds
WO1996011917A1 (en) * 1994-10-12 1996-04-25 Euro-Celtique, S.A. Novel benzoxazoles
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"

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